Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
USERS' SCORE
Good
Based on 7 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
320 mg
356%
Calcium (from Calcium Carbonate)
36 mg
3%
Grape Seed Extract (Vitis vinifera) (min. 90% Total Polyphenols)
100 mg
†
Top Medical Research Studies
9
We sought to understand how ascorbic acid, commonly known as vitamin C, impacts blood clotting during living donor liver transplantation (LDLT). In our study, we analyzed blood samples from 21 recipients before and after their surgeries.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
8
We explored the impact of different calcium infusions on clotting risks in neonates undergoing cardiac surgery. Our study involved analyzing data from 135 babies who received either calcium chloride or calcium gluconate during their treatment.
The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.
With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.
The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.
With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.
8
We explored a unique case of a 14-year-old boy with autism who presented with deep vein thrombosis (DVT) due to large bilateral subperiosteal hematomas caused by vitamin C deficiency, known as scurvy. This rare situation is noteworthy as scurvy is typically associated with other symptoms, but here it led to an unusual complication of DVT.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
Most Useful Reviews
9.5
Eased leg swelling
Helps with leg swelling and blood clots. I’ve had multiple blood clots with resulting edema. This product is extremely helpful for the pain and swelling, and I recommend it to everyone I know.
9.5
Lowers cholesterol
Does the job! This excellent product has significantly lowered my blood cholesterol from 220 to 150 in just a few months and triglycerides from 240 to 145.
8.8
Strengthens vessels
It acts as an antioxidant to render free radicals harmless, strengthens vascular walls and capillaries, combats high blood pressure and arterial hardening, facilitates healing for varicose veins and varicocele, and provides a blood-thinning effect while enhancing blood circulation.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
- All Researches
9
In our investigation, we looked at how vitamin C, in combination with a fibrin clot, influences the healing of Achilles tendon injuries in rats. We used 52 adult Wistar-Albino rats and divided them into four distinct groups to assess various treatments.
The results showed that vitamin C, when paired with fibrin clot, significantly improved tendon healing. Not only did it enhance the mechanical strength of the tendon, but it also led to better histological and biochemical outcomes, suggesting a more robust healing process. We noted increased levels of important growth factors in the groups treated with fibrin clot and vitamin C.
Importantly, the findings indicated that vitamin C plays a beneficial role in recovery, especially when combined with other treatment strategies. While further research may be necessary to fully understand its isolated effects, the data suggests that vitamin C is a valuable component in the healing bundle for Achilles tendon injuries.
The results showed that vitamin C, when paired with fibrin clot, significantly improved tendon healing. Not only did it enhance the mechanical strength of the tendon, but it also led to better histological and biochemical outcomes, suggesting a more robust healing process. We noted increased levels of important growth factors in the groups treated with fibrin clot and vitamin C.
Importantly, the findings indicated that vitamin C plays a beneficial role in recovery, especially when combined with other treatment strategies. While further research may be necessary to fully understand its isolated effects, the data suggests that vitamin C is a valuable component in the healing bundle for Achilles tendon injuries.
9
We sought to understand how ascorbic acid, commonly known as vitamin C, impacts blood clotting during living donor liver transplantation (LDLT). In our study, we analyzed blood samples from 21 recipients before and after their surgeries.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
9
We explored the role of calcium in promoting blood coagulation using a new zeolite-embedded regenerated cellulose aerogel (Z-RCA). This innovative hemostatic agent was designed to minimize common issues seen with previous zeolite-based products, like heat-induced tissue damage and unwanted blood clotting elsewhere in the body.
Our results showed that this aerogel effectively absorbed blood while releasing calcium ions, which play a crucial role in the blood clotting process. By combining the properties of zeolite and the calcium-releasing ability of the aerogel, we found that Z-RCA not only facilitated quicker blood clotting but did so safely, with less risk of adverse effects.
In animal trials, we observed that Z-RCA stopped bleeding faster than existing options like Quikclot and notably reduced blood loss by over 62%. This combination of effectiveness and safety makes Z-RCA a promising solution for achieving efficient hemostasis during emergencies.
Our results showed that this aerogel effectively absorbed blood while releasing calcium ions, which play a crucial role in the blood clotting process. By combining the properties of zeolite and the calcium-releasing ability of the aerogel, we found that Z-RCA not only facilitated quicker blood clotting but did so safely, with less risk of adverse effects.
In animal trials, we observed that Z-RCA stopped bleeding faster than existing options like Quikclot and notably reduced blood loss by over 62%. This combination of effectiveness and safety makes Z-RCA a promising solution for achieving efficient hemostasis during emergencies.
