Overview
SCIENTIFIC SCORE
Questionable
Based on 35 Researches
6.9
USERS' SCORE
Good
Based on 24 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
< 1%**
Vitamin A (from Retinyl Palmitate and Cod Liver Oil)
750 mcg
83%
Vitamin D3 (from Cholecalciferol and Cod Liver Oil)
6.75 mcg (270 IU)
34%
Cod Liver Oil
650 mg
†
Top Medical Research Studies
9
We investigated how cod liver oil affects coronary artery disease in pigs on a high-fat diet over eight months. By comparing 7 pigs that received cod liver oil to 11 control pigs, we observed significantly less disease in the oil-fed group. Notably, lesion size and arterial narrowing were reduced, suggesting that cod liver oil may influence heart health. Both groups had high lipid levels, but the differences in atherosclerosis weren't linked to these levels. This study hints at the oil's potential to slow coronary disease progression via changes in metabolism.
Read More
9
We delved into how cod liver oil (CLO) influences heart health, especially in the context of diabetes. Using a study with streptozotocin (STZ)-induced diabetic rats, we treated them with CLO and monitored various cardiovascular metrics over 12 weeks. What we found was quite telling: untreated diabetic rats faced significant increases in blood sugar and harmful lipid levels, while those receiving CLO showed improved weight gain and complete prevention of lipid problems.
Moreover, the study revealed that CLO-treated rats exhibited healthier blood vessel responses and heart function. For instance, we observed that CLO effectively corrected some vasoconstriction issues and improved heart rhythm responses that were otherwise diminished in diabetic rats. The treatment also helped preserve the structural integrity of heart tissue, which often suffers in diabetes.
Overall, this research strongly suggests that cod liver oil can be a valuable supplement for mitigating heart disease risks associated with diabetes. With its rich omega-3 fatty acids and antioxidants, CLO appears to play a protective role in maintaining cardiovascular health in diabetic settings.
Moreover, the study revealed that CLO-treated rats exhibited healthier blood vessel responses and heart function. For instance, we observed that CLO effectively corrected some vasoconstriction issues and improved heart rhythm responses that were otherwise diminished in diabetic rats. The treatment also helped preserve the structural integrity of heart tissue, which often suffers in diabetes.
Overall, this research strongly suggests that cod liver oil can be a valuable supplement for mitigating heart disease risks associated with diabetes. With its rich omega-3 fatty acids and antioxidants, CLO appears to play a protective role in maintaining cardiovascular health in diabetic settings.
Read More
9
We examined the effects of cod liver oil, enriched with essential fatty acids, on heart stability after inducing myocardial infarction in rats. Over 30 days, we found that the oil significantly raised the heart's fibrillation threshold by 50% and halved the occurrence of spontaneous extrasystoles. While there were improvements in the heart's functionality during rest, overall heart pressures and contraction speeds showed no significant changes. This suggests that cod liver oil may contribute positively to heart stability, but it doesn't dramatically alter all heart functions.
Read More
Most Useful Reviews
9
Promotes heart health
3 people found this helpful
Great Cod Liver Oil 650mg is an excellent dosage. It's beneficial for heart disease and general health.
Read More
10
Supports immunity
2 people found this helpful
Cod liver oil significantly benefits skin health and delays ageing. It supports heart health, memory, and reduces diabetes risk. Additionally, it boosts immunity against infections and aids in lowering triglycerides and cholesterol. It’s derived from cod liver, providing higher vitamins A and D than regular fish oils.
Read More
9
Combats inflammation
2 people found this helpful
The quality is excellent with clear ingredients, making it one of the best supplements for ageing. I noticed benefits quickly, especially in combating inflammation. The taste is almost non-existent and it supports heart health. The packaging is substantial and it is great for hair health as well.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 35 Researches
6.9
- All Researches
9
We explored the effects of docosahexaenoic acid (DHA), found in cod liver oil, on heart health after a heart attack. Using lab tests on heart cells and mouse models, we found that DHA helped protect heart cells from damage due to low oxygen levels.
Remarkably, DHA not only reduced heart damage but also improved heart function overall. It seemed to support a process called autophagy, which helps clear out damaged cells, thereby benefiting heart health after injury.
However, it's important to note that while DHA shows promising results, more research is needed to fully understand its role.
