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SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
2
No benefit observed in epilepsy
Effects of essential fatty acid supplementation in dogs with idiopathic epilepsy: a clinical trial.
Direct examination of EPA effects.
We conducted a study to investigate whether essential fatty acid supplementation, specifically eicosapentaenoic acid (EPA), could help control idiopathic epilepsy in dogs. This involved a carefully designed approach where fifteen dogs received a daily dose of purified Omega-3 oil for 12 weeks, followed by a 12-week placebo period using olive oil.
Throughout the study, dog owners diligently recorded seizure frequency and severity, along with any side effects that may have arisen. Despite hopes that these essential fatty acids would provide some benefit, the results were quite clear: we found no significant reduction in seizure frequency or severity for those dogs receiving the Omega-3 supplement compared to the placebo group.
These findings suggest that while EPA is a popular supplement often touted for various health benefits, it does not appear to have a positive effect on managing idiopathic epilepsy in dogs. This research can help pet owners make informed decisions about treatment options for their furry companions struggling with seizures.
Throughout the study, dog owners diligently recorded seizure frequency and severity, along with any side effects that may have arisen. Despite hopes that these essential fatty acids would provide some benefit, the results were quite clear: we found no significant reduction in seizure frequency or severity for those dogs receiving the Omega-3 supplement compared to the placebo group.
These findings suggest that while EPA is a popular supplement often touted for various health benefits, it does not appear to have a positive effect on managing idiopathic epilepsy in dogs. This research can help pet owners make informed decisions about treatment options for their furry companions struggling with seizures.
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9
DHA and EPA improve cognitive deficits
A Compared Study of Eicosapentaenoic Acid and Docosahexaenoic Acid in Improving Seizure-Induced Cognitive Deficiency in a Pentylenetetrazol-Kindling Young Mice Model.
Direct relevance to epilepsy treatment
We set out to explore how docosahexaenoic acid (DHA) might improve cognitive challenges associated with epilepsy, particularly in young mice experiencing seizures. Using a rodent model, we compared the effects of both DHA and eicosapentaenoic acid (EPA) on cognitive impairment induced by seizures caused by pentylenetetrazol (PTZ).
Over 21 days, mice were given diets enriched with either DHA or EPA and then subjected to PTZ treatment. Our findings revealed that both fatty acids showed potential in easing seizure-related cognitive issues, though EPA seemed to work even better in this context.
Upon further investigation, we found that both DHA and EPA helped restore certain brain chemicals and appeared to reduce ferroptosis—a process linked to cell death and involved in cognitive decline following seizures. They did this by stabilizing iron levels and decreasing harmful substances in the brain. Especially notable was how EPA outperformed DHA in fixing iron imbalances, likely thanks to its stronger influence on a specific signaling pathway.
Over 21 days, mice were given diets enriched with either DHA or EPA and then subjected to PTZ treatment. Our findings revealed that both fatty acids showed potential in easing seizure-related cognitive issues, though EPA seemed to work even better in this context.
Upon further investigation, we found that both DHA and EPA helped restore certain brain chemicals and appeared to reduce ferroptosis—a process linked to cell death and involved in cognitive decline following seizures. They did this by stabilizing iron levels and decreasing harmful substances in the brain. Especially notable was how EPA outperformed DHA in fixing iron imbalances, likely thanks to its stronger influence on a specific signaling pathway.
Read More
9
Eicosapentaenoic acid improves cognition
A Compared Study of Eicosapentaenoic Acid and Docosahexaenoic Acid in Improving Seizure-Induced Cognitive Deficiency in a Pentylenetetrazol-Kindling Young Mice Model.
Directly impacts seizure cognition
We investigated the potential effects of eicosapentaenoic acid (EPA) on cognitive impairment triggered by seizures, particularly in a model involving young mice. Our focus was on understanding how EPA, when compared to docosahexaenoic acid (DHA), could play a role in mitigating cognitive deficiencies related to epilepsy.
