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SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
8
5,6-DiHETE alleviates diarrhea
Efficient Attenuation of Dextran Sulfate Sodium-Induced Colitis by Oral Administration of 5,6-Dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic Acid in Mice.
High relevance to diarrhea treatment
We examined how eicosapentaenoic acid, specifically a compound called 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE), affects diarrhea caused by inflammation in mice. In our study, the mice were given a substance that induces colitis, known as dextran sulfate sodium (DSS), and then treated with different doses of 5,6-DiHETE orally.
What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.
We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.
We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
Read More
8
Fatty acids combat swine viruses
DHA and EPA inhibit porcine coronavirus replication by alleviating ER stress.
Significant antiviral effects noted
Our exploration into the impact of fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on porcine coronaviruses revealed noteworthy findings. We found that these acids significantly reduce the viral load of several dangerous porcine viruses, including the ones responsible for diarrhea in pigs, like porcine epidemic diarrhea virus (PEDV). This reduction occurs during viral replication, rather than hindering the virus's ability to enter the cells, indicating a specific action against the viral lifecycle.
We confirmed that both DHA and EPA help in reducing inflammation and lowering reactive oxygen species (ROS) levels within cells infected by these viruses. By doing so, they also enhance the overall antioxidant capacity of the cells, providing a protective effect against the stress caused by the viruses. Overall, our findings suggest that EPA, along with DHA, could play a critical role in developing new approaches to managing infection and, consequently, controlling outbreaks of diarrhea-causing viruses in the swine industry.
These findings are particularly relevant as we look for effective treatments to combat the viral threats facing livestock and, by extension, the agricultural economy. Thus, the antiviral properties of these fatty acids provide a promising avenue for future research and therapeutic development.
We confirmed that both DHA and EPA help in reducing inflammation and lowering reactive oxygen species (ROS) levels within cells infected by these viruses. By doing so, they also enhance the overall antioxidant capacity of the cells, providing a protective effect against the stress caused by the viruses. Overall, our findings suggest that EPA, along with DHA, could play a critical role in developing new approaches to managing infection and, consequently, controlling outbreaks of diarrhea-causing viruses in the swine industry.
These findings are particularly relevant as we look for effective treatments to combat the viral threats facing livestock and, by extension, the agricultural economy. Thus, the antiviral properties of these fatty acids provide a promising avenue for future research and therapeutic development.
Read More
8
Dietary ω3 fatty acids' benefits
Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut.
Indicates potential for diarrhea treatment
We explored the effects of eicosapentaenoic acid (EPA), a crucial metabolite derived from dietary ω3 fatty acids, particularly α-linolenic acid (ALA). Our investigation aimed to understand how these compounds can potentially reduce allergic reactions, including those that lead to diarrhea.
In our study, we observed that mice consuming ALA-rich linseed oil exhibited lower instances of allergic diarrhea. This decrease seemed to stem from impaired mast cell degranulation, which is a process crucial for allergic responses. Interestingly, it didn’t affect allergen-specific serum IgE levels, suggesting a targeted response against the symptoms rather than the underlying allergy itself.
Through our detailed analyses, we identified 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) as a major metabolite produced in the gut from EPA. Notably, this compound demonstrated anti-allergic properties when administered in vivo, highlighting its potential role as a therapeutic target for managing intestinal allergies, including diarrhea.
While the research provides promising insights into the benefits of EPA, it's essential to note that the specific mechanisms and isolated effects need further clarity. Overall, our findings point to a compelling link between dietary ω3 fatty acids and their capability to ameliorate diarrhea through their metabolic pathways.
In our study, we observed that mice consuming ALA-rich linseed oil exhibited lower instances of allergic diarrhea. This decrease seemed to stem from impaired mast cell degranulation, which is a process crucial for allergic responses. Interestingly, it didn’t affect allergen-specific serum IgE levels, suggesting a targeted response against the symptoms rather than the underlying allergy itself.
Through our detailed analyses, we identified 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) as a major metabolite produced in the gut from EPA. Notably, this compound demonstrated anti-allergic properties when administered in vivo, highlighting its potential role as a therapeutic target for managing intestinal allergies, including diarrhea.
While the research provides promising insights into the benefits of EPA, it's essential to note that the specific mechanisms and isolated effects need further clarity. Overall, our findings point to a compelling link between dietary ω3 fatty acids and their capability to ameliorate diarrhea through their metabolic pathways.
Read More
Most Useful Reviews
0
Severe reactions reported
After taking DHA-500, I had several severe allergic reactions, becoming violently ill with diarrhoea all day, which led to dehydration and a hospital visit. I am sure some people might not have this problem, but it affected me severely.
