5/24/2025
Last update
5/24/2025
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 6 Reviews
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
320 mg
356%
Calcium (from Calcium Carbonate)
36 mg
3%
Grape Seed Extract (Vitis vinifera) (min. 90% Total Polyphenols)
100 mg
†
Top Medical Research Studies
9
We investigated how an ascorbic acid-based solution could help treat recurrent cold sores, also known as mucocutaneous herpes. This study was carefully designed as a randomized, double-blind, placebo-controlled trial, which helps ensure the results are reliable and trustworthy.
Participants used a strong solution of Ascoxal, rich in vitamin C, applied to their cold sores multiple times on the first day of the outbreak. We monitored various symptoms daily, including the severity of scabs, redness, and blisters, comparing the experiences of those using the vitamin C solution to a placebo group.
Our findings were promising: the active treatment resulted in fewer days with scabbing and less severe symptoms overall. Moreover, those using the vitamin C solution showed reduced persistence of scabs compared to the placebo group, along with a lower frequency of detected herpes virus after treatment.
In conclusion, this brief course of vitamin C treatment appears to have significant clinical benefits against cold sores, opening the door for future research on more extensive and frequent treatment regimes.
Participants used a strong solution of Ascoxal, rich in vitamin C, applied to their cold sores multiple times on the first day of the outbreak. We monitored various symptoms daily, including the severity of scabs, redness, and blisters, comparing the experiences of those using the vitamin C solution to a placebo group.
Our findings were promising: the active treatment resulted in fewer days with scabbing and less severe symptoms overall. Moreover, those using the vitamin C solution showed reduced persistence of scabs compared to the placebo group, along with a lower frequency of detected herpes virus after treatment.
In conclusion, this brief course of vitamin C treatment appears to have significant clinical benefits against cold sores, opening the door for future research on more extensive and frequent treatment regimes.
Read More
8
We conducted a clinical pilot study to evaluate the effects of a combination treatment of lignin—a substance derived from pine cones—mixed with vitamin C on cold sores caused by the herpes simplex virus type 1 (HSV-1). Our study included 48 healthy participants, ranging from 4 to 61 years old, who had active lesions of HSV-1.
Participants received a daily dose of the lignin-ascorbic acid treatment for one month. Notably, those who began the treatment within the first 48 hours after the onset of symptoms did not develop typical cold sore lesions. For others who started later, we observed a shorter duration of cold sores and less severe symptoms compared to their previous outbreaks.
Many participants reported a reduction in both the severity and frequency of their cold sore episodes during treatment. Although the results suggest some benefits of this combination treatment, it’s important to note that vitamin C was part of the blend, making it challenging to evaluate its individual effect on cold sores directly.
Thus, while the combination of lignin and vitamin C appears promising for preventing and treating HSV-1 infection, further studies isolating vitamin C's effects would be helpful to understand its specific role in managing cold sores.
Participants received a daily dose of the lignin-ascorbic acid treatment for one month. Notably, those who began the treatment within the first 48 hours after the onset of symptoms did not develop typical cold sore lesions. For others who started later, we observed a shorter duration of cold sores and less severe symptoms compared to their previous outbreaks.
Many participants reported a reduction in both the severity and frequency of their cold sore episodes during treatment. Although the results suggest some benefits of this combination treatment, it’s important to note that vitamin C was part of the blend, making it challenging to evaluate its individual effect on cold sores directly.
Thus, while the combination of lignin and vitamin C appears promising for preventing and treating HSV-1 infection, further studies isolating vitamin C's effects would be helpful to understand its specific role in managing cold sores.
Read More
8
We evaluated the effectiveness of a water-soluble complex combining bioflavonoids and ascorbic acid, which is commonly known as vitamin C, for treating cold sores caused by recurrent herpes labialis. The study involved 50 episodes of cold sores, with patients receiving different dosages of the vitamin C and bioflavonoid combination, while others were given a lactose placebo.
The regimen was followed for three days after participants felt the initial symptoms. We noted that the combination appeared to reduce the formation of blisters and helped maintain the integrity of the vesicular membrane. The best results came when treatment started during the early warning signs of an outbreak, leading to symptom relief in an average of about 4.2 days with the lower dosage.
