'
NOW Supplements Grape Seed
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.5
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
320 mg
356%
Calcium (from Calcium Carbonate)
36 mg
3%
Grape Seed Extract (Vitis vinifera) (min. 90% Total Polyphenols)
100 mg

Top Medical Research Studies

8
Vitamin C intake reduces migraines
Association between dietary vitamin C intake and migraine in adults: A cross-sectional study of the National Health and Nutrition Examination Survey.
Study suggests vitamin C effectiveness.
We aimed to understand how dietary vitamin C affects migraines by analyzing data from the National Health and Nutrition Examination Survey, conducted from 1999 to 2004. In this survey, we identified adults who reported experiencing severe headaches or migraines over the past three months.

Our findings were quite revealing. Out of 4,101 participants, 702 individuals reported having a migraine, which represents about 17% of the group. We discovered an interesting trend: higher dietary vitamin C intake seemed to correlate with a lower likelihood of experiencing migraines. Specifically, participants with the highest vitamin C intake had a 36% reduced odds of suffering from migraines compared to those with the lowest intake.

We employed various statistical methods to confirm our results, including logistic regression and restricted cubic spline regression, which showed a clear linear relationship between vitamin C intake and the frequency of migraines.

Overall, this study suggests that increasing our dietary vitamin C might help minimize migraines, which is promising news for those who suffer from these intense headaches. However, as with all studies, further research is necessary to solidify these findings and fully understand the relationship between vitamin C and headache relief.
Read More
9.5
Calcium's uncertain headache impact
Reversible Cerebral Vasoconstriction Syndrome Secondary to Escitalopram.
Study raises questions on effectiveness
We explored the connection between calcium treatment and headaches, particularly in patients with reversible cerebral vasoconstriction syndrome (RCVS). In this case, we observed a healthy young woman who had been using escitalopram for a long time. She presented with bilateral neurological deficits, and after treatment with intra-arterial calcium channel blockers, her symptoms improved significantly.

However, it’s important to note that while calcium channel blockers were administered, the study does not specifically isolate calcium’s effects on headache relief. This combination of treatments makes it challenging to understand how much calcium alone contributes to alleviating headache symptoms, if at all.

As we considered the overall findings, it became clear that while calcium channel blockers can lead to symptom improvement in RCVS, the direct impact of calcium on headaches remains uncertain. Therefore, individuals experiencing thunderclap headaches, especially those on selective serotonin reuptake inhibitors, should consider RCVS as a possible diagnosis, but we cannot definitively conclude that calcium treatment is effective for headaches based on this case alone.
Read More
8
Vitamin C linked to reduced migraines
The association between dietary antioxidant quality score and intensity and frequency of migraine headaches among women: a cross-sectional study.
High relevance for migraine studies
In our exploration of how dietary factors might influence migraine headaches, we examined the connection between vitamin C intake and headache intensity and frequency among women. The study included 265 participants who reported their dietary intake, and we focused particularly on their antioxidant quality score, which reflects the quality of their dietary antioxidants.

We observed noteworthy findings. Women with a higher dietary antioxidant quality score had significantly lower levels of migraine pain and fewer headache days. This trend was especially true for those who consumed more vitamin C. We found that higher vitamin C intake was associated with less severe headache pain, indicating that including more of this vitamin in our diets could potentially help alleviate migraine symptoms.

Furthermore, we noted that other antioxidants might also play a role, but vitamin C stood out in its association with reduced migraine severity. Overall, this research reinforces the idea that dietary choices, particularly those rich in vitamin C, could benefit those grappling with migraine headaches and should be closely monitored.
Read More

