Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.1
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
< 1%**
Vitamin A (from Retinyl Palmitate and Cod Liver Oil)
750 mcg
83%
Vitamin D3 (from Cholecalciferol and Cod Liver Oil)
6.75 mcg (270 IU)
34%
Cod Liver Oil
650 mg
†
Top Medical Research Studies
We aimed to explore how vitamin D3 supplementation affects liver disease, specifically in patients with cirrhosis. In a thorough double-blind, randomized controlled trial involving 60 participants, we offered patients either a weekly dose of 50,000 IU of vitamin D or a placebo for 12 weeks. Our goal was to assess various health indicators, including serum vitamin D levels, blood glucose measures, and liver function tests.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
Read More
9
We explored the potential of vitamin D3 in mitigating liver disease associated with a high-fat diet. In our study, male mice were placed on a high-fat diet for 16 weeks while receiving regular vitamin D3 injections. This setup allowed us to effectively gauge the compound's impact on liver health.
As we examined the results, we observed that vitamin D3 supplementation notably reduced weight gain and improved liver function in these mice. Beyond mere weight management, vitamin D3 also showed promising effects on serum lipid levels and insulin sensitivity, key metrics related to liver health.
Even more encouraging, we found that vitamin D3 helped inhibit harmful processes in liver cells, particularly ferroptosis, which is a type of cell death associated with many liver diseases. It achieved this by enhancing antioxidant capacity and regulating iron levels within the liver. These findings were further validated using human liver cells treated with a saturated fat equivalent, reinforcing the compound's potential as a supportive treatment for liver issues.
Overall, our research suggests that vitamin D3 holds promise for improving liver health and could be a valuable addition to treatment strategies for fatty liver disease, particularly in populations at risk.
As we examined the results, we observed that vitamin D3 supplementation notably reduced weight gain and improved liver function in these mice. Beyond mere weight management, vitamin D3 also showed promising effects on serum lipid levels and insulin sensitivity, key metrics related to liver health.
Even more encouraging, we found that vitamin D3 helped inhibit harmful processes in liver cells, particularly ferroptosis, which is a type of cell death associated with many liver diseases. It achieved this by enhancing antioxidant capacity and regulating iron levels within the liver. These findings were further validated using human liver cells treated with a saturated fat equivalent, reinforcing the compound's potential as a supportive treatment for liver issues.
Overall, our research suggests that vitamin D3 holds promise for improving liver health and could be a valuable addition to treatment strategies for fatty liver disease, particularly in populations at risk.
Read More
9
We explored how vitamin D3 impacts non-alcoholic fatty liver disease (NAFLD) and its influence on liver immune cells. In an exciting study, researchers set up an experiment using mice on a high-fat diet to create a model of NAFLD. The mice received 1,25-dihydroxyvitamin D, a potent form of vitamin D3, to see if it could counteract the detrimental effects of fatty liver condition.
The findings were promising. The treatment improved liver fat levels and enhanced lipid metabolism. It achieved this, in part, by reversing the polarization of inflammatory immune cells in the liver. Specifically, the vitamin D3 appeared to lower the presence of pro-inflammatory M1 macrophages, which are linked to greater liver fat accumulation. The research suggested that vitamin D3 works through specific pathways in the body, hinting at its potential as a helpful supplement for individuals struggling with liver fat issues.
Overall, this study highlights the therapeutic promise of 1,25(OH)D for improving liver health in the context of obesity-related conditions. While there’s more to uncover, the results offer hope for better management strategies for NAFLD in the future.
The findings were promising. The treatment improved liver fat levels and enhanced lipid metabolism. It achieved this, in part, by reversing the polarization of inflammatory immune cells in the liver. Specifically, the vitamin D3 appeared to lower the presence of pro-inflammatory M1 macrophages, which are linked to greater liver fat accumulation. The research suggested that vitamin D3 works through specific pathways in the body, hinting at its potential as a helpful supplement for individuals struggling with liver fat issues.
