We evaluated how vitamin C might improve endothelial function in patients with obstructive sleep apnea (OSA). In our study, we compared 10 individuals with untreated OSA to 10 matched control subjects without sleep issues. We measured how well blood vessels reacted to increased blood flow, known as flow-mediated dilation (FMD), using ultrasound before and after administering vitamin C.
Our findings revealed a significant difference: baseline FMD was lower in OSA patients compared to the control group. However, after an intravenous injection of vitamin C, the FMD in OSA patients improved dramatically, reaching levels similar to those seen in the healthy controls. Interestingly, vasoreactivity in the control subjects remained unchanged.
These results suggest that oxidative stress might be a key factor contributing to the endothelial dysfunction experienced by individuals with OSA. The positive response to vitamin C opens up exciting possibilities for exploring antioxidant treatments in managing cardiovascular issues related to OSA.
Read More
9
Vitamin C mitigates sleep apnea effects
Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link.
We explored how vitamin C treatment affects individuals suffering from sleep apnea, particularly through the lens of intermittent hypoxia. In a study where male Sprague-Dawley rats were subjected to 5% oxygen levels, we observed that intermittent hypoxia led to notable changes in the body. These alterations included heightened carotid body responses to low oxygen, shifts in heart rate variability, and an increase in blood pressure.
The research specifically focused on the effects of ascorbic acid, or vitamin C, at a concentration of 1.25 g/L added to the drinking water of these rats over 21 days. What we found was quite promising: vitamin C treatment significantly reduced markers of oxidative stress in the plasma and carotid body. This antioxidant appeared to counteract the negative effects typically seen during intermittent hypoxia, including improved ventilatory responses to low oxygen levels and stabilization of heart rate and blood pressure.
Overall, our findings suggest that oxidative stress plays a crucial role in the heightened sensitivity and respiratory changes associated with sleep apnea. By mitigating these oxidative effects through vitamin C, we could potentially improve the quality of life for those affected by this condition.
Read More
8
Vitamin C may reduce sleep apnea
The Association Between Dietary Vitamin C and Sleep Disorders: A Cohort Study Based on UK Biobank.
We delved into an interesting question: can dietary vitamin C help alleviate sleep apnea? To explore this, we examined data from over 68,000 participants in the UK Biobank and focused on their dietary habits, particularly how much vitamin C they consumed. By using a detailed questionnaire to assess their intake and applying advanced statistical methods, we aimed to uncover any potential connections between vitamin C and sleep disorders, especially sleep apnea.
The results were quite revealing. Participants who consumed higher levels of vitamin C, particularly those in the top intake bracket (around 132.88 to 191.51 mg per day), showed a significant reduction in the risk of developing sleep disorders, including sleep apnea. Specifically, we found that this group had a 25% lower risk of sleep apnea compared to those with lower vitamin C intake.
What's even more encouraging is that this protective effect seemed particularly strong among men and those under 60 years old, suggesting that a sufficient intake of vitamin C could be a worthwhile strategy for preventing sleep apnea. Our findings highlight the importance of diet in managing sleep health and point to vitamin C as a valuable nutrient for those struggling with sleep issues.
Read More
Most Useful Reviews
9
No more snoring
2 people found this helpful
My husband can snore, but since taking this grape seed supplement, there has been no snoring, allowing me to sleep well.
Read More
7.5
Enhanced alertness
4 people found this helpful
I've been taking this supplement for nearly a year. After starting it, I became more alert and energetic, my complexion improved, and my sleep has also enhanced.
Read More
7.5
Improved sleep quality
I recommend this product as I appreciate the quality and brand. The size is average and the packaging is good and airtight. My sleep has improved significantly, and there is no noticeable taste.
We explored how vitamin C treatment affects individuals suffering from sleep apnea, particularly through the lens of intermittent hypoxia. In a study where male Sprague-Dawley rats were subjected to 5% oxygen levels, we observed that intermittent hypoxia led to notable changes in the body. These alterations included heightened carotid body responses to low oxygen, shifts in heart rate variability, and an increase in blood pressure.