Remarkably, DHA not only reduced heart damage but also improved heart function overall. It seemed to support a process called autophagy, which helps clear out damaged cells, thereby benefiting heart health after injury.
However, it's important to note that while DHA shows promising results, more research is needed to fully understand its role.
Read More
9
We delved into how cod liver oil (CLO) influences heart health, especially in the context of diabetes. Using a study with streptozotocin (STZ)-induced diabetic rats, we treated them with CLO and monitored various cardiovascular metrics over 12 weeks. What we found was quite telling: untreated diabetic rats faced significant increases in blood sugar and harmful lipid levels, while those receiving CLO showed improved weight gain and complete prevention of lipid problems.
Moreover, the study revealed that CLO-treated rats exhibited healthier blood vessel responses and heart function. For instance, we observed that CLO effectively corrected some vasoconstriction issues and improved heart rhythm responses that were otherwise diminished in diabetic rats. The treatment also helped preserve the structural integrity of heart tissue, which often suffers in diabetes.
Overall, this research strongly suggests that cod liver oil can be a valuable supplement for mitigating heart disease risks associated with diabetes. With its rich omega-3 fatty acids and antioxidants, CLO appears to play a protective role in maintaining cardiovascular health in diabetic settings.
Moreover, the study revealed that CLO-treated rats exhibited healthier blood vessel responses and heart function. For instance, we observed that CLO effectively corrected some vasoconstriction issues and improved heart rhythm responses that were otherwise diminished in diabetic rats. The treatment also helped preserve the structural integrity of heart tissue, which often suffers in diabetes.
Overall, this research strongly suggests that cod liver oil can be a valuable supplement for mitigating heart disease risks associated with diabetes. With its rich omega-3 fatty acids and antioxidants, CLO appears to play a protective role in maintaining cardiovascular health in diabetic settings.
Read More
9
We examined the effects of cod liver oil, enriched with essential fatty acids, on heart stability after inducing myocardial infarction in rats. Over 30 days, we found that the oil significantly raised the heart's fibrillation threshold by 50% and halved the occurrence of spontaneous extrasystoles. While there were improvements in the heart's functionality during rest, overall heart pressures and contraction speeds showed no significant changes. This suggests that cod liver oil may contribute positively to heart stability, but it doesn't dramatically alter all heart functions.
Read More
9
Cod liver oil's potential heart benefits
We explored the relationship between n-3 polyunsaturated fatty acids, particularly from cod liver oil, and coronary heart disease (CHD). The research found that cod liver oil significantly reduced harmful arachidonic acid levels in heart cells, promoting a healthier balance with beneficial docosahexaenoic acid. This balance may lower risks of heart issues, including sudden cardiac death. However, while diets rich in fish oil show promise, the study does not claim that cod liver oil is a guaranteed solution to heart disease.
Read More
9
We investigated how cod liver oil affects coronary artery disease in pigs on a high-fat diet over eight months. By comparing 7 pigs that received cod liver oil to 11 control pigs, we observed significantly less disease in the oil-fed group. Notably, lesion size and arterial narrowing were reduced, suggesting that cod liver oil may influence heart health. Both groups had high lipid levels, but the differences in atherosclerosis weren't linked to these levels. This study hints at the oil's potential to slow coronary disease progression via changes in metabolism.
Read More
User Reviews
USERS' SCORE
Good
Based on 24 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Promotes heart health
3 people found this helpful
Great Cod Liver Oil 650mg is an excellent dosage. It's beneficial for heart disease and general health.
Read More
10
Supports immunity
2 people found this helpful
Cod liver oil significantly benefits skin health and delays ageing. It supports heart health, memory, and reduces diabetes risk. Additionally, it boosts immunity against infections and aids in lowering triglycerides and cholesterol. It’s derived from cod liver, providing higher vitamins A and D than regular fish oils.
Read More
9
Combats inflammation
2 people found this helpful
The quality is excellent with clear ingredients, making it one of the best supplements for ageing. I noticed benefits quickly, especially in combating inflammation. The taste is almost non-existent and it supports heart health. The packaging is substantial and it is great for hair health as well.
Read More
9
Lowers bad cholesterol
This product is fantastic; it's known to lower bad cholesterol, making it highly recommended for heart disease. A relative reported improved blood sugar levels as well.