Overall, this study highlights the therapeutic promise of 1,25(OH)D for improving liver health in the context of obesity-related conditions. While there’s more to uncover, the results offer hope for better management strategies for NAFLD in the future.
Read More
Most Useful Reviews
7.5
Cholesterol improvement
3 people found this helpful
Cholesterol was raised. With my doctor’s guidance, we enhanced my nutrition, aerobic exercise, and dietary supplements. I took unrefined vegetable oils, lecithin, omega-3, sorbents, probiotics, antioxidants, and cod liver oil, prescribed as iHerb Now Foods Cod Liver Oil (650 mg). I consumed 2 capsules twice daily. The capsules are large, reasonably priced, and I liked the product. Cholesterol began to decline after a month.
Read More
2
Skin issues noted
2 people found this helpful
In the name of God, I learned that cod liver oil is rich in vitamin D and different from omega-3. I found it helped improve my skin, but after a month of use, I experienced numerous small pimples. I did not find benefits for my hair or face, nor did I observe negative reactions related to liver disease.
Read More
9
Skin dryness relief
1 people found this helpful
I take vitamin A from cod liver oil for hypothyroidism, as this form is necessary. When I take it, my skin stops drying out. If I skip it for 2-3 months, dryness returns. One capsule suffices, despite it not providing the full daily requirement.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.1
- All Researches
9
We examined the effects of cod liver oil on liver inflammation caused by sodium nitrite, a common food additive known for its harmful effects at high levels. In this study, we treated thirty-two adult male rats with sodium nitrite and observed the potential protective role of cod liver oil.
The rats received either sodium nitrite alone or sodium nitrite along with cod liver oil. We assessed liver damage through various markers and tissue staining. The results indicated that cod liver oil significantly reduced liver cell damage. Furthermore, it helped lower levels of inflammatory cytokines and markers associated with tissue fibrosis and cell death compared to the group that received sodium nitrite alone.
Our findings suggest that cod liver oil can play a beneficial role in protecting the liver from inflammation and injury caused by sodium nitrite exposure. This highlights the potential of dietary interventions in managing liver health.
The rats received either sodium nitrite alone or sodium nitrite along with cod liver oil. We assessed liver damage through various markers and tissue staining. The results indicated that cod liver oil significantly reduced liver cell damage. Furthermore, it helped lower levels of inflammatory cytokines and markers associated with tissue fibrosis and cell death compared to the group that received sodium nitrite alone.
Our findings suggest that cod liver oil can play a beneficial role in protecting the liver from inflammation and injury caused by sodium nitrite exposure. This highlights the potential of dietary interventions in managing liver health.
Read More
9
We explored how cod liver oil may help protect the liver from damage caused by sodium nitrite, a substance known for its harmful effects. Thirty-two male rats were used in our study, where some received sodium nitrite alone while others were treated with both sodium nitrite and cod liver oil.
After treatment, we examined the liver sections for any changes and measured markers indicating oxidative stress and liver function. Our findings showed that cod liver oil significantly reduced harmful liver enzymes, preventing liver cell damage.
Additionally, we observed that cod liver oil lowered levels of oxidative stress indicators and improved mitochondrial function, which are crucial for liver health. It also reduced inflammation and DNA damage caused by sodium nitrite.
Overall, the study suggests that dietary cod liver oil can be beneficial in combating liver damage linked to sodium nitrite exposure through several protective mechanisms.
After treatment, we examined the liver sections for any changes and measured markers indicating oxidative stress and liver function. Our findings showed that cod liver oil significantly reduced harmful liver enzymes, preventing liver cell damage.
Additionally, we observed that cod liver oil lowered levels of oxidative stress indicators and improved mitochondrial function, which are crucial for liver health. It also reduced inflammation and DNA damage caused by sodium nitrite.
Overall, the study suggests that dietary cod liver oil can be beneficial in combating liver damage linked to sodium nitrite exposure through several protective mechanisms.