The research specifically focused on the effects of ascorbic acid, or vitamin C, at a concentration of 1.25 g/L added to the drinking water of these rats over 21 days. What we found was quite promising: vitamin C treatment significantly reduced markers of oxidative stress in the plasma and carotid body. This antioxidant appeared to counteract the negative effects typically seen during intermittent hypoxia, including improved ventilatory responses to low oxygen levels and stabilization of heart rate and blood pressure.
Overall, our findings suggest that oxidative stress plays a crucial role in the heightened sensitivity and respiratory changes associated with sleep apnea. By mitigating these oxidative effects through vitamin C, we could potentially improve the quality of life for those affected by this condition.
Read More
9
Vitamin C improves sleep apnea endothelial function
Antioxidant vitamin C improves endothelial function in obstructive sleep apnea.
We evaluated how vitamin C might improve endothelial function in patients with obstructive sleep apnea (OSA). In our study, we compared 10 individuals with untreated OSA to 10 matched control subjects without sleep issues. We measured how well blood vessels reacted to increased blood flow, known as flow-mediated dilation (FMD), using ultrasound before and after administering vitamin C.
Our findings revealed a significant difference: baseline FMD was lower in OSA patients compared to the control group. However, after an intravenous injection of vitamin C, the FMD in OSA patients improved dramatically, reaching levels similar to those seen in the healthy controls. Interestingly, vasoreactivity in the control subjects remained unchanged.
These results suggest that oxidative stress might be a key factor contributing to the endothelial dysfunction experienced by individuals with OSA. The positive response to vitamin C opens up exciting possibilities for exploring antioxidant treatments in managing cardiovascular issues related to OSA.
Read More
8
Vitamin C may reduce sleep apnea
The Association Between Dietary Vitamin C and Sleep Disorders: A Cohort Study Based on UK Biobank.
We delved into an interesting question: can dietary vitamin C help alleviate sleep apnea? To explore this, we examined data from over 68,000 participants in the UK Biobank and focused on their dietary habits, particularly how much vitamin C they consumed. By using a detailed questionnaire to assess their intake and applying advanced statistical methods, we aimed to uncover any potential connections between vitamin C and sleep disorders, especially sleep apnea.
The results were quite revealing. Participants who consumed higher levels of vitamin C, particularly those in the top intake bracket (around 132.88 to 191.51 mg per day), showed a significant reduction in the risk of developing sleep disorders, including sleep apnea. Specifically, we found that this group had a 25% lower risk of sleep apnea compared to those with lower vitamin C intake.
What's even more encouraging is that this protective effect seemed particularly strong among men and those under 60 years old, suggesting that a sufficient intake of vitamin C could be a worthwhile strategy for preventing sleep apnea. Our findings highlight the importance of diet in managing sleep health and point to vitamin C as a valuable nutrient for those struggling with sleep issues.
Read More
8
Vitamin C in sleep apnea treatment
Antioxidant therapies for obstructive sleep apnea: A systematic review and meta-analysis.
We explored how antioxidant therapies, including Vitamin C, can benefit individuals suffering from obstructive sleep apnea (OSA). A systematic review and meta-analysis looked into six studies involving various antioxidants, with the inclusion of Vitamin C among other treatments.
Our findings indicated that Vitamin C, alongside other antioxidants, contributed to improvements in several critical areas. We observed enhancements in endothelial function, which is essential for maintaining healthy blood flow. Additionally, the studies reported significant reductions in markers of oxidative stress and noteworthy improvements in sleep quality indicators.
While Vitamin C was part of the combination therapies assessed, it is essential to note that we cannot draw definitive conclusions about its standalone effectiveness for OSA. The overall positive results call for further exploration in future research to better understand the specific contributions of Vitamin C in treating this condition.
