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SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.1
USERS' SCORE
Good
Based on 3 Reviews
8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
< 1%**
Vitamin A (from Retinyl Palmitate and Cod Liver Oil)
750 mcg
83%
Vitamin D3 (from Cholecalciferol and Cod Liver Oil)
6.75 mcg (270 IU)
34%
Cod Liver Oil
650 mg
†
Top Medical Research Studies
9.5
Cod liver oil prevents clotting
Prevention of platelet aggregation by dietary polyunsaturated fatty acids in the biodegradable polyurethane vascular prosthesis: an experimental model in pigs.
Essential fatty acids are beneficial
In a fascinating experiment involving young pigs, we observed how cod liver oil can prevent blood clotting in biodegradable vascular prostheses. The study included a total of 25 pigs, with 15 of them fed cod liver oil alongside their regular diets. They were compared against 10 control pigs that weren’t given any additional fatty acids.
Over the course of several months, we performed imaging tests and found that all the control implants were completely thrombosed by day 30. In stark contrast, the pigs who received the cod liver oil showed 100% patency—or openness—of their grafts even at later stages of the study.
Upon retrieval, 7 out of 9 grafts in the cod liver oil group remained patent, indicating that the fish oil's rich content of n-3 polyunsaturated fatty acids could significantly modify lipid metabolism. This modification appears to prevent the clumping of platelets, which is a crucial factor in blood clot formation.
Tissue analysis revealed that the patent grafts were well-integrated with tissue resembling natural blood vessel lining, complete with muscle cells that indicate healthy growth. This study clearly shows that a diet enriched with essential fatty acids can play a substantial role in preventing thrombosis in biodegradable vascular prostheses. The combination of our innovative materials and dietary strategies could pave the way for better heart surgery outcomes in the future.
Over the course of several months, we performed imaging tests and found that all the control implants were completely thrombosed by day 30. In stark contrast, the pigs who received the cod liver oil showed 100% patency—or openness—of their grafts even at later stages of the study.
Upon retrieval, 7 out of 9 grafts in the cod liver oil group remained patent, indicating that the fish oil's rich content of n-3 polyunsaturated fatty acids could significantly modify lipid metabolism. This modification appears to prevent the clumping of platelets, which is a crucial factor in blood clot formation.
Tissue analysis revealed that the patent grafts were well-integrated with tissue resembling natural blood vessel lining, complete with muscle cells that indicate healthy growth. This study clearly shows that a diet enriched with essential fatty acids can play a substantial role in preventing thrombosis in biodegradable vascular prostheses. The combination of our innovative materials and dietary strategies could pave the way for better heart surgery outcomes in the future.
Read More
8
Vitamin D may influence blood clotting
Relationship between vitamin D deficiency and thrombus load in patients with ST-elevation myocardial infarction.
Study highlights vitamin D's impact
We explored the connection between vitamin D levels and coronary thrombus load in patients who experienced ST-elevation myocardial infarction (STEMI). The study included 77 patients where we measured serum vitamin D levels, thrombus degree, and other relevant factors.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
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8
Cod liver oil affects clotting
Fish oil feeding lowers thromboxane- and prostacyclin production by rat platelets and aorta and does not result in the formation of prostaglandin I3.
Strong relevance to blood clotting
We observed interesting effects when feeding cod liver oil to rats, particularly regarding blood clotting. The study aimed to determine how this treatment influences the production of certain compounds involved in thromboregulation, specifically thromboxane A2 (TxA2) and prostacyclin (PGI2).
What we found was that cod liver oil significantly lowered the levels of both TxA2 and PGI2, which are critical players in blood clotting. Notably, we did not detect any significant formation of other compounds like TxA3 and PGI3, often thought to have roles in managing clotting behaviors.
Interestingly, even with the reduced formation of these compounds, we noted a decrease in arterial thrombosis alongside a prolonged bleeding time. This indicates that while there may be some influence on blood clotting, the presence of the so-called “3-series” prostaglandins seems less critical than previously suggested.
Overall, this study reveals that cod liver oil does not enhance blood clot formation and suggests possible contradictions to previous beliefs about certain prostaglandins in clot regulation. Hence, it may not deliver the expected benefits in managing blood clotting effectively.