Read More
5
Initial diarrhoea experience
If you're seeking high-quality omega 3s, this option is good. Each capsule contains 750mg of omega 3 (500 DHA + 250 EPA), so I take at least 2 capsules daily, as the minimum recommended dose is 1200mg/day for benefits. Initially, I experienced diarrhoea, but I've adjusted now. I advise consulting a doctor regarding blood thinners and stopping omega 3 at least 2 weeks before any surgery. The product is distilled and comes well packaged, although it has less taste and smell.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
8
Nutritious formula aids diarrhea control
Gastrointestinal tolerance and plasma status of carotenoids, EPA and DHA with a fiber-enriched tube feed in hospitalized patients initiated on tube nutrition: Randomized controlled trial.
Docosahexaenoic acid's unclear impact
We conducted a study to investigate the effects of a tube feeding formula enriched with dietary fiber, fish oil, and carotenoids on gastrointestinal tolerance, particularly focusing on diarrhea. Our research involved a multi-center, randomized, double-blind trial, where we compared this nutrient-rich formula to a standard isocaloric formula in 51 hospitalized patients requiring tube nutrition.
Over the course of the trial, we recorded the incidence of diarrhea and constipation based on stool frequency and consistency. Our findings suggested that patients receiving the enriched formula experienced fewer incidents of diarrhea than those on the standard formula. Additionally, after seven days, we noted significant improvements in plasma levels of essential nutrients like EPA, DHA, and carotenoids.
Overall, our study indicates that incorporating docosahexaenoic acid (DHA) along with dietary fiber and carotenoids in tube feeding could enhance gastrointestinal tolerance. This means that not only may it help reduce diarrhea among hospitalized patients, but it also potentially improves their nutritional status during a critical period of recovery.
Over the course of the trial, we recorded the incidence of diarrhea and constipation based on stool frequency and consistency. Our findings suggested that patients receiving the enriched formula experienced fewer incidents of diarrhea than those on the standard formula. Additionally, after seven days, we noted significant improvements in plasma levels of essential nutrients like EPA, DHA, and carotenoids.
Overall, our study indicates that incorporating docosahexaenoic acid (DHA) along with dietary fiber and carotenoids in tube feeding could enhance gastrointestinal tolerance. This means that not only may it help reduce diarrhea among hospitalized patients, but it also potentially improves their nutritional status during a critical period of recovery.
Read More
8
DHA reduces diarrhea risk in infants
Infants fed formula with added long chain polyunsaturated fatty acids have reduced incidence of respiratory illnesses and diarrhea during the first year of life.
Study shows dietary intervention impact
We explored the effects of adding docosahexaenoic acid (DHA) to infant formula to find out if it influences the incidence of diarrhea among other illnesses. In a large, multicenter study, a total of 325 healthy infants participated, with 233 receiving formula enriched with DHA and arachidonic acid (ARA), while 92 were given standard formula without these supplements.
Throughout the year, pediatricians observed and documented the health of these infants, especially focusing on respiratory illnesses and instances of diarrhea. Our findings revealed that infants who consumed the DHA/ARA enhanced formula had a significantly lower rate of diarrhea that required medical attention compared to those who did not receive these fatty acids.
This research suggests that incorporating DHA into infant nutrition could potentially lead to fewer cases of diarrhea during the critical first year of life, among other health benefits. Overall, this highlights the importance of considering nutritional components in infant formulas to support better health outcomes.
Throughout the year, pediatricians observed and documented the health of these infants, especially focusing on respiratory illnesses and instances of diarrhea. Our findings revealed that infants who consumed the DHA/ARA enhanced formula had a significantly lower rate of diarrhea that required medical attention compared to those who did not receive these fatty acids.
This research suggests that incorporating DHA into infant nutrition could potentially lead to fewer cases of diarrhea during the critical first year of life, among other health benefits. Overall, this highlights the importance of considering nutritional components in infant formulas to support better health outcomes.
Read More
8
Fish oil may aid colitis symptoms
Dietary supplementation with fish oil in ulcerative colitis.
Moderate relevance to diarrhea effects
We conducted a multicenter study to examine the impact of fish oil supplementation, rich in docosahexaenoic acid (DHA), on patients suffering from active ulcerative colitis and the associated symptom of diarrhea. The study included 24 patients who were randomly assigned to receive either fish oil or a placebo over four months, with treatment periods separated by a one-month washout.
Throughout the study, participants continued their regular medications, which included prednisone and sulfasalazine. The results were promising; we observed noticeable improvements in the patients' histology, reduced levels of leukotriene B4—which is linked to inflammation—and even some weight gain. However, while there were benefits related to inflammation markers and histologic findings, we cannot exclusively credit DHA for improvements in diarrhea, as other treatments were also in play.
Ultimately, the findings indicated that fish oil, with its DHA component, may contribute positively to managing ulcerative colitis, but further investigation is needed to clarify its specific effects on diarrhea alone. Thus, while there is potential, we should approach the results with some caution regarding the direct link to diarrhea relief.