Read More
9
Enhances heart health
Omega supplements are beneficial for heart health by lowering cholesterol. The quality of the ingredients is impressive, contributing positively to managing heart disease.
Read More
Frequently Asked Questions
9
Supports heart health
Cod Liver Oil is now a key part of my daily routine. It provides essential omega-3 fatty acids and vitamins A and D, which are beneficial for heart disease, joint function, and cognitive well-being. The liquid form is easy to use, with a mild taste. Since taking it, I’ve noticed improvements in my skin and energy levels. The packaging is practical, protecting the oil from light. I highly recommend Cod Liver Oil for anyone needing a comprehensive supplement for overall health.
7.5
Improves cholesterol levels
2 people found this helpful
The large jar of 250 capsules offers excellent Omega-3s. I notice improvements in my health and decreased cholesterol levels, crucial for managing heart disease effectively.
7.5
Rich in omega
2 people found this helpful
This product is wonderful, with a pleasant dosage. Though it may have a fishy smell after a while, it’s fortified with vitamin A and rich omega. It’s beneficial for heart and blood vessel health, and has anti-inflammatory properties. The packaging is economical and I recommend it.
9
Lowers bad cholesterol
This product is fantastic; it's known to lower bad cholesterol, making it highly recommended for heart disease. A relative reported improved blood sugar levels as well.
9
Promotes heart health
3 people found this helpful
Great Cod Liver Oil 650mg is an excellent dosage. It's beneficial for heart disease and general health.
9
Reduces inflammation
This supplement boosts good cholesterol levels, reduces inflammation, and supports heart health effectively, crucial for combatting heart disease.
10
Supports immunity
2 people found this helpful
Cod liver oil significantly benefits skin health and delays ageing. It supports heart health, memory, and reduces diabetes risk. Additionally, it boosts immunity against infections and aids in lowering triglycerides and cholesterol. It’s derived from cod liver, providing higher vitamins A and D than regular fish oils.
9
Enhances heart health
Omega supplements are beneficial for heart health by lowering cholesterol. The quality of the ingredients is impressive, contributing positively to managing heart disease.
7.5
Effective Omega-3
1 people found this helpful
One of my favourite Omega-3 supplements. I take six capsules daily and it effectively decreases my cholesterol levels, improving the management of heart disease.
9
We explored the effects of docosahexaenoic acid (DHA), found in cod liver oil, on heart health after a heart attack. Using lab tests on heart cells and mouse models, we found that DHA helped protect heart cells from damage due to low oxygen levels.
Remarkably, DHA not only reduced heart damage but also improved heart function overall. It seemed to support a process called autophagy, which helps clear out damaged cells, thereby benefiting heart health after injury.
However, it's important to note that while DHA shows promising results, more research is needed to fully understand its role.
Remarkably, DHA not only reduced heart damage but also improved heart function overall. It seemed to support a process called autophagy, which helps clear out damaged cells, thereby benefiting heart health after injury.
However, it's important to note that while DHA shows promising results, more research is needed to fully understand its role.
8
We assessed the long-term relationship between cod liver oil supplements and heart disease mortality in a large UK cohort over 22 years. By analyzing data from 22,035 participants, we looked at various factors that could affect heart health, including age and lifestyle choices.
While we found that recent use of omega-3 supplements was linked to a lower risk of dying from coronary heart disease, uncertainties remain. Some factors may still confound these results, but the connection primarily seemed to benefit those using n-3 supplements.
While we found that recent use of omega-3 supplements was linked to a lower risk of dying from coronary heart disease, uncertainties remain. Some factors may still confound these results, but the connection primarily seemed to benefit those using n-3 supplements.
8
Cod liver oil shows mixed benefits
We examined the effects of cod liver oil on heart disease, particularly its potential to reduce clot formation and inflammation. Research indicates that while marine fish consumption lowers the risk of heart disease, the supplement isn't always recommended due to mixed effects on cholesterol and possible bleeding risks. However, in studies with swine, cod liver oil improved vascular health by decreasing monocyte and platelet adhesion in coronary arteries. Despite these benefits, the study results suggest that the supplement may not universally improve heart disease outcomes.
