Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
The product is found useful for the following medical conditions
Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.5
USERS' SCORE
Good
Based on 14 Reviews
8.7
9
DHA enhances calf growth, reduces inflammation
We investigated how different fat sources in calf starter diets influence growth, health, and inflammation, particularly during cold weather. Our study involved 48 Holstein calves, divided into four diet groups: one without added fat, one with calcium-salts of soybean oil (Ca-SBO), another with calcium-salts of fish oil (Ca-FO), and a mix of both.
We found that calves fed the Ca-FO diet, which contains DHA and other beneficial fats, had significantly better growth performance and higher final body weights compared to the other groups. In fact, these calves showed enhanced feed efficiency and increased average daily gains, suggesting that DHA, often found in fish oils, plays a crucial role in improving growth in challenging cold conditions.
Furthermore, the calves on the Ca-FO diet exhibited lower levels of inflammatory markers compared to their counterparts, which indicates a potential of DHA in reducing inflammation, a common issue in cold environments. In contrast, the Ca-SBO group had higher levels of certain fats and inflammation markers, pointing to the advantages of including DHA in calf diets during cold seasons.
Overall, our findings suggest that enriching calf diets with DHA not only supports better growth in cold climates but also helps in managing inflammation.
We found that calves fed the Ca-FO diet, which contains DHA and other beneficial fats, had significantly better growth performance and higher final body weights compared to the other groups. In fact, these calves showed enhanced feed efficiency and increased average daily gains, suggesting that DHA, often found in fish oils, plays a crucial role in improving growth in challenging cold conditions.
Furthermore, the calves on the Ca-FO diet exhibited lower levels of inflammatory markers compared to their counterparts, which indicates a potential of DHA in reducing inflammation, a common issue in cold environments. In contrast, the Ca-SBO group had higher levels of certain fats and inflammation markers, pointing to the advantages of including DHA in calf diets during cold seasons.
Overall, our findings suggest that enriching calf diets with DHA not only supports better growth in cold climates but also helps in managing inflammation.
9
No colds experienced
Most Useful Review
1 people found this helpful
We take omega as a family. For adults, we specifically opt for this company's omega. The dosage is good, as it is convenient to take one capsule daily. Previously, we frequently fell ill, but since we started taking omega and D3, we have forgotten what a cold is, or we only experience it mildly. One jar lasts us three months. The price and quality match well.
Updated: Mar 2026
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.5
USERS' SCORE
Good
Based on 11 Reviews
8.6
9.5
We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
9
Fatigue decreased
Most Useful Review
8 people found this helpful
Fatigue has diminished significantly! Just a month ago, I felt completely worn out after 20 hours, but now I hardly notice it. I highly recommend this, especially for mothers of multiple children. It truly helps in combating chronic fatigue syndrome!
Updated: Mar 2026
Constipation details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
10
Cured constipation
Most Useful Review
1 people found this helpful
I purchased it to address my fish shortage diet, but it also unexpectedly cured my constipation. Despite eating less on my diet, I have experienced regular bowel movements, which I hadn’t managed daily before. This is remarkable, especially as previous remedies like Biofermin and Colac failed to help. The notion that its fat coating aids in easing the process may indeed be accurate.
Updated: Mar 2026
Gastritis details
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
We aimed to understand how docosahexaenoic acid (DHA) impacts the growth of Helicobacter pylori, a common bacteria linked to gastritis and other stomach disorders. Our research focused on how DHA influences bacterial adhesion to stomach cells and reduces inflammation associated with infection.
At concentrations of 100 µM, DHA effectively reduced H. pylori growth, while higher amounts of 250 µM or more led to irreversible effects on bacterial survival. We noted that DHA not only hindered bacterial growth but also decreased the bacteria's ability to attach to gastric epithelial cells. Moreover, we found that cells infected with DHA-treated H. pylori showed significantly lower levels of Interleukin-8 (IL-8), an inflammatory marker, alongside reductions in other inflammatory proteins.
Through our analysis, we discovered that DHA alters the outer membrane proteins of H. pylori, which are involved in its stress response and metabolism. These changes seem to contribute to lesser adhesion to stomach cells and a reduced inflammatory response. These findings suggest that DHA could be a beneficial alternative in managing H. pylori-related gastritis by targeting the bacteria and its effects on the stomach.
At concentrations of 100 µM, DHA effectively reduced H. pylori growth, while higher amounts of 250 µM or more led to irreversible effects on bacterial survival. We noted that DHA not only hindered bacterial growth but also decreased the bacteria's ability to attach to gastric epithelial cells. Moreover, we found that cells infected with DHA-treated H. pylori showed significantly lower levels of Interleukin-8 (IL-8), an inflammatory marker, alongside reductions in other inflammatory proteins.
Through our analysis, we discovered that DHA alters the outer membrane proteins of H. pylori, which are involved in its stress response and metabolism. These changes seem to contribute to lesser adhesion to stomach cells and a reduced inflammatory response. These findings suggest that DHA could be a beneficial alternative in managing H. pylori-related gastritis by targeting the bacteria and its effects on the stomach.
9
No discomfort experienced
Most Useful Review
1 people found this helpful
Omega for those with stomach issues is brilliant! Being enteric, it has no adverse effects on my stomach. I have chronic gastritis, and unlike other omega supplements that caused me pain, this one brings me no discomfort.
Updated: Mar 2026
Reflux details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.6
9
No reflux issues
Most Useful Review
2 people found this helpful
DHA is an essential part of my diet and the best omega I have tried. It leaves no odour, doesn't cause reflux, and is safe from mercury. As a nutritionist, I highly recommend this product.
Updated: Apr 2025
Allergies details
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8.1
USERS' SCORE
Good
Based on 4 Reviews
8.5
We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
9
Allergy relief
Most Useful Review
This fish oil works wonders for me and my husband; we no longer suffer from allergies and our focus has improved.
