NOW Supplements BioCell CollagenÂ® Hydrolyzed Type II

Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis.

Most Relevant Research

We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.

Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.

Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.

9.5

Significant improvement

Most Useful Review

After completing a course of collagen, I've noticed a marked improvement in my joints. Previously, I struggled with discomfort and bone pain, especially in my knees. However, after a month of taking this product, the pain has significantly decreased, often disappearing entirely. On days when the pain returns, it's far less intense than before, which is a relief.

Pelvic Pain details

SCIENTIFIC SCORE

Moderately Effective

Based on 16 Researches

Effective, safe pelvic pain treatment

Safety and efficacy of Intravesical hyaluronic acid/chondroitin sulfate in the treatment of refractory painful bladder syndrome.

Most Relevant Research

We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.

Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.

Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.

9.5

Significant joint relief

Most Useful Review

I took collagen with Eicherb, and after the course, I noted significant improvements. My previous issues with joint pain, particularly knee discomfort, lessened considerably. After a month of taking this collagen, the pain in my knees decreased drastically, with some days completely pain-free. Should the pain return, it is not as severe as it was before.

Autoimmune Disorder details

SCIENTIFIC SCORE

Moderately Effective

Based on 16 Researches

Hyaluronic acid shows promise

Self-assembled hyaluronic acid nanoparticles delivered by polymeric microneedles for targeted and long-acting therapy of psoriasis.

Most Relevant Research

We examined a new treatment method for psoriasis using a dissolvable microneedle patch that delivers hyaluronic acid nanoparticles combined with methotrexate. This approach aims for better targeting of inflammatory skin cells while reducing side effects associated with traditional therapies. In our study with a mouse model, just one application of the patch led to a significant decrease in skin thickening and inflammation over a week. The results suggest that this innovative delivery method could improve treatment outcomes for some psoriasis patients.

9.5

Consistent results achieved

Most Useful Review

I ordered this collagen on my doctor's advice. At 38, with a diagnosis of coxarthrosis, I took 2 capsules each morning for three months. I saw results after a month and a half, with discomfort fading away. I now take it once a year for prophylaxis and will continue ordering.

Leg Cramps details

Life-enhancing results

Most Useful Review

My mother was initially sceptical about dietary supplements until severe knee arthrosis made it impossible for her to get out of bed. Doctors prescribed a pharmacy collagen with chondroitin, but I insisted she try iHerb's collagen. Now, five months later, she's on her third can, delighting in life again without leg pain, and enjoys walks with her grandchildren. She also takes chondroitin, calcium, magnesium, and vitamin D. Wishing all our mothers good health!

Arthritis details

SCIENTIFIC SCORE

Possibly Effective

Based on 24 Researches

Hyaluronic acid eases shoulder arthritis

Retrospective evaluation of the efficacy of ultrasound-guided intra-articular hyaluronic-acid-based injections (Hyalubrix) in patients with glenohumeral osteoarthritis.

Most Relevant Research

We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.

By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.

Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.

9.5

Pain reduction observed

Most Useful Review

This really works! I was informed that I had severe arthritis in my left hip and needed a replacement. After researching, I discovered that this collagen greatly aids in rebuilding cartilage between joints. After one month of taking it, I experienced significant improvement in pain and mobility. Hopefully, I will avoid a hip replacement!

Chest Pain details

I started taking this product because my hand joints were painful. After a week, the pain was gone. A good tool; I recommend it.

Frozen Shoulder details

SCIENTIFIC SCORE

Questionable

Based on 16 Researches

No additional benefits from HA injections

Addition of intra-articular hyaluronate injection to physical therapy program produces no extra benefits in patients with adhesive capsulitis of the shoulder: a randomized controlled trial.

Most Relevant Research

We examined whether adding hyaluronic acid (HA) injections to physical therapy (PT) could improve outcomes for patients with frozen shoulder. In a well-structured study, 70 participants were divided into two groups—with one receiving HA injections alongside PT, while the other focused solely on PT.

After assessing their shoulder movement, pain, and quality of life, we found no significant extra benefits from the HA injections. This suggests that continuing with just PT could be a more cost-effective approach for managing this condition.

8.3

Effective rehabilitation

Most Useful Review

This has been definitely helpful in the rehabilitation of my shoulder injury. I have completely recovered, confirming its effectiveness. Unfortunately, it does not contain vitamin C, which I had to purchase separately.

Intraarticular hyaluronic acid versus glucocorticoid injections for nonradicular pain in the lumbar spine.

Most Relevant Research

We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.

Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.

8.5

Knee pain relief

Most Useful Review

After years of knee pain, I took one collagen capsule and noticed a dramatic improvement within 24 hours. My knee pain has almost vanished, and notably, my back pain feels better too. I am genuinely thrilled with these results!

Menopause details

My wife is ageing and experiencing menopause, using NOW Collagen for her hair and skin. It appears to be working particularly well for her skin, which has improved significantly with increased smoothness and elasticity.

Knee Pain details

Acne details

SCIENTIFIC SCORE

Moderately Effective

Based on 6 Researches

Microneedling depth impacts scars

Evaluation of microneedling depth of penetration in management of atrophic acne scars: a split-face comparative study.

Most Relevant Research

In our exploration of treating atrophic acne scars, we focused on the effects of different microneedling depths using Dermapen. We designed a split-face study involving 14 individuals, where each side of their face received a different treatment depth over six sessions, spaced two weeks apart.

On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.

The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.

8.8

Skin improvement

Most Useful Review

This is the best collagen I’ve ever tried. After taking it for two weeks, I really like it. It’s notable that the acne beneath my skin began to appear as I started using it (two capsules daily), leading to more elastic and nourished skin.