References
- Shi Y, Li H, Wu T, Wang Q, Zhu Q, et al. Docosahexaenoic Acid-Enhanced Autophagic Flux Improves Cardiac Dysfunction after Myocardial Infarction by Targeting the AMPK/mTOR Signaling Pathway. Oxid Med Cell Longev. 2022;2022:1509421. 10.1155/2022/1509421
- Nilsen DWT, Myhre PL, Kalstad A, Schmidt EB, Arnesen H, et al. Serum Levels of Dihomo-Gamma (γ)-Linolenic Acid (DGLA) Are Inversely Associated with Linoleic Acid and Total Death in Elderly Patients with a Recent Myocardial Infarction. Nutrients. 2021;13. 10.3390/nu13103475
- Lentjes MAH, Keogh RH, Welch AA, Mulligan AA, Luben RN, et al. Longitudinal associations between marine omega-3 supplement users and coronary heart disease in a UK population-based cohort. BMJ Open. 2017;7:e017471. 10.1136/bmjopen-2017-017471
- Ceylan-Isik A, Hünkar T, Aşan E, Kaymaz F, Ari N, et al. Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats. J Pharm Pharmacol. 2007;59:1629.
- Vermel' AE. [Clinical application of omega-3-fatty acids (cod-liver oil)]. Klin Med (Mosk). 2005;83:51.
- Pedersen JI, Tverdal A, Kirkhus B. [Diet changes and the rise and fall of cardiovascular disease mortality in Norway]. Tidsskr Nor Laegeforen. 2004;124:1532.
- Kulakova SN, Gapparova KM, Pogozheva AV, Levachev MM. [Evaluation of the effects of fish and vegetable omega-3 PUFA complex on the erythrocyte fatty acid composition in patients with ischemic heart disease and impaired glucose tolerance]. Vopr Pitan. 1999;68:26.
- Kim DN, Eastman A, Baker JE, Mastrangelo A, Sethi S, et al. Fish oil, atherogenesis, and thrombogenesis. Ann N Y Acad Sci. 1995;748:474.
- Meerson FZ, Belkina LM, Fu STs, Isaev VA. [Correction of disorders of cardiac electric stability in post-infarction cardiosclerosis using a diet enriched with polyunsaturated fatty acids]. Biull Eksp Biol Med. 1993;115:343.
- Skúladóttir GV, Gudmundsdóttir E, Olafsdóttir E, Gudmundsson TV, Hardarson T, et al. Influence of dietary cod liver oil on fatty acid composition of plasma lipids in human male subjects after myocardial infarction. J Intern Med. 1990;228:563.
- Schmidt EB, Pedersen JO, Ekelund S, Grunnet N, Jersild C, et al. Cod liver oil inhibits neutrophil and monocyte chemotaxis in healthy males. Atherosclerosis. 1989;77:53.
- Gudbjarnason S, Benediktsdóttir VE, Skúladóttir G. Effects of n-3 polyunsaturated fatty acids on coronary heart disease. Bibl Nutr Dieta. 1989.
- Gudbjarnason S. Dynamics of n-3 and n-6 fatty acids in phospholipids of heart muscle. J Intern Med Suppl. 1989;731:117.
- Simonsen T, Nordøy A. Ischaemic heart disease, serum lipids and platelets in Norwegian populations with traditionally low or high fish consumption. J Intern Med Suppl. 1989;731:83.
- Shimokawa H, Vanhoutte PM. Dietary cod-liver oil improves endothelium-dependent responses in hypercholesterolemic and atherosclerotic porcine coronary arteries. Circulation. 1988;78:1421.
- Vanhoutte PM. Platelets, endothelium and blood vessel wall. Experientia. 1988;44:105.
- Weiner BH, Ockene IS, Levine PH, Cuénoud HF, Fisher M, et al. Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model. N Engl J Med. 1986;315:841.