Read More
We aimed to explore how vitamin D3 supplementation affects liver disease, specifically in patients with cirrhosis. In a thorough double-blind, randomized controlled trial involving 60 participants, we offered patients either a weekly dose of 50,000 IU of vitamin D or a placebo for 12 weeks. Our goal was to assess various health indicators, including serum vitamin D levels, blood glucose measures, and liver function tests.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
Read More
9
We explored the potential of vitamin D3 in mitigating liver disease associated with a high-fat diet. In our study, male mice were placed on a high-fat diet for 16 weeks while receiving regular vitamin D3 injections. This setup allowed us to effectively gauge the compound's impact on liver health.
As we examined the results, we observed that vitamin D3 supplementation notably reduced weight gain and improved liver function in these mice. Beyond mere weight management, vitamin D3 also showed promising effects on serum lipid levels and insulin sensitivity, key metrics related to liver health.
Even more encouraging, we found that vitamin D3 helped inhibit harmful processes in liver cells, particularly ferroptosis, which is a type of cell death associated with many liver diseases. It achieved this by enhancing antioxidant capacity and regulating iron levels within the liver. These findings were further validated using human liver cells treated with a saturated fat equivalent, reinforcing the compound's potential as a supportive treatment for liver issues.
Overall, our research suggests that vitamin D3 holds promise for improving liver health and could be a valuable addition to treatment strategies for fatty liver disease, particularly in populations at risk.
As we examined the results, we observed that vitamin D3 supplementation notably reduced weight gain and improved liver function in these mice. Beyond mere weight management, vitamin D3 also showed promising effects on serum lipid levels and insulin sensitivity, key metrics related to liver health.
Even more encouraging, we found that vitamin D3 helped inhibit harmful processes in liver cells, particularly ferroptosis, which is a type of cell death associated with many liver diseases. It achieved this by enhancing antioxidant capacity and regulating iron levels within the liver. These findings were further validated using human liver cells treated with a saturated fat equivalent, reinforcing the compound's potential as a supportive treatment for liver issues.
Overall, our research suggests that vitamin D3 holds promise for improving liver health and could be a valuable addition to treatment strategies for fatty liver disease, particularly in populations at risk.
Read More
9
Calcitriol mitigates liver toxicity
We examined the potential of calcitriol, also known as vitamin D3, to protect the liver from damage caused by cisplatin, a commonly used chemotherapy drug. In this study, mice were split into groups to assess the effects of calcitriol alone, cisplatin alone, and the combination of both. Notably, calcitriol was given to some mice leading up to the administration of cisplatin.
Our observations showed that calcitriol significantly helped in reversing the liver damage induced by cisplatin. This was noticeable through improved liver and kidney function tests, as well as better histological results. Additionally, calcitriol appeared to reduce oxidative stress and inflammation in both the liver and kidneys while enhancing the expression of certain protective proteins.
We also noted that calcitriol played a role in lowering inflammation markers and promoting cell survival by downregulating harmful proteins. Interestingly, when calcitriol was given alongside cisplatin, the liver's resilience against cisplatin's toxic effects was markedly enhanced. Overall, our findings suggest that calcitriol may offer a protective strategy against liver damage caused by chemotherapy, primarily through its anti-inflammatory and antioxidant properties.
Our observations showed that calcitriol significantly helped in reversing the liver damage induced by cisplatin. This was noticeable through improved liver and kidney function tests, as well as better histological results. Additionally, calcitriol appeared to reduce oxidative stress and inflammation in both the liver and kidneys while enhancing the expression of certain protective proteins.
We also noted that calcitriol played a role in lowering inflammation markers and promoting cell survival by downregulating harmful proteins. Interestingly, when calcitriol was given alongside cisplatin, the liver's resilience against cisplatin's toxic effects was markedly enhanced. Overall, our findings suggest that calcitriol may offer a protective strategy against liver damage caused by chemotherapy, primarily through its anti-inflammatory and antioxidant properties.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Cholesterol improvement
3 people found this helpful
Cholesterol was raised. With my doctor’s guidance, we enhanced my nutrition, aerobic exercise, and dietary supplements. I took unrefined vegetable oils, lecithin, omega-3, sorbents, probiotics, antioxidants, and cod liver oil, prescribed as iHerb Now Foods Cod Liver Oil (650 mg). I consumed 2 capsules twice daily. The capsules are large, reasonably priced, and I liked the product. Cholesterol began to decline after a month.