Importantly, throughout the study, no adverse reactions were reported by participants. Although the combination product shows promise, it was difficult to isolate the specific impact of vitamin C alone due to its synergy with bioflavonoids.
The regimen was followed for three days after participants felt the initial symptoms. We noted that the combination appeared to reduce the formation of blisters and helped maintain the integrity of the vesicular membrane. The best results came when treatment started during the early warning signs of an outbreak, leading to symptom relief in an average of about 4.2 days with the lower dosage.
Importantly, throughout the study, no adverse reactions were reported by participants. Although the combination product shows promise, it was difficult to isolate the specific impact of vitamin C alone due to its synergy with bioflavonoids.
Read More
Most Useful Reviews
9
Long-term health aid
Excellent product! I highly recommend it. I take these capsules daily, and during the cold and flu season or at the first signs of a cold or sore throat, I take several additional capsules throughout the day. I haven't experienced a cold or flu in several years.
Read More
9
Boosts immune system
2 people found this helpful
An amazing product at a reasonable price. We've been taking grape seed extract as a supplement for our immune system, and it works exceptionally well. I have avoided illnesses like colds and fevers numerous times by taking about 3 pills before they develop.
Read More
7.5
Quick cold relief
1 people found this helpful
A very fast way to overcome a cold or prevent one from starting.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
- All Researches
9
We investigated how an ascorbic acid-based solution could help treat recurrent cold sores, also known as mucocutaneous herpes. This study was carefully designed as a randomized, double-blind, placebo-controlled trial, which helps ensure the results are reliable and trustworthy.
Participants used a strong solution of Ascoxal, rich in vitamin C, applied to their cold sores multiple times on the first day of the outbreak. We monitored various symptoms daily, including the severity of scabs, redness, and blisters, comparing the experiences of those using the vitamin C solution to a placebo group.
Our findings were promising: the active treatment resulted in fewer days with scabbing and less severe symptoms overall. Moreover, those using the vitamin C solution showed reduced persistence of scabs compared to the placebo group, along with a lower frequency of detected herpes virus after treatment.
In conclusion, this brief course of vitamin C treatment appears to have significant clinical benefits against cold sores, opening the door for future research on more extensive and frequent treatment regimes.
Participants used a strong solution of Ascoxal, rich in vitamin C, applied to their cold sores multiple times on the first day of the outbreak. We monitored various symptoms daily, including the severity of scabs, redness, and blisters, comparing the experiences of those using the vitamin C solution to a placebo group.
Our findings were promising: the active treatment resulted in fewer days with scabbing and less severe symptoms overall. Moreover, those using the vitamin C solution showed reduced persistence of scabs compared to the placebo group, along with a lower frequency of detected herpes virus after treatment.
In conclusion, this brief course of vitamin C treatment appears to have significant clinical benefits against cold sores, opening the door for future research on more extensive and frequent treatment regimes.
Read More
8
We conducted a clinical pilot study to evaluate the effects of a combination treatment of lignin—a substance derived from pine cones—mixed with vitamin C on cold sores caused by the herpes simplex virus type 1 (HSV-1). Our study included 48 healthy participants, ranging from 4 to 61 years old, who had active lesions of HSV-1.
Participants received a daily dose of the lignin-ascorbic acid treatment for one month. Notably, those who began the treatment within the first 48 hours after the onset of symptoms did not develop typical cold sore lesions. For others who started later, we observed a shorter duration of cold sores and less severe symptoms compared to their previous outbreaks.
Many participants reported a reduction in both the severity and frequency of their cold sore episodes during treatment. Although the results suggest some benefits of this combination treatment, it’s important to note that vitamin C was part of the blend, making it challenging to evaluate its individual effect on cold sores directly.
Thus, while the combination of lignin and vitamin C appears promising for preventing and treating HSV-1 infection, further studies isolating vitamin C's effects would be helpful to understand its specific role in managing cold sores.
Participants received a daily dose of the lignin-ascorbic acid treatment for one month. Notably, those who began the treatment within the first 48 hours after the onset of symptoms did not develop typical cold sore lesions. For others who started later, we observed a shorter duration of cold sores and less severe symptoms compared to their previous outbreaks.