Updated: Mar 2026
Athlete’s Foot details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Warts disappeared
Most Useful Review
1 people found this helpful
We take omega regularly as a family; this variant has a higher DHA content, which is more beneficial for the brain without causing excitement. Since starting, my child's warts on his feet have disappeared. There’s no fish oil aftertaste, and although the capsules are large, my 7 and 8-year-old children manage fine. I also feel more alert and energetic, with thicker hair and stronger nails. I'd certainly recommend it!
Updated: Mar 2025
Hashimoto details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 2 Reviews
8.5
7
We explored the role of a gluten-free diet supplemented with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in influencing the inflammation associated with Hashimoto’s thyroiditis (HT). Our study focused on 39 Caucasian women diagnosed with autoimmune HT to assess how these dietary changes might affect inflammatory responses.
Through careful analysis of metabolites, we observed that introducing a gluten-free diet with omega-3 fatty acids, including DHA, may help alleviate inflammation related to Hashimoto’s. We noted an increase in anti-inflammatory fatty acid mediators after dietary changes, suggesting potential benefits of such dietary interventions for people with HT.
However, it is important to clarify that while we saw significant changes in inflammatory markers, the specific impact of DHA alone remains unclear. Moreover, our findings did not reveal any improvements in thyroid antibodies. This indicates that while dietary changes can have a positive impact on inflammation, the direct effects of DHA on Hashimoto's may require further investigation.
Through careful analysis of metabolites, we observed that introducing a gluten-free diet with omega-3 fatty acids, including DHA, may help alleviate inflammation related to Hashimoto’s. We noted an increase in anti-inflammatory fatty acid mediators after dietary changes, suggesting potential benefits of such dietary interventions for people with HT.
However, it is important to clarify that while we saw significant changes in inflammatory markers, the specific impact of DHA alone remains unclear. Moreover, our findings did not reveal any improvements in thyroid antibodies. This indicates that while dietary changes can have a positive impact on inflammation, the direct effects of DHA on Hashimoto's may require further investigation.
9
Reduced inflammation
Most Useful Review
3 people found this helpful
Now Foods offers great quality at a reasonable price. I appreciate this product as it serves as an excellent source of omega 3, significantly aiding my Hashimoto's. My hair is regrowing and my symptoms are improving, resulting in decreased inflammation. Moreover, there is thankfully no fishy aftertaste when I burp.
Updated: Apr 2025
Premenstrual Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
9
Less migraines
Most Useful Review
Super result! I have been taking DHA500 for over nine months now, two capsules per day without interruption. I immediately felt more cheerful and energetic, making it easier to engage in sports. My skin became more moisturised, despite frequent handwashing, and it remained delicate even on my elbows. My hair has less split ends and appears livelier. I was ill every month last year, but only once this year, and I had a mild case of Covid, all thanks to fish oil. My head aches have decreased, and migraines have vanished during PMS. I am happy and will continue to take it. If my review was helpful, click Yes)) I would be very grateful))
Updated: Apr 2025
Stroke details
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.5
9
We aimed to find out whether docosahexaenoic acid (DHA) could offer protection against ischemic stroke in diabetic mice and better understand how it works. In our study, we administered DHA to diabetic mice after they experienced an ischemic stroke and evaluated their recovery over 24 hours and again at three days.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
9
Stimulates recovery
Most Useful Review
This is a great supplement for the brain, particularly beneficial for schoolchildren and those recovering from a stroke, as it aids memory and concentration.
Updated: Mar 2026
Autism details
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.4
USERS' SCORE
Good
Based on 18 Reviews
8.4
We explored the effects of DHA and EPA supplementation on children with autism spectrum disorder (ASD) through a randomized, double-blind, placebo-controlled trial. Involving 54 children aged 2 to 6, we tracked changes in their omega-3 fatty acid profiles and plasma cytokines over 6 months.
Despite hopes for positive outcomes, our findings revealed no significant clinical improvements or anti-inflammatory benefits from the supplementation. This suggests that such dietary interventions may not be warranted unless specific omega-3 deficiencies are confirmed.
Despite hopes for positive outcomes, our findings revealed no significant clinical improvements or anti-inflammatory benefits from the supplementation. This suggests that such dietary interventions may not be warranted unless specific omega-3 deficiencies are confirmed.
9
Cognitive progress noted
Most Useful Review
5 people found this helpful
I purchased the DHA-500 for my 5-year-old son on the autism spectrum, and he has been taking it for over a month. He swallows the capsule with a spoonful of lemon water easily. In this past month, I've noticed significant progress in his cognitive development and motor skills. There’s no fishy aftertaste; I take it with lemon water too. I've already bought a second bottle!
Updated: Mar 2026
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.2
USERS' SCORE
Good
Based on 3 Reviews
8.4
8
We conducted a study to find out whether docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could effectively help those dealing with major depressive disorder (MDD). Over the course of 12 weeks, 60 participants were involved in a double-blind, placebo-controlled trial. They were divided into two groups: one received 3.2 grams of DHA daily, while the other group was given an equivalent amount of soybean oil as a placebo.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.
9
Postpartum depression prevention
Most Useful Review
1 people found this helpful
Recommended by my gynecologist, DHA 500 significantly benefits memory, particularly during pregnancy when the body's demands increase. In countries like Germany, it's a mandatory supplement for expectant mothers. I took it and did not experience postpartum depression, finding it an excellent support during that time.
Updated: Mar 2026
Hypertension details
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.8
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
Eicosapentaenoic acid benefits hypertension
We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
9
Healthy brain development
Most Useful Review
3 people found this helpful
Necessary for pregnant women! From conception to 2 years, consuming DHA is vital for a child’s brain, nervous system, and eye development. The World Health Organization recommends at least 500 mg of DHA daily for pregnant and breastfeeding women. A study from the University of Kansas demonstrated that a daily intake of 600 mg of DHA during pregnancy aids heart development and may protect against hypertension with excess weight.