- Li W, Liu S, Meng X, Liu H. A nutrient wide association study of cardiovascular disease prevalence in older adults from NHANES 2007 to 2018. Sci Rep. 2025;15:12710. 10.1038/s41598-025-97143-8
- Rettkowski J, Romero-Mulero MC, Singh I, Wadle C, Wrobel J, et al. Modulation of bone marrow haematopoietic stem cell activity as a therapeutic strategy after myocardial infarction: a preclinical study. Nat Cell Biol. 2025;27:591. 10.1038/s41556-025-01639-4
- Kawai S, Pak K, Iwamoto S, Kawakami C, Inuzuka R, et al. Association Between Maternal Factors in Early Pregnancy and Congenital Heart Defects in Offspring: The Japan Environment and Children's Study. J Am Heart Assoc. 2023;12:e029268. 10.1161/JAHA.122.029268
- Tan YZ, Shen HR, Wang YL, Wang QL, Wu XP, et al. Retinoic acid released from self-assembling peptide activates cardiomyocyte proliferation and enhances repair of infarcted myocardium. Exp Cell Res. 2023;422:113440. 10.1016/j.yexcr.2022.113440
- Naasner L, Froese N, Hofmann W, Galuppo P, Werlein C, et al. Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity. Am J Physiol Heart Circ Physiol. 2022;323:H1352. 10.1152/ajpheart.00514.2022
- Huang J. Circulating Concentrations of Nutrition-Related Factors Are Not Causally Associated With Atrial Fibrillation: A Mendelian Randomization Study. J Cardiovasc Pharmacol. 2022;80:210. 10.1097/FJC.0000000000001263
- Huang J, Weinstein SJ, Yu K, Männistö S, Albanes D. Association between serum retinol and overall and cause-specific mortality in a 30-year prospective cohort study. Nat Commun. 2021;12:6418. 10.1038/s41467-021-26639-4
- Astani A, Maroofi A, Hekmatimoghaddam S, Sarebanhassanabadi M, Safari F. Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts. Mol Biol Rep. 2024;52:96. 10.1007/s11033-024-10168-6
- Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. 10.4103/abr.abr_380_23
- Sato AY, Cregor M, McAndrews K, Schurman CA, Schaible E, et al. Pharmacologic or genetic interference with atrogene signaling protects against glucocorticoid-induced musculoskeletal and cardiac disease. JCI Insight. 2024;9. 10.1172/jci.insight.182664
- Stankiewicz B, Mieszkowski J, Kochanowicz A, Brzezińska P, Niespodziński B, et al. Effect of Single High-Dose Vitamin D Supplementation on Post-Ultra Mountain Running Heart Damage and Iron Metabolism Changes: A Double-Blind Randomized Controlled Trial. Nutrients. 2024;16. 10.3390/nu16152479
- Koroglu R, Koroglu M, Aygun H. Electrocardiographic, biochemical, and scintigraphic evidence for the cardioprotective effect of paricalcitol and vitamin D3 on doxorubicin-induced acute cardiotoxicity in rats. Bratisl Lek Listy. 2024;125:281. 10.4149/BLL_2024_42
- Hao N, Yong H, Zhang F, Liu C, Qiu Y, et al. Aortic calcification accelerates cardiac dysfunction via inducing apoptosis of cardiomyocytes. Int J Med Sci. 2024;21:306. 10.7150/ijms.90324
- Samavati I, Ranjbar A, Haddadi R. Cardioprotective effect of vitamin D3 on cisplatin-induced cardiotoxicity in male mice: role of oxidative stress. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:4761. 10.1007/s00210-023-02848-0
- Ogata S, Manson JE, Kang JH, Buring JE, Lee IM, et al. Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease: A Novel Analysis of the VITAL Trial Using Win Ratio and Hierarchical Composite Outcomes. Nutrients. 2023;15. 10.3390/nu15194235
- Arroyo E, Leber CA, Burney HN, Li Y, Li X, et al. Epimeric vitamin D and cardiovascular structure and function in advanced CKD and after kidney transplantation. Nephrol Dial Transplant. 2024;39:264. 10.1093/ndt/gfad168
- Hasific S, Øvrehus KA, Hosbond S, Lambrechtsen J, Kumarathurai P, et al. Effects of vitamins K2 and D3 supplementation in patients with severe coronary artery calcification: a study protocol for a randomised controlled trial. BMJ Open. 2023;13:e073233. 10.1136/bmjopen-2023-073233
- Thompson B, Waterhouse M, English DR, McLeod DS, Armstrong BK, et al. Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial. BMJ. 2023;381:e075230. 10.1136/bmj-2023-075230