Throughout the study, participants continued their regular medications, which included prednisone and sulfasalazine. The results were promising; we observed noticeable improvements in the patients' histology, reduced levels of leukotriene B4—which is linked to inflammation—and even some weight gain. However, while there were benefits related to inflammation markers and histologic findings, we cannot exclusively credit DHA for improvements in diarrhea, as other treatments were also in play.
Ultimately, the findings indicated that fish oil, with its DHA component, may contribute positively to managing ulcerative colitis, but further investigation is needed to clarify its specific effects on diarrhea alone. Thus, while there is potential, we should approach the results with some caution regarding the direct link to diarrhea relief.
Read More
8
Fatty acids combat swine viruses
DHA and EPA inhibit porcine coronavirus replication by alleviating ER stress.
Significant antiviral effects noted
Our exploration into the impact of fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on porcine coronaviruses revealed noteworthy findings. We found that these acids significantly reduce the viral load of several dangerous porcine viruses, including the ones responsible for diarrhea in pigs, like porcine epidemic diarrhea virus (PEDV). This reduction occurs during viral replication, rather than hindering the virus's ability to enter the cells, indicating a specific action against the viral lifecycle.
We confirmed that both DHA and EPA help in reducing inflammation and lowering reactive oxygen species (ROS) levels within cells infected by these viruses. By doing so, they also enhance the overall antioxidant capacity of the cells, providing a protective effect against the stress caused by the viruses. Overall, our findings suggest that EPA, along with DHA, could play a critical role in developing new approaches to managing infection and, consequently, controlling outbreaks of diarrhea-causing viruses in the swine industry.
These findings are particularly relevant as we look for effective treatments to combat the viral threats facing livestock and, by extension, the agricultural economy. Thus, the antiviral properties of these fatty acids provide a promising avenue for future research and therapeutic development.
We confirmed that both DHA and EPA help in reducing inflammation and lowering reactive oxygen species (ROS) levels within cells infected by these viruses. By doing so, they also enhance the overall antioxidant capacity of the cells, providing a protective effect against the stress caused by the viruses. Overall, our findings suggest that EPA, along with DHA, could play a critical role in developing new approaches to managing infection and, consequently, controlling outbreaks of diarrhea-causing viruses in the swine industry.
These findings are particularly relevant as we look for effective treatments to combat the viral threats facing livestock and, by extension, the agricultural economy. Thus, the antiviral properties of these fatty acids provide a promising avenue for future research and therapeutic development.
Read More
8
Nutritional management in SAH patients
Early Enteral Nutrition with High-Protein Whey Peptide Digestive Nutrients May Improve Prognosis in Subarachnoid Hemorrhage Patients.
Diarrhea findings inconclusive with EPA
We explored the effect of early enteral nutrition on patients who suffered a subarachnoid hemorrhage (SAH). In a retrospective study involving 245 patients, we compared two different liquid diets: one rich in high-protein whey peptide and the other containing eicosapentaenoic acid (EPA).
Our focus was on understanding how these diets impacted patients' health outcomes, especially regarding diarrhea. While we noticed that the high-protein whey peptide group had a lower rate of diarrhea (about 15.8%) compared to the EPA group (34.3%), we couldn’t isolate the effects of EPA specifically on gastrointestinal issues.
Overall, the study indicated that the choice of nutrients in enteral feeding could influence recovery and comfort for SAH patients. However, it’s important to note that the findings on eicosapentaenoic acid alone did not demonstrate any significant benefit regarding diarrhea in this context.
Our focus was on understanding how these diets impacted patients' health outcomes, especially regarding diarrhea. While we noticed that the high-protein whey peptide group had a lower rate of diarrhea (about 15.8%) compared to the EPA group (34.3%), we couldn’t isolate the effects of EPA specifically on gastrointestinal issues.
Overall, the study indicated that the choice of nutrients in enteral feeding could influence recovery and comfort for SAH patients. However, it’s important to note that the findings on eicosapentaenoic acid alone did not demonstrate any significant benefit regarding diarrhea in this context.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.3
5
Initial diarrhoea experience
If you're seeking high-quality omega 3s, this option is good. Each capsule contains 750mg of omega 3 (500 DHA + 250 EPA), so I take at least 2 capsules daily, as the minimum recommended dose is 1200mg/day for benefits. Initially, I experienced diarrhoea, but I've adjusted now. I advise consulting a doctor regarding blood thinners and stopping omega 3 at least 2 weeks before any surgery. The product is distilled and comes well packaged, although it has less taste and smell.
Read More
0
Severe reactions reported
After taking DHA-500, I had several severe allergic reactions, becoming violently ill with diarrhoea all day, which led to dehydration and a hospital visit. I am sure some people might not have this problem, but it affected me severely.
