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SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8.5
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
9
Eicosapentaenoic acid aids ulcer healing
Eicosapentaenoic acid mitigates ulcerative colitis-induced by acetic acid through modulation of NF-κB and TGF-β/ EGFR signaling pathways.
Directly addresses EPA effects
We examined how Eicosapentaenoic acid (EPA) could protect against ulcerative colitis (UC), a chronic condition that inflames the large intestine. In our research, we used acetic acid to induce UC in rats, administering oral EPA for 28 days in doses of 300 and 1000 mg/kg before the acetic acid treatment.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
Read More
9
Eicosapentaenoic Acid Improves UC
EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.
Significant effects on ulcerative colitis
In our investigation, we focused on the effects of eicosapentaenoic acid (EPA) on ulcerative colitis (UC), a chronic condition characterized by inflammation in the colon. We conducted experiments using mice with dextran sodium sulfate (DSS)-induced colitis to understand how EPA might improve this condition compared to docosahexaenoic acid (DHA).
What we found was quite striking. Mice treated with high doses of EPA showed a significantly reduced severity of colitis symptoms. This improvement was linked to the presence of a stronger mucus barrier in the gut, which is essential for protecting the colon and managing interactions between the host and gut bacteria.
Additionally, we observed that EPA encouraged the production of mucin and enhanced the diversity of beneficial gut microbiota. This suggests that EPA not only helps to fortify the mucus lining of the colon but also supports a healthy balance of gut bacteria, which may further alleviate UC symptoms.
Therefore, our results highlight the potential of EPA as a promising therapeutic option for those suffering from ulcerative colitis.
What we found was quite striking. Mice treated with high doses of EPA showed a significantly reduced severity of colitis symptoms. This improvement was linked to the presence of a stronger mucus barrier in the gut, which is essential for protecting the colon and managing interactions between the host and gut bacteria.
Additionally, we observed that EPA encouraged the production of mucin and enhanced the diversity of beneficial gut microbiota. This suggests that EPA not only helps to fortify the mucus lining of the colon but also supports a healthy balance of gut bacteria, which may further alleviate UC symptoms.
Therefore, our results highlight the potential of EPA as a promising therapeutic option for those suffering from ulcerative colitis.
Read More
9
Eicosapentaenoic acid reduces inflammation
Eicosapentaenoic Acid Reduces Fecal Levels of Calprotectin and Prevents Relapse in Patients With Ulcerative Colitis.
High relevance to UC management
We conducted a study to figure out how eicosapentaenoic acid (EPA) affects patients with ulcerative colitis (UC), particularly its role in reducing inflammation and preventing relapse. This was a well-structured trial involving 60 participants who had stable UC therapy for at least three months. They were randomly assigned to receive either EPA in its free fatty acid form (500 mg, twice daily) or a placebo over six months.
Throughout the study, we tracked levels of calprotectin in fecal samples, a marker indicating inflammation in the intestines. Our goal was to see if EPA could lead to a significant reduction in these levels, as well as maintain remission from symptoms. The results were promising—after six months, we found that those taking EPA had lower calprotectin levels, suggesting less inflammation and contributing to fewer relapses.
Importantly, no serious side effects were reported during the study, which adds to the potential appeal of using EPA as a treatment option. Overall, our findings suggest that EPA could be a useful component in the management of UC, helping patients achieve and sustain symptom-free periods.
Throughout the study, we tracked levels of calprotectin in fecal samples, a marker indicating inflammation in the intestines. Our goal was to see if EPA could lead to a significant reduction in these levels, as well as maintain remission from symptoms. The results were promising—after six months, we found that those taking EPA had lower calprotectin levels, suggesting less inflammation and contributing to fewer relapses.
Importantly, no serious side effects were reported during the study, which adds to the potential appeal of using EPA as a treatment option. Overall, our findings suggest that EPA could be a useful component in the management of UC, helping patients achieve and sustain symptom-free periods.
Read More
Most Useful Reviews
9.5
Regulates ulcer conditions
Omega-3 helps in promoting overall health, particularly for children with developmental issues. It effectively regulates conditions like ulcers and prevents cardiovascular diseases. I noticed a marked difference in well-being, especially with managing ulcer-related problems while consuming Omega-3 regularly. I believe its anti-inflammatory effects are beneficial.
Read More
1.3
Ulcer intolerance noted
Unfortunately, this Omega 3 caused a rash of subcutaneous ulcers on my face, which ceased once I stopped taking it. This reaction may suggest an internal intolerance, as it worked well for my mother. While it didn’t suit me, I’ve heard of others benefitting from it in ulcer treatment.
Read More
8.8
Ulcer treatment benefits
I find Omega 3 beneficial as it aids in treating ulcers. Within days of starting, the pain eased, and healing commenced quickly. Omega 3’s properties are crucial for digestive health and aid in regulating cholesterol. More research supports its effectiveness for various health concerns, including joint issues and inflammation. Overall, I believe Omega 3 plays a significant role in enriching my wellbeing.
