5/14/2025
Last update
5/14/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 26 Researches
8.5
USERS' SCORE
Good
Based on 5 Reviews
8
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
9
We examined how Eicosapentaenoic acid (EPA) could protect against ulcerative colitis (UC), a chronic condition that inflames the large intestine. In our research, we used acetic acid to induce UC in rats, administering oral EPA for 28 days in doses of 300 and 1000 mg/kg before the acetic acid treatment.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
9
In our investigation, we focused on the effects of eicosapentaenoic acid (EPA) on ulcerative colitis (UC), a chronic condition characterized by inflammation in the colon. We conducted experiments using mice with dextran sodium sulfate (DSS)-induced colitis to understand how EPA might improve this condition compared to docosahexaenoic acid (DHA).
What we found was quite striking. Mice treated with high doses of EPA showed a significantly reduced severity of colitis symptoms. This improvement was linked to the presence of a stronger mucus barrier in the gut, which is essential for protecting the colon and managing interactions between the host and gut bacteria.
Additionally, we observed that EPA encouraged the production of mucin and enhanced the diversity of beneficial gut microbiota. This suggests that EPA not only helps to fortify the mucus lining of the colon but also supports a healthy balance of gut bacteria, which may further alleviate UC symptoms.
Therefore, our results highlight the potential of EPA as a promising therapeutic option for those suffering from ulcerative colitis.
What we found was quite striking. Mice treated with high doses of EPA showed a significantly reduced severity of colitis symptoms. This improvement was linked to the presence of a stronger mucus barrier in the gut, which is essential for protecting the colon and managing interactions between the host and gut bacteria.
Additionally, we observed that EPA encouraged the production of mucin and enhanced the diversity of beneficial gut microbiota. This suggests that EPA not only helps to fortify the mucus lining of the colon but also supports a healthy balance of gut bacteria, which may further alleviate UC symptoms.
Therefore, our results highlight the potential of EPA as a promising therapeutic option for those suffering from ulcerative colitis.
9
We conducted a study to figure out how eicosapentaenoic acid (EPA) affects patients with ulcerative colitis (UC), particularly its role in reducing inflammation and preventing relapse. This was a well-structured trial involving 60 participants who had stable UC therapy for at least three months. They were randomly assigned to receive either EPA in its free fatty acid form (500 mg, twice daily) or a placebo over six months.
Throughout the study, we tracked levels of calprotectin in fecal samples, a marker indicating inflammation in the intestines. Our goal was to see if EPA could lead to a significant reduction in these levels, as well as maintain remission from symptoms. The results were promising—after six months, we found that those taking EPA had lower calprotectin levels, suggesting less inflammation and contributing to fewer relapses.
Importantly, no serious side effects were reported during the study, which adds to the potential appeal of using EPA as a treatment option. Overall, our findings suggest that EPA could be a useful component in the management of UC, helping patients achieve and sustain symptom-free periods.
Throughout the study, we tracked levels of calprotectin in fecal samples, a marker indicating inflammation in the intestines. Our goal was to see if EPA could lead to a significant reduction in these levels, as well as maintain remission from symptoms. The results were promising—after six months, we found that those taking EPA had lower calprotectin levels, suggesting less inflammation and contributing to fewer relapses.
Importantly, no serious side effects were reported during the study, which adds to the potential appeal of using EPA as a treatment option. Overall, our findings suggest that EPA could be a useful component in the management of UC, helping patients achieve and sustain symptom-free periods.
Most Useful Reviews
9
Regulates ulcer conditions
2 people found this helpful
Omega-3 helps in promoting overall health, particularly for children with developmental issues. It effectively regulates conditions like ulcers and prevents cardiovascular diseases. I noticed a marked difference in well-being, especially with managing ulcer-related problems while consuming Omega-3 regularly. I believe its anti-inflammatory effects are beneficial.
0
Ulcer intolerance noted
1 people found this helpful
Unfortunately, this Omega 3 caused a rash of subcutaneous ulcers on my face, which ceased once I stopped taking it. This reaction may suggest an internal intolerance, as it worked well for my mother. While it didn’t suit me, I’ve heard of others benefitting from it in ulcer treatment.