What we found was that cod liver oil significantly lowered the levels of both TxA2 and PGI2, which are critical players in blood clotting. Notably, we did not detect any significant formation of other compounds like TxA3 and PGI3, often thought to have roles in managing clotting behaviors.
Interestingly, even with the reduced formation of these compounds, we noted a decrease in arterial thrombosis alongside a prolonged bleeding time. This indicates that while there may be some influence on blood clotting, the presence of the so-called “3-series” prostaglandins seems less critical than previously suggested.
Overall, this study reveals that cod liver oil does not enhance blood clot formation and suggests possible contradictions to previous beliefs about certain prostaglandins in clot regulation. Hence, it may not deliver the expected benefits in managing blood clotting effectively.
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Most Useful Reviews
7.5
Improved heart health
This omega improves blood vessel and heart health, effectively lowering cholesterol levels. The ingredients and quality are excellent.
Read More
5.8
Decreased cholesterol levels
Large jar of 250 capsules. This omega-3 is excellent quality. I take two capsules daily, which helps me feel better and has lowered my cholesterol levels. If heart problems or blood clots exist, you should aim for a daily intake of 3 grams of omega-3 (EPA and DHA combined). Be cautious about the content of omega-3 in each capsule before purchasing.
Read More
5.8
Lowered cholesterol levels
One of my preferred omega-3 supplements, good quality. I consume six capsules daily, which has effectively improved my health and reduced my cholesterol levels. If there are heart issues or blood clots, it's advisable to take 3 grams of omega-3 per day, from the omega-3 fatty acids in fish oil. Always check the omega-3 content before buying.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.1
9.5
Cod liver oil aids blood flow
Long-term patency of regenerated neoaortic wall following the implant of a fully biodegradable polyurethane prosthesis: experimental lipid diet model in pigs.
Study indicates positive impact
We investigated how a diet rich in cod liver oil affects blood clot formation by studying young pigs implanted with biodegradable polyurethane vascular prostheses. In this research, we used three groups of pigs: a control group, one group receiving a daily dose of aspirin, and another following a lipid-rich diet featuring cod liver oil. Over the course of the study, we noted the patency of vascular grafts at various intervals, particularly focusing on the impact of the lipid diet.
The results indicated promising findings for the pigs on the lipid diet. While the control group showed a 100% thrombosis rate, a remarkable 100% of the pigs receiving cod liver oil had patent grafts. Even at the final retrieval period, most of the pigs on the lipid-rich diet maintained a functioning graft, suggesting that cod liver oil may play a beneficial role in preventing blood clots. This effect could be linked to the diet’s ability to promote better endothelial growth within the graft.
Overall, the study points out that incorporating a lipid-rich diet, particularly with polyunsaturated fatty acids like those found in cod liver oil, may help enhance long-term success for vascular implants. It appears that this dietary strategy could improve outcomes by preventing blood clots and supporting the formation of new tissues in the vascular system.
The results indicated promising findings for the pigs on the lipid diet. While the control group showed a 100% thrombosis rate, a remarkable 100% of the pigs receiving cod liver oil had patent grafts. Even at the final retrieval period, most of the pigs on the lipid-rich diet maintained a functioning graft, suggesting that cod liver oil may play a beneficial role in preventing blood clots. This effect could be linked to the diet’s ability to promote better endothelial growth within the graft.
Overall, the study points out that incorporating a lipid-rich diet, particularly with polyunsaturated fatty acids like those found in cod liver oil, may help enhance long-term success for vascular implants. It appears that this dietary strategy could improve outcomes by preventing blood clots and supporting the formation of new tissues in the vascular system.
Read More
9.5
Cod liver oil prevents clotting
Prevention of platelet aggregation by dietary polyunsaturated fatty acids in the biodegradable polyurethane vascular prosthesis: an experimental model in pigs.
Essential fatty acids are beneficial
In a fascinating experiment involving young pigs, we observed how cod liver oil can prevent blood clotting in biodegradable vascular prostheses. The study included a total of 25 pigs, with 15 of them fed cod liver oil alongside their regular diets. They were compared against 10 control pigs that weren’t given any additional fatty acids.
