Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 6 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Selenium (elemental) (from 5 mg L-Selenomethionine)
25 mcg
45%
N-Acetyl Cysteine (NAC)
600 mg
†

Top Medical Research Studies

8
Selenium shows promise for migraines
We explored the effects of selenium supplementation in a double-blinded trial involving 72 patients with migraines. Over 12 weeks, participants received either selenium or a placebo. We observed that those taking selenium experienced reduced headache frequency and severity.

Additionally, selenium improved antioxidant levels and lowered oxidative stress markers. However, it appears that many other factors related to migraine symptoms did not see significant changes. While this research shows promise, further studies are necessary to confirm these findings.
Read More
7
Higher selenium may reduce migraines
We examined how dietary selenium affects the occurrence of migraines, especially looking at age differences. Analyzing data from nearly 10,000 adults in the NHANES survey, we found that higher selenium intake is linked to fewer migraines.

This beneficial effect seems particularly significant for adults aged 20 to 50, where increasing selenium to about 101.9 µg/day appears to help prevent migraines. However, the relationship is complex and influenced by age, highlighting the importance of adequate selenium-rich foods for this age group.
Read More
7
Sodium selenite shows symptom improvement
We explored how sodium selenite affects symptoms in patients with brain tumors. This study included 32 patients who experienced increased intracranial pressure after previous treatments.

Notably, 76% of participants reported significant improvements in their symptoms, including headaches, while 24% experienced slight improvements.

Treatments also positively impacted blood cell counts and enhanced the effects of oxygen therapy. Overall, sodium selenite could be a promising part of supportive care for brain tumor patients experiencing multiple symptoms.
Read More

Most Useful Reviews

9
Reduces hangover headaches
412 people found this helpful
NAC truly benefits my OCD and social anxiety, providing better focus and creativity. It alleviates hangover headaches, which I used to experience after drinking. I can now enjoy social events without dread of the next day.
Read More
9
No sinus headaches
97 people found this helpful
After starting NAC for a toothache, I found my sleep improved significantly and have not encountered sinus headaches as before. It truly assists with my overall health.
Read More
7.5
Helps brain injuries
26 people found this helpful
Following a traumatic brain injury, my chiropractor recommended NAC. It aided my recovery by alleviating brain fog and headaches, and I'd highly recommend it to others in similar situations.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
  • All Researches
8
Selenium shows promise for migraines
We explored the effects of selenium supplementation in a double-blinded trial involving 72 patients with migraines. Over 12 weeks, participants received either selenium or a placebo. We observed that those taking selenium experienced reduced headache frequency and severity.

Additionally, selenium improved antioxidant levels and lowered oxidative stress markers. However, it appears that many other factors related to migraine symptoms did not see significant changes. While this research shows promise, further studies are necessary to confirm these findings.
Read More
7
Higher selenium may reduce migraines
We examined how dietary selenium affects the occurrence of migraines, especially looking at age differences. Analyzing data from nearly 10,000 adults in the NHANES survey, we found that higher selenium intake is linked to fewer migraines.

This beneficial effect seems particularly significant for adults aged 20 to 50, where increasing selenium to about 101.9 µg/day appears to help prevent migraines. However, the relationship is complex and influenced by age, highlighting the importance of adequate selenium-rich foods for this age group.
Read More
7
Sodium selenite shows symptom improvement
We explored how sodium selenite affects symptoms in patients with brain tumors. This study included 32 patients who experienced increased intracranial pressure after previous treatments.

Notably, 76% of participants reported significant improvements in their symptoms, including headaches, while 24% experienced slight improvements.

Treatments also positively impacted blood cell counts and enhanced the effects of oxygen therapy. Overall, sodium selenite could be a promising part of supportive care for brain tumor patients experiencing multiple symptoms.
Read More

User Reviews

USERS' SCORE
Good
Based on 6 Reviews
8.7
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Reduces hangover headaches
412 people found this helpful
NAC truly benefits my OCD and social anxiety, providing better focus and creativity. It alleviates hangover headaches, which I used to experience after drinking. I can now enjoy social events without dread of the next day.
Read More
9
No sinus headaches
97 people found this helpful
After starting NAC for a toothache, I found my sleep improved significantly and have not encountered sinus headaches as before. It truly assists with my overall health.
Read More
7.5
Helps brain injuries
26 people found this helpful
Following a traumatic brain injury, my chiropractor recommended NAC. It aided my recovery by alleviating brain fog and headaches, and I'd highly recommend it to others in similar situations.
Read More
9
No hangovers
274 people found this helpful
NAC has transformed my health tremendously. I've avoided feeling sluggish or having hangovers, even after a night out. Since starting this supplement, I wake up with a headache only once a year now, if that.
Read More
7.5
Prevents hangover headaches
18 people found this helpful
I adore wine, perhaps too much. I began taking NAC to safeguard my liver during drinking sessions, especially when my in-laws visit. My father-in-law insists on keeping our glasses filled, making it easy to lose track of consumption. If I take NAC beforehand, I feel perfectly fine the next day—no headaches or tummy troubles. It also seems to delay the feeling of intoxication, which can mislead you about your intake. I don’t drink and drive, but if you do, I caution against it while on NAC, as you might not feel how much you've had.
Read More

Frequently Asked Questions

No FAQs are available for this product and symptom.

References

  1. Yu X, Wu L, Zheng H, Wu W, Tian S. Interaction between dietary selenium intake and age on severe headache or migraine in the United States: a population-based study. Front Nutr. 2025;12:1537151. 10.3389/fnut.2025.1537151
  2. Balali A, Sadeghi O, Khorvash F, Rouhani MH, Askari G. The effect of selenium supplementation on oxidative stress, clinical and physiological symptoms in patients with migraine: a double-blinded randomized clinical trial. Front Nutr. 2024;11:1369373. 10.3389/fnut.2024.1369373
  3. Pakdaman A. Symptomatic treatment of brain tumor patients with sodium selenite, oxygen, and other supportive measures. Biol Trace Elem Res. 1998;62:1.
image