7.5
Ulcer treatment benefits
32 people found this helpful
I find Omega 3 beneficial as it aids in treating ulcers. Within days of starting, the pain eased, and healing commenced quickly. Omega 3’s properties are crucial for digestive health and aid in regulating cholesterol. More research supports its effectiveness for various health concerns, including joint issues and inflammation. Overall, I believe Omega 3 plays a significant role in enriching my wellbeing.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 26 Researches
8.5
- All Researches
9.5
We explored the potential of omega-3-acid ethyl esters, particularly docosahexaenoic acid, as a treatment for difficult-to-heal pressure ulcers and stasis dermatitis. In the cases we examined, we noted remarkable healing effects from oral administration of this supplement.
Our first case involved a young woman with paralysis who had stubborn pressure ulcers on her foot. Despite using various topical treatments, there was little improvement. However, after integrating omega-3-acid ethyl esters into her regimen, we observed significant healing in just ten weeks.
In another instance, an elderly man suffering from chronic conditions also developed stasis dermatitis characterized by painful erosive ulcers. With numerous topical treatments failing, we turned to the same omega-3 supplement and were pleased to see almost complete healing in twelve weeks.
This report highlights a potential new avenue for managing pressure ulcers and stasis dermatitis, specifically where other treatments have fallen short. Overall, our findings indicate that omega-3-acid ethyl esters could be a valuable addition to treatment plans for these challenging skin conditions.
Our first case involved a young woman with paralysis who had stubborn pressure ulcers on her foot. Despite using various topical treatments, there was little improvement. However, after integrating omega-3-acid ethyl esters into her regimen, we observed significant healing in just ten weeks.
In another instance, an elderly man suffering from chronic conditions also developed stasis dermatitis characterized by painful erosive ulcers. With numerous topical treatments failing, we turned to the same omega-3 supplement and were pleased to see almost complete healing in twelve weeks.
This report highlights a potential new avenue for managing pressure ulcers and stasis dermatitis, specifically where other treatments have fallen short. Overall, our findings indicate that omega-3-acid ethyl esters could be a valuable addition to treatment plans for these challenging skin conditions.
9
We examined how Eicosapentaenoic acid (EPA) could protect against ulcerative colitis (UC), a chronic condition that inflames the large intestine. In our research, we used acetic acid to induce UC in rats, administering oral EPA for 28 days in doses of 300 and 1000 mg/kg before the acetic acid treatment.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
9
We explored how icosapent ethyl, a form of eicosapentaenoic acid, affects ulcerative colitis, a significant inflammatory bowel disease impacting many individuals globally. In our assessment involving 36 male Wistar rats, we divided them into six groups, including a control, those with ulcerative colitis induced by acetic acid, and various treatment groups receiving either mesalamine or different doses of icosapent ethyl.
Through this structured approach, we observed that the rats with colitis displayed higher levels of harmful substances and lower levels of protective ones. However, upon administering icosapent ethyl, we noted a remarkable reduction in the severity of the inflammation, along with improvements in several biological markers, including reduced levels of malondialdehyde and certain inflammatory cytokines. The more significant dosage of icosapent, at 300 mg/kg, produced effects similar to the widely used drug, mesalamine.
We must highlight that the beneficial effects of icosapent were partially reversed by EX527, which suggests that its protective actions may involve activation of the SIRT1 signaling pathway. Our findings point toward the potential of icosapent ethyl to be an effective treatment option for ulcerative colitis, showcasing its anti-inflammatory and antioxidant properties.
Through this structured approach, we observed that the rats with colitis displayed higher levels of harmful substances and lower levels of protective ones. However, upon administering icosapent ethyl, we noted a remarkable reduction in the severity of the inflammation, along with improvements in several biological markers, including reduced levels of malondialdehyde and certain inflammatory cytokines. The more significant dosage of icosapent, at 300 mg/kg, produced effects similar to the widely used drug, mesalamine.