Updated: Mar 2026
Arthritis details
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.3
8
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
7.5
Less pain felt
Most Useful Review
2 people found this helpful
It seems to work. I have arthritis in my lower back, and I have had considerably less pain since taking this, presumably due to its anti-inflammatory properties. This indicates to me that it is a quality product that is genuinely effective.
Updated: Mar 2026
Blurred Vision details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 16 Reviews
8.3
9
Supports nervous system
Most Useful Review
26 people found this helpful
This Omega product emphasises DHA, known as the most valuable omega-3 fatty acid. Essential for the nervous system and beneficial for vision, it is free from any fishy aftertaste due to its enteric coating. I found no significant downsides and give it a thumbs up for its quality and effectiveness.
Updated: Mar 2026
Common Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 6 Reviews
8.3
8
We conducted a double-blind randomized controlled trial to understand how prenatal supplementation of docosahexaenoic acid (DHA) might influence infant health, particularly concerning the common cold. Pregnant women were given either a daily dose of 400 mg of DHA or a placebo starting at 18 to 22 weeks of gestation until childbirth.
Caregivers then reported on their infants’ health at 1, 3, and 6 months, sharing details about common illness symptoms. We found that DHA supplementation appeared to reduce the number of colds at one month and also seemed to lessen the duration of various cold symptoms in infants. Specifically, infants in the DHA group experienced fewer cold symptoms and had shorter durations of cough and wheezing.
While the overall occurrence of specific illness symptoms was similar between the DHA and placebo groups, DHA did bring about noteworthy benefits. At 1 month, infants in the DHA group had a 26% shorter duration of cough and 30% shorter wheezing; however, they experienced a longer duration of rash.
Furthermore, by the time the infants reached 3 months, those whose mothers took DHA were ill for 14% less time overall. At 6 months, the DHA group showed significantly reduced durations of several illness indicators, although they did experience longer episodes of vomiting.
This study suggests that prenatal DHA not only seems to impact the occurrence of colds in children but may also play a role in the duration of symptoms over the first half-year of life.
Caregivers then reported on their infants’ health at 1, 3, and 6 months, sharing details about common illness symptoms. We found that DHA supplementation appeared to reduce the number of colds at one month and also seemed to lessen the duration of various cold symptoms in infants. Specifically, infants in the DHA group experienced fewer cold symptoms and had shorter durations of cough and wheezing.
While the overall occurrence of specific illness symptoms was similar between the DHA and placebo groups, DHA did bring about noteworthy benefits. At 1 month, infants in the DHA group had a 26% shorter duration of cough and 30% shorter wheezing; however, they experienced a longer duration of rash.
Furthermore, by the time the infants reached 3 months, those whose mothers took DHA were ill for 14% less time overall. At 6 months, the DHA group showed significantly reduced durations of several illness indicators, although they did experience longer episodes of vomiting.
This study suggests that prenatal DHA not only seems to impact the occurrence of colds in children but may also play a role in the duration of symptoms over the first half-year of life.
9
Common cold relief
Most Useful Review
1 people found this helpful
We all take omega together as a family. We buy this brand specifically for adults as it offers a good dosage. Since we started taking omega and vitamin D3, we rarely get sick, or if we do, it’s in a milder form. One jar lasts us three months, and I believe the price and quality are good.
Updated: Apr 2025
Flu details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.3
7.5
Fewer illnesses
Most Useful Review
I've always had a weak immune system, but I’ve noticed fewer illnesses since starting this supplement. It's a significant relief, especially during flu season.
Updated: Apr 2025
Heart Attack details
SCIENTIFIC SCORE
Possibly Effective
Based on 36 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.3
2
We explored the effects of omega-3 fatty acids, specifically EPA and DHA, on heart failure markers in patients who had suffered a heart attack. In a large study involving nearly 4,837 participants aged 60-80, we administered various types of margarine for 40 months, some enriched with these fatty acids.
However, our results indicated that there was no significant change in NT-proBNP levels, a crucial heart failure biomarker, among those taking the supplements compared to a placebo group. Thus, it appears that modest EPA and DHA supplementation does not significantly affect heart failure risks after a myocardial infarction.
However, our results indicated that there was no significant change in NT-proBNP levels, a crucial heart failure biomarker, among those taking the supplements compared to a placebo group. Thus, it appears that modest EPA and DHA supplementation does not significantly affect heart failure risks after a myocardial infarction.
7.5
Supports cardiovascular health
Most Useful Review
Excellent quality supplement! This product offers a high dose of DHA, promoting healthy brain function and reducing inflammation and cholesterol. It’s crucial for heart and blood vessel health.
Updated: Mar 2026
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8.3
9
DHA lowers cholesterol; boosts metabolism
We aimed to investigate how docosahexaenoic acid (DHA) impacts cholesterol levels and brain glucose metabolism. In our study, we focused on aged SAMP8 mice, dividing them into two groups: a control group and one receiving DHA supplementation.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
9
Improved cholesterol levels
Most Useful Review
211 people found this helpful
Omega 3 lowers cholesterol, reduces inflammation, and enhances skin and hair quality. Despite the fishy taste, the quality suits me fine. Although prices have surged due to currency fluctuations, investing in health is essential. We take it as a family, and the large packaging accommodates everyone.
Updated: Mar 2026
Hypothyroidism details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
We set out to explore how hypothyroidism affects cognitive functions in adult male rats and whether omega-3 supplementation could help. In our study, we divided thirty rats into three groups: a control group, one with induced hypothyroidism, and another that received omega-3 treatment.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
7.5
Improved symptoms
Most Useful Review
One of the best omega forms. I consume this regularly, and it has alleviated symptoms associated with my hypothyroidism, such as skin deterioration, concentration loss, sleep issues, irritability, mood swings, chronic fatigue, and worsened allergies. I rely on it due to my AIT and Hashimoto's disease, and my eldest son, aged 16, also takes it as he experiences fatigue from studying remotely.
Updated: Mar 2026
Knee Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.3
We examined whether docosahexaenoic acid (DHA) could help reduce knee pain and inflammation in a specific mouse model of arthritis. The study involved administering DHA either orally or directly into the joint over a set period.