Read More
8
Vitamin C may enhance sleep apnea
Oxidative stress and obstructive sleep apnoea syndrome.
We explored the impact of vitamin C and antioxidant treatment on patients suffering from obstructive sleep apnea syndrome (OSAS). The study involved 20 male patients who first underwent continuous positive airway pressure (CPAP) therapy for two nights. Afterward, they took vitamin C (100 mg twice daily) and vitamin E (400 IU twice daily) for 45 days, followed by another sleep assessment through polysomnography (PSG).
Our findings revealed that oxidative stress seemed to play a significant role in sleep disturbances for OSAS patients. Treatment with vitamin C, alongside vitamin E and CPAP, led to improvements in sleep quality. Patients experienced a decrease in the number of apneic episodes and reported better overall sleep. Notably, there was a reduction in plasma lipid peroxidation and a restoration of reduced glutathione levels.
Even though the study combined various treatments, the data still suggests that antioxidants like vitamin C can bolster sleep quality for those with sleep apnea. Patients spent more time in restorative sleep stages and reported feeling less sleepy during the day.
Overall, while we should consider the combined effects of the treatments, this study highlights potential benefits of vitamin C in enhancing sleep for individuals affected by OSAS—supporting the idea that managing oxidative stress may improve sleep outcomes.
My husband can snore, but since taking this grape seed supplement, there has been no snoring, allowing me to sleep well.
Read More
7.5
Enhanced alertness
4 people found this helpful
I've been taking this supplement for nearly a year. After starting it, I became more alert and energetic, my complexion improved, and my sleep has also enhanced.
Read More
7.5
Improved sleep quality
I recommend this product as I appreciate the quality and brand. The size is average and the packaging is good and airtight. My sleep has improved significantly, and there is no noticeable taste.
Read More
Frequently Asked Questions
Sleep apnea is a common and potentially serious sleep disorder characterized by irregular breathing patterns during sleep. Individuals with sleep apnea experience episodes of disrupted or paused breathing, which can occur multiple times throughout the night. These interruptions can last a few seconds to several minutes and often lead to fragmented sleep, which may result in excessive daytime sleepiness, irritability, and difficulty concentrating. The condition can be broadly classified into two main types: obstructive sleep apnea (OSA), caused by a blockage of the upper airway, and central sleep apnea (CSA), which occurs when the brain fails to send the proper signals to the muscles that control breathing.
The diagnosis of sleep apnea typically involves a sleep study, either conducted in a sleep clinic or at home using portable monitoring devices. Treatment options vary depending on the severity of the condition but may include lifestyle changes, the use of continuous positive airway pressure (CPAP) machines, oral appliances, or even surgery in some cases. If left untreated, sleep apnea can lead to various health complications, including cardiovascular issues, metabolic disorders, and impaired cognitive function, making it essential to consult a healthcare professional if you suspect you or someone you know may be affected by this disorder.
Grape seed extract is a dietary supplement derived from the seeds of grapes, particularly those of the Vitis vinifera species. It is rich in antioxidants, particularly oligomeric proanthocyanidin complexes (OPCs), which are believed to provide various health benefits. These antioxidants help to combat oxidative stress in the body, potentially reducing damage caused by free radicals. Grape seed extract is often marketed for its purported benefits related to cardiovascular health, including improved circulation, lower blood pressure, and decreased cholesterol levels. Additionally, some studies suggest it may have anti-inflammatory effects and support skin health.
The extract can be found in various forms, including capsules, tablets, and liquid extracts. When considering grape seed extract as a supplement, it’s important to choose a high-quality product from a reputable manufacturer to ensure potency and purity. While many people may benefit from grape seed extract, it's always advisable to consult with a healthcare professional before adding any new supplement to your routine, especially if you have existing health conditions or are taking other medications.