Most Useful Reviews

3.8
Caused headaches
This product was not good; it gave me a headache every time I took it. I’m unsure if it was just a bad batch. Also, they claim it’s nonrefundable, so I wouldn't recommend buying it.
Read More
9.5
Helpful for migraines
Excellent product! I have found this to be very helpful for migraine headaches.
Read More
1.8
Headache and reflux
Initially fine, but I experienced increased heart rate, dizziness, and headache. I later had severe acid reflux, which I had not suffered from in years. I discovered it might not mix well with vitamin C and am looking for a brand without it.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.5
  • All Researches
9.5
Calcium's uncertain headache impact
Reversible Cerebral Vasoconstriction Syndrome Secondary to Escitalopram.
Study raises questions on effectiveness
We explored the connection between calcium treatment and headaches, particularly in patients with reversible cerebral vasoconstriction syndrome (RCVS). In this case, we observed a healthy young woman who had been using escitalopram for a long time. She presented with bilateral neurological deficits, and after treatment with intra-arterial calcium channel blockers, her symptoms improved significantly.

However, it’s important to note that while calcium channel blockers were administered, the study does not specifically isolate calcium’s effects on headache relief. This combination of treatments makes it challenging to understand how much calcium alone contributes to alleviating headache symptoms, if at all.

As we considered the overall findings, it became clear that while calcium channel blockers can lead to symptom improvement in RCVS, the direct impact of calcium on headaches remains uncertain. Therefore, individuals experiencing thunderclap headaches, especially those on selective serotonin reuptake inhibitors, should consider RCVS as a possible diagnosis, but we cannot definitively conclude that calcium treatment is effective for headaches based on this case alone.
Read More
8
Vitamin C intake reduces migraines
Association between dietary vitamin C intake and migraine in adults: A cross-sectional study of the National Health and Nutrition Examination Survey.
Study suggests vitamin C effectiveness.
We aimed to understand how dietary vitamin C affects migraines by analyzing data from the National Health and Nutrition Examination Survey, conducted from 1999 to 2004. In this survey, we identified adults who reported experiencing severe headaches or migraines over the past three months.

Our findings were quite revealing. Out of 4,101 participants, 702 individuals reported having a migraine, which represents about 17% of the group. We discovered an interesting trend: higher dietary vitamin C intake seemed to correlate with a lower likelihood of experiencing migraines. Specifically, participants with the highest vitamin C intake had a 36% reduced odds of suffering from migraines compared to those with the lowest intake.

We employed various statistical methods to confirm our results, including logistic regression and restricted cubic spline regression, which showed a clear linear relationship between vitamin C intake and the frequency of migraines.

Overall, this study suggests that increasing our dietary vitamin C might help minimize migraines, which is promising news for those who suffer from these intense headaches. However, as with all studies, further research is necessary to solidify these findings and fully understand the relationship between vitamin C and headache relief.
Read More
8
Vitamin C linked to reduced migraines
The association between dietary antioxidant quality score and intensity and frequency of migraine headaches among women: a cross-sectional study.
High relevance for migraine studies
In our exploration of how dietary factors might influence migraine headaches, we examined the connection between vitamin C intake and headache intensity and frequency among women. The study included 265 participants who reported their dietary intake, and we focused particularly on their antioxidant quality score, which reflects the quality of their dietary antioxidants.

We observed noteworthy findings. Women with a higher dietary antioxidant quality score had significantly lower levels of migraine pain and fewer headache days. This trend was especially true for those who consumed more vitamin C. We found that higher vitamin C intake was associated with less severe headache pain, indicating that including more of this vitamin in our diets could potentially help alleviate migraine symptoms.

Furthermore, we noted that other antioxidants might also play a role, but vitamin C stood out in its association with reduced migraine severity. Overall, this research reinforces the idea that dietary choices, particularly those rich in vitamin C, could benefit those grappling with migraine headaches and should be closely monitored.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 3 Reviews
7.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
3.8
Caused headaches
This product was not good; it gave me a headache every time I took it. I’m unsure if it was just a bad batch. Also, they claim it’s nonrefundable, so I wouldn't recommend buying it.
9.5
Helpful for migraines
Excellent product! I have found this to be very helpful for migraine headaches.
1.8
Headache and reflux
Initially fine, but I experienced increased heart rate, dizziness, and headache. I later had severe acid reflux, which I had not suffered from in years. I discovered it might not mix well with vitamin C and am looking for a brand without it.
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