Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 40 Researches
7.7
USERS' SCORE
Good
Based on 10 Reviews
8.4
Supplement Facts
Serving Size: 2 Veg Capsules
Serving Per Container: 60
Amount Per Serving
%DV
BioCell Collagen® (Hydrolyzed Chicken Sternal Cartilage Extract) providing
1 g (1,000 mg)
**
Hydrolyzed Type II Collagen
570 mg
**
Chondroitin Sulfate
190 mg
**
Hyaluronic Acid
95 mg
**

Top Medical Research Studies

9.5
Hyaluronic acid eases shoulder arthritis
We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.

By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.

Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
Read More
We explored the effects of collagen-based supplements on knee osteoarthritis (OA) by analyzing data from 11 randomized controlled trials, involving 870 participants.

The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.

Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
Read More
8
Collagen supplement benefits knee osteoarthritis
We conducted a robust multicenter, double-blind trial involving 212 patients with knee osteoarthritis to assess the effectiveness and safety of the Artneo complex, which contains undenatured type II collagen.

Participants were divided into two groups: one received the collagen supplement for 180 days, while the other was given a placebo. Our findings indicated a significant improvement in pain, quality of life, and reduction of NSAID use among those taking the collagen compared to the placebo group.

Overall, the study supports the use of Artneo collagen as a beneficial treatment for knee osteoarthritis.
Read More

Most Useful Reviews

9
Pain reduction observed
68 people found this helpful
This really works! I was informed that I had severe arthritis in my left hip and needed a replacement. After researching, I discovered that this collagen greatly aids in rebuilding cartilage between joints. After one month of taking it, I experienced significant improvement in pain and mobility. Hopefully, I will avoid a hip replacement!
Read More
9
Wonderful relief
This is good collagen. I purchased it for my mother who has arthritis, and it has helped her wonderfully with decreased joint pain.
Read More
7.5
Great help
This collagen product aids in protecting my bones; as someone who suffers from arthritis, I find that it provides great assistance so far.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 40 Researches
7.7
  • All Researches
9.5
Hyaluronic acid eases shoulder arthritis
We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.

By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.

Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
Read More
We looked into how BD400 could potentially help with collagen-induced arthritis (CIA) in rats. Using a model to mimic the disease, we observed that BD400 significantly reduced arthritis scores and paw swelling.

It also decreased harmful inflammatory markers and improved gut health by enhancing intestinal barrier function. Essentially, BD400 seems to help alter gut bacteria and metabolism, which may slow down the progression of rheumatoid arthritis.
Read More
We explored the effects of collagen-based supplements on knee osteoarthritis (OA) by analyzing data from 11 randomized controlled trials, involving 870 participants.

The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.

Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
Read More
9
We evaluated how a nutritional supplement containing hydrolyzed collagen and other ingredients affects osteoarthritis (OA) pain. In a multicenter study involving 186 participants, we found that after 6 months, participants reported a significant decrease in pain and improved physical function. Specifically, scores on self-perceived pain and functional indices showed notable improvement, indicating that the supplement may effectively help manage OA symptoms. Importantly, the treatment was well-tolerated with no severe adverse events reported.
Read More
9
Collagen peptides may prevent osteoarthritis
We examined how collagen peptides derived from Atlantic salmon impact osteoarthritis development. Using both controlled laboratory conditions and an animal model, we observed that these peptides improve cartilage health by reducing inflammation and promoting collagen production.

The results indicated enhanced tolerance to pain in rats and decreases in inflammatory markers. Despite these positive findings, more research is needed to fully understand the mechanisms behind these benefits.