Our findings indicated that DHA not only reduced pain-related behaviors and swelling but also improved overall function in the mice. This research suggests that DHA might be a promising option to ease the suffering of individuals with arthritis. However, further research is needed to understand its effectiveness in humans.
Our findings indicated that DHA not only reduced pain-related behaviors and swelling but also improved overall function in the mice. This research suggests that DHA might be a promising option to ease the suffering of individuals with arthritis. However, further research is needed to understand its effectiveness in humans.
8
Knee mobility
Most Useful Review
4 people found this helpful
This Omega-3 has greatly improved my knee pain. I felt a notable difference when moving my knees, allowing me to train without discomfort. While I haven't noticed other effects, such as hair health, I found it more cost-effective than alternatives I considered. I plan to continue my intake.
Updated: Mar 2026
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.3
7.5
Reduced pain
Most Useful Review
I regularly consume Omega-3, and I've noticed an improvement in my health. My leg cramps and lower back pain have decreased.
Updated: Mar 2026
Liver Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
We investigated the potential of DHA-enriched phosphatidylserine (DHA-PS) in addressing liver injuries caused by cyclophosphamide in mice. By administering cyclophosphamide over five days, we created a model to simulate this liver damage. Following this, we treated the mice with different doses of DHA-PS for a week to see if it could help heal their livers.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
7.5
Supports liver protection
Most Useful Review
High-quality ingredients with no fishy taste and a high omega-3 DHA content. This supplement reduces inflammation and protects the liver, heart, and hair while also lowering cholesterol as we age. All these benefits are packed into one product.
Updated: Mar 2026
Menopause details
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.2
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
We explored how docosahexaenoic acid (DHA), at a dosage of 625 mg, affects menopausal symptoms among perimenopausal women. Our study involved 42 participants who were assessed for various symptoms using the Kupperman Index, along with quality of life and sexual function measured through standardized scales.
After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.
Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.
Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.
After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.
Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.
Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.
7.5
Menopause guidance
Most Useful Review
I consistently repurchase this fish oil and take one capsule at a time, on my gynaecologist's advice during menopause. Although the capsule is large, it's easy to swallow!
Updated: Mar 2026
Multiple Sclerosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.3
8
Eicosapentaenoic acid reduces MS symptoms
We explored the therapeutic effects of eicosapentaenoic acid (EPA) in tackling multiple sclerosis through a study involving mice with experimental autoimmune encephalomyelitis (EAE). The mice were given diets enriched with or without EPA. Remarkably, the mice that received the EPA-infused diet displayed significantly lower clinical scores compared to those that did not.
Furthermore, we observed that the production of inflammatory markers like IFN-γ and IL-17 was notably reduced in the EPA-treated mice. This reduction is particularly important, as these markers are associated with the progression of multiple sclerosis. Additionally, there was an enhancement in the expression levels of peroxisome proliferator-activated receptors within the CD4T cells infiltrating the central nervous system.
These findings suggest that EPA could serve as a promising new approach to therapy for multiple sclerosis, showcasing its potential in reducing inflammation and improving clinical outcomes in those affected by this condition.
Furthermore, we observed that the production of inflammatory markers like IFN-γ and IL-17 was notably reduced in the EPA-treated mice. This reduction is particularly important, as these markers are associated with the progression of multiple sclerosis. Additionally, there was an enhancement in the expression levels of peroxisome proliferator-activated receptors within the CD4T cells infiltrating the central nervous system.
These findings suggest that EPA could serve as a promising new approach to therapy for multiple sclerosis, showcasing its potential in reducing inflammation and improving clinical outcomes in those affected by this condition.
7.5
Myelin sheath support
Most Useful Review
23 people found this helpful
Excellent! DHA plays an important role in the omega-3 chain and aids in maintaining the myelin sheath, which is crucial for nerve impulse conduction. As a person with multiple sclerosis, preserving my myelin sheath is vital, and DHA is beneficial. NOW's DHA is cost-effective, offers a generous quantity for the price, and has good quality. The capsule size may be an issue for some, but it doesn't bother me. If you found my comment helpful, please give it a like.
Updated: Mar 2026
Osteoporosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
DHA's role in osteoporosis treatment
We recently looked into how docosahexaenoic acid (DHA), through its enriched phosphatidylcholine form (DHA-PC), affects osteoporosis. Using a model that simulates the condition in women after ovariectomy, we compared the impact of DHA-PC with eicosapentaenoic acid (EPA) enriched phosphatidylcholine (EPA-PC). Our findings revealed that both DHA-PC and EPA-PC significantly improved the structural quality of trabecular bone, boosted the rate of new bone formation, and elevated bone mineral density, which are crucial factors in combating osteoporosis.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
7.5
Reduced inflammation benefits
Most Useful Review
97 people found this helpful
Omega-3s support joint health and osteoporosis prevention. They combat inflammation, mitigate bone loss, and relieve joint pain. Moreover, they help lessen rheumatoid arthritis symptoms and slow the degeneration of articular cartilage in cases of arthrosis.
Updated: Apr 2025
Adhd details
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
5.7
USERS' SCORE
Good
Based on 13 Reviews
8.2
3
DHA showed limited benefits for ADHD
We evaluated the effects of docosahexaenoic acid (DHA) supplementation on behavior and cognition in children aged 7 to 14 with ADHD. Over six months, 50 participants were randomly assigned to receive either DHA or a placebo in a controlled clinical trial.
While DHA showed some minor positive effects on psychosocial functioning and attention, it did not significantly improve primary ADHD symptoms. Importantly, no side effects were reported, suggesting that further research into DHA's potential benefits for ADHD-related difficulties is worthwhile.
While DHA showed some minor positive effects on psychosocial functioning and attention, it did not significantly improve primary ADHD symptoms. Importantly, no side effects were reported, suggesting that further research into DHA's potential benefits for ADHD-related difficulties is worthwhile.