For our study, we fed young mice either a DHA-rich or EPA-rich diet for 21 days while exposing them to pentylenetetrazol (PTZ) injections to induce seizures. Through this approach, we observed that both EPA and DHA provided some improvement against seizure-related cognitive decline; however, EPA stood out with more significant benefits, particularly in maintaining iron balance in the brain.
We also found that both fatty acids helped balance neurotransmitter levels and reduced indicators of ferroptosis—a form of cell death linked to epilepsy. Notably, EPA was more effective in this aspect due to its ability to enhance certain signaling pathways in the brain. This suggests that incorporating EPA might be advantageous for managing cognitive impairments associated with seizures in children.
For our study, we fed young mice either a DHA-rich or EPA-rich diet for 21 days while exposing them to pentylenetetrazol (PTZ) injections to induce seizures. Through this approach, we observed that both EPA and DHA provided some improvement against seizure-related cognitive decline; however, EPA stood out with more significant benefits, particularly in maintaining iron balance in the brain.
We also found that both fatty acids helped balance neurotransmitter levels and reduced indicators of ferroptosis—a form of cell death linked to epilepsy. Notably, EPA was more effective in this aspect due to its ability to enhance certain signaling pathways in the brain. This suggests that incorporating EPA might be advantageous for managing cognitive impairments associated with seizures in children.
Read More
Most Useful Reviews
9.5
Great relief
EXCELLENT OMEGA AND THE PRICE IS VERY reasonable. I take omega due to severe epilepsy, which leads to dementia, and it significantly alleviates my condition.
Read More
9.5
Decent price
Ensure you buy; you won’t regret it! It's fantastic for a reasonable price. I take it for epilepsy and feel considerable relief. My housemates also take it, as we all miss omega-rich foods.
Read More
8.8
Improved memory
Docosahexaenoic acid is essential for the brain, enhancing concentration and memory while reducing seizure frequency in epilepsy.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
9
DHA and EPA mitigate epileptic depression
DHA and EPA Alleviate Epileptic Depression in PTZ-Treated Young Mice Model by Inhibiting Neuroinflammation through Regulating Microglial M2 Polarization and Improving Mitochondrial Metabolism.
Study highlights EPA's effectiveness
We explored the effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on depression associated with epilepsy in young mice. Using a well-structured approach, we treated three-week-old mice with a diet rich in either DHA or EPA for 21 days, followed by a series of pentylenetetrazole (PTZ) injections to induce depressive symptoms.
Our findings revealed that EPA was particularly effective in alleviating these symptoms compared to DHA. Both fatty acids significantly reduced neuronal damage in the hippocampus and improved myelin integrity, indicating potential protective effects on brain health.
Delving deeper, we discovered that DHA and EPA reduced neuroinflammation by helping microglial cells switch to a protective M2 phenotype. Moreover, both compounds lowered oxidative stress levels and enhanced mitochondrial function, which plays a crucial role in energy production and overall cellular health.
These results suggest that incorporating DHA and EPA into the diet may serve as an effective strategy to combat depression in children dealing with epilepsy, with EPA emerging as the more beneficial option.
Our findings revealed that EPA was particularly effective in alleviating these symptoms compared to DHA. Both fatty acids significantly reduced neuronal damage in the hippocampus and improved myelin integrity, indicating potential protective effects on brain health.
Delving deeper, we discovered that DHA and EPA reduced neuroinflammation by helping microglial cells switch to a protective M2 phenotype. Moreover, both compounds lowered oxidative stress levels and enhanced mitochondrial function, which plays a crucial role in energy production and overall cellular health.
These results suggest that incorporating DHA and EPA into the diet may serve as an effective strategy to combat depression in children dealing with epilepsy, with EPA emerging as the more beneficial option.
Read More
9
DHA and EPA improve cognitive deficits
A Compared Study of Eicosapentaenoic Acid and Docosahexaenoic Acid in Improving Seizure-Induced Cognitive Deficiency in a Pentylenetetrazol-Kindling Young Mice Model.