Overall, collagen peptides could be a promising dietary option for managing osteoarthritis.
Read More

User Reviews

USERS' SCORE
Good
Based on 10 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Pain reduction observed
68 people found this helpful
This really works! I was informed that I had severe arthritis in my left hip and needed a replacement. After researching, I discovered that this collagen greatly aids in rebuilding cartilage between joints. After one month of taking it, I experienced significant improvement in pain and mobility. Hopefully, I will avoid a hip replacement!
Read More
9
Wonderful relief
This is good collagen. I purchased it for my mother who has arthritis, and it has helped her wonderfully with decreased joint pain.
Read More
7.5
Great help
This collagen product aids in protecting my bones; as someone who suffers from arthritis, I find that it provides great assistance so far.
Read More
7.5
Joint improvement noticed
7 people found this helpful
Better than expected! I was advised to start collagen for skin issues and possible help with various types of arthritis. As I cannot take beef due to an allergy, I was thrilled to find chicken collagen by NOW. After just two days of use, I felt a significant difference in my joints, especially my hands, knees, and neck. For the first time in years, I don’t need to rest multiple times a day, and I'm optimistic it will only improve. I've set it to automatic delivery to ensure I never run out.
Read More
7.5
Helpful for pain
This product has assisted me in coping with the pain from arthritis, and it also benefits your skin.
Read More

Frequently Asked Questions

6
Effects on digestion
It seems to assist with my arthritis, although it may take a few weeks to notice reduced pain. Additionally, it appears to help my digestion a little.
9
Wonderful relief
This is good collagen. I purchased it for my mother who has arthritis, and it has helped her wonderfully with decreased joint pain.
7.5
Some improvements
I bought this for my mum who has rheumatoid arthritis. She reports some improvements, though not to the extent that her joint pains have disappeared entirely.
4
Limited effect
I should have purchased Type II and III collagen, as they’re more effective, but I couldn’t find them in one formulation during shopping. There hasn’t been much change from when I started taking it until now, and though it’s meant to help with hair, arthritis, bones, and cartilage, I mainly took it for my skin. The effect seems limited, as it merely maintained my existing condition.
7.5
Improved joint health
I ordered this for my husband who suffers from rheumatoid arthritis, and it has improved his joint health significantly, regardless of age.
7.5
Great help
This collagen product aids in protecting my bones; as someone who suffers from arthritis, I find that it provides great assistance so far.
7.5
Inflammation reduction
Collagen helps reduce inflammation in joints and is used in the combined treatment of rheumatism and arthritis. It prevents cartilage tissue destruction, treats arthrosis, and alleviates joint strain during workouts.
7.5
Helpful for pain
This product has assisted me in coping with the pain from arthritis, and it also benefits your skin.
7
Collagen shows promise for OA relief
We conducted a double-blind, randomized, placebo-controlled study to explore how a collagen supplement affects osteoarthritis (OA) symptoms.

Involving 31 participants aged 35-65, we divided them into two groups: one received the collagen supplement while the other received a placebo.

After eight weeks, our results indicated that the collagen supplement did improve pain levels and quality of life, alongside some enhancements in physical function. Overall, collagen supplements may offer promising relief for those managing OA.
We explored the effects of collagen-based supplements on knee osteoarthritis (OA) by analyzing data from 11 randomized controlled trials, involving 870 participants.

The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.

Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
8
Collagen supplements aid arthritis relief
We explored the effects of oral chicken collagen supplements on arthritis in a study with Wistar rats.

The results showed that various forms of collagen significantly reduced pain sensitivity and cartilage damage linked to osteoarthritis.

Particularly, the protease-soluble type II collagen (PSCC-II) proved to be effective in improving bone health and reducing inflammation, showing better results compared to untreated rats.

Overall, this study suggests that collagen supplements could offer promising benefits for arthritis management.