Over the course of several months, we performed imaging tests and found that all the control implants were completely thrombosed by day 30. In stark contrast, the pigs who received the cod liver oil showed 100% patency—or openness—of their grafts even at later stages of the study.
Upon retrieval, 7 out of 9 grafts in the cod liver oil group remained patent, indicating that the fish oil's rich content of n-3 polyunsaturated fatty acids could significantly modify lipid metabolism. This modification appears to prevent the clumping of platelets, which is a crucial factor in blood clot formation.
Tissue analysis revealed that the patent grafts were well-integrated with tissue resembling natural blood vessel lining, complete with muscle cells that indicate healthy growth. This study clearly shows that a diet enriched with essential fatty acids can play a substantial role in preventing thrombosis in biodegradable vascular prostheses. The combination of our innovative materials and dietary strategies could pave the way for better heart surgery outcomes in the future.
Over the course of several months, we performed imaging tests and found that all the control implants were completely thrombosed by day 30. In stark contrast, the pigs who received the cod liver oil showed 100% patency—or openness—of their grafts even at later stages of the study.
Upon retrieval, 7 out of 9 grafts in the cod liver oil group remained patent, indicating that the fish oil's rich content of n-3 polyunsaturated fatty acids could significantly modify lipid metabolism. This modification appears to prevent the clumping of platelets, which is a crucial factor in blood clot formation.
Tissue analysis revealed that the patent grafts were well-integrated with tissue resembling natural blood vessel lining, complete with muscle cells that indicate healthy growth. This study clearly shows that a diet enriched with essential fatty acids can play a substantial role in preventing thrombosis in biodegradable vascular prostheses. The combination of our innovative materials and dietary strategies could pave the way for better heart surgery outcomes in the future.
Read More
9
Vitamin D3 impacts blood clotting
1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.
Significant effects seen in study
We explored the effects of vitamin D3 on blood clot formation in mice lacking the klotho protein, which plays a role in regulating vitamin D3 levels. In our analysis, we focused on how klotho deficiency impacts platelet function and calcium signaling, pivotal mechanisms involved in clotting.
Our findings revealed that klotho-deficient platelets exhibited significantly reduced responses to activation, indicating that they might not form clots effectively. Specifically, we observed that calcium signaling pathways, essential for platelet activation and aggregation, were notably inhibited in these mice. The investigation utilized multiple methods, including measuring calcium levels and evaluating platelet function through various biochemical and cellular techniques.
Interestingly, when klotho-deficient mice were given a low-vitamin D diet, we discovered that their platelet function improved, suggesting a direct link between vitamin D3 levels and platelet activity. The reduced activity was associated with decreased expression of critical signaling proteins involved in calcium entry, which vitamin D3 helps regulate. Overall, our study presents evidence that vitamin D3 deficiency due to klotho absence may hinder proper blood clotting mechanisms.
Our findings revealed that klotho-deficient platelets exhibited significantly reduced responses to activation, indicating that they might not form clots effectively. Specifically, we observed that calcium signaling pathways, essential for platelet activation and aggregation, were notably inhibited in these mice. The investigation utilized multiple methods, including measuring calcium levels and evaluating platelet function through various biochemical and cellular techniques.
Interestingly, when klotho-deficient mice were given a low-vitamin D diet, we discovered that their platelet function improved, suggesting a direct link between vitamin D3 levels and platelet activity. The reduced activity was associated with decreased expression of critical signaling proteins involved in calcium entry, which vitamin D3 helps regulate. Overall, our study presents evidence that vitamin D3 deficiency due to klotho absence may hinder proper blood clotting mechanisms.
Read More
9
Vitamin D3 reduces blood clot risk
Renin angiotensin system blockade and activated vitamin D as a means of preventing deep vein thrombosis in renal transplant recipients.
Moderate relevance to vitamin D3
We evaluated the potential of vitamin D3, specifically calcitriol, in combination with other medications to prevent deep vein thrombosis (VTE) in renal transplant recipients (RTR). Focusing on how these treatments might influence the occurrence of blood clots, we followed a group of 769 RTRs over several months post-transplant.