Based on user reviews, it appears that individuals taking this supplement for sleep-related issues, including Sleep Apnea, may notice improvements fairly quickly, often within a few weeks. For instance, one user reported significant enhancement in sleep quality after nearly a year of consistent use, attributing increased alertness and energy levels to the supplement as well Read Review. Another user mentioned an immediate effect of reduced snoring since starting the grape seed supplement, leading to a better sleep experience Read Review.
While the timeline can vary among users, many seem to experience noticeable benefits in their sleep quality after a few weeks of regular intake. However, it's essential to remember that individual results may depend on several factors, including overall health, adherence to dosage, and lifestyle changes.
Vitamin C is emerging as a potentially beneficial supplement for individuals dealing with sleep apnea, with scientific research shedding light on its effects. A comprehensive study involving over 68,000 participants indicated that higher dietary vitamin C intake was correlated with a reduced risk of developing sleep apnea symptoms, especially among younger males. Specifically, those with the highest intake had a 25% lower risk of sleep disorders including sleep apnea [1]. Furthermore, vitamin C has shown promise in improving various aspects of health related to obstructive sleep apnea (OSA), including enhancements in endothelial function and reductions in oxidative stress, factors that are critical in managing OSA complications [2][7].
While the findings are promising, it's important to note that many studies evaluated vitamin C as part of a combination therapy along with other antioxidants, which makes it difficult to ascertain its standalone effects on sleep apnea [4]. However, the data does suggest that vitamin C could play a role in alleviating some of the oxidative stress associated with sleep apnea and enhancing sleep quality, especially when used alongside other treatments like continuous positive airway pressure (CPAP) therapy [9]. Overall, while the ongoing research points to potential benefits, further investigation is necessary to fully understand the direct impact of vitamin C on sleep apnea management.
Users have reported a variety of improvements in their symptoms after taking the grape seed supplement. Many have noted a significant reduction in snoring, which has positively impacted their sleep quality. For instance, one user mentioned that their husband's snoring ceased altogether after incorporating the supplement into their routine, leading to a much better sleep experience for both Read Review.
In addition to enhanced sleep, others have observed benefits such as increased alertness and energy levels, as well as improvements in complexion. One user highlighted that after nearly a year of consistent use, they felt more energetic and noted marked enhancements in their overall sleeping patterns Read Review. Another user echoed this sentiment by stating they experienced significant improvements in sleep quality. However, it is essential to keep in mind that individual results can vary based on personal health conditions and lifestyle choices.
Users have shared mixed experiences when combining this supplement with other interventions for managing Sleep Apnea. Some users report positive outcomes when using the supplement alongside their existing sleep apnea treatments, citing notable improvements in sleep quality. For instance, one user observed a complete cessation of their husband's snoring after introducing the grape seed supplement into their routine, leading to a significantly better sleep experience for both partners Read Review.
Moreover, several users highlighted that the supplement seems to enhance their overall alertness and energy levels, complementing their sleep apnea management efforts. One user indicated feeling more energetic and experiencing better sleep patterns after using the supplement for almost a year, suggesting that it could be beneficial when combined with other treatments Read Review. In summary, while anecdotal evidence suggests positive synergies, the effects can vary among individuals, and users are advised to consult healthcare professionals when altering their supplement regimens.
7.5
Enhanced alertness
4 people found this helpful
I've been taking this supplement for nearly a year. After starting it, I became more alert and energetic, my complexion improved, and my sleep has also enhanced.
9
No more snoring
2 people found this helpful
My husband can snore, but since taking this grape seed supplement, there has been no snoring, allowing me to sleep well.
8
Vitamin C may reduce sleep apnea
The Association Between Dietary Vitamin C and Sleep Disorders: A Cohort Study Based on UK Biobank.
We delved into an interesting question: can dietary vitamin C help alleviate sleep apnea? To explore this, we examined data from over 68,000 participants in the UK Biobank and focused on their dietary habits, particularly how much vitamin C they consumed. By using a detailed questionnaire to assess their intake and applying advanced statistical methods, we aimed to uncover any potential connections between vitamin C and sleep disorders, especially sleep apnea.
