Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.2
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Selenium (elemental) (from 5 mg L-Selenomethionine)
25 mcg
45%
N-Acetyl Cysteine (NAC)
600 mg
â€
Top Medical Research Studies
9
We examined how selenium, a trace element known for its role in health, can help those suffering from allergic dermatitis. In our exploration, we focused on how selenium nanoparticles, specifically designed for easier manufacturing and use, can activate the body's natural defenses against allergies.
The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.
Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.
Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.
The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.
Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.
Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.
Read More
9
We explored the role of selenium-rich tea polysaccharides (Se-TPS) in managing allergies, focusing on how they influence immune responses and gut health. Using a method called high hydrostatic pressure, we extracted Se-TPS at a pressure of 400 MPa for a specific duration. This process allowed us to isolate several polysaccharide components, particularly Se-TPS3-4, which turned out to be the most effective.
Our research involved both laboratory experiments and tests on mice sensitized to a specific allergen. We observed that these polysaccharides reduced the release of various inflammatory substances, including histamine and interleukin-4, both of which are known to play roles in allergic reactions. In the treated mice, levels of undesirable immune markers decreased, while those associated with a balanced immune response increased.
Importantly, we found that Se-TPS also encouraged the growth of beneficial gut bacteria, such as Lactobacillus, while enhancing metabolites that can support overall gut health. These findings indicate the strong potential of selenium-rich tea polysaccharides as a natural way to reduce allergic reactions by improving immune balance and gut microbiota.
Our research involved both laboratory experiments and tests on mice sensitized to a specific allergen. We observed that these polysaccharides reduced the release of various inflammatory substances, including histamine and interleukin-4, both of which are known to play roles in allergic reactions. In the treated mice, levels of undesirable immune markers decreased, while those associated with a balanced immune response increased.
Importantly, we found that Se-TPS also encouraged the growth of beneficial gut bacteria, such as Lactobacillus, while enhancing metabolites that can support overall gut health. These findings indicate the strong potential of selenium-rich tea polysaccharides as a natural way to reduce allergic reactions by improving immune balance and gut microbiota.
Read More
9
We investigated the impact of dietary selenium on cow's milk allergy, a common condition affecting infants. In our study, we used a mouse model and sensitized three-week-old female C3H/HeOuJ mice with whey protein and cholera toxin. These mice were then divided into groups and fed diets with varying levels of selenium: control, low, medium, or high.
After subjecting the mice to a whey challenge, we noted some interesting changes. Notably, the body temperature of mice on a medium selenium diet was significantly higher 60 minutes post-challenge, suggesting a less severe allergic reaction. We also observed decreased levels of allergen-specific immunoglobulin E and reduced release of mouse mast cell protease-1, indicating a dampened immune response.
This research points towards selenium supplementation as a potential method to modulate allergic reactions to whey. By lowering specific antibody responses and mast cell activity, selenium might help lessen the severity of allergies associated with cow's milk. Overall, our findings could open up new avenues for managing food allergies effectively.
After subjecting the mice to a whey challenge, we noted some interesting changes. Notably, the body temperature of mice on a medium selenium diet was significantly higher 60 minutes post-challenge, suggesting a less severe allergic reaction. We also observed decreased levels of allergen-specific immunoglobulin E and reduced release of mouse mast cell protease-1, indicating a dampened immune response.
This research points towards selenium supplementation as a potential method to modulate allergic reactions to whey. By lowering specific antibody responses and mast cell activity, selenium might help lessen the severity of allergies associated with cow's milk. Overall, our findings could open up new avenues for managing food allergies effectively.
Read More
Most Useful Reviews
9
Eases sinus congestion
89 people found this helpful
Alleviates sinus congestion and boosts the immune system. I've been intermittently taking N-A-C for over three years, and it's significantly helped alleviate sinus congestion and improve lung capacity. N-A-C enhances our body's supply of Glutathione, crucial for maintaining antioxidant defences. The boost of Glutathione noticeably reduces my sinus congestion during allergy season. Within days of starting the supplement, I breathe easier, especially with dust allergies. I notice I can jog and play soccer without difficulty, improving my stamina.
