' 
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
320 mg
356%
Calcium (from Calcium Carbonate)
36 mg
3%
Grape Seed Extract (Vitis vinifera) (min. 90% Total Polyphenols)
100 mg
†
Top Medical Research Studies
9
Vitamin C impacts autoimmune response
Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies.
Direct evaluation of vitamin C
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Read More
9
Vitamin C helps rheumatoid arthritis
Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance.
Directly evaluates vitamin C effects
We explored how vitamin C supplementation might affect rheumatoid arthritis (RA), an autoimmune disorder that causes chronic inflammation. Our research focused on whether vitamin C could help restore balance in gut microbiota, which previous findings indicated could worsen RA by breaking down vitamin C.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Read More
8
Vitamin C may lower hypothyroidism risk
Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012.
Highly relevant to autoimmune research
We aimed to understand how vitamin C intake influences hypothyroidism in patients with Hashimoto thyroiditis (HT). Through a detailed analysis of data collected in the National Health and Nutrition Examination Survey from 2007 to 2012, we found notable results that shed light on this relationship.
Our study involved looking at various participants categorized by their total vitamin C intake. We discovered a significant negative correlation between the amount of vitamin C consumed and the likelihood of developing hypothyroidism in those with HT. In essence, individuals drinking higher amounts of vitamin C—up to 1,258.9 mg per day—exhibited a lower probability of experiencing hypothyroidism compared to those with minimal intake.
Furthermore, this connection remained apparent even when we examined different age groups and genders, indicating that vitamin C could play a protective role against hypothyroidism related to Hashimoto's thyroiditis. Thus, our findings suggest that enhancing vitamin C consumption might be a beneficial strategy for those managing this autoimmune condition.
Our study involved looking at various participants categorized by their total vitamin C intake. We discovered a significant negative correlation between the amount of vitamin C consumed and the likelihood of developing hypothyroidism in those with HT. In essence, individuals drinking higher amounts of vitamin C—up to 1,258.9 mg per day—exhibited a lower probability of experiencing hypothyroidism compared to those with minimal intake.
Furthermore, this connection remained apparent even when we examined different age groups and genders, indicating that vitamin C could play a protective role against hypothyroidism related to Hashimoto's thyroiditis. Thus, our findings suggest that enhancing vitamin C consumption might be a beneficial strategy for those managing this autoimmune condition.
Read More
Most Useful Reviews
8.8
Balances autoimmune system
It is a good aid in balancing the body's autoimmune system, and it also safeguards the eyes and liver while helping to clear the liver.
Read More
8.8
Effective supplement
An excellent product, providing great value for the number of capsules at the price. I really appreciate the Now brand; it's usually my first choice for supplements. The effect of these capsules is definitely noticeable, and I recommend them over alternative products. They were previously unavailable, so I tried others instead.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.1
- All Researches
9.5
Calcium's role in RA treatment
Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.
Focus on calcium's therapeutic potential
We investigated how calcium, specifically in the form of two-dimensional layered calcium disilicide nanoparticles (CSNs), can play a role in treating rheumatoid arthritis (RA). Unlike typical RA treatments that primarily focus on reducing inflammation, we observed that CSNs have multifunctional properties that can address the inflammatory aspect while also promoting bone health and repair.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Read More
9
Vitamin C impacts autoimmune response
Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies.
Direct evaluation of vitamin C
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Read More
9
Vitamin C aids rheumatoid arthritis treatment
A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis.
Combined effects of treatments explored
This study investigated the effects of a specially formulated hydrogel that combines vitamin C with 9-aminoacridine (9AA) on a model of rheumatoid arthritis (RA). We saw that this hydrogel is not only bioactive but also biodegradable, making it a potential candidate for treating this chronic autoimmune condition.
Our research showed that the combination of vitamin C—specifically in the form of 6-stearoyl-L-ascorbic acid—and 9AA could significantly reduce inflammation in our experimental model. By acting on specific pathways, such as the NR4A1 nuclear receptor, the hydrogel appears to exert anti-inflammatory effects that could alleviate some symptoms of arthritis.
We also noted that vitamin C plays a dual role by promoting collagen production, which is essential for joint health. This is crucial since RA leads to the deterioration of joint tissues.
In conclusion, our findings suggest that using this hydrogel could represent a more effective treatment strategy for RA compared to existing options. With its ability to reduce inflammation and promote tissue healing, this innovative approach offers hope to those suffering from this debilitating condition.
Our research showed that the combination of vitamin C—specifically in the form of 6-stearoyl-L-ascorbic acid—and 9AA could significantly reduce inflammation in our experimental model. By acting on specific pathways, such as the NR4A1 nuclear receptor, the hydrogel appears to exert anti-inflammatory effects that could alleviate some symptoms of arthritis.
We also noted that vitamin C plays a dual role by promoting collagen production, which is essential for joint health. This is crucial since RA leads to the deterioration of joint tissues.
In conclusion, our findings suggest that using this hydrogel could represent a more effective treatment strategy for RA compared to existing options. With its ability to reduce inflammation and promote tissue healing, this innovative approach offers hope to those suffering from this debilitating condition.
Read More
9
Vitamin C helps rheumatoid arthritis
Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance.
Directly evaluates vitamin C effects
We explored how vitamin C supplementation might affect rheumatoid arthritis (RA), an autoimmune disorder that causes chronic inflammation. Our research focused on whether vitamin C could help restore balance in gut microbiota, which previous findings indicated could worsen RA by breaking down vitamin C.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Read More
9
Ascorbyl palmitate targets inflammation
Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome.
Focus on novel treatment approach
We examined the effects of ascorbyl palmitate (AP), a derivative of vitamin C, on the NLRP3 inflammasome, which plays a significant role in various autoimmune disorders. The research shows that AP effectively inhibits the activation of this inflammasome, suggesting it could be a powerful tool in managing inflammation-driven diseases.
Notably, AP showed greater potency and specificity in inhibiting the inflammasome compared to regular vitamin C. It appears to achieve this by scavenging harmful reactive oxygen species and disrupting key interactions necessary for inflammasome assembly.
Furthermore, we found that AP exhibited more pronounced protective effects in models of systemic inflammation and conditions like colitis and autoimmune encephalomyelitis than standard vitamin C treatments. This strengthens the case that AP could be a viable therapeutic option for combating NLRP3-driven diseases, presenting an exciting avenue for further research and potential clinical applications.
Notably, AP showed greater potency and specificity in inhibiting the inflammasome compared to regular vitamin C. It appears to achieve this by scavenging harmful reactive oxygen species and disrupting key interactions necessary for inflammasome assembly.
Furthermore, we found that AP exhibited more pronounced protective effects in models of systemic inflammation and conditions like colitis and autoimmune encephalomyelitis than standard vitamin C treatments. This strengthens the case that AP could be a viable therapeutic option for combating NLRP3-driven diseases, presenting an exciting avenue for further research and potential clinical applications.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Balances autoimmune system
It is a good aid in balancing the body's autoimmune system, and it also safeguards the eyes and liver while helping to clear the liver.
8.8
Effective supplement
An excellent product, providing great value for the number of capsules at the price. I really appreciate the Now brand; it's usually my first choice for supplements. The effect of these capsules is definitely noticeable, and I recommend them over alternative products. They were previously unavailable, so I tried others instead.
Read More