Read More
2
Skin issues noted
2 people found this helpful
In the name of God, I learned that cod liver oil is rich in vitamin D and different from omega-3. I found it helped improve my skin, but after a month of use, I experienced numerous small pimples. I did not find benefits for my hair or face, nor did I observe negative reactions related to liver disease.
Read More
9
Skin dryness relief
1 people found this helpful
I take vitamin A from cod liver oil for hypothyroidism, as this form is necessary. When I take it, my skin stops drying out. If I skip it for 2-3 months, dryness returns. One capsule suffices, despite it not providing the full daily requirement.
Read More
6
Liver function improvement
1 people found this helpful
For liver function enhancement.
Read More
Frequently Asked Questions
7.5
Cholesterol improvement
3 people found this helpful
Cholesterol was raised. With my doctor’s guidance, we enhanced my nutrition, aerobic exercise, and dietary supplements. I took unrefined vegetable oils, lecithin, omega-3, sorbents, probiotics, antioxidants, and cod liver oil, prescribed as iHerb Now Foods Cod Liver Oil (650 mg). I consumed 2 capsules twice daily. The capsules are large, reasonably priced, and I liked the product. Cholesterol began to decline after a month.
2
Skin issues noted
2 people found this helpful
In the name of God, I learned that cod liver oil is rich in vitamin D and different from omega-3. I found it helped improve my skin, but after a month of use, I experienced numerous small pimples. I did not find benefits for my hair or face, nor did I observe negative reactions related to liver disease.
9
Skin dryness relief
1 people found this helpful
I take vitamin A from cod liver oil for hypothyroidism, as this form is necessary. When I take it, my skin stops drying out. If I skip it for 2-3 months, dryness returns. One capsule suffices, despite it not providing the full daily requirement.
9
We examined the effects of cod liver oil on liver inflammation caused by sodium nitrite, a common food additive known for its harmful effects at high levels. In this study, we treated thirty-two adult male rats with sodium nitrite and observed the potential protective role of cod liver oil.
The rats received either sodium nitrite alone or sodium nitrite along with cod liver oil. We assessed liver damage through various markers and tissue staining. The results indicated that cod liver oil significantly reduced liver cell damage. Furthermore, it helped lower levels of inflammatory cytokines and markers associated with tissue fibrosis and cell death compared to the group that received sodium nitrite alone.
Our findings suggest that cod liver oil can play a beneficial role in protecting the liver from inflammation and injury caused by sodium nitrite exposure. This highlights the potential of dietary interventions in managing liver health.
The rats received either sodium nitrite alone or sodium nitrite along with cod liver oil. We assessed liver damage through various markers and tissue staining. The results indicated that cod liver oil significantly reduced liver cell damage. Furthermore, it helped lower levels of inflammatory cytokines and markers associated with tissue fibrosis and cell death compared to the group that received sodium nitrite alone.
Our findings suggest that cod liver oil can play a beneficial role in protecting the liver from inflammation and injury caused by sodium nitrite exposure. This highlights the potential of dietary interventions in managing liver health.
9
We explored how cod liver oil may help protect the liver from damage caused by sodium nitrite, a substance known for its harmful effects. Thirty-two male rats were used in our study, where some received sodium nitrite alone while others were treated with both sodium nitrite and cod liver oil.
After treatment, we examined the liver sections for any changes and measured markers indicating oxidative stress and liver function. Our findings showed that cod liver oil significantly reduced harmful liver enzymes, preventing liver cell damage.
Additionally, we observed that cod liver oil lowered levels of oxidative stress indicators and improved mitochondrial function, which are crucial for liver health. It also reduced inflammation and DNA damage caused by sodium nitrite.
Overall, the study suggests that dietary cod liver oil can be beneficial in combating liver damage linked to sodium nitrite exposure through several protective mechanisms.