Read More
Most Recommended Products for Ulcer
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8.5
9.5
Omega-3 aids ulcer healing
New therapy using omega-3-Acid ethyl esters for decubitus ulcers and stasis dermatitis: a case report.
Focus on omega-3 efficacy
We explored the potential of omega-3-acid ethyl esters, particularly docosahexaenoic acid, as a treatment for difficult-to-heal pressure ulcers and stasis dermatitis. In the cases we examined, we noted remarkable healing effects from oral administration of this supplement.
Our first case involved a young woman with paralysis who had stubborn pressure ulcers on her foot. Despite using various topical treatments, there was little improvement. However, after integrating omega-3-acid ethyl esters into her regimen, we observed significant healing in just ten weeks.
In another instance, an elderly man suffering from chronic conditions also developed stasis dermatitis characterized by painful erosive ulcers. With numerous topical treatments failing, we turned to the same omega-3 supplement and were pleased to see almost complete healing in twelve weeks.
This report highlights a potential new avenue for managing pressure ulcers and stasis dermatitis, specifically where other treatments have fallen short. Overall, our findings indicate that omega-3-acid ethyl esters could be a valuable addition to treatment plans for these challenging skin conditions.
Our first case involved a young woman with paralysis who had stubborn pressure ulcers on her foot. Despite using various topical treatments, there was little improvement. However, after integrating omega-3-acid ethyl esters into her regimen, we observed significant healing in just ten weeks.
In another instance, an elderly man suffering from chronic conditions also developed stasis dermatitis characterized by painful erosive ulcers. With numerous topical treatments failing, we turned to the same omega-3 supplement and were pleased to see almost complete healing in twelve weeks.
This report highlights a potential new avenue for managing pressure ulcers and stasis dermatitis, specifically where other treatments have fallen short. Overall, our findings indicate that omega-3-acid ethyl esters could be a valuable addition to treatment plans for these challenging skin conditions.
Read More
9
Eicosapentaenoic acid aids ulcer healing
Eicosapentaenoic acid mitigates ulcerative colitis-induced by acetic acid through modulation of NF-κB and TGF-β/ EGFR signaling pathways.
Directly addresses EPA effects
We examined how Eicosapentaenoic acid (EPA) could protect against ulcerative colitis (UC), a chronic condition that inflames the large intestine. In our research, we used acetic acid to induce UC in rats, administering oral EPA for 28 days in doses of 300 and 1000 mg/kg before the acetic acid treatment.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
Read More
9
Effective treatment for ulcerative colitis
Icosapent ethyl alleviates acetic acid-induced ulcerative colitis via modulation of SIRT1 signaling pathway in rats.
Relevant but not isolated findings
We explored how icosapent ethyl, a form of eicosapentaenoic acid, affects ulcerative colitis, a significant inflammatory bowel disease impacting many individuals globally. In our assessment involving 36 male Wistar rats, we divided them into six groups, including a control, those with ulcerative colitis induced by acetic acid, and various treatment groups receiving either mesalamine or different doses of icosapent ethyl.
Through this structured approach, we observed that the rats with colitis displayed higher levels of harmful substances and lower levels of protective ones. However, upon administering icosapent ethyl, we noted a remarkable reduction in the severity of the inflammation, along with improvements in several biological markers, including reduced levels of malondialdehyde and certain inflammatory cytokines. The more significant dosage of icosapent, at 300 mg/kg, produced effects similar to the widely used drug, mesalamine.
We must highlight that the beneficial effects of icosapent were partially reversed by EX527, which suggests that its protective actions may involve activation of the SIRT1 signaling pathway. Our findings point toward the potential of icosapent ethyl to be an effective treatment option for ulcerative colitis, showcasing its anti-inflammatory and antioxidant properties.
Through this structured approach, we observed that the rats with colitis displayed higher levels of harmful substances and lower levels of protective ones. However, upon administering icosapent ethyl, we noted a remarkable reduction in the severity of the inflammation, along with improvements in several biological markers, including reduced levels of malondialdehyde and certain inflammatory cytokines. The more significant dosage of icosapent, at 300 mg/kg, produced effects similar to the widely used drug, mesalamine.
We must highlight that the beneficial effects of icosapent were partially reversed by EX527, which suggests that its protective actions may involve activation of the SIRT1 signaling pathway. Our findings point toward the potential of icosapent ethyl to be an effective treatment option for ulcerative colitis, showcasing its anti-inflammatory and antioxidant properties.
Read More
9
Long-chain fatty acids and ulcers
Long-chain polyunsaturated fatty acid supplementation increases levels in red blood cells and reduces the prevalence and severity of squamous gastric ulcers in exercised Thoroughbreds.
Moderate relevance due to mixture limits
We set out to understand how different types of fatty acids might affect the development and severity of gastric ulcers in fit Thoroughbred horses. Our research involved 13 horses undergoing strenuous training, and we assessed their gastric health before and after three months of supplementation with two types of polyunsaturated fatty acids.