8
We explored a unique case of a 14-year-old boy with autism who presented with deep vein thrombosis (DVT) due to large bilateral subperiosteal hematomas caused by vitamin C deficiency, known as scurvy. This rare situation is noteworthy as scurvy is typically associated with other symptoms, but here it led to an unusual complication of DVT.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
8
We explored how vitamin C influences blood clotting in response to inflammation, specifically focusing on how it affects certain proteins involved in this process. In our study, we tested vitamin C at clinically relevant doses within human monocyte-derived macrophages. This investigation involved examining its effects on tissue factor (TF) and Factor VII Activating Protease (FSAP), two key proteins that play a role in triggering blood clotting after exposure to lipopolysaccharide (LPS), which is often associated with infection and inflammation.
Our findings showed that vitamin C can prevent the activation of a protein called NF-kB, which is crucial for the inflammatory response. It turns out that vitamin C not only reduces the DNA-binding activity of NF-kB but also decreases the expression of TF and FSAP, suggesting it can effectively modulate clots formed in response to inflammation. Overall, we observed that vitamin C offers promising benefits in altering pro-inflammatory and pro-coagulation processes.
This means that aside from being a potent antioxidant, vitamin C might also support cardiovascular health by reducing the risk factors associated with clot formation during inflammatory responses. While more research is needed to validate these effects fully, our study opens the door to the potential role of vitamin C in managing clot-related disorders linked to inflammation.
Our findings showed that vitamin C can prevent the activation of a protein called NF-kB, which is crucial for the inflammatory response. It turns out that vitamin C not only reduces the DNA-binding activity of NF-kB but also decreases the expression of TF and FSAP, suggesting it can effectively modulate clots formed in response to inflammation. Overall, we observed that vitamin C offers promising benefits in altering pro-inflammatory and pro-coagulation processes.
This means that aside from being a potent antioxidant, vitamin C might also support cardiovascular health by reducing the risk factors associated with clot formation during inflammatory responses. While more research is needed to validate these effects fully, our study opens the door to the potential role of vitamin C in managing clot-related disorders linked to inflammation.
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Eased leg swelling
Helps with leg swelling and blood clots. I’ve had multiple blood clots with resulting edema. This product is extremely helpful for the pain and swelling, and I recommend it to everyone I know.
9.5
Lowers cholesterol
Does the job! This excellent product has significantly lowered my blood cholesterol from 220 to 150 in just a few months and triglycerides from 240 to 145.
8.8
Strengthens vessels
It acts as an antioxidant to render free radicals harmless, strengthens vascular walls and capillaries, combats high blood pressure and arterial hardening, facilitates healing for varicose veins and varicocele, and provides a blood-thinning effect while enhancing blood circulation.
8.8
Improved vein strength
Good for blood vessel ageing and inflammation. My parents' vein valves were weakened due to ageing, but after consuming them, they have shown improvement. They are effective for varicose veins and ageing blood vessels.
8.8
Enhanced circulation
This product helps with blood circulation, making me feel healthy again, and also aids in collagen production. It is certainly a quality ingredient.
Frequently Asked Questions
9.5
Lowers cholesterol
Does the job! This excellent product has significantly lowered my blood cholesterol from 220 to 150 in just a few months and triglycerides from 240 to 145.
8.8
Enhanced circulation
This product helps with blood circulation, making me feel healthy again, and also aids in collagen production. It is certainly a quality ingredient.
8.8
Improved vein strength
Good for blood vessel ageing and inflammation. My parents' vein valves were weakened due to ageing, but after consuming them, they have shown improvement. They are effective for varicose veins and ageing blood vessels.
8.8
Strengthens vessels
It acts as an antioxidant to render free radicals harmless, strengthens vascular walls and capillaries, combats high blood pressure and arterial hardening, facilitates healing for varicose veins and varicocele, and provides a blood-thinning effect while enhancing blood circulation.
8.5
Enhances circulation
Anti-aging LS! I have taken grape seed daily for twenty years, especially the `Now Foods` brand. It feels like having a glass of red wine in pill form, sans the negative effects of alcohol. This relates to the `French Paradox`, where the French remain relatively healthy, likely due to red wine intake despite consuming fatty foods. Grape seed benefits my blood circulation and enhances my skin, making it one of the best anti-aging supplements available.
8
We explored a unique case of a 14-year-old boy with autism who presented with deep vein thrombosis (DVT) due to large bilateral subperiosteal hematomas caused by vitamin C deficiency, known as scurvy. This rare situation is noteworthy as scurvy is typically associated with other symptoms, but here it led to an unusual complication of DVT.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
4
We explored the use of ascorbic acid, commonly known as vitamin C, as an additional treatment option for patients critically ill with COVID-19. This study was conducted across two large hospitals in Saudi Arabia and involved a thorough look at the outcomes for these patients, especially concerning blood clotting and overall health.
After evaluating 739 patients, 296 were matched for a fair comparison. Notably, the findings suggest that while there was no significant reduction in mortality rates for those receiving vitamin C compared to those who did not, the use of vitamin C was linked to a lower occurrence of thrombosis—an abnormal blood clotting condition. The incidence of thrombosis in the vitamin C group was 6.1%, compared to 13% in the non-vitamin C group, indicating a possible protective effect against blood clots.