After treatment, we examined the liver sections for any changes and measured markers indicating oxidative stress and liver function. Our findings showed that cod liver oil significantly reduced harmful liver enzymes, preventing liver cell damage.
Additionally, we observed that cod liver oil lowered levels of oxidative stress indicators and improved mitochondrial function, which are crucial for liver health. It also reduced inflammation and DNA damage caused by sodium nitrite.
Overall, the study suggests that dietary cod liver oil can be beneficial in combating liver damage linked to sodium nitrite exposure through several protective mechanisms.
We aimed to explore how vitamin D3 supplementation affects liver disease, specifically in patients with cirrhosis. In a thorough double-blind, randomized controlled trial involving 60 participants, we offered patients either a weekly dose of 50,000 IU of vitamin D or a placebo for 12 weeks. Our goal was to assess various health indicators, including serum vitamin D levels, blood glucose measures, and liver function tests.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
9
We explored the potential of vitamin D3 in mitigating liver disease associated with a high-fat diet. In our study, male mice were placed on a high-fat diet for 16 weeks while receiving regular vitamin D3 injections. This setup allowed us to effectively gauge the compound's impact on liver health.
As we examined the results, we observed that vitamin D3 supplementation notably reduced weight gain and improved liver function in these mice. Beyond mere weight management, vitamin D3 also showed promising effects on serum lipid levels and insulin sensitivity, key metrics related to liver health.
Even more encouraging, we found that vitamin D3 helped inhibit harmful processes in liver cells, particularly ferroptosis, which is a type of cell death associated with many liver diseases. It achieved this by enhancing antioxidant capacity and regulating iron levels within the liver. These findings were further validated using human liver cells treated with a saturated fat equivalent, reinforcing the compound's potential as a supportive treatment for liver issues.
Overall, our research suggests that vitamin D3 holds promise for improving liver health and could be a valuable addition to treatment strategies for fatty liver disease, particularly in populations at risk.
As we examined the results, we observed that vitamin D3 supplementation notably reduced weight gain and improved liver function in these mice. Beyond mere weight management, vitamin D3 also showed promising effects on serum lipid levels and insulin sensitivity, key metrics related to liver health.
Even more encouraging, we found that vitamin D3 helped inhibit harmful processes in liver cells, particularly ferroptosis, which is a type of cell death associated with many liver diseases. It achieved this by enhancing antioxidant capacity and regulating iron levels within the liver. These findings were further validated using human liver cells treated with a saturated fat equivalent, reinforcing the compound's potential as a supportive treatment for liver issues.
Overall, our research suggests that vitamin D3 holds promise for improving liver health and could be a valuable addition to treatment strategies for fatty liver disease, particularly in populations at risk.
9
Vitamin D3 shows potential in NAFLD
We aimed to understand how Vitamin D3 can affect liver disease, specifically non-alcoholic fatty liver disease (NAFLD). NAFLD is characterized by inflammation and fat accumulation in the liver, leading to metabolic disorders. In a zebrafish model of NAFLD, we tested Vitamin D3 alongside a compound called DOPA-33, which is known for its properties that reduce inflammation and oxidative stress.
Our research showed that when used together, Vitamin D3 and DOPA-33 significantly reduced liver fat accumulation and improved markers of oxidative stress. Zebrafish that received this combination treatment exhibited enhanced movement and maintained healthier weight, indicating overall better metabolic health.
We observed that these treatments led to lower triglycerides and glucose levels in the zebrafish. Additionally, there was a noticeable decrease in harmful liver inflammation and a reduction in the expression of genes related to fat production. We also confirmed that the combination therapy decreased liver cholesterol levels, further highlighting its effectiveness against the symptoms of NAFLD.
In summary, our findings suggest that Vitamin D3, especially when combined with DOPA-33, plays a beneficial role in targeting the pathways involved in lipid metabolism and oxidative stress associated with NAFLD.
Our research showed that when used together, Vitamin D3 and DOPA-33 significantly reduced liver fat accumulation and improved markers of oxidative stress. Zebrafish that received this combination treatment exhibited enhanced movement and maintained healthier weight, indicating overall better metabolic health.