We must highlight that the beneficial effects of icosapent were partially reversed by EX527, which suggests that its protective actions may involve activation of the SIRT1 signaling pathway. Our findings point toward the potential of icosapent ethyl to be an effective treatment option for ulcerative colitis, showcasing its anti-inflammatory and antioxidant properties.
9
Eicosapentaenoic acid aids ulcer healing
We set out to explore the effects of eicosapentaenoic acid (EPA), a key ingredient in a marine oil supplement called LIPINOVA, on wound healing in diabetic mice. This study focused on chronic inflammation, a common issue in type 2 diabetes that often hinders the healing of ulcers.
To understand how EPA influences healing, we applied LIPINOVA to wounds created in test mice. We observed that this marine oil not only helped in closing the wounds faster but also reduced pro-inflammatory macrophages—potentially harmful immune cells that can slow down healing. Additionally, the oil encouraged better blood vessel formation and helped to balance macrophage polarization, transitioning from the inflammatory type (Mφ1) to the healing type (Mφ2).
Our findings highlight the promising role of EPA-rich marine oil in improving wound healing for diabetic patients. With its unique ability to resolve inflammation and speed up tissue repair, LIPINOVA may serve as a valuable therapeutic option for treating diabetic ulcers.
To understand how EPA influences healing, we applied LIPINOVA to wounds created in test mice. We observed that this marine oil not only helped in closing the wounds faster but also reduced pro-inflammatory macrophages—potentially harmful immune cells that can slow down healing. Additionally, the oil encouraged better blood vessel formation and helped to balance macrophage polarization, transitioning from the inflammatory type (Mφ1) to the healing type (Mφ2).
Our findings highlight the promising role of EPA-rich marine oil in improving wound healing for diabetic patients. With its unique ability to resolve inflammation and speed up tissue repair, LIPINOVA may serve as a valuable therapeutic option for treating diabetic ulcers.
9
We explored how eicosapentaenoic acid (EPA), a key omega-3 fatty acid found in fish skin grafts, plays a role in treating chronic ulcers. Specifically, we were interested in its effects on conditions like diabetic foot ulcers that notoriously resist standard treatments. Our focus was on understanding whether EPA could significantly speed up the healing process.
Research indicates that EPA may help wounds heal faster by influencing various biological processes. Its properties enhance wound closure by providing a protective barrier against bacteria and modifying the wound's inflammatory response. When fish skin grafts rich in omega-3s were used for ulcers, patients experienced improved healing rates compared to traditional methods. This suggests that EPA's inclusion could be a valuable aspect of treatment.
While our findings highlight EPA's beneficial effects, it's essential to note that these results are part of a composite treatment approach that includes other factors at play. Thus, while EPA shows promise, the isolating impact of this specific fatty acid on wound healing remains an area for further investigation.
Research indicates that EPA may help wounds heal faster by influencing various biological processes. Its properties enhance wound closure by providing a protective barrier against bacteria and modifying the wound's inflammatory response. When fish skin grafts rich in omega-3s were used for ulcers, patients experienced improved healing rates compared to traditional methods. This suggests that EPA's inclusion could be a valuable aspect of treatment.
While our findings highlight EPA's beneficial effects, it's essential to note that these results are part of a composite treatment approach that includes other factors at play. Thus, while EPA shows promise, the isolating impact of this specific fatty acid on wound healing remains an area for further investigation.
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Regulates ulcer conditions
2 people found this helpful
Omega-3 helps in promoting overall health, particularly for children with developmental issues. It effectively regulates conditions like ulcers and prevents cardiovascular diseases. I noticed a marked difference in well-being, especially with managing ulcer-related problems while consuming Omega-3 regularly. I believe its anti-inflammatory effects are beneficial.
0
Ulcer intolerance noted
1 people found this helpful
Unfortunately, this Omega 3 caused a rash of subcutaneous ulcers on my face, which ceased once I stopped taking it. This reaction may suggest an internal intolerance, as it worked well for my mother. While it didn’t suit me, I’ve heard of others benefitting from it in ulcer treatment.
