I have a chronic inflammatory disorder currently diagnosed as undifferentiated connective tissue disease. My ANA is elevated but no other labs point to anything specific. I have gi issues, migraines, bone and muscle pain, brain fog, fatigue, blurred vision, cardiac arrhythmias, skin rashes and tinnitus. Since this all started in 2013, I've tried every supplement and vitamin out there with no improvement. I've had some relief with biologic injections, plaquenil and steroids prescribed my my rheumatologist and neurologist but taking this along with L- glutamine and a digestive enzyme has been life saving. My symptoms are virtually gone and my energy and mood is up. I also love now supplements and have found their products to be cost effective and high quality