Read More
7.5
Life-changing relief
41 people found this helpful
A gift from above. I've had persistent sinus and lung issues, with massive sinusitis and occasional asthma-like symptoms. My breathing deteriorated to the point of anxiety attacks. I bought this product, hoping to manage sulfite sensitivity. Shockingly, within an hour, my head cleared and my breathing improved significantly. Up to this point, only a steroid shot had provided relief. This product works like a charm; two pills daily reduce my symptoms to a mild level. Although it allows for relief, it hasn’t cured me.
Read More
9
Recommended for allergies
33 people found this helpful
I was thrilled to find NAC. I don't often review, but when I do, it's because the product genuinely helped me. I've consistently suffered from sinus infections and seasonal allergies, leading to bronchitis. This winter was particularly challenging, but after six days on NAC, my breathing and sinuses are normal. My doctor approves an ongoing daily dose for prevention. I've noticed I no longer breathe heavily after workouts. I found Mucinex ineffective, and recommend NAC for others suffering from similar issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.2
- All Researches
9
We explored the role of selenium-rich tea polysaccharides (Se-TPS) in managing allergies, focusing on how they influence immune responses and gut health. Using a method called high hydrostatic pressure, we extracted Se-TPS at a pressure of 400 MPa for a specific duration. This process allowed us to isolate several polysaccharide components, particularly Se-TPS3-4, which turned out to be the most effective.
Our research involved both laboratory experiments and tests on mice sensitized to a specific allergen. We observed that these polysaccharides reduced the release of various inflammatory substances, including histamine and interleukin-4, both of which are known to play roles in allergic reactions. In the treated mice, levels of undesirable immune markers decreased, while those associated with a balanced immune response increased.
Importantly, we found that Se-TPS also encouraged the growth of beneficial gut bacteria, such as Lactobacillus, while enhancing metabolites that can support overall gut health. These findings indicate the strong potential of selenium-rich tea polysaccharides as a natural way to reduce allergic reactions by improving immune balance and gut microbiota.
Our research involved both laboratory experiments and tests on mice sensitized to a specific allergen. We observed that these polysaccharides reduced the release of various inflammatory substances, including histamine and interleukin-4, both of which are known to play roles in allergic reactions. In the treated mice, levels of undesirable immune markers decreased, while those associated with a balanced immune response increased.
Importantly, we found that Se-TPS also encouraged the growth of beneficial gut bacteria, such as Lactobacillus, while enhancing metabolites that can support overall gut health. These findings indicate the strong potential of selenium-rich tea polysaccharides as a natural way to reduce allergic reactions by improving immune balance and gut microbiota.
Read More
9
We examined how selenium, a trace element known for its role in health, can help those suffering from allergic dermatitis. In our exploration, we focused on how selenium nanoparticles, specifically designed for easier manufacturing and use, can activate the body's natural defenses against allergies.
The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.
Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.
Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.
The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.
Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.
Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.
Read More
9
We investigated the impact of dietary selenium on cow's milk allergy, a common condition affecting infants. In our study, we used a mouse model and sensitized three-week-old female C3H/HeOuJ mice with whey protein and cholera toxin. These mice were then divided into groups and fed diets with varying levels of selenium: control, low, medium, or high.
After subjecting the mice to a whey challenge, we noted some interesting changes. Notably, the body temperature of mice on a medium selenium diet was significantly higher 60 minutes post-challenge, suggesting a less severe allergic reaction. We also observed decreased levels of allergen-specific immunoglobulin E and reduced release of mouse mast cell protease-1, indicating a dampened immune response.
This research points towards selenium supplementation as a potential method to modulate allergic reactions to whey. By lowering specific antibody responses and mast cell activity, selenium might help lessen the severity of allergies associated with cow's milk. Overall, our findings could open up new avenues for managing food allergies effectively.