7.5
Ulcer treatment benefits
32 people found this helpful
I find Omega 3 beneficial as it aids in treating ulcers. Within days of starting, the pain eased, and healing commenced quickly. Omega 3’s properties are crucial for digestive health and aid in regulating cholesterol. More research supports its effectiveness for various health concerns, including joint issues and inflammation. Overall, I believe Omega 3 plays a significant role in enriching my wellbeing.
7.5
Ulcer pain relief
After two years of taking these vitamins, I can confidently say they support my health. I’ve noticed skin and mood improvements and a reduction in joint inflammation. They work effectively for treating ulcers, as I experienced less discomfort when following the daily dosage. However, I need to be cautious about certain conditions and interactions.
7.5
Ulcer healing support
I’ve found Omega 3 to be exceptional for my overall health, particularly its role in treating ulcers and providing relief from inflammation. Along with enhancing brain function and improving skin condition, it effectively addresses ulcer-related issues. The benefits I’ve experienced affirm its importance for my wellness.
Frequently Asked Questions
7.5
Ulcer treatment benefits
32 people found this helpful
I find Omega 3 beneficial as it aids in treating ulcers. Within days of starting, the pain eased, and healing commenced quickly. Omega 3’s properties are crucial for digestive health and aid in regulating cholesterol. More research supports its effectiveness for various health concerns, including joint issues and inflammation. Overall, I believe Omega 3 plays a significant role in enriching my wellbeing.
7.5
Ulcer pain relief
After two years of taking these vitamins, I can confidently say they support my health. I’ve noticed skin and mood improvements and a reduction in joint inflammation. They work effectively for treating ulcers, as I experienced less discomfort when following the daily dosage. However, I need to be cautious about certain conditions and interactions.
9
Regulates ulcer conditions
2 people found this helpful
Omega-3 helps in promoting overall health, particularly for children with developmental issues. It effectively regulates conditions like ulcers and prevents cardiovascular diseases. I noticed a marked difference in well-being, especially with managing ulcer-related problems while consuming Omega-3 regularly. I believe its anti-inflammatory effects are beneficial.
0
Ulcer intolerance noted
1 people found this helpful
Unfortunately, this Omega 3 caused a rash of subcutaneous ulcers on my face, which ceased once I stopped taking it. This reaction may suggest an internal intolerance, as it worked well for my mother. While it didn’t suit me, I’ve heard of others benefitting from it in ulcer treatment.
9
We conducted a study to figure out how eicosapentaenoic acid (EPA) affects patients with ulcerative colitis (UC), particularly its role in reducing inflammation and preventing relapse. This was a well-structured trial involving 60 participants who had stable UC therapy for at least three months. They were randomly assigned to receive either EPA in its free fatty acid form (500 mg, twice daily) or a placebo over six months.
Throughout the study, we tracked levels of calprotectin in fecal samples, a marker indicating inflammation in the intestines. Our goal was to see if EPA could lead to a significant reduction in these levels, as well as maintain remission from symptoms. The results were promising—after six months, we found that those taking EPA had lower calprotectin levels, suggesting less inflammation and contributing to fewer relapses.
Importantly, no serious side effects were reported during the study, which adds to the potential appeal of using EPA as a treatment option. Overall, our findings suggest that EPA could be a useful component in the management of UC, helping patients achieve and sustain symptom-free periods.
Throughout the study, we tracked levels of calprotectin in fecal samples, a marker indicating inflammation in the intestines. Our goal was to see if EPA could lead to a significant reduction in these levels, as well as maintain remission from symptoms. The results were promising—after six months, we found that those taking EPA had lower calprotectin levels, suggesting less inflammation and contributing to fewer relapses.
Importantly, no serious side effects were reported during the study, which adds to the potential appeal of using EPA as a treatment option. Overall, our findings suggest that EPA could be a useful component in the management of UC, helping patients achieve and sustain symptom-free periods.
9
In our investigation, we focused on the effects of eicosapentaenoic acid (EPA) on ulcerative colitis (UC), a chronic condition characterized by inflammation in the colon. We conducted experiments using mice with dextran sodium sulfate (DSS)-induced colitis to understand how EPA might improve this condition compared to docosahexaenoic acid (DHA).