7.5
Improved reasoning
Most Useful Review
7 people found this helpful
Great! ADHD, best of all. Natal - Rio Grande do Norte, Brazil, all my products took 7 consecutive days to arrive at my house. Very good, I often forgot things, but after taking it for over 5 months, I’m now writing. My reasoning has improved significantly; I’m still on this journey, taking 2 a day, equivalent to 1000 DHA. The doctor recommended a maximum of 3, but it is costly. Congratulations.
Updated: Apr 2025
Alzheimer details
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7
USERS' SCORE
Good
Based on 5 Reviews
8.2
9
We investigated the potential benefits of docosahexaenoic acid (DHA) in fighting Alzheimer's disease (AD) through a novel intranasal administration method. By using a specially formulated nanoemulsion that protects DHA from oxidation, we aimed to enhance its delivery to the brain. In our study, we administered this DHA-rich nanoemulsion to J20 mice, a well-known transgenic model for AD.
The results were promising. After treatment, the mice showed notable improvements in their well-being and memory performance, which we measured through their ability to navigate spatial tasks. Additionally, we observed a significant reduction in harmful amyloid deposits, oxidative stress, and neuroinflammation within their brain tissues. This positive outcome could potentially stem from DHA's ability to affect specific processes in the brain, such as the inactivation of GSK3β, a kinase associated with AD.
Overall, our findings suggest that intranasal DHA treatment not only has therapeutic effects but may also modify the progression of Alzheimer's disease. Considering that DHA has already demonstrated safety in humans, we believe there is a strong case for conducting clinical trials to explore this approach further for Alzheimer's patients.
The results were promising. After treatment, the mice showed notable improvements in their well-being and memory performance, which we measured through their ability to navigate spatial tasks. Additionally, we observed a significant reduction in harmful amyloid deposits, oxidative stress, and neuroinflammation within their brain tissues. This positive outcome could potentially stem from DHA's ability to affect specific processes in the brain, such as the inactivation of GSK3β, a kinase associated with AD.
Overall, our findings suggest that intranasal DHA treatment not only has therapeutic effects but may also modify the progression of Alzheimer's disease. Considering that DHA has already demonstrated safety in humans, we believe there is a strong case for conducting clinical trials to explore this approach further for Alzheimer's patients.
9
Essential nutrition
Most Useful Review
Very good, very good! This is essential nutrition for preventing Alzheimer's disease.
Updated: Mar 2026
Atrial Septal Defect details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.2
7.5
Positive social impact
Most Useful Review
7 people found this helpful
We have been on this omega for 5 years for certain. I bought it for my son, who began taking two capsules daily from the age of 7 due to signs of an atrial septal defect. He takes it consistently with short breaks, and I also take it. The high DHA content is beneficial for us, with 250 EPA, amounting to 750 pure Omegas per capsule. Although the packaging is large, my son managed to swallow them easily. I recommend this omega as it has helped many children, enabling improvements in speech and eye contact alongside other dietary supplements.
Updated: Apr 2025
Food Poisoning details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 2 Reviews
8.2
9
We explored the effects of docosahexaenoic acid (DHA) on cadmium (Cd) exposure, a common pollutant that risks human health through the food chain. Our investigation focused on how DHA might help mitigate the harmful effects of Cd, particularly by looking at changes in gut microbiota.
The study involved examining mice that had been exposed to cadmium. We observed that DHA significantly boosted the amount of cadmium expelled in feces while reducing the levels of cadmium accumulated in various organs. Our findings highlighted a particularly encouraging increase in Parabacteroides, a beneficial bacteria in the gut that appeared to play a crucial role in this process.
We noted that the representative strain of Parabacteroides not only demonstrated the ability to reduce Cd toxicity but also helped repair gut damage inflicted by cadmium exposure. Furthermore, DHA effectively reduced cadmium levels in organs such as the liver, spleen, and kidneys, leading to a noticeable increase in cadmium excretion.
Overall, our results suggest that DHA may have significant potential in promoting the excretion of cadmium in instances of exposure. This insight offers a fascinating avenue for considering DHA as a supportive treatment option for handling heavy metal toxicity.
The study involved examining mice that had been exposed to cadmium. We observed that DHA significantly boosted the amount of cadmium expelled in feces while reducing the levels of cadmium accumulated in various organs. Our findings highlighted a particularly encouraging increase in Parabacteroides, a beneficial bacteria in the gut that appeared to play a crucial role in this process.
We noted that the representative strain of Parabacteroides not only demonstrated the ability to reduce Cd toxicity but also helped repair gut damage inflicted by cadmium exposure. Furthermore, DHA effectively reduced cadmium levels in organs such as the liver, spleen, and kidneys, leading to a noticeable increase in cadmium excretion.
Overall, our results suggest that DHA may have significant potential in promoting the excretion of cadmium in instances of exposure. This insight offers a fascinating avenue for considering DHA as a supportive treatment option for handling heavy metal toxicity.
7
Relief from pain
Most Useful Review
4 people found this helpful
This fish oil product is among the best available, and I highly recommend it. It works wonders for joint pain and inflammation, providing relief swiftly. Just take 2 to 4 softgels daily with food, depending on your pain level, dividing the doses. This is an excellent addition to my routine for managing discomfort.
Updated: Apr 2025
Frozen Shoulder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.2
9
Aches alleviated
Most Useful Review
8 people found this helpful
Since taking this supplement, my frozen shoulder aches have gone. I started on 1st January 2021, and after a couple of weeks, I discovered I could sleep through the night without pain. The product has no aftertaste and offers a high level of omega-3 at an economical price. I would recommend it to anyone seeking a good omega supplement.
Updated: Mar 2026
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 35 Researches
7.1
USERS' SCORE
Good
Based on 28 Reviews
8.2
9
We examined how different doses and durations of omega-3 fatty acids (PUFAs) affect heart failure management. Our study analyzed data from 14 randomized controlled trials, involving nearly 9,100 participants. We found that high doses of omega-3 (2000-4000 mg daily) for at least a year significantly improved heart function, particularly left ventricular ejection fraction and peak oxygen consumption. However, lower doses and shorter durations didn't yield the same benefits, and no increased risk of adverse events was noted. More research is needed to solidify these results.