The results were quite revealing. Participants who consumed higher levels of vitamin C, particularly those in the top intake bracket (around 132.88 to 191.51 mg per day), showed a significant reduction in the risk of developing sleep disorders, including sleep apnea. Specifically, we found that this group had a 25% lower risk of sleep apnea compared to those with lower vitamin C intake.
What's even more encouraging is that this protective effect seemed particularly strong among men and those under 60 years old, suggesting that a sufficient intake of vitamin C could be a worthwhile strategy for preventing sleep apnea. Our findings highlight the importance of diet in managing sleep health and point to vitamin C as a valuable nutrient for those struggling with sleep issues.
8
Vitamin C in sleep apnea treatment
Antioxidant therapies for obstructive sleep apnea: A systematic review and meta-analysis.
We explored how antioxidant therapies, including Vitamin C, can benefit individuals suffering from obstructive sleep apnea (OSA). A systematic review and meta-analysis looked into six studies involving various antioxidants, with the inclusion of Vitamin C among other treatments.
Our findings indicated that Vitamin C, alongside other antioxidants, contributed to improvements in several critical areas. We observed enhancements in endothelial function, which is essential for maintaining healthy blood flow. Additionally, the studies reported significant reductions in markers of oxidative stress and noteworthy improvements in sleep quality indicators.
While Vitamin C was part of the combination therapies assessed, it is essential to note that we cannot draw definitive conclusions about its standalone effectiveness for OSA. The overall positive results call for further exploration in future research to better understand the specific contributions of Vitamin C in treating this condition.
7
Vitamin C may improve endothelial health
Microvascular endothelial dysfunction in obstructive sleep apnea is caused by oxidative stress and improved by continuous positive airway pressure therapy.
We set out to understand the connection between oxidative stress and microvascular endothelial function in people with obstructive sleep apnea (OSA), particularly focusing on the possible benefits of vitamin C treatment. This study involved patients with and without OSA, using medications to measure their endothelial function before and after a vitamin C infusion.
Our findings indicated that endothelial dysfunction is closely linked to increased oxidative stress in OSA patients. When we introduced vitamin C, an antioxidant, we observed improvements in endothelial function. This suggests that oxidative stress plays a significant role in the complications associated with OSA, and that vitamin C may help mitigate some of these effects.
Notably, after six months of continuous positive airway pressure (CPAP) treatment for OSA, we noted further improvements, reinforcing the idea that managing OSA can enhance endothelial health primarily by reducing oxidative stress. However, we acknowledge that while vitamin C showed promise, more controlled studies are needed to fully establish its effects on sleep apnea.
7
Vitamin C's potential in OSAS
Evaluation of oxidative stress markers in obstructive sleep apnea syndrome and additional antioxidant therapy: a review article.
We explored the effectiveness of vitamin C as an antioxidant therapy for individuals suffering from obstructive sleep apnea syndrome (OSAS). This review focused on understanding how oxidative stress, a condition where harmful reactive oxygen species accumulate in the body, plays a role in OSAS. It was noted that the cycles of hypoxia and reoxygenation, common in OSAS, lead to this harmful build-up, making antioxidant treatment a potential avenue for relief.
Among various antioxidant agents, vitamin C showed promise in reducing oxidative stress levels. Specific markers like thioredoxin, malondialdehyde, and superoxide dismutase indicated a clear relationship between elevated oxidative stress and sleep apnea. Additionally, studies cited in the review pointed to vitamin C and another antioxidant, N-acetylcysteine (NAC), as potentially beneficial in improving conditions for OSAS patients.
While the findings suggest that vitamin C could be part of a complementary treatment strategy for sleep apnea, the individual effects of vitamin C alone were not fully established. Therefore, while it's an exciting prospect, further research may be needed to entirely understand its impact in isolation.