Direct relevance to epilepsy treatment
We set out to explore how docosahexaenoic acid (DHA) might improve cognitive challenges associated with epilepsy, particularly in young mice experiencing seizures. Using a rodent model, we compared the effects of both DHA and eicosapentaenoic acid (EPA) on cognitive impairment induced by seizures caused by pentylenetetrazol (PTZ).
Over 21 days, mice were given diets enriched with either DHA or EPA and then subjected to PTZ treatment. Our findings revealed that both fatty acids showed potential in easing seizure-related cognitive issues, though EPA seemed to work even better in this context.
Upon further investigation, we found that both DHA and EPA helped restore certain brain chemicals and appeared to reduce ferroptosis—a process linked to cell death and involved in cognitive decline following seizures. They did this by stabilizing iron levels and decreasing harmful substances in the brain. Especially notable was how EPA outperformed DHA in fixing iron imbalances, likely thanks to its stronger influence on a specific signaling pathway.
Over 21 days, mice were given diets enriched with either DHA or EPA and then subjected to PTZ treatment. Our findings revealed that both fatty acids showed potential in easing seizure-related cognitive issues, though EPA seemed to work even better in this context.
Upon further investigation, we found that both DHA and EPA helped restore certain brain chemicals and appeared to reduce ferroptosis—a process linked to cell death and involved in cognitive decline following seizures. They did this by stabilizing iron levels and decreasing harmful substances in the brain. Especially notable was how EPA outperformed DHA in fixing iron imbalances, likely thanks to its stronger influence on a specific signaling pathway.
Read More
9
DHA shows promise for epilepsy
Effects of high-dose docosahexaenoic acid supplementation as an add-on therapy for canine idiopathic epilepsy: A pilot study.
Significant reduction in seizures
We explored the potential effects of high-dose docosahexaenoic acid (DHA) on dogs suffering from idiopathic epilepsy in a pilot study. This open-label clinical trial involved six dogs, all diagnosed with epilepsy and experiencing between 5 to 45 seizures in the month before starting DHA supplementation. The dogs were administered DHA at doses ranging from 69-166 mg/kg/day, while continuing their existing treatments.
After a period of observation, we observed that four out of the six dogs completed the full 6-month study. Notably, all the dogs showed at least a 50% reduction in seizure frequency within 2 to 3 months. By the end of the study, three dogs managed to reduce their seizures to just 0-1 per month. Importantly, we did not find any significant adverse effects in the dogs' overall health or blood tests, suggesting that this treatment was safe.
While the sample size is small and lacks control groups, the data provides promising insights into the potential of DHA as an adjunct therapy for canine idiopathic epilepsy. Our findings encourage further research but indicate that there may be a role for DHA in managing seizure frequency in dogs.
After a period of observation, we observed that four out of the six dogs completed the full 6-month study. Notably, all the dogs showed at least a 50% reduction in seizure frequency within 2 to 3 months. By the end of the study, three dogs managed to reduce their seizures to just 0-1 per month. Importantly, we did not find any significant adverse effects in the dogs' overall health or blood tests, suggesting that this treatment was safe.
While the sample size is small and lacks control groups, the data provides promising insights into the potential of DHA as an adjunct therapy for canine idiopathic epilepsy. Our findings encourage further research but indicate that there may be a role for DHA in managing seizure frequency in dogs.
Read More
9
ALA reduces seizures in zebrafish
Early α-linolenic acid exposure to embryo reduces pentylenetetrazol-induced seizures in zebrafish larva.
Relevant to omega-3 epilepsy research
We explored how early exposure to alpha-linolenic acid (ALA), an essential omega-3 fatty acid, influences susceptibility to seizures in zebrafish, which serve as a valuable model for studying epilepsy. Healthy zebrafish embryos were incubated in water with different concentrations of ALA before being tested for their response to pentylenetetrazol (PTZ), a chemical known to induce seizures.