9
Corrected my heart issues
Most Useful Review
6 people found this helpful
This supplement was crucial for my heart health at 27. I initially thought my issues were from other vitamins, but discovered I lacked omega-3 fatty acids, leading to high cholesterol. Since taking omega-3, my heart sensations have ceased, and I feel much healthier now.
Updated: Mar 2026
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 6 Reviews
8.2
9.5
We conducted a thorough investigation into how eicosapentaenoic acid (EPA) can impact episodic migraines. In a carefully designed study, we gathered 70 participants who experienced these migraines and divided them into two groups. One group received a high dose of EPA, while the other was given a placebo. This approach ensured that we could see the true effects of EPA without bias.
After 12 weeks, the results were compelling. We noticed that those taking EPA had significantly fewer migraine days compared to the placebo group. In fact, participants on EPA reported an average reduction of 4.4 days per month, while those on the placebo had barely any change. The EPA group also experienced less need for acute headache medication and marked improvements in headache severity, disability, anxiety, depression, and overall quality of life.
Perhaps most striking was how particularly beneficial EPA seemed to be for female participants. Overall, the study demonstrated that high-dose EPA not only helped reduce the frequency and severity of migraines but also positively influenced the psychological aspects of living with migraines.
This suggests that incorporating EPA into migraine management could be a valuable option for those suffering from episodic migraines, especially as there were no major adverse effects reported.
After 12 weeks, the results were compelling. We noticed that those taking EPA had significantly fewer migraine days compared to the placebo group. In fact, participants on EPA reported an average reduction of 4.4 days per month, while those on the placebo had barely any change. The EPA group also experienced less need for acute headache medication and marked improvements in headache severity, disability, anxiety, depression, and overall quality of life.
Perhaps most striking was how particularly beneficial EPA seemed to be for female participants. Overall, the study demonstrated that high-dose EPA not only helped reduce the frequency and severity of migraines but also positively influenced the psychological aspects of living with migraines.
This suggests that incorporating EPA into migraine management could be a valuable option for those suffering from episodic migraines, especially as there were no major adverse effects reported.
7.5
Helpful migraine relief
Most Useful Review
107 people found this helpful
Best! I love this fish oil! It has undoubtedly rejuvenated my skin, which has become more elastic and smoother. At 56, post-menopause, my skin was fading despite hormonal treatments. This supplement, which I call “fish”, has saved my skin, hair, and nails. My sister’s thin hair has become stronger too. The high docosahexaenoic acid content is great for cardiovascular health and brain function. My migraines have reduced significantly. I highly recommend it, but remember to consult your doctor about the dosage.
Updated: Mar 2026
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 17 Reviews
8.1
9
Best value for DHA
Most Useful Review
3 people found this helpful
I use high DHA together with Turmeric, Boswellia, and Tart Cherry for my joint pain at night. The Now Foods DHA-500 offers excellent value and works wonderfully without any fishy aftertaste.
Updated: Apr 2025
Cholecystitis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.1
9
Surge of strength from Omega
Most Useful Review
I learned about Dr. Magera Ilya, an endocrinologist, and purchased vitamins he suggested (including fish oil - Now Foods, DHA-500). After starting these in January 2021, my life transformed. I felt an immediate surge of strength and improved mood. Omega-3 inhibits bile stagnation and alleviates headaches, enhancing gallbladder function. If I experience a headache while fasting, I know to take Omega as it eases toxins—not hunger. I take 1 capsule daily and ensure I drink liquid to allow fats to enter the brain rapidly.
Updated: Apr 2025
Hair Loss details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 13 Reviews
8.1
7.5
Reduced hair loss
Most Useful Review
6 people found this helpful
After following my endocrinologist's advice to take Omega-3, I noticed a significant reduction in hair loss during washing. My hair has become shinier, softer, and my mood has improved markedly. The 180 capsules in the jar should last me for 90 days, and I feel stronger with better stress resilience. My nails are now more robust as well.
Updated: Mar 2026
Mild Cognitive Impairment details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.1
9
Beneficial for parents
Most Useful Review
1 people found this helpful
This DHA is excellent for my elderly parents, both of whom have Mild Cognitive Impairment.
Updated: Apr 2025
Back Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.9
USERS' SCORE
Good
Based on 9 Reviews
8
9
We aimed to find out how docosahexaenoic acid (DHA), a key omega-3 fatty acid, could affect intervertebral disc (IVD) degeneration, a common cause of lower back pain. In our study, we used a group of 12 rats, all of whom underwent a procedure to induce disc degeneration.
After the injury, half of the rats were given a daily supplement of omega-3 fatty acids, while the other half received only a sugar solution as control. Over the course of the study, we measured various outcomes related to inflammation and disc health.
We observed that the omega-3 group showed a significant reduction in blood markers associated with inflammation. Additionally, the results indicated that those receiving DHA were less affected by disc dehydration, and the tissue damage due to the induced injury was noticeably less severe in this group.
Overall, this suggests that increasing our intake of omega-3 fatty acids, like DHA, may offer protective effects against the degeneration of intervertebral discs and could potentially ease back pain related to this condition.
After the injury, half of the rats were given a daily supplement of omega-3 fatty acids, while the other half received only a sugar solution as control. Over the course of the study, we measured various outcomes related to inflammation and disc health.
We observed that the omega-3 group showed a significant reduction in blood markers associated with inflammation. Additionally, the results indicated that those receiving DHA were less affected by disc dehydration, and the tissue damage due to the induced injury was noticeably less severe in this group.
Overall, this suggests that increasing our intake of omega-3 fatty acids, like DHA, may offer protective effects against the degeneration of intervertebral discs and could potentially ease back pain related to this condition.