We observed that these treatments led to lower triglycerides and glucose levels in the zebrafish. Additionally, there was a noticeable decrease in harmful liver inflammation and a reduction in the expression of genes related to fat production. We also confirmed that the combination therapy decreased liver cholesterol levels, further highlighting its effectiveness against the symptoms of NAFLD.
In summary, our findings suggest that Vitamin D3, especially when combined with DOPA-33, plays a beneficial role in targeting the pathways involved in lipid metabolism and oxidative stress associated with NAFLD.
2
We investigated how vitamin D3 influences liver disease, particularly non-alcoholic fatty liver disease (NAFLD). Using gene knockout mice as lean models, we administered high doses of vitamin D3 or the active form, calcipotriol, to determine their effects over a 12-week period.
Our findings revealed a concerning outcome. Vitamin D3 actually worsened liver fat accumulation, known as hepatic steatosis, in these mice. This increase was linked to higher levels of certain liver genes. On the other hand, calcipotriol didn't seem to affect liver fat levels significantly but showed promise in reducing inflammation markers in the liver.
Interestingly, both forms of vitamin D did not cause harm to liver cells or worsen scarring in the liver, which are key concerns in liver disease. While vitamin D3 raised certain serum vitamin D markers, calcipotriol decreased them without affecting calcium or phosphate levels in the body.
Overall, we learned that vitamin D3 might not be the solution for treating liver fat issues and that calcipotriol could offer some benefits by lowering inflammation. These differences likely arise from how each form of vitamin D interacts with liver cells. This study could be a pivotal reference for future discussions on treating lean NAFLD with vitamin D.
Our findings revealed a concerning outcome. Vitamin D3 actually worsened liver fat accumulation, known as hepatic steatosis, in these mice. This increase was linked to higher levels of certain liver genes. On the other hand, calcipotriol didn't seem to affect liver fat levels significantly but showed promise in reducing inflammation markers in the liver.
Interestingly, both forms of vitamin D did not cause harm to liver cells or worsen scarring in the liver, which are key concerns in liver disease. While vitamin D3 raised certain serum vitamin D markers, calcipotriol decreased them without affecting calcium or phosphate levels in the body.
Overall, we learned that vitamin D3 might not be the solution for treating liver fat issues and that calcipotriol could offer some benefits by lowering inflammation. These differences likely arise from how each form of vitamin D interacts with liver cells. This study could be a pivotal reference for future discussions on treating lean NAFLD with vitamin D.
References
- Sherif IO, Al-Gayyar MM. Cod liver oil in sodium nitrite induced hepatic injury: does it have a potential protective effect?. Redox Rep. 2015;20:11. 10.1179/1351000214Y.0000000097
- Salama MF, Abbas A, Darweish MM, El-Hawwary AA, Al-Gayyar MM. Hepatoprotective effects of cod liver oil against sodium nitrite toxicity in rats. Pharm Biol. 2013;51:1435. 10.3109/13880209.2013.796564
- Derogar Kasmaei SR, Parastouei K, Hosseini Ahangar B, Saberifiroozi M, Taghdir M. Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial. BMJ Nutr Prev Health. 2024;7:e000938. 10.1136/bmjnph-2024-000938
- Liu N, Zhao P, Cao P, Hui J, Pan Y, et al. Vitamin D3/VDR alleviates double-stranded RNA virus -induced biliary epithelial cell damage by inhibiting autophagy. BMC Gastroenterol. 2025;25:44. 10.1186/s12876-025-03640-5