At concentrations of 10 µM and 20 µM, we observed a notable reduction in seizure-like behaviors among the larvae. This was indicated by a decrease in how far and how fast they moved during the seizures. Additionally, treated larvae displayed longer times before experiencing full-blown clonus-like seizures.
We also found lower levels of c-fos mRNA, which suggests reduced neuronal activation linked to seizure activity. Interestingly, higher concentrations of ALA led to increased levels of both ALA and docosahexaenoic acid (DHA) in the zebrafish. Overall, our study showed that early exposure to ALA effectively reduces PTZ-induced seizures in zebrafish larvae, highlighting its potential role in managing epilepsy.
At concentrations of 10 µM and 20 µM, we observed a notable reduction in seizure-like behaviors among the larvae. This was indicated by a decrease in how far and how fast they moved during the seizures. Additionally, treated larvae displayed longer times before experiencing full-blown clonus-like seizures.
We also found lower levels of c-fos mRNA, which suggests reduced neuronal activation linked to seizure activity. Interestingly, higher concentrations of ALA led to increased levels of both ALA and docosahexaenoic acid (DHA) in the zebrafish. Overall, our study showed that early exposure to ALA effectively reduces PTZ-induced seizures in zebrafish larvae, highlighting its potential role in managing epilepsy.
Read More
9
Protectin D1 improves epilepsy outcomes
n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis.
Addressed DHA-derived effects
We focused on understanding how specialized lipids derived from docosahexaenoic acid (DHA) influence epilepsy, particularly looking into a compound known as protectin D1. Through a study with a mouse model of epilepsy, we found that inflammation in the brain is a significant contributor to seizures.
Our research showed that during a critical period when seizures were expected to start, the processes that help resolve inflammation were activated but delayed compared to the inflammatory response itself. We measured levels of various inflammatory markers and the genes involved in resolving inflammation, revealing that these protective pathways had not been properly engaged in the context of developing epilepsy.
Notably, we found that injecting protectin D1 into the brains of mice reduced the levels of harmful inflammatory markers and led to significant improvements in their recovery. The treated mice not only regained weight but also demonstrated better cognitive function and showed a substantial reduction in both the frequency and duration of their seizures.
This suggests that boosting the body's natural resolution processes could offer new therapeutic options for epilepsy, highlighting that current treatments primarily manage symptoms rather than address the underlying problem.
Our research showed that during a critical period when seizures were expected to start, the processes that help resolve inflammation were activated but delayed compared to the inflammatory response itself. We measured levels of various inflammatory markers and the genes involved in resolving inflammation, revealing that these protective pathways had not been properly engaged in the context of developing epilepsy.
Notably, we found that injecting protectin D1 into the brains of mice reduced the levels of harmful inflammatory markers and led to significant improvements in their recovery. The treated mice not only regained weight but also demonstrated better cognitive function and showed a substantial reduction in both the frequency and duration of their seizures.
This suggests that boosting the body's natural resolution processes could offer new therapeutic options for epilepsy, highlighting that current treatments primarily manage symptoms rather than address the underlying problem.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.7
9.5
Great relief
EXCELLENT OMEGA AND THE PRICE IS VERY reasonable. I take omega due to severe epilepsy, which leads to dementia, and it significantly alleviates my condition.
9.5
Decent price
Ensure you buy; you won’t regret it! It's fantastic for a reasonable price. I take it for epilepsy and feel considerable relief. My housemates also take it, as we all miss omega-rich foods.
8.8
Improved memory
Docosahexaenoic acid is essential for the brain, enhancing concentration and memory while reducing seizure frequency in epilepsy.
8.8
Blocks seizures
DHA, a docosahexaenoic fatty acid in Omega-3, is crucial for brain health and may reduce seizures in epilepsy by up to 30%. A very economical package for an adequate price; I take one capsule daily.