Many participants reported a reduction in both the severity and frequency of their cold sore episodes during treatment. Although the results suggest some benefits of this combination treatment, it’s important to note that vitamin C was part of the blend, making it challenging to evaluate its individual effect on cold sores directly.
Thus, while the combination of lignin and vitamin C appears promising for preventing and treating HSV-1 infection, further studies isolating vitamin C's effects would be helpful to understand its specific role in managing cold sores.
Read More
8
We evaluated the effectiveness of a water-soluble complex combining bioflavonoids and ascorbic acid, which is commonly known as vitamin C, for treating cold sores caused by recurrent herpes labialis. The study involved 50 episodes of cold sores, with patients receiving different dosages of the vitamin C and bioflavonoid combination, while others were given a lactose placebo.
The regimen was followed for three days after participants felt the initial symptoms. We noted that the combination appeared to reduce the formation of blisters and helped maintain the integrity of the vesicular membrane. The best results came when treatment started during the early warning signs of an outbreak, leading to symptom relief in an average of about 4.2 days with the lower dosage.
Importantly, throughout the study, no adverse reactions were reported by participants. Although the combination product shows promise, it was difficult to isolate the specific impact of vitamin C alone due to its synergy with bioflavonoids.
The regimen was followed for three days after participants felt the initial symptoms. We noted that the combination appeared to reduce the formation of blisters and helped maintain the integrity of the vesicular membrane. The best results came when treatment started during the early warning signs of an outbreak, leading to symptom relief in an average of about 4.2 days with the lower dosage.
Importantly, throughout the study, no adverse reactions were reported by participants. Although the combination product shows promise, it was difficult to isolate the specific impact of vitamin C alone due to its synergy with bioflavonoids.
Read More
7
Calcium spirulan may help cold sores
We investigated the potential of calcium spirulan, a compound derived from the microalga Spirulina platensis, to help prevent cold sores caused by the herpes simplex virus type 1 (HSV-1). In a thorough study, we assessed the effectiveness of this sulfated polysaccharide both in laboratory tests and through a practical trial involving people with recurring herpes labialis, also known as cold sores.
Our approach included examining how calcium spirulan affected the virus’s ability to attach to human skin cells. Using various experiments such as plaque reduction assays and analyzing viral proteins, we confirmed that calcium spirulan had significant inhibitory effects on HSV-1. In the practical trial, we compared the effects of topical calcium spirulan treatment against other commonly used antiviral medications among 198 participants, all of whom dealt with repeat cold sore outbreaks.
The results suggest that calcium spirulan could be a valuable option for topical treatment, offering new hope for those who suffer from cold sores. Additionally, our findings indicate that calcium spirulan may also show effectiveness against other herpesviruses. This points to the broader clinical implications of using natural compounds like calcium spirulan in managing viral infections.
Our approach included examining how calcium spirulan affected the virus’s ability to attach to human skin cells. Using various experiments such as plaque reduction assays and analyzing viral proteins, we confirmed that calcium spirulan had significant inhibitory effects on HSV-1. In the practical trial, we compared the effects of topical calcium spirulan treatment against other commonly used antiviral medications among 198 participants, all of whom dealt with repeat cold sore outbreaks.
The results suggest that calcium spirulan could be a valuable option for topical treatment, offering new hope for those who suffer from cold sores. Additionally, our findings indicate that calcium spirulan may also show effectiveness against other herpesviruses. This points to the broader clinical implications of using natural compounds like calcium spirulan in managing viral infections.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Long-term health aid
Excellent product! I highly recommend it. I take these capsules daily, and during the cold and flu season or at the first signs of a cold or sore throat, I take several additional capsules throughout the day. I haven't experienced a cold or flu in several years.
Read More
9
Boosts immune system
2 people found this helpful
An amazing product at a reasonable price. We've been taking grape seed extract as a supplement for our immune system, and it works exceptionally well. I have avoided illnesses like colds and fevers numerous times by taking about 3 pills before they develop.
Read More
7.5
Quick cold relief
1 people found this helpful
A very fast way to overcome a cold or prevent one from starting.
Read More
9
Instant cold remedy
I use it at the first sign of a cold and the issues disappear the next day.