After subjecting the mice to a whey challenge, we noted some interesting changes. Notably, the body temperature of mice on a medium selenium diet was significantly higher 60 minutes post-challenge, suggesting a less severe allergic reaction. We also observed decreased levels of allergen-specific immunoglobulin E and reduced release of mouse mast cell protease-1, indicating a dampened immune response.
This research points towards selenium supplementation as a potential method to modulate allergic reactions to whey. By lowering specific antibody responses and mast cell activity, selenium might help lessen the severity of allergies associated with cow's milk. Overall, our findings could open up new avenues for managing food allergies effectively.
Read More
9
Selenium compound reduces allergy symptoms
We explored how a novel water-soluble selenium compound, known as SeTal, impacts atopic dermatitis (AD), a common allergic skin condition. In experiments, we applied 2,4-dinitrochlorobenzene (DNCB) to sensitized mice, creating a model for AD symptoms. By treating these mice with either SeTal or hydrocortisone, we aimed to measure the severity of skin lesions and related inflammation.
The results were compelling. SeTal, at concentrations of 1% and 2%, showed significant effectiveness in reducing the symptoms and inflammatory indicators of AD. In fact, the results were comparable to, and in some cases, even better than the results achieved with hydrocortisone, a traditional steroid treatment often used for such conditions.
This study suggests that SeTal could offer a promising alternative for treating atopic dermatitis, providing a new avenue for those seeking relief from this chronic and often bothersome allergy-related skin issue. With common steroid treatments posing potential side effects, our findings around SeTal support exploring safer, more effective options in the future.
The results were compelling. SeTal, at concentrations of 1% and 2%, showed significant effectiveness in reducing the symptoms and inflammatory indicators of AD. In fact, the results were comparable to, and in some cases, even better than the results achieved with hydrocortisone, a traditional steroid treatment often used for such conditions.
This study suggests that SeTal could offer a promising alternative for treating atopic dermatitis, providing a new avenue for those seeking relief from this chronic and often bothersome allergy-related skin issue. With common steroid treatments posing potential side effects, our findings around SeTal support exploring safer, more effective options in the future.
Read More
9
We examined how seleno-L-methionine, a form of selenium, impacts allergic reactions. In our study, female mice were sensitized to a common allergen, ovalbumin, and then given selenium for two weeks before being re-exposed to the allergen to trigger an allergic response.
Our findings showed that selenium significantly reduced allergic reactions in a dose-dependent manner, cutting down specific immune responses associated with allergies. Notably, levels of certain inflammatory markers decreased, suggesting selenium might help regulate allergic responses in the body.
Our findings showed that selenium significantly reduced allergic reactions in a dose-dependent manner, cutting down specific immune responses associated with allergies. Notably, levels of certain inflammatory markers decreased, suggesting selenium might help regulate allergic responses in the body.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Eases sinus congestion
89 people found this helpful
Alleviates sinus congestion and boosts the immune system. I've been intermittently taking N-A-C for over three years, and it's significantly helped alleviate sinus congestion and improve lung capacity. N-A-C enhances our body's supply of Glutathione, crucial for maintaining antioxidant defences. The boost of Glutathione noticeably reduces my sinus congestion during allergy season. Within days of starting the supplement, I breathe easier, especially with dust allergies. I notice I can jog and play soccer without difficulty, improving my stamina.
Read More
7.5
Life-changing relief
41 people found this helpful
A gift from above. I've had persistent sinus and lung issues, with massive sinusitis and occasional asthma-like symptoms. My breathing deteriorated to the point of anxiety attacks. I bought this product, hoping to manage sulfite sensitivity. Shockingly, within an hour, my head cleared and my breathing improved significantly. Up to this point, only a steroid shot had provided relief. This product works like a charm; two pills daily reduce my symptoms to a mild level. Although it allows for relief, it hasn’t cured me.
