Last update
3/22/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 1 Review
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Selenium (elemental) (from 5 mg L-Selenomethionine)
25 mcg
45%
N-Acetyl Cysteine (NAC)
600 mg
†
Top Medical Research Studies
9
We explored the effectiveness of a novel selenium nanocomposite, AANL-SeNPs, in treating lung cancer. This innovative compound, created from a natural ingredient, demonstrated significant inhibition of lung cancer cell growth in various cell lines, showing up to a 67% reduction in viability.
Furthermore, AANL-SeNPs slowed tumor growth in live models and appeared safe for normal cells. While promising, our findings indicate that although AANL-SeNPs upregulate the protein CLK2 and can enhance therapeutic response, further studies are needed to fully understand its potential.
Furthermore, AANL-SeNPs slowed tumor growth in live models and appeared safe for normal cells. While promising, our findings indicate that although AANL-SeNPs upregulate the protein CLK2 and can enhance therapeutic response, further studies are needed to fully understand its potential.
Read More
9
Effective selenium treatment for lung cancer
We aimed to explore the potential of selenium nanoparticles synthesized from Epimedium brevicornum in combating lung cancer. Using various techniques, we characterized these nanoparticles and evaluated their effects in both lab and live models.
Although the nanoparticles were not harmful to healthy liver cells, they effectively triggered cell death in lung cancer cells, reducing tumor growth and suppressing migration.
Our findings suggest that these selenium nanoparticles could be a promising and safe avenue for lung cancer treatment.
Although the nanoparticles were not harmful to healthy liver cells, they effectively triggered cell death in lung cancer cells, reducing tumor growth and suppressing migration.
Our findings suggest that these selenium nanoparticles could be a promising and safe avenue for lung cancer treatment.
Read More
9
Selenium nanoparticles may inhibit lung cancer
We examined how selenium nanoparticles, stabilized by Sargassum fusiforme polysaccharide, affect lung cancer cells. In lab tests, these nanoparticles were shown to inhibit the growth of A549 lung cancer cells and initiate cell apoptosis by increasing reactive oxygen species (ROS).
We also noticed that they impacted the mitochondria, altering important proteins linked to cancer cell survival. While animal studies showed a significant reduction in tumor growth without harming the animals, the potential for these nanoparticles as a viable treatment for non-small cell lung cancer seems promising.
We also noticed that they impacted the mitochondria, altering important proteins linked to cancer cell survival. While animal studies showed a significant reduction in tumor growth without harming the animals, the potential for these nanoparticles as a viable treatment for non-small cell lung cancer seems promising.
Read More
Most Useful Reviews
7.5
Improves breathing
40 people found this helpful
This helps me breathe more easily despite serious pulmonary issues. As a lung cancer survivor with COPD, I find that taking two 600 mg capsules at once is most effective. I plan to return to the higher dose after this bottle.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
- All Researches
9.5
We examined the role of selenium (Se) in treating advanced non-small-cell lung cancer (NSCLC). Our research revealed that a lack of selenium leads to weakened immunity and faster tumor growth in mice. Interestingly, using selenium nanoparticles showed promising results.
These nanoparticles enhanced natural killer cell activity, boosting the immune response against cancer. In a clinical trial, patients receiving selenium nanoparticles alongside standard treatments had an impressive 83.3% response rate and complete disease control.
Overall, selenium shows potential to strengthen lung cancer therapy through immune enhancement.
These nanoparticles enhanced natural killer cell activity, boosting the immune response against cancer. In a clinical trial, patients receiving selenium nanoparticles alongside standard treatments had an impressive 83.3% response rate and complete disease control.
Overall, selenium shows potential to strengthen lung cancer therapy through immune enhancement.
Read More
9
Effective selenium treatment for lung cancer
We aimed to explore the potential of selenium nanoparticles synthesized from Epimedium brevicornum in combating lung cancer. Using various techniques, we characterized these nanoparticles and evaluated their effects in both lab and live models.