Ultimately, while the addition of vitamin C did not show a direct mortality benefit, it may offer some hope for reducing blood clot complications in these severely affected patients. However, further research will be necessary to validate these findings and clarify the role of vitamin C in treatment protocols for COVID-19.
After evaluating 739 patients, 296 were matched for a fair comparison. Notably, the findings suggest that while there was no significant reduction in mortality rates for those receiving vitamin C compared to those who did not, the use of vitamin C was linked to a lower occurrence of thrombosis—an abnormal blood clotting condition. The incidence of thrombosis in the vitamin C group was 6.1%, compared to 13% in the non-vitamin C group, indicating a possible protective effect against blood clots.
Ultimately, while the addition of vitamin C did not show a direct mortality benefit, it may offer some hope for reducing blood clot complications in these severely affected patients. However, further research will be necessary to validate these findings and clarify the role of vitamin C in treatment protocols for COVID-19.
2
We examined the impact of high doses of vitamin C on blood clotting, particularly focusing on its effect on red blood cells (RBCs). Through our research, we discovered that vitamin C, when injected intravenously in doses of 0.5 to 5 mM, can increase the tendency of RBCs to become procoagulant. This increase was linked to a process where a molecule called phosphatidylserine is exposed on the outer membrane of these cells, which can lead to blood clot formation.
The molecular changes in RBCs were attributed to oxidative stress induced by high vitamin C levels, disrupting important calcium and thiol balance in the cells. Furthermore, our findings showed that administering vitamin C at 0.5 to 1.0 g/kg in rats resulted in a significant increase in thrombosis events. More importantly, RBCs from cancer patients displayed an increased sensitivity to these prothrombotic effects compared to healthy individuals.
Given these observations, it’s crucial to approach high-dose vitamin C therapy with caution, particularly in patients already at a higher risk for blood clotting. While vitamin C is often thought to have health benefits, our study reveals a potential risk that must not be overlooked.
The molecular changes in RBCs were attributed to oxidative stress induced by high vitamin C levels, disrupting important calcium and thiol balance in the cells. Furthermore, our findings showed that administering vitamin C at 0.5 to 1.0 g/kg in rats resulted in a significant increase in thrombosis events. More importantly, RBCs from cancer patients displayed an increased sensitivity to these prothrombotic effects compared to healthy individuals.
Given these observations, it’s crucial to approach high-dose vitamin C therapy with caution, particularly in patients already at a higher risk for blood clotting. While vitamin C is often thought to have health benefits, our study reveals a potential risk that must not be overlooked.
References
- de Boer HC, Sawhney JS. Pediatric scurvy case report: a novel presentation with deep vein thrombosis secondary to large bilateral spontaneous iliac subperiosteal hematomas. BMC Pediatr. 2024;24:126. doi:10.1186/s12887-024-04579-4
- Al Sulaiman K, Aljuhani O, Saleh KB, Badreldin HA, Al Harthi A, et al. Ascorbic acid as an adjunctive therapy in critically ill patients with COVID-19: a propensity score matched study. Sci Rep. 2021;11:17648. doi:10.1038/s41598-021-96703-y
- Çelik M, Bayrak A, Duramaz A, Başaran SH, Kızılkaya C, et al. The effect of fibrin clot and C vitamin on the surgical treatment of Achilles tendon injury in the rat model✰. Foot Ankle Surg. 2021;27:681. doi:10.1016/j.fas.2020.09.006
- Kwon JH, Kim D, Cho H, Shin BS. Ascorbic acid improves thrombotic function of platelets during living donor liver transplantation by modulating the function of the E3 ubiquitin ligases c-Cbl and Cbl-b. J Int Med Res. 2019;47:1856. doi:10.1177/0300060518817408
- Parahuleva MS, Jung J, Burgazli M, Erdogan A, Parviz B, et al. Vitamin C suppresses lipopolysaccharide-induced procoagulant response of human monocyte-derived macrophages. Eur Rev Med Pharmacol Sci. 2016;20:2174.
- Kim K, Bae ON, Koh SH, Kang S, Lim KM, et al. High-Dose Vitamin C Injection to Cancer Patients May Promote Thrombosis Through Procoagulant Activation of Erythrocytes. Toxicol Sci. 2015;147:350. doi:10.1093/toxsci/kfv133
- Jin Z, Chen L, Liu X, Xia R, Li W, et al. Zeolite firmly anchored regenerated cellulose aerogel for efficient and biosafe hemostasis. Int J Biol Macromol. 2025;304:140743. doi:10.1016/j.ijbiomac.2025.140743
- Tran VA, Griffin EM, Elliott JD, Scholl RL, Hill RB, et al. Thrombotic Complications Associated With Right Atrial Lines in Neonates and Infants Undergoing Cardiac Surgery. Is Calcium Chloride a Culprit?. J Cardiothorac Vasc Anesth. 2025. doi:10.1053/j.jvca.2025.01.008