The horses completed a standardized exercise test to simulate the stress of racing. We specifically looked at the impact of long-chain polyunsaturated fatty acids (like eicosapentaenoic acid) found in fish oil, compared to short-chain fatty acids derived from a blend of corn and flax oil.
We observed that the long-chain fatty acid supplementation resulted in higher levels of important fatty acids, including eicosapentaenoic acid, and was linked to a reduced incidence and severity of gastric ulcers. This suggests that eicosapentaenoic acid may play a beneficial role in gastric health for high-performance horses.
However, since our findings were based on a blend of various fatty acids, isolating the specific effects of eicosapentaenoic acid on ulcers required further investigation. Thus, while our study indicates a promising trend, more research will be essential to explore this area thoroughly.
The horses completed a standardized exercise test to simulate the stress of racing. We specifically looked at the impact of long-chain polyunsaturated fatty acids (like eicosapentaenoic acid) found in fish oil, compared to short-chain fatty acids derived from a blend of corn and flax oil.
We observed that the long-chain fatty acid supplementation resulted in higher levels of important fatty acids, including eicosapentaenoic acid, and was linked to a reduced incidence and severity of gastric ulcers. This suggests that eicosapentaenoic acid may play a beneficial role in gastric health for high-performance horses.
However, since our findings were based on a blend of various fatty acids, isolating the specific effects of eicosapentaenoic acid on ulcers required further investigation. Thus, while our study indicates a promising trend, more research will be essential to explore this area thoroughly.
Read More
9
Eicosapentaenoic acid aids ulcer healing
Topical Administration of a Marine Oil Rich in Pro-Resolving Lipid Mediators Accelerates Wound Healing in Diabetic Mice through Angiogenesis and Macrophage Polarization.
Relevant but includes other components
We set out to explore the effects of eicosapentaenoic acid (EPA), a key ingredient in a marine oil supplement called LIPINOVA, on wound healing in diabetic mice. This study focused on chronic inflammation, a common issue in type 2 diabetes that often hinders the healing of ulcers.
To understand how EPA influences healing, we applied LIPINOVA to wounds created in test mice. We observed that this marine oil not only helped in closing the wounds faster but also reduced pro-inflammatory macrophages—potentially harmful immune cells that can slow down healing. Additionally, the oil encouraged better blood vessel formation and helped to balance macrophage polarization, transitioning from the inflammatory type (Mφ1) to the healing type (Mφ2).
Our findings highlight the promising role of EPA-rich marine oil in improving wound healing for diabetic patients. With its unique ability to resolve inflammation and speed up tissue repair, LIPINOVA may serve as a valuable therapeutic option for treating diabetic ulcers.
To understand how EPA influences healing, we applied LIPINOVA to wounds created in test mice. We observed that this marine oil not only helped in closing the wounds faster but also reduced pro-inflammatory macrophages—potentially harmful immune cells that can slow down healing. Additionally, the oil encouraged better blood vessel formation and helped to balance macrophage polarization, transitioning from the inflammatory type (Mφ1) to the healing type (Mφ2).
Our findings highlight the promising role of EPA-rich marine oil in improving wound healing for diabetic patients. With its unique ability to resolve inflammation and speed up tissue repair, LIPINOVA may serve as a valuable therapeutic option for treating diabetic ulcers.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
9.5
Regulates ulcer conditions
Omega-3 helps in promoting overall health, particularly for children with developmental issues. It effectively regulates conditions like ulcers and prevents cardiovascular diseases. I noticed a marked difference in well-being, especially with managing ulcer-related problems while consuming Omega-3 regularly. I believe its anti-inflammatory effects are beneficial.
Read More
8.8
Ulcer treatment benefits
I find Omega 3 beneficial as it aids in treating ulcers. Within days of starting, the pain eased, and healing commenced quickly. Omega 3’s properties are crucial for digestive health and aid in regulating cholesterol. More research supports its effectiveness for various health concerns, including joint issues and inflammation. Overall, I believe Omega 3 plays a significant role in enriching my wellbeing.
Read More
8.8
Ulcer pain relief
After two years of taking these vitamins, I can confidently say they support my health. I’ve noticed skin and mood improvements and a reduction in joint inflammation. They work effectively for treating ulcers, as I experienced less discomfort when following the daily dosage. However, I need to be cautious about certain conditions and interactions.
Read More
8.8
Ulcer healing support
I’ve found Omega 3 to be exceptional for my overall health, particularly its role in treating ulcers and providing relief from inflammation. Along with enhancing brain function and improving skin condition, it effectively addresses ulcer-related issues. The benefits I’ve experienced affirm its importance for my wellness.
Read More
1.3
Ulcer intolerance noted
Unfortunately, this Omega 3 caused a rash of subcutaneous ulcers on my face, which ceased once I stopped taking it. This reaction may suggest an internal intolerance, as it worked well for my mother. While it didn’t suit me, I’ve heard of others benefitting from it in ulcer treatment.
Read More