Read More
9
Recommended for allergies
33 people found this helpful
I was thrilled to find NAC. I don't often review, but when I do, it's because the product genuinely helped me. I've consistently suffered from sinus infections and seasonal allergies, leading to bronchitis. This winter was particularly challenging, but after six days on NAC, my breathing and sinuses are normal. My doctor approves an ongoing daily dose for prevention. I've noticed I no longer breathe heavily after workouts. I found Mucinex ineffective, and recommend NAC for others suffering from similar issues.
Read More
7.5
Effective for allergies
14 people found this helpful
A not-so-secret weapon. After turning 30, I developed seasonal allergies and sensitivity to alcoholic beverages, leading to uncomfortable symptoms. After sinus surgery, I grew tired of Zyrtec and other pricey treatments. NAC has lessened my allergy effects, and I haven't needed an allergy pill yet this Spring. While enjoying wine, I remain congestion-free. When I know a night out is coming, I take an extra dose, avoiding hangovers. There is definitely a connection here.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. 10.1159/000540376
- Ma J, Zhao M, Wang Y, Lv L, Qin L, et al. Se-rich tea polysaccharide extracted by high hydrostatic pressure attenuated anaphylaxis by improving gut microbiota and metabolic regulation. Int J Biol Macromol. 2024;269:132128. 10.1016/j.ijbiomac.2024.132128
- Miyazaki J, Ikehara S, Tanigawa K, Kimura T, Ueda K, et al. Prenatal exposure to selenium, mercury, and manganese during pregnancy and allergic diseases in early childhood: The Japan Environment and Children's study. Environ Int. 2023;179:108123. 10.1016/j.envint.2023.108123
- Xie B, Zeng D, Yang M, Tang Z, He L, et al. Translational Selenium Nanoparticles to Attenuate Allergic Dermatitis through Nrf2-Keap1-Driven Activation of Selenoproteins. ACS Nano. 2023;17:14053. 10.1021/acsnano.3c04344
- Zhao X, Thijssen S, Chen H, Garssen J, Knippels LMJ, et al. Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow's Milk Allergy. Nutrients. 2021;13. 10.3390/nu13082479
- Voss GT, de Oliveira RL, Davies MJ, Domingues WB, Campos VF, et al. Suppressive effect of 1,4-anhydro-4-seleno-D-talitol (SeTal) on atopic dermatitis-like skin lesions in mice through regulation of inflammatory mediators. J Trace Elem Med Biol. 2021;67:126795. 10.1016/j.jtemb.2021.126795
- Dubrovina VI, Starovoitova TP, Yur'eva OV, Pyatidesyatnikova AB, Potapov VA, et al. Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV. Bull Exp Biol Med. 2021;171:651. 10.1007/s10517-021-05287-0
- Groth S, Budke C, Weber T, Neugart S, Brockmann S, et al. Relationship between Phenolic Compounds, Antioxidant Properties, and the Allergenic Protein Mal d 1 in Different Selenium-Biofortified Apple Cultivars (). Molecules. 2021;26. 10.3390/molecules26092647
- Lodge CJ, Dharmage SC. Breastfeeding and perinatal exposure, and the risk of asthma and allergies. Curr Opin Allergy Clin Immunol. 2016;16:231. 10.1097/ACI.0000000000000266
- Qin S, Huang B, Ma J, Wang X, Zhang J, et al. Effects of selenium-chitosan on blood selenium concentration, antioxidation status, and cellular and humoral immunity in mice. Biol Trace Elem Res. 2015;165:145. 10.1007/s12011-015-0243-5
- Arakawa T, Deguchi T, Sakazaki F, Ogino H, Okuno T, et al. Supplementary seleno-L-methionine suppresses active cutaneous anaphylaxis reaction. Biol Pharm Bull. 2013;36:1969.
- Carneiro MF, Rhoden CR, Amantéa SL, Barbosa F. Low concentrations of selenium and zinc in nails are associated with childhood asthma. Biol Trace Elem Res. 2011;144:244. 10.1007/s12011-011-9080-3