9
Mood improvement
Most Useful Review
21 people found this helpful
Fish oil has become essential for me! I take nine capsules daily and have noticed a significant improvement in my mood, with osteoarthritis pain considerably reduced. I no longer have loose stools, my weight remains stable, and my blood pressure has dropped from 135/90 to 115/75. It truly works!
Updated: Mar 2026
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.8
USERS' SCORE
Good
Based on 3 Reviews
8
9
We set out to explore how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects colorectal cancer (CRC) cells. In this study, we treated five different colorectal cancer cell lines with varying concentrations of DHA, along with other fatty acids like eicosapentaenoic acid (EPA) and linoleic acid (LA). This allowed us to see if DHA could impact the methylation patterns of the PPARγ promoter, a key player in cancer regulation, and affect the relationship between PPARγ and COX2, two important molecules involved in cancer growth.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
7.5
Brain activity support
Most Useful Review
Docosahexaenoic acid is a vital omega-3 fatty acid for health. Consuming at least 250 mg of DHA daily may lower the risk of cancer. I purchased this for my mother to support her brain function.
Updated: Apr 2025
Chest Pain details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.5
USERS' SCORE
Good
Based on 6 Reviews
8
7
We examined how eicosapentaenoic acid (EPA), a key ingredient found in fish oil, impacts chest pain in patients with variant angina. Our study followed 22 individuals with this condition, where we infused acetylcholine, a substance known to cause coronary vasospasm, both before and after a four-month course of EPA treatment (1.8 g/day for 12 patients).
In the group that did not receive EPA, we observed no changes in how their coronary arteries responded to acetylcholine over time. However, for those treated with EPA, the results were quite intriguing. In non-spastic areas, the response shifted from vasoconstriction (narrowing) to vasodilation (widening). This indicates a notable improvement in how these arteries are functioning.
Yet, when it came to spastic sites where vasospasm had occurred, the coronary arteries remained responsive to acetylcholine, and the vasospasm persisted despite the EPA treatment. Thus, while EPA enhanced coronary responsiveness in some areas, it did not eliminate the acetylcholine-induced coronary vasospasms associated with variant angina.
In the group that did not receive EPA, we observed no changes in how their coronary arteries responded to acetylcholine over time. However, for those treated with EPA, the results were quite intriguing. In non-spastic areas, the response shifted from vasoconstriction (narrowing) to vasodilation (widening). This indicates a notable improvement in how these arteries are functioning.
Yet, when it came to spastic sites where vasospasm had occurred, the coronary arteries remained responsive to acetylcholine, and the vasospasm persisted despite the EPA treatment. Thus, while EPA enhanced coronary responsiveness in some areas, it did not eliminate the acetylcholine-induced coronary vasospasms associated with variant angina.
9
Joint pain relief
Most Useful Review
5 people found this helpful
This product was recommended by my doctor, and after a few weeks, my joint and back pain vanished. It's beneficial for the brain, heart, and eyes as well. I believe its anti-inflammatory properties surpass any pharmaceutical alternatives. I wholeheartedly recommend it for anyone suffering from chest pain.
Updated: Apr 2025
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.8
USERS' SCORE
Good
Based on 7 Reviews
8
9.5
We conducted a 12-week study to explore how eicosapentaenoic acid (EPA) affects individuals suffering from episodic migraines. In our trial, 70 participants were randomly split into two groups—one received 2 grams of fish oil with 1.8 grams of pure EPA daily, while the other group got a placebo made of soybean oil.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
7.5
Calmed headaches
Most Useful Review
210 people found this helpful
After recovering from Covid, my memory suffered, making it difficult to focus on work. I purchased two cans of this excellent brand. After a month of taking one capsule daily, I've become calmer and my headaches have disappeared. Additionally, this omega does not cause belching and is pleasant to consume.
Updated: Mar 2026
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.5
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.9
9
We explored the effectiveness of omega-3 fatty acid (PUFA) supplements in improving heart failure. Through a comprehensive network meta-analysis, we examined data from 14 randomized controlled trials involving over 9,000 participants.
Our findings showed that taking high doses of omega-3s (2000-4000 mg daily) for a year or more led to significant improvements in heart function, specifically in left ventricular ejection fraction and peak oxygen consumption. However, lower doses or shorter use didn’t yield these benefits, and there were no notable increases in dropout rates or overall mortality.
This suggests that while omega-3s can be beneficial for heart function in heart failure patients, careful consideration of the dosage and duration is essential.
Our findings showed that taking high doses of omega-3s (2000-4000 mg daily) for a year or more led to significant improvements in heart function, specifically in left ventricular ejection fraction and peak oxygen consumption. However, lower doses or shorter use didn’t yield these benefits, and there were no notable increases in dropout rates or overall mortality.
This suggests that while omega-3s can be beneficial for heart function in heart failure patients, careful consideration of the dosage and duration is essential.
9
Good price
Most Useful Review
21 people found this helpful
Great product at a good price! The capsules are large but easy to swallow, and the dosage is rich. Recommended for cardiovascular health, taken by the whole family for three months with a break.
Updated: Mar 2026
Rheumatoid Arthritis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.9
9
Maintains healthy joints
Most Useful Review
A good product, Omega-3 fatty acids help to prevent osteoporosis, keeping joints healthy, and alleviating pain during flare-ups. They combat bone loss, reduce inflammation, diminish symptoms of rheumatoid arthritis, and slow the destruction of articular cartilage in arthrosis.
Updated: Apr 2025
Acne details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.8
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.8
9
We explored the connection between docosahexaenoic acid (DHA), a type of polyunsaturated fatty acid (PUFA), and the risk of developing acne. Using genetic data from over 478,000 participants, we used a method called Mendelian randomization to determine if higher levels of DHA could truly lead to lower acne risk.
Our findings were quite enlightening. We discovered that higher DHA levels were significantly associated with a decreased risk of acne. Specifically, when looking at the percentage of total fatty acids that were DHA, we saw even stronger protective effects against acne flare-ups. In contrast, we found that higher levels of linoleic acid (LA) and a higher omega-6 to omega-3 ratio were linked to an increased risk of acne.