8
Vitamin C may enhance sleep apnea
Oxidative stress and obstructive sleep apnoea syndrome.
We explored the impact of vitamin C and antioxidant treatment on patients suffering from obstructive sleep apnea syndrome (OSAS). The study involved 20 male patients who first underwent continuous positive airway pressure (CPAP) therapy for two nights. Afterward, they took vitamin C (100 mg twice daily) and vitamin E (400 IU twice daily) for 45 days, followed by another sleep assessment through polysomnography (PSG).
Our findings revealed that oxidative stress seemed to play a significant role in sleep disturbances for OSAS patients. Treatment with vitamin C, alongside vitamin E and CPAP, led to improvements in sleep quality. Patients experienced a decrease in the number of apneic episodes and reported better overall sleep. Notably, there was a reduction in plasma lipid peroxidation and a restoration of reduced glutathione levels.
Even though the study combined various treatments, the data still suggests that antioxidants like vitamin C can bolster sleep quality for those with sleep apnea. Patients spent more time in restorative sleep stages and reported feeling less sleepy during the day.
Overall, while we should consider the combined effects of the treatments, this study highlights potential benefits of vitamin C in enhancing sleep for individuals affected by OSAS—supporting the idea that managing oxidative stress may improve sleep outcomes.
References
Zhang Q, Qi X, Wang Z, Zhang D, Wang T. The Association Between Dietary Vitamin C and Sleep Disorders: A Cohort Study Based on UK Biobank. Nutrients. 2024;16. 10.3390/nu16213661
Boppana TK, Mittal S, Madan K, Tiwari P, Mohan A, et al. Antioxidant therapies for obstructive sleep apnea: A systematic review and meta-analysis. Sleep Breath. 2024;28:1513. 10.1007/s11325-024-03050-z
Moya EA, Arias P, Iturriaga R. Nitration of MnSOD in the Carotid Body and Adrenal Gland Induced by Chronic Intermittent Hypoxia. J Histochem Cytochem. 2018;66:753. 10.1369/0022155418776229
Lira AB, de Sousa Rodrigues CF. Evaluation of oxidative stress markers in obstructive sleep apnea syndrome and additional antioxidant therapy: a review article. Sleep Breath. 2016;20:1155. 10.1007/s11325-016-1367-3
Randolph BJ, Patel HM, Muller MD. Ascorbic acid attenuates the pressor response to voluntary apnea in postmenopausal women. Physiol Rep. 2015;3. 10.14814/phy2.12384
Celec P, Jurkovičová I, Buchta R, Bartík I, Gardlík R, et al. Antioxidant vitamins prevent oxidative and carbonyl stress in an animal model of obstructive sleep apnea. Sleep Breath. 2013;17:867. 10.1007/s11325-012-0728-9
Büchner NJ, Quack I, Woznowski M, Stähle C, Wenzel U, et al. Microvascular endothelial dysfunction in obstructive sleep apnea is caused by oxidative stress and improved by continuous positive airway pressure therapy. Respiration. 2011;82:409. 10.1159/000323266
Cox SE, L'Esperance V, Makani J, Soka D, Hill CM, et al. Nocturnal haemoglobin oxygen saturation variability is associated with vitamin C deficiency in Tanzanian children with sickle cell anaemia. Acta Paediatr. 2011;100:594. 10.1111/j.1651-2227.2010.02078.x
Singh TD, Patial K, Vijayan VK, Ravi K. Oxidative stress and obstructive sleep apnoea syndrome. Indian J Chest Dis Allied Sci. 2009;51:217.
Del Rio R, Moya EA, Iturriaga R. Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link. Eur Respir J. 2010;36:143. 10.1183/09031936.00158109
Grebe M, Eisele HJ, Weissmann N, Schaefer C, Tillmanns H, et al. Antioxidant vitamin C improves endothelial function in obstructive sleep apnea. Am J Respir Crit Care Med. 2006;173:897.