Read More
9
Effective sickness prevention
I love it! I take 2 capsules a day. We've been using grape seed extract as an immune supplement, and it works remarkably well. I’ve avoided illnesses like colds and fever countless times by taking around 3 pills right before they appear. It's a lovely health supplement and is said to help lower blood pressure.
Read More
Frequently Asked Questions
9
Effective sickness prevention
I love it! I take 2 capsules a day. We've been using grape seed extract as an immune supplement, and it works remarkably well. I’ve avoided illnesses like colds and fever countless times by taking around 3 pills right before they appear. It's a lovely health supplement and is said to help lower blood pressure.
7.5
Prevents colds effectively
2 people found this helpful
Great product! I consistently take grape seed extract twice daily. When I'm feeling run down, I increase my intake. I truly believe this helps eliminate cold sores and reduces their duration. If I sense I'm catching a cold or developing a sore throat, I start taking 2-3 capsules every hour.
9
Instant cold remedy
I use it at the first sign of a cold and the issues disappear the next day.
8
We conducted a clinical pilot study to evaluate the effects of a combination treatment of lignin—a substance derived from pine cones—mixed with vitamin C on cold sores caused by the herpes simplex virus type 1 (HSV-1). Our study included 48 healthy participants, ranging from 4 to 61 years old, who had active lesions of HSV-1.
Participants received a daily dose of the lignin-ascorbic acid treatment for one month. Notably, those who began the treatment within the first 48 hours after the onset of symptoms did not develop typical cold sore lesions. For others who started later, we observed a shorter duration of cold sores and less severe symptoms compared to their previous outbreaks.
Many participants reported a reduction in both the severity and frequency of their cold sore episodes during treatment. Although the results suggest some benefits of this combination treatment, it’s important to note that vitamin C was part of the blend, making it challenging to evaluate its individual effect on cold sores directly.
Thus, while the combination of lignin and vitamin C appears promising for preventing and treating HSV-1 infection, further studies isolating vitamin C's effects would be helpful to understand its specific role in managing cold sores.
Participants received a daily dose of the lignin-ascorbic acid treatment for one month. Notably, those who began the treatment within the first 48 hours after the onset of symptoms did not develop typical cold sore lesions. For others who started later, we observed a shorter duration of cold sores and less severe symptoms compared to their previous outbreaks.
Many participants reported a reduction in both the severity and frequency of their cold sore episodes during treatment. Although the results suggest some benefits of this combination treatment, it’s important to note that vitamin C was part of the blend, making it challenging to evaluate its individual effect on cold sores directly.
Thus, while the combination of lignin and vitamin C appears promising for preventing and treating HSV-1 infection, further studies isolating vitamin C's effects would be helpful to understand its specific role in managing cold sores.
9
We investigated how an ascorbic acid-based solution could help treat recurrent cold sores, also known as mucocutaneous herpes. This study was carefully designed as a randomized, double-blind, placebo-controlled trial, which helps ensure the results are reliable and trustworthy.
Participants used a strong solution of Ascoxal, rich in vitamin C, applied to their cold sores multiple times on the first day of the outbreak. We monitored various symptoms daily, including the severity of scabs, redness, and blisters, comparing the experiences of those using the vitamin C solution to a placebo group.
Our findings were promising: the active treatment resulted in fewer days with scabbing and less severe symptoms overall. Moreover, those using the vitamin C solution showed reduced persistence of scabs compared to the placebo group, along with a lower frequency of detected herpes virus after treatment.
In conclusion, this brief course of vitamin C treatment appears to have significant clinical benefits against cold sores, opening the door for future research on more extensive and frequent treatment regimes.
Participants used a strong solution of Ascoxal, rich in vitamin C, applied to their cold sores multiple times on the first day of the outbreak. We monitored various symptoms daily, including the severity of scabs, redness, and blisters, comparing the experiences of those using the vitamin C solution to a placebo group.
Our findings were promising: the active treatment resulted in fewer days with scabbing and less severe symptoms overall. Moreover, those using the vitamin C solution showed reduced persistence of scabs compared to the placebo group, along with a lower frequency of detected herpes virus after treatment.