- Miao Y, Jiang Z, Song H, Zhang Y, Chen H, et al. Vitamin D supplementation alleviates high fat diet-induced metabolic associated fatty liver disease by inhibiting ferroptosis pathway. Eur J Nutr. 2024;64:50. 10.1007/s00394-024-03554-0
- Morsy MA, Abdel-Latif R, Ibrahim MF, Marey H, Abdel-Gaber SA. Calcitriol ameliorates cisplatin-induced hepatorenal toxicity via regulation of Nrf2-Mrp2/p38 MAPK signaling in mice. Int J Immunopathol Pharmacol. 2024;38:3946320241306276. 10.1177/03946320241306276
- Luo WJ, Dong XW, Ye H, Zhao QS, Zhang QB, et al. Vitamin D 1,25-Dihydroxyvitamin D reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization. World J Gastrointest Oncol. 2024;16:4685. 10.4251/wjgo.v16.i12.4685
- Kilani Y, Alsakarneh S, Madi MY, Mosquera DAG, Ferreira MN, et al. Autoimmune Hepatitis and Vitamin D Deficiency: A Nationwide Perspective. Aliment Pharmacol Ther. 2025;61:682. 10.1111/apt.18438
- Dai J, Song J, Chen X, Ding F, Ding Y, et al. 1,25(OH)D-treated mouse bone marrow-derived dendritic cells alleviate autoimmune hepatitis in mice by improving TFR/TFH imbalance. Immunopharmacol Immunotoxicol. 2025;47:59. 10.1080/08923973.2024.2435314
- Yaribeygi H, Ramezani M, Katsiki N, Mirmohammadkhani M, Tabaei NS. Efficacy of Adding Sitagliptin to Ongoing Metformin on Metabolic Profile, Triglyceride-Glucose Index, Vitamin D3, and Liver Tests in Patients Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease: A Double-Blind Randomized Clinical Trial. Curr Ther Res Clin Exp. 2024;101:100764. 10.1016/j.curtheres.2024.100764
- Farrash WF, Idris S, Elzubier ME, Khidir EBA, Aslam A, et al. Enhanced hepatoprotective effects of empagliflozin and vitamin D dual therapy against metabolic dysfunction-associated steatohepatitis in mice by boosted modulation of metabolic, oxidative stress, and inflammatory pathways. Int J Exp Pathol. 2024;105:219. 10.1111/iep.12519
- Dharshan SS, Ramamurthy K, Kaliraj S, Manikandan K, Chitra V, et al. Combined effects of vitamin D3 and dioxopiperidinamide derivative on lipid homeostasis, inflammatory pathways, and redox imbalance in non-alcoholic fatty liver disease in vivo zebrafish model. Biotechnol Appl Biochem. 2024. 10.1002/bab.2666
- Fogacci F, Giovannini M, Di Micoli V, Grandi E, Borghi C, et al. Effect of Supplementation of a Butyrate-Based Formula in Individuals with Liver Steatosis and Metabolic Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Nutrients. 2024;16. 10.3390/nu16152454
- Abdel-Hamid GR, Mostafa DM, Fathy RM, Lotfy DM, Osman S. Cytokine storm modulation using cholecalciferol and low dose gamma radiation in Escherichia coli infected mice. Cell Biochem Funct. 2024;42:e4026. 10.1002/cbf.4026
- Yang A, Chen Y, Gao Y, Lv Q, Li Y, et al. Vitamin D exacerbates steatosis while calcipotriol inhibits inflammation in non-alcoholic fatty liver disease in knockout mice: a comparative study of two forms of vitamin D. Food Funct. 2024;15:4614. 10.1039/d4fo00215f
- Lu Y, Chen H, Chen Y, Zhao L, Hou S. Accumulated LPS induced by colitis altered the activities of vitamin D-metabolizing hydroxylases and decreased the generation of 25-hydroxyvitamin D. Chem Biol Interact. 2024;395:110997. 10.1016/j.cbi.2024.110997
- Lee SB, Jin MH, Yoon JH. The contribution of vitamin D insufficiency to the onset of steatotic liver disease among individuals with metabolic dysfunction. Sci Rep. 2024;14:6714. 10.1038/s41598-024-57380-9
- Guo E, Yuan H, Li R, Yang J, Liu S, et al. Calcitriol ameliorates the progression of hepatic fibrosis through autophagy-related gene 16-like 1-mediated autophagy. Am J Med Sci. 2024;367:382. 10.1016/j.amjms.2024.02.010