Notably, the results hinted at a connection to a genetic variant related to the fatty acid desaturase 1 (FADS1) gene, emphasizing that genetics plays a role in how these fatty acids affect skin health. Overall, our study supports the idea that boosting DHA intake could be beneficial for acne prevention, while cautioning against high intakes of LA.
Our findings were quite enlightening. We discovered that higher DHA levels were significantly associated with a decreased risk of acne. Specifically, when looking at the percentage of total fatty acids that were DHA, we saw even stronger protective effects against acne flare-ups. In contrast, we found that higher levels of linoleic acid (LA) and a higher omega-6 to omega-3 ratio were linked to an increased risk of acne.
Notably, the results hinted at a connection to a genetic variant related to the fatty acid desaturase 1 (FADS1) gene, emphasizing that genetics plays a role in how these fatty acids affect skin health. Overall, our study supports the idea that boosting DHA intake could be beneficial for acne prevention, while cautioning against high intakes of LA.
8
Reduced inflamed skin
Most Useful Review
1 people found this helpful
After taking it daily for a month, my skin looks less inflamed and red, with no new acne spots. The capsules are quite large, but I managed to take them without any issue. There was no aftertaste.
Updated: Mar 2026
Attention Deficit Hyperactivity Disorder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 41 Reviews
7.7
9
Improved reasoning skills
Most Useful Review
7 people found this helpful
Great! This has been the best product for ADHD. My order arrived in 7 days. I often forgot things, but after taking it for over 5 months, I’ve noticed a substantial improvement in my reasoning. I take two capsules a day, which provides 1000mg of DHA, though the doctor suggested taking up to three.
Updated: Mar 2026
Nausea details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.4
7
We conducted a retrospective cohort study to investigate the relationship between nausea and vomiting in pregnancy (NVP) and dysmenorrhea measured by a verbal rating scale. Our research included 443 pregnant women, divided into those experiencing NVP and a control group.
From our findings, we noticed a clear association between moderate to severe dysmenorrhea and a heightened risk of NVP, especially during the first trimester. This suggests that those with painful menstrual symptoms may face an increased likelihood of nausea and vomiting as part of their pregnancy experience.
Importantly, we also examined the impact of periconceptional supplementation with docosahexaenoic acid (DHA). Our results indicated that taking DHA could potentially lower the risk of NVP, offering a glimmer of hope for managing nausea during pregnancy. This suggests that combining DHA with standard prenatal care might be beneficial for those who struggle with these symptoms.
Overall, our study sheds light on the intricate connections between menstrual pain and pregnancy-related nausea, emphasizing the potential protective role of DHA in improving women's health during this time.
From our findings, we noticed a clear association between moderate to severe dysmenorrhea and a heightened risk of NVP, especially during the first trimester. This suggests that those with painful menstrual symptoms may face an increased likelihood of nausea and vomiting as part of their pregnancy experience.
Importantly, we also examined the impact of periconceptional supplementation with docosahexaenoic acid (DHA). Our results indicated that taking DHA could potentially lower the risk of NVP, offering a glimmer of hope for managing nausea during pregnancy. This suggests that combining DHA with standard prenatal care might be beneficial for those who struggle with these symptoms.
Overall, our study sheds light on the intricate connections between menstrual pain and pregnancy-related nausea, emphasizing the potential protective role of DHA in improving women's health during this time.
9
No nausea noted
Most Useful Review
1 people found this helpful
We take this fish oil as a family. I give my 8-year-old 1 capsule and adults 2 capsules daily. We tolerate this fish oil well without side effects such as nausea, dizziness, or a bad aftertaste. There are no fish burps either. Although the capsules are slightly larger than average, they are easy to swallow. I've noticed an improvement in my skin and hair.
Updated: Mar 2026
Diarrhea details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.1
8
We examined how eicosapentaenoic acid, specifically a compound called 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE), affects diarrhea caused by inflammation in mice. In our study, the mice were given a substance that induces colitis, known as dextran sulfate sodium (DSS), and then treated with different doses of 5,6-DiHETE orally.
What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.
We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.
We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
0
Initial diarrhoea experience
Most Useful Review
1 people found this helpful
If you're seeking high-quality omega 3s, this option is good. Each capsule contains 750mg of omega 3 (500 DHA + 250 EPA), so I take at least 2 capsules daily, as the minimum recommended dose is 1200mg/day for benefits. Initially, I experienced diarrhoea, but I've adjusted now. I advise consulting a doctor regarding blood thinners and stopping omega 3 at least 2 weeks before any surgery. The product is distilled and comes well packaged, although it has less taste and smell.
Updated: Apr 2025
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.3
USERS' SCORE
Moderately Good
Based on 7 Reviews
7
8
DHA improves milk and reduces anxiety
We explored how supplementing obese mothers with docosahexaenoic acid (DHA) affects milk composition and the anxiety behavior of their offspring. In a study involving female Wistar rats, some were placed on a high-fat diet while others ate regular chow. We supplemented half of the mothers from one month before mating until they weaned their pups with DHA. The goal was to see if this supplementation could improve the quality of their milk and influence the anxiety levels of their babies.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
9
Significant decrease
Most Useful Review
I first bought these capsules for my son while starting the Nemechek protocol. Previous capsules had unpleasant fishy smells, but these do not. After a few months of taking them, my anxiety and depressive mood significantly decreased.
Updated: Mar 2026
Heartburn details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 13 Reviews
7
10
No heartburn experienced
Most Useful Review
1 people found this helpful
Thinking more clearly. I was introduced to DHA by an article I read. This is the first fish oil product I’ve taken that doesn't give me heartburn or fish burps. I take one in the morning and one at dinner and can definitely feel the clarity it provides. I encourage you to research DHA and its benefits for your brain and heart.
Updated: Mar 2026
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