In conclusion, this brief course of vitamin C treatment appears to have significant clinical benefits against cold sores, opening the door for future research on more extensive and frequent treatment regimes.
8
We evaluated the effectiveness of a water-soluble complex combining bioflavonoids and ascorbic acid, which is commonly known as vitamin C, for treating cold sores caused by recurrent herpes labialis. The study involved 50 episodes of cold sores, with patients receiving different dosages of the vitamin C and bioflavonoid combination, while others were given a lactose placebo.
The regimen was followed for three days after participants felt the initial symptoms. We noted that the combination appeared to reduce the formation of blisters and helped maintain the integrity of the vesicular membrane. The best results came when treatment started during the early warning signs of an outbreak, leading to symptom relief in an average of about 4.2 days with the lower dosage.
Importantly, throughout the study, no adverse reactions were reported by participants. Although the combination product shows promise, it was difficult to isolate the specific impact of vitamin C alone due to its synergy with bioflavonoids.
The regimen was followed for three days after participants felt the initial symptoms. We noted that the combination appeared to reduce the formation of blisters and helped maintain the integrity of the vesicular membrane. The best results came when treatment started during the early warning signs of an outbreak, leading to symptom relief in an average of about 4.2 days with the lower dosage.
Importantly, throughout the study, no adverse reactions were reported by participants. Although the combination product shows promise, it was difficult to isolate the specific impact of vitamin C alone due to its synergy with bioflavonoids.
7
Calcium spirulan may help cold sores
We investigated the potential of calcium spirulan, a compound derived from the microalga Spirulina platensis, to help prevent cold sores caused by the herpes simplex virus type 1 (HSV-1). In a thorough study, we assessed the effectiveness of this sulfated polysaccharide both in laboratory tests and through a practical trial involving people with recurring herpes labialis, also known as cold sores.
Our approach included examining how calcium spirulan affected the virus’s ability to attach to human skin cells. Using various experiments such as plaque reduction assays and analyzing viral proteins, we confirmed that calcium spirulan had significant inhibitory effects on HSV-1. In the practical trial, we compared the effects of topical calcium spirulan treatment against other commonly used antiviral medications among 198 participants, all of whom dealt with repeat cold sore outbreaks.
The results suggest that calcium spirulan could be a valuable option for topical treatment, offering new hope for those who suffer from cold sores. Additionally, our findings indicate that calcium spirulan may also show effectiveness against other herpesviruses. This points to the broader clinical implications of using natural compounds like calcium spirulan in managing viral infections.
Our approach included examining how calcium spirulan affected the virus’s ability to attach to human skin cells. Using various experiments such as plaque reduction assays and analyzing viral proteins, we confirmed that calcium spirulan had significant inhibitory effects on HSV-1. In the practical trial, we compared the effects of topical calcium spirulan treatment against other commonly used antiviral medications among 198 participants, all of whom dealt with repeat cold sore outbreaks.
The results suggest that calcium spirulan could be a valuable option for topical treatment, offering new hope for those who suffer from cold sores. Additionally, our findings indicate that calcium spirulan may also show effectiveness against other herpesviruses. This points to the broader clinical implications of using natural compounds like calcium spirulan in managing viral infections.
References
- Lopez BS, Yamamoto M, Utsumi K, Aratsu C, Sakagami H. A clinical pilot study of lignin--ascorbic acid combination treatment of herpes simplex virus. In Vivo. 2009;23:1011.
- Hovi T, Hirvimies A, Stenvik M, Vuola E, Pippuri R. Topical treatment of recurrent mucocutaneous herpes with ascorbic acid-containing solution. Antiviral Res. 1995;27:263.
- Terezhalmy GT, Bottomley WK, Pelleu GB. The use of water-soluble bioflavonoid-ascorbic acid complex in the treatment of recurrent herpes labialis. Oral Surg Oral Med Oral Pathol. 1978;45:56.
- Mader J, Gallo A, Schommartz T, Handke W, Nagel CH, et al. Calcium spirulan derived from Spirulina platensis inhibits herpes simplex virus 1 attachment to human keratinocytes and protects against herpes labialis. J Allergy Clin Immunol. 2016;137:197. 10.1016/j.jaci.2015.07.027