Although the nanoparticles were not harmful to healthy liver cells, they effectively triggered cell death in lung cancer cells, reducing tumor growth and suppressing migration.
Our findings suggest that these selenium nanoparticles could be a promising and safe avenue for lung cancer treatment.
Although the nanoparticles were not harmful to healthy liver cells, they effectively triggered cell death in lung cancer cells, reducing tumor growth and suppressing migration.
Our findings suggest that these selenium nanoparticles could be a promising and safe avenue for lung cancer treatment.
Read More
9
Selenium nanoparticles may inhibit lung cancer
We examined how selenium nanoparticles, stabilized by Sargassum fusiforme polysaccharide, affect lung cancer cells. In lab tests, these nanoparticles were shown to inhibit the growth of A549 lung cancer cells and initiate cell apoptosis by increasing reactive oxygen species (ROS).
We also noticed that they impacted the mitochondria, altering important proteins linked to cancer cell survival. While animal studies showed a significant reduction in tumor growth without harming the animals, the potential for these nanoparticles as a viable treatment for non-small cell lung cancer seems promising.
We also noticed that they impacted the mitochondria, altering important proteins linked to cancer cell survival. While animal studies showed a significant reduction in tumor growth without harming the animals, the potential for these nanoparticles as a viable treatment for non-small cell lung cancer seems promising.
Read More
9
We explored the effectiveness of a novel selenium nanocomposite, AANL-SeNPs, in treating lung cancer. This innovative compound, created from a natural ingredient, demonstrated significant inhibition of lung cancer cell growth in various cell lines, showing up to a 67% reduction in viability.
Furthermore, AANL-SeNPs slowed tumor growth in live models and appeared safe for normal cells. While promising, our findings indicate that although AANL-SeNPs upregulate the protein CLK2 and can enhance therapeutic response, further studies are needed to fully understand its potential.
Furthermore, AANL-SeNPs slowed tumor growth in live models and appeared safe for normal cells. While promising, our findings indicate that although AANL-SeNPs upregulate the protein CLK2 and can enhance therapeutic response, further studies are needed to fully understand its potential.
Read More
9
We explored how selenium-enriched phycocyanin (Se-PC) improves photodynamic therapy for lung cancer. This combination significantly reduced the survival of lung cancer cells in mice compared to traditional treatment methods.
Our findings showed that Se-PC therapy led to a greater decrease in tumor volume and enhanced immune responses in normal tissues. Additionally, Se-PC effectively promoted cell death in cancerous cells.
Overall, while selenium has shown promise in enhancing lung cancer treatments, more research is needed to fully understand its potential benefits.
Our findings showed that Se-PC therapy led to a greater decrease in tumor volume and enhanced immune responses in normal tissues. Additionally, Se-PC effectively promoted cell death in cancerous cells.