References

  1. Yang Y, Hong Q, Zhang X, Liu Z. BD400 protects from collagen-induced arthritis through histidine metabolism. Front Immunol. 2025;16:1518181. doi:10.3389/fimmu.2025.1518181
  2. Genç AS, Yılmaz AK, Anıl B, Korkmaz Salkılıç E, Akdemir E, et al. Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study. Jt Dis Relat Surg. 2025;36:85. doi:10.52312/jdrs.2025.1965
  3. Stabile M, Fracassi L, Lacitignola L, Garcia-Pedraza E, Girelli CR, et al. Effects of a feed supplement, containing undenatured type II collagen (UC II®) and Boswellia Serrata, in the management of mild/moderate mobility disorders in dogs: A randomized, double-blind, placebo controlled, cross-over study. PLoS One. 2024;19:e0305697. doi:10.1371/journal.pone.0305697
  4. Dobenecker B, Böswald LF, Reese S, Steigmeier-Raith S, Trillig L, et al. The oral intake of specific Bioactive Collagen Peptides (BCP) improves gait and quality of life in canine osteoarthritis patients-A translational large animal model for a nutritional therapy option. PLoS One. 2024;19:e0308378. doi:10.1371/journal.pone.0308378
  5. Simental-Mendía M, Ortega-Mata D, Acosta-Olivo CA, Simental-Mendía LE, Peña-Martínez VM, et al. Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials. Clin Exp Rheumatol. 2025;43:126. doi:10.55563/clinexprheumatol/kflfr5
  6. Zhao Q, Li Z, Liu Z, Zhao X, Fan Y, et al. Preparation, typical structural characteristics and relieving effects on osteoarthritis of squid cartilage type II collagen peptides. Food Res Int. 2024;191:114697. doi:10.1016/j.foodres.2024.114697
  7. Yu M, Park C, Son YB, Jo SE, Jeon SH, et al. Time-Dependent Effect of Eggshell Membrane on Monosodium-Iodoacetate-Induced Osteoarthritis: Early-Stage Inflammation Control and Late-Stage Cartilage Protection. Nutrients. 2024;16. doi:10.3390/nu16121885
  8. Alekseeva LI, Kashevarova NG, Taskina EA, Strebkova EA, Korotkova TA, et al. [Efficacy and safety of undenatured type II collagen in patients with knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial]. Ter Arkh. 2024;96:500. doi:10.26442/00403660.2024.05.202788
  9. Devasia S, Joseph JT, P S S, Koizumi S, Clarke L, et al. Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability. Cartilage. 2024;15:363. doi:10.1177/19476035231221211
  10. Puigdellívol Grifell J, Comellas Berenguer C, Steinbacher G, Kranjcec T, Álvarez Díaz P, et al. Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction. J Diet Suppl. 2024;21:374. doi:10.1080/19390211.2023.2284982
  11. Thomas DT, Prabhakar AJ, Eapen C, Patel VD, Palaniswamy V, et al. Comparison of Single and Combined Treatment with Exercise Therapy and Collagen Supplementation on Early Knee Arthritis among Athletes-A Quasi-Randomized Trial. Int J Environ Res Public Health. 2023;20. doi:10.3390/ijerph20237088
  12. Chen NF, Lin YY, Yao ZK, Tseng CC, Liu YW, et al. Oral Administration of Protease-Soluble Chicken Type II Collagen Ameliorates Anterior Cruciate Ligament Transection-Induced Osteoarthritis in Rats. Nutrients. 2023;15. doi:10.3390/nu15163589
  13. Kviatkovsky SA, Hickner RC, Cabre HE, Small SD, Ormsbee MJ. Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults. J Int Soc Sports Nutr. 2023;20:2243252. doi:10.1080/15502783.2023.2243252
  14. Kwon SB, Chinta G, Kundimi S, Kim S, Cho YD, et al. A Blend of and Extracts Alleviates Monosodium Iodoacetate (MIA)-Induced Osteoarthritic Pain and Joint Inflammation in Rats. J Am Nutr Assoc. 2024;43:48. doi:10.1080/27697061.2023.2209880