Our findings revealed that 96 of these recipients experienced a first episode of VTE. We noticed a significant difference in rates of blood clots among those who received calcitriol alongside angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs). In fact, recipients on the combination therapy had a markedly lower rate of VTE, showing a promising 60% reduction in risk.
However, it is important to note that the isolated effect of vitamin D3 without other treatments wasn't fully determined in this study. While calcitriol showed favorable outcomes when used with blood pressure medications, further research could help clarify its individual impact on clot prevention. Overall, this research highlights the importance of collaborative strategies in managing thrombotic complications for transplant patients.
Our findings revealed that 96 of these recipients experienced a first episode of VTE. We noticed a significant difference in rates of blood clots among those who received calcitriol alongside angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs). In fact, recipients on the combination therapy had a markedly lower rate of VTE, showing a promising 60% reduction in risk.
However, it is important to note that the isolated effect of vitamin D3 without other treatments wasn't fully determined in this study. While calcitriol showed favorable outcomes when used with blood pressure medications, further research could help clarify its individual impact on clot prevention. Overall, this research highlights the importance of collaborative strategies in managing thrombotic complications for transplant patients.
Read More
9
Cod liver oil and thrombo-protection
Fish oil, atherogenesis, and thrombogenesis.
Significant findings on clotting
We explored the effects of cod liver oil on blood clotting within the context of a broader dietary analysis. The study found that marine fish consumption decreases the likelihood of dying from ischemic heart disease. However, the use of fish oil as a supplement isn't universally recommended due to some potential issues. In high doses, fish oil can lower cholesterol and triglycerides but might also increase low-density lipoprotein (LDL) levels and raise the risks of free radical formation and bleeding.
Our observations with swine indicated that when an atherogenic diet was supplemented with cod liver oil, there was a noticeable decrease in monocyte adhesion and platelet clumps on damaged coronary arteries, even when cholesterol levels were similar to the untreated group. This suggests that fish oil could have a thrombo-protective effect. We also conducted an in vitro assay to understand how fish oil seems to lessen these blood cell interactions.
In our tests, we found that eicosapentaenoic acid (EPA) was particularly effective in reducing the adhesion of human monocyte-like cells to endothelial cells stimulated by lipopolysaccharide (LPS). The improvements were noticeable only when EPA was administered soon after LPS stimulation. Furthermore, EPA exposure also lowered the expression of adhesion molecules on human umbilical vein endothelial cells. These findings imply that EPA could play a role in limiting the inflammation-related mechanisms associated with blood clotting.
Our observations with swine indicated that when an atherogenic diet was supplemented with cod liver oil, there was a noticeable decrease in monocyte adhesion and platelet clumps on damaged coronary arteries, even when cholesterol levels were similar to the untreated group. This suggests that fish oil could have a thrombo-protective effect. We also conducted an in vitro assay to understand how fish oil seems to lessen these blood cell interactions.
In our tests, we found that eicosapentaenoic acid (EPA) was particularly effective in reducing the adhesion of human monocyte-like cells to endothelial cells stimulated by lipopolysaccharide (LPS). The improvements were noticeable only when EPA was administered soon after LPS stimulation. Furthermore, EPA exposure also lowered the expression of adhesion molecules on human umbilical vein endothelial cells. These findings imply that EPA could play a role in limiting the inflammation-related mechanisms associated with blood clotting.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8
7.5
Improved heart health
This omega improves blood vessel and heart health, effectively lowering cholesterol levels. The ingredients and quality are excellent.
5.8
Decreased cholesterol levels
Large jar of 250 capsules. This omega-3 is excellent quality. I take two capsules daily, which helps me feel better and has lowered my cholesterol levels. If heart problems or blood clots exist, you should aim for a daily intake of 3 grams of omega-3 (EPA and DHA combined). Be cautious about the content of omega-3 in each capsule before purchasing.
Read More
5.8
Lowered cholesterol levels
One of my preferred omega-3 supplements, good quality. I consume six capsules daily, which has effectively improved my health and reduced my cholesterol levels. If there are heart issues or blood clots, it's advisable to take 3 grams of omega-3 per day, from the omega-3 fatty acids in fish oil. Always check the omega-3 content before buying.
Read More