What we found was quite striking. Mice treated with high doses of EPA showed a significantly reduced severity of colitis symptoms. This improvement was linked to the presence of a stronger mucus barrier in the gut, which is essential for protecting the colon and managing interactions between the host and gut bacteria.
Additionally, we observed that EPA encouraged the production of mucin and enhanced the diversity of beneficial gut microbiota. This suggests that EPA not only helps to fortify the mucus lining of the colon but also supports a healthy balance of gut bacteria, which may further alleviate UC symptoms.
Therefore, our results highlight the potential of EPA as a promising therapeutic option for those suffering from ulcerative colitis.
What we found was quite striking. Mice treated with high doses of EPA showed a significantly reduced severity of colitis symptoms. This improvement was linked to the presence of a stronger mucus barrier in the gut, which is essential for protecting the colon and managing interactions between the host and gut bacteria.
Additionally, we observed that EPA encouraged the production of mucin and enhanced the diversity of beneficial gut microbiota. This suggests that EPA not only helps to fortify the mucus lining of the colon but also supports a healthy balance of gut bacteria, which may further alleviate UC symptoms.
Therefore, our results highlight the potential of EPA as a promising therapeutic option for those suffering from ulcerative colitis.
8
We evaluated how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, may assist in preventing peptic ulcer disease (PUD). The research employed a Mendelian randomization approach, which used specific genetic variants linked to plasma levels of omega-3 PUFAs as natural experiments. This method allowed us to draw conclusions without the biases present in typical observational studies.
Our findings indicated a significant relationship between higher plasma levels of total omega-3 PUFAs and a lower risk of developing PUD. Specifically for EPA, we observed an odds ratio of 0.81, suggesting that for every standard deviation increase in plasma EPA, there may be a reduced likelihood of ulcer development. This points toward EPA being a potentially beneficial player in ulcer prevention.
However, it’s important to note that while we saw promising results for EPA and other marine-based omega-3s such as DPA and DHA, the same could not be said for alpha-linolenic acid, another omega-3. This specific plant-derived fatty acid did not show any significant association with PUD risk. Overall, the research suggests that increasing marine-derived omega-3 intake, particularly EPA, may provide a viable strategy for reducing the risk of peptic ulcers, while the role of plant-based omega-3s remains unclear.
Our findings indicated a significant relationship between higher plasma levels of total omega-3 PUFAs and a lower risk of developing PUD. Specifically for EPA, we observed an odds ratio of 0.81, suggesting that for every standard deviation increase in plasma EPA, there may be a reduced likelihood of ulcer development. This points toward EPA being a potentially beneficial player in ulcer prevention.
However, it’s important to note that while we saw promising results for EPA and other marine-based omega-3s such as DPA and DHA, the same could not be said for alpha-linolenic acid, another omega-3. This specific plant-derived fatty acid did not show any significant association with PUD risk. Overall, the research suggests that increasing marine-derived omega-3 intake, particularly EPA, may provide a viable strategy for reducing the risk of peptic ulcers, while the role of plant-based omega-3s remains unclear.
8
EPA+DHA improves inflammation in ulcers
We explored the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on inflammation levels in older adults, particularly those with chronic venous leg ulcers. In a well-designed, randomized controlled study, we looked at 35 participants who were either given an EPA+DHA supplement or a placebo for eight weeks.
Our findings revealed that those who took the EPA+DHA supplements experienced significantly greater reductions in proinflammatory cytokines—substances in the body that can cause inflammation—compared to those on the placebo. This suggests that EPA and DHA could play a beneficial role in easing the chronic inflammation often seen in older adults, which is linked to various age-related health concerns, including nonhealing wounds.
Thus, incorporating EPA and DHA into the diet may be a promising and low-risk way to help manage the harmful effects of chronic inflammation in aging adults, potentially enhancing healing processes for ulcers and improving overall health.
Our findings revealed that those who took the EPA+DHA supplements experienced significantly greater reductions in proinflammatory cytokines—substances in the body that can cause inflammation—compared to those on the placebo. This suggests that EPA and DHA could play a beneficial role in easing the chronic inflammation often seen in older adults, which is linked to various age-related health concerns, including nonhealing wounds.