  15. Chen CC, Chang SS, Chang CH, Hu CC, Nakao Y, et al. Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions. Nutr J. 2023;22:17. doi:10.1186/s12937-023-00837-w
  16. Luo X, Liu W, Zhao M, Liu T, Xiong F, et al. A novel Atlantic salmon (Salmo salar) bone collagen peptide delays osteoarthritis development by inhibiting cartilage matrix degradation and anti-inflammatory. Food Res Int. 2022;162:112148. doi:10.1016/j.foodres.2022.112148
  17. Gupta N, Khatri K, Lakhani A, Dahuja A, Randhawa A, et al. Long-term effectiveness of intra-articular injectables in patients with knee osteoarthritis: a systematic review and Bayesian network meta-analysis. J Orthop Surg Res. 2025;20:227. doi:10.1186/s13018-025-05574-w
  18. Powantia Pontoh LA, Fiolin J, Dilogo IH, Prasetyo M, Antarianto RD, et al. Combined exosome of adipose-derived mesenchymal stem cell and hyaluronic acid delays early osteoarthritis progression of ovine sheep model: Clinical, radiographic, macroscopic and microscopic evaluation. F1000Res. 2024;13:494.
  19. Bernetti A, Agostini F, Finamore N, Dal Borgo M, Mangone M, et al. Effectiveness of ultrasound-guided hip injections on pain and functioning in patients with hip osteoarthritis: A systematic review. J Back Musculoskelet Rehabil. 2025;38:19. doi:10.1177/10538127241296338
  20. Migliorini F, Maffulli N, Pipino G, Jeyaraman M, Ramasubramanian S, et al. Intra-articular injections of hyaluronic acid versus plasma rich in growth factors (PRGF) for knee osteoarthritis: a meta-analysis of randomised controlled trials : A meta-analysis. Orthopadie (Heidelb). 2025;54:218. doi:10.1007/s00132-025-04615-w
  21. Zhang C, Lu Y, Huang Y. Clinical efficacy of cell-free fat extract and its effects on bone marrow edema in patients with early to mid-stage knee osteoarthritis: a clinical trial in comparison with hyaluronic acid. J Orthop Surg Res. 2025;20:153. doi:10.1186/s13018-025-05543-3
  22. Nisha M, Adnan M, Sakure K, Jain P. Innovations in Glycosaminoglycan Delivery: Transforming Joint Health Therapies. Pharm Nanotechnol. 2025. doi:10.2174/0122117385329819241212040246
  23. Zhang Z, Wang G, Zhang Z, Liang X, Wang G, et al. Locally administered liposomal drug depot enhances rheumatoid arthritis treatment by inhibiting inflammation and promoting cartilage repair. J Nanobiotechnology. 2025;23:69. doi:10.1186/s12951-025-03110-w
  24. Heller S, Seemann RJ, Burgkart R, Obermeier A, Locher H. Lidocaine Shows Significant Antimicrobial Effects Against Species: An In-Vitro Study Comparing Different Combinations of Lidocaine and Clinically Used Injectables, like Steroids and Hyaluronan, in the Context of Arthritis Management. Biomedicines. 2025;13. doi:10.3390/biomedicines13010106
  25. Kumaran K, Vasudevan AK, Jayakumar R, Biswas R. Injectable vancomycin loaded hyaluronic acid-chitosan hydrogel for the treatment of Staphylococcus aureus septic arthritis. Carbohydr Res. 2025;550:109384. doi:10.1016/j.carres.2025.109384
  26. Du D, Liang Y. A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA). J Orthop Surg Res. 2025;20:57. doi:10.1186/s13018-024-05429-w
  27. Zhou Q, Chen J, Yu W, Cao D, Ye Y, et al. A critical overview of systematic reviews and meta-analyses of intra-articular injection of platelet rich plasma versus hyaluronic acid for knee osteoarthritis. Clin Rheumatol. 2025;44:547. doi:10.1007/s10067-024-07264-0