Overall, while selenium has shown promise in enhancing lung cancer treatments, more research is needed to fully understand its potential benefits.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improves breathing
40 people found this helpful
This helps me breathe more easily despite serious pulmonary issues. As a lung cancer survivor with COPD, I find that taking two 600 mg capsules at once is most effective. I plan to return to the higher dose after this bottle.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Fu G, Tong J. Synthesis of Epimedium extract selenium nanoparticles and evaluation their efficacy against lung cancer. Gen Physiol Biophys. 2025;44:123. 10.4149/gpb_2024046
- Yu Y, Xie B, Wang J, Luo W, Yang M, et al. Translational Selenium Nanoparticles Promotes Clinical Non-small-cell Lung Cancer Chemotherapy via Activating Selenoprotein-driven Immune Manipulation. Adv Mater. 2025. 10.1002/adma.202415818
- Shehata NS, Elwakil BH, Elshewemi SS, Ghareeb DA, Olama ZA. In vitro and in vivo studies of selenium nanoparticles coated bacterial polysaccharide as anti-lung cancer agents. Microb Cell Fact. 2024;23:339. 10.1186/s12934-024-02601-z
- Chen Y, Jin Y, Wang W, Zhang Y, Sun H, et al. Preparation and antitumor activity of selenium nanocomposite stabilized by AAGL from Agerocybe aegerita. Int J Biol Macromol. 2024;282:137002. 10.1016/j.ijbiomac.2024.137002
- Chen Y, Zhu F, Ou J, Chen J, Liu X, et al. Mitochondrion-targeted selenium nanoparticles stabilized by Sargassum fusiforme polysaccharides increase reactive oxygen species-mediated antitumour activity. Int J Biol Macromol. 2024;281:136545. 10.1016/j.ijbiomac.2024.136545
- Luo X, Wang J, Wang R, Lian J, Guo M, et al. SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells the AKT/mTOR signaling pathway. RSC Med Chem. 2024;15:3460. 10.1039/d4md00405a
- Ohlinger J, Vordermark D, Ostheimer C, Bache M, Tzschoppe T, et al. Change in the serum selenium level of patients with non-metastatic and metastatic non-small cell lung cancer (NSCLC) during radiotherapy as a predictive factor for survival. Strahlenther Onkol. 2024. 10.1007/s00066-024-02276-w
- Shi H, Wang B, Ma H, Li Y, Du J, et al. Preparation of Biomimetic Selenium-Baicalein Nanoparticles and Their Targeted Therapeutic Application in Nonsmall Cell Lung Cancer. Mol Pharm. 2024;21:4476. 10.1021/acs.molpharmaceut.4c00390
- Cui B, Cheng X, Zhang X, Chen L, Pang W, et al. Anti-cancer activity and mechanism of flurbiprofen organoselenium compound RY-1-92 in non-small cell lung cancer. RSC Med Chem. 2024;15:1737. 10.1039/d4md00058g
- Zhang Y, Chen Y, Wang B, Cai Y, Zhang M, et al. A novel selenium nanocomposite modified by AANL inhibits tumor growth by upregulating CLK2 in lung cancer. Bioorg Chem. 2024;148:107459. 10.1016/j.bioorg.2024.107459
- Chen Y, Zhu F, Chen J, Liu X, Li R, et al. Selenium nanoparticles stabilized by Sargassum fusiforme polysaccharides: Synthesis, characterization and bioactivity. Int J Biol Macromol. 2024;269:132073. 10.1016/j.ijbiomac.2024.132073
- Shehata NS, Elwakil BH, Elshewemi SS, Ghareeb DA, Olama ZA. Selenium nanoparticles coated bacterial polysaccharide with potent antimicrobial and anti-lung cancer activities. Sci Rep. 2023;13:21871. 10.1038/s41598-023-48921-9
- Shen J, Xia H, Zhou X, Zhang L, Gao Q, et al. Selenium enhances photodynamic therapy of C-phycocyanin against lung cancer via dual regulation of cytotoxicity and antioxidant activity. Acta Biochim Biophys Sin (Shanghai). 2023;55:1925. 10.3724/abbs.2023159
- Zhang K, Zhu T, Quan X, Qian Y, Liu Y, et al. Association between blood heavy metals and lung cancer risk: A case-control study in China. Chemosphere. 2023;343:140200. 10.1016/j.chemosphere.2023.140200
- Zhu Y, Pu Q, Zhang Q, Liu Y, Ma Y, et al. Selenium-binding protein 1 inhibits malignant progression and induces apoptosis via distinct mechanisms in non-small cell lung cancer. Cancer Med. 2023;12:17149. 10.1002/cam4.6309
- Lubiński J, Lener MR, Marciniak W, Pietrzak S, Derkacz R, et al. Serum Essential Elements and Survival after Cancer Diagnosis. Nutrients. 2023;15. 10.3390/nu15112611
Data last updated:
