Medical Researches
Questionable
Based on 3 Researches
DHA reduces H. pylori effectsCrosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid.
Direct relevance to gastritis treatment
We aimed to understand how docosahexaenoic acid (DHA) impacts the growth of Helicobacter pylori, a common bacteria linked to gastritis and other stomach disorders. Our research focused on how DHA influences bacterial adhesion to stomach cells and reduces inflammation associated with infection.
At concentrations of 100 µM, DHA effectively reduced H. pylori growth, while higher amounts of 250 µM or more led to irreversible effects on bacterial survival. We noted that DHA not only hindered bacterial growth but also decreased the bacteria's ability to attach to gastric epithelial cells. Moreover, we found that cells infected with DHA-treated H. pylori showed significantly lower levels of Interleukin-8 (IL-8), an inflammatory marker, alongside reductions in other inflammatory proteins.
Through our analysis, we discovered that DHA alters the outer membrane proteins of H. pylori, which are involved in its stress response and metabolism. These changes seem to contribute to lesser adhesion to stomach cells and a reduced inflammatory response. These findings suggest that DHA could be a beneficial alternative in managing H. pylori-related gastritis by targeting the bacteria and its effects on the stomach.
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We aimed to understand how docosahexaenoic acid (DHA) influences Helicobacter pylori growth and its associated impact on gastritis. The study methodically examined DHA’s effects both in a lab setting and in a mouse model. Our focus was on the ability of DHA to inhibit the growth of this harmful bacteria and its potential role in improving gastric health.
Through rigorous testing, we learned that DHA does indeed reduce H. pylori growth significantly. This effect continues in living models, reducing the bacteria's presence in the stomach lining and easing inflammation in the gastric mucosa. Furthermore, when combined with standard treatments, DHA showed promising results in lowering the chances of infection recurrence.
It’s encouraging to note that DHA not only fights against H. pylori but may also provide relief from gastritis symptoms. Overall, our findings suggest that DHA could complement conventional therapies and help combat H. pylori-related gastric conditions effectively.
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We aimed to understand the role of docosahexaenoic acid (DHA) in atrophic gastritis (AG) by analyzing a group of 208 Japanese individuals who participated in a health screening. Out of these, 92 were diagnosed with AG based on low levels of specific enzymes, pepsinogen I and II.
Our findings revealed that individuals with AG had higher levels of n-3 polyunsaturated fatty acids, particularly DHA. Interestingly, those with AG showed significantly lower levels of gamma-linolenic acid (GLA). Statistically speaking, the odds of having high DHA levels were 2.20 times more in AG subjects, while high GLA levels seemed to protect against AG, reducing the risk by about 66%.
While these results hint at the complex relationship between fatty acids and gastritis, we observed that DHA might increase the risk of AG, contrasting with GLA's protective effect. This raises important questions about the dietary sources of these fatty acids and their implications for gastric health.
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User Reviews
No discomfort experienced
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