  28. Rieger R, Kaderli S, Boulocher C. In vivo impact on rabbit subchondral bone of viscosupplementation with a hyaluronic acid antioxidant conjugate. BMC Musculoskelet Disord. 2024;25:1018. doi:10.1186/s12891-024-07921-0
  29. Migliorini F, Schäfer L, Pilone M, Bell A, Simeone F, et al. Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. Arch Orthop Trauma Surg. 2024;145:68. doi:10.1007/s00402-024-05614-w
  30. Monti L, Franchi E, Verde F, Sgherzi S, Anghilieri FM. Retrospective evaluation of the efficacy of ultrasound-guided intra-articular hyaluronic-acid-based injections (Hyalubrix) in patients with glenohumeral osteoarthritis. Reumatismo. 2025;77. doi:10.4081/reumatismo.2024.1699
  31. Oon SF, Lazarakis S, Mallawa G, Nguyen C. Intra-articular hyaluronic acid and platelet-rich plasma as monotherapy or combination therapy in knee osteoarthritis?. Regen Med. 2024;19:637. doi:10.1080/17460751.2024.2439221
  32. Zhou C, Hao W, Yao J, Zhu T, Sun M, et al. Anti-inflammatory supramolecular hydrogel loaded chicoric acid based on graphene oxide modified hyaluronic acid and polyethylene glycol for rheumatoid arthritis treatment. Int J Biol Macromol. 2025;287:138610. doi:10.1016/j.ijbiomac.2024.138610
  33. Said M, Tavakoli C, Dumot C, Toupet K, Olivier C, et al. A self-healing radiopaque hyaluronic acid hydrogel as a new injectable biomaterial for precision medicine in osteoarthritis. Theranostics. 2025;15:4054. doi:10.7150/thno.104551
  34. Liu Q, Ye H, Yang Y, Chen H. The efficacy and safety of intra-articular platelet-rich plasma versus sodium hyaluronate for the treatment of osteoarthritis: Meta-analysis. PLoS One. 2025;20:e0314878. doi:10.1371/journal.pone.0314878
  35. Woo I, Park JJ, Park CH. Dual intra-articular injections of corticosteroid and hyaluronic acid versus single corticosteroid injection for ankle osteoarthritis: a randomized comparative trial. BMC Musculoskelet Disord. 2025;26:239. doi:10.1186/s12891-025-08488-0
  36. Bensa A, Bianco Prevot L, Moraca G, Sangiorgio A, Boffa A, et al. Corticosteroids, hyaluronic acid, platelet-rich plasma, and cell-based therapies for knee osteoarthritis - literature trends are shifting in the injectable treatments' evidence: a systematic review and expert opinion. Expert Opin Biol Ther. 2025;25:309. doi:10.1080/14712598.2025.2465833
  37. Mirghaderi P, Mortezaei A, Javidan A, Ghaseminejad-Raeini A, Nematollahi B. Efficacy and safety of biological products in hip osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Clin Rheumatol. 2025;44:1403. doi:10.1007/s10067-025-07366-3
  38. Wu J, Tang Q, Tan X. Sodium hyaluronate and acupotomy bone decompression alleviates inflammatory responses in patients with knee osteoarthritis. Inflammopharmacology. 2025;33:1997. doi:10.1007/s10787-025-01667-4
  39. Chowdary P, Puppala ER, Putta CL, Maddila JR, Pulavarthy V, et al. Hyaluronic-Acid-Functionalized Tofacitinib Loaded Transethosomes for Targeted Drug Delivery in Rheumatoid Arthritis. ACS Appl Bio Mater. 2025;8:1594. doi:10.1021/acsabm.4c01743
  40. Ma Y, Yang X, Jiang M, Ye W, Qin H, et al. Alone or in combination, hyaluronic acid and chondroitin sulfate alleviate ECM degradation in osteoarthritis by inhibiting the NF-κB pathway. J Orthop Surg Res. 2025;20:11. doi:10.1186/s13018-024-05411-6
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