Thus, incorporating EPA and DHA into the diet may be a promising and low-risk way to help manage the harmful effects of chronic inflammation in aging adults, potentially enhancing healing processes for ulcers and improving overall health.
References
- Pagan JD, Hauss AA, Pagan EC, Simons JL, Waldridge BM. Long-chain polyunsaturated fatty acid supplementation increases levels in red blood cells and reduces the prevalence and severity of squamous gastric ulcers in exercised Thoroughbreds. J Am Vet Med Assoc. 2022;260:S121. 10.2460/javma.22.06.0275
- Kitsukawa Y, Saito H, Suzuki Y, Kasanuki J, Tamura Y, et al. Effect of ingestion of eicosapentaenoic acid ethyl ester on carrageenan-induced colitis in guinea pigs. Gastroenterology. 1992;102:1859.
- Ioannidis O, Cheva A, Varnalidis I, Koutelidakis I, Papaziogas V, et al. The Combined Administration of Eicosapentaenoic Acid (EPA) and Gamma-Linolenic Acid (GLA) in Experimentally Induced Colitis: An Experimental Study in Rats. J Clin Med. 2024;13. 10.3390/jcm13226661
- Dai Z, Wang Q, He B, Shi F, Chen W, et al. Causal association of plasma -3 PUFA with peptic ulcer disease: a two-sample Mendelian randomisation study. Br J Nutr. 2024;132:1014. 10.1017/S0007114524001752
- El Mahdy RN, Nader MA, Helal MG, Abu-Risha SE, Abdelmageed ME. Eicosapentaenoic acid mitigates ulcerative colitis-induced by acetic acid through modulation of NF-κB and TGF-β/ EGFR signaling pathways. Life Sci. 2023;327:121820. 10.1016/j.lfs.2023.121820
- Abdelsameea AA, Alsemeh AE, Alabassery N, Samy W, Fawzy A, et al. Icosapent ethyl alleviates acetic acid-induced ulcerative colitis via modulation of SIRT1 signaling pathway in rats. Int Immunopharmacol. 2023;115:109621. 10.1016/j.intimp.2022.109621
- Ontoria-Oviedo I, Amaro-Prellezo E, Castellano D, Venegas-Venegas E, González-Santos F, et al. Topical Administration of a Marine Oil Rich in Pro-Resolving Lipid Mediators Accelerates Wound Healing in Diabetic Mice through Angiogenesis and Macrophage Polarization. Int J Mol Sci. 2022;23. 10.3390/ijms23179918
- Seth N, Chopra D, Lev-Tov H. Fish Skin Grafts with Omega-3 for Treatment of Chronic Wounds: Exploring the Role of Omega-3 Fatty Acids in Wound Healing and A Review of Clinical Healing Outcomes. Surg Technol Int. 2022;40:38.
- Fang J, Zhang Z, Cheng Y, Yang H, Zhang H, et al. EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier. Food Funct. 2022;13:4399. 10.1039/d1fo03815j
- Zhang Z, Xue Z, Yang H, Zhao F, Liu C, et al. Differential effects of EPA and DHA on DSS-induced colitis in mice and possible mechanisms involved. Food Funct. 2021;12:1803. 10.1039/d0fo02308f
- McDaniel JC, Rausch J, Tan A. Impact of omega-3 fatty acid oral therapy on healing of chronic venous leg ulcers in older adults: Study protocol for a randomized controlled single-center trial. Trials. 2020;21:93. 10.1186/s13063-019-3970-7
- Tan A, Sullenbarger B, Prakash R, McDaniel JC. Supplementation with eicosapentaenoic acid and docosahexaenoic acid reduces high levels of circulating proinflammatory cytokines in aging adults: A randomized, controlled study. Prostaglandins Leukot Essent Fatty Acids. 2018;132:23. 10.1016/j.plefa.2018.03.010
- Scaioli E, Sartini A, Bellanova M, Campieri M, Festi D, et al. Eicosapentaenoic Acid Reduces Fecal Levels of Calprotectin and Prevents Relapse in Patients With Ulcerative Colitis. Clin Gastroenterol Hepatol. 2018;16:1268. 10.1016/j.cgh.2018.01.036
- Prossomariti A, Scaioli E, Piazzi G, Fazio C, Bellanova M, et al. Short-term treatment with eicosapentaenoic acid improves inflammation and affects colonic differentiation markers and microbiota in patients with ulcerative colitis. Sci Rep. 2017;7:7458. 10.1038/s41598-017-07992-1
- McDaniel JC, Szalacha L, Sales M, Roy S, Chafee S, et al. EPA + DHA supplementation reduces PMN activation in microenvironment of chronic venous leg ulcers: A randomized, double-blind, controlled study. Wound Repair Regen. 2017;25:680. 10.1111/wrr.12558
- Han YM, Park JM, Kang JX, Cha JY, Lee HJ, et al. Mitigation of indomethacin-induced gastrointestinal damages in fat-1 transgenic mice via gate-keeper action of ω-3-polyunsaturated fatty acids. Sci Rep. 2016;6:33992. 10.1038/srep33992
- Reddy KVK, Naidu KA. Oleic acid, hydroxytyrosol and n-3 fatty acids collectively modulate colitis through reduction of oxidative stress and IL-8 synthesis; in vitro and in vivo studies. Int Immunopharmacol. 2016;35:29. 10.1016/j.intimp.2016.03.019
- Ariturk LA, Cilingir S, Kolgazi M, Elmas M, Arbak S, et al. Docosahexaenoic acid (DHA) alleviates inflammation and damage induced by experimental colitis. Eur J Nutr. 2024;63:2801. 10.1007/s00394-024-03468-x
- Sánchez-Trigueros MI, Martínez-Vieyra IA, Pineda-Peña EA, Castañeda-Hernández G, Perez-Cruz C, et al. Role of antioxidative activity in the docosahexaenoic acid's enteroprotective effect in the indomethacin-induced small intestinal injury model. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:4275. 10.1007/s00210-023-02881-z
- Khoshnood S, Negahdari B, Kaviar VH, Sadeghifard N, Abdullah MA, et al. Amoxicillin-docosahexaenoic acid encapsulated chitosan-alginate nanoparticles as a delivery system with enhanced biocidal activities against and improved ulcer healing. Front Microbiol. 2023;14:1083330. 10.3389/fmicb.2023.1083330
- Zha R, Ge E, Guo L, Gao Q, Lin Q, et al. A newly identified polyunsaturated macamide alleviates dextran sulfate sodium-induced colitis in mice. Fitoterapia. 2021;152:104916. 10.1016/j.fitote.2021.104916
- Pham TL, Bazan HEP. Docosanoid signaling modulates corneal nerve regeneration: effect on tear secretion, wound healing, and neuropathic pain. J Lipid Res. 2021;62:100033. 10.1194/jlr.TR120000954
- Nakanishi M, Matz A, Klemashevich C, Rosenberg DW. Dietary Walnut Supplementation Alters Mucosal Metabolite Profiles During DSS-Induced Colonic Ulceration. Nutrients. 2019;11. 10.3390/nu11051118
- Ungaro F, Tacconi C, Massimino L, Corsetto PA, Correale C, et al. MFSD2A Promotes Endothelial Generation of Inflammation-Resolving Lipid Mediators and Reduces Colitis in Mice. Gastroenterology. 2017;153:1363. 10.1053/j.gastro.2017.07.048
- Nagai K, Matsumaru K, Hirai I, Takae Y, Andoh K. New therapy using omega-3-Acid ethyl esters for decubitus ulcers and stasis dermatitis: a case report. Iran Red Crescent Med J. 2014;16:e19500. 10.5812/ircmj.19500
- Köhnke T, Gomolka B, Bilal S, Zhou X, Sun Y, et al. Acetylsalicylic Acid reduces the severity of dextran sodium sulfate-induced colitis and increases the formation of anti-inflammatory lipid mediators. Biomed Res Int. 2013;2013:748160. 10.1155/2013/748160
