' 
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.4
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Polygonum cuspidatum Extract Complex (Root/Rhizome) (Japanese Knotweed) (Trans-Resveratrol - 200 mg)
400 mg
**
Grape Seed Extract (Vitis vinifera)(Standardized for Polyphenols)
10 mg
**
Top Medical Research Studies
9
Resveratrol shows potential for gout
Investigating the mechanisms of resveratrol in the treatment of gouty arthritis through the integration of network pharmacology and metabolics.
Highly relevant to gout treatment.
We set out to understand how resveratrol, a compound often linked to various health benefits, could potentially help people suffering from gouty arthritis (GA). To explore this, we combined network pharmacology with advanced metabolomics techniques. This approach allowed us to predict how resveratrol interacts with biological processes related to gout and verify its effects in an experimental setting.
Using a rat model of gout induced by monosodium urate (MSU), we observed significant changes in the rats when subjected to resveratrol treatment. The results revealed that resveratrol might exert its effects by regulating important inflammatory pathways such as NF-κB, MAPK, and JAK/STAT. With these pathways activated, we saw that resveratrol helped reduce inflammation and pathological damage in the rats, indicating its potential role in managing GA symptoms.
Further analysis through metabolomics showed that resveratrol positively influenced the metabolic pathways associated with gout. These included pathways related to the metabolism of arachidonic acid and amino acids, among others. By restoring key metabolic processes disrupted in gout, resveratrol demonstrated a multi-faceted approach to mitigating inflammation during gout attacks.
This study highlights resveratrol's promise as a natural treatment for gout, showcasing its ability to address inflammation and metabolic disturbances. The findings encourage further exploration of resveratrol while emphasizing its complexity in treating this painful condition.
Using a rat model of gout induced by monosodium urate (MSU), we observed significant changes in the rats when subjected to resveratrol treatment. The results revealed that resveratrol might exert its effects by regulating important inflammatory pathways such as NF-κB, MAPK, and JAK/STAT. With these pathways activated, we saw that resveratrol helped reduce inflammation and pathological damage in the rats, indicating its potential role in managing GA symptoms.
Further analysis through metabolomics showed that resveratrol positively influenced the metabolic pathways associated with gout. These included pathways related to the metabolism of arachidonic acid and amino acids, among others. By restoring key metabolic processes disrupted in gout, resveratrol demonstrated a multi-faceted approach to mitigating inflammation during gout attacks.
This study highlights resveratrol's promise as a natural treatment for gout, showcasing its ability to address inflammation and metabolic disturbances. The findings encourage further exploration of resveratrol while emphasizing its complexity in treating this painful condition.
Read More
9
Resveratrol shows promise for GN
Integrating network pharmacology and renal metabonomics to reveal the protective mechanism of resveratrol on gouty nephropathy.
High relevance for gout treatment
We explored the effects of resveratrol, a natural compound found in grapes and berries, specifically on gouty nephropathy (GN). Utilizing a combination of network pharmacology and renal metabonomics, we aimed to uncover the mechanisms behind resveratrol's benefits for this condition.
In our analysis, we identified 24 important metabolites that changed in kidney tissues of rats with GN after they were treated with resveratrol. Remarkably, these metabolite levels returned to normal after treatment. This suggests a significant restorative effect of resveratrol on the kidney.
We also pinpointed 24 key targets linked to resveratrol's action against GN. Among these, two genes, PTGS1 and PTGS2, were crucial as they play roles in the arachidonic acid metabolism pathway. Molecular docking experiments confirmed that resveratrol effectively binds to these targets, supporting its therapeutic potential.
Overall, the data points to resveratrol possibly mitigating the impact of GN by regulating arachidonic acid metabolism, indicating a promising avenue for future treatments.
In our analysis, we identified 24 important metabolites that changed in kidney tissues of rats with GN after they were treated with resveratrol. Remarkably, these metabolite levels returned to normal after treatment. This suggests a significant restorative effect of resveratrol on the kidney.
We also pinpointed 24 key targets linked to resveratrol's action against GN. Among these, two genes, PTGS1 and PTGS2, were crucial as they play roles in the arachidonic acid metabolism pathway. Molecular docking experiments confirmed that resveratrol effectively binds to these targets, supporting its therapeutic potential.
Overall, the data points to resveratrol possibly mitigating the impact of GN by regulating arachidonic acid metabolism, indicating a promising avenue for future treatments.
Read More
9
Resveratrol shows promise for gout
Resveratrol alleviates MSU-induced gouty arthritis in rats through inhibition of HIF-1α- and NLRP3-derived IL-1β secretion in macrophages.
Highly relevant gout treatment findings
In our investigation, we explored how resveratrol, a natural compound found in various plants, impacts gouty arthritis in rats. We set up experiments where we induced gouty symptoms by injecting monosodium urate (MSU) crystals into the rats’ ankles. To complement this, we also used THP-1-derived macrophages to study inflammation induced by lipopolysaccharide and MSU in a lab setting.
Our results showed that resveratrol was effective in reducing ankle swelling and inflammation linked to acute gouty arthritis. Interestingly, the effects were comparable to colchicine, a medication frequently used to treat gout.
Moreover, we observed that resveratrol works by inhibiting the activation of the NLRP3 inflammasome and reducing the secretion of IL-1β—key players in the inflammatory process. Resveratrol also seemed to influence HIF-1α, an important factor in managing inflammation. This combination of actions highlights resveratrol's potential as a promising treatment option for gouty arthritis.
Our results showed that resveratrol was effective in reducing ankle swelling and inflammation linked to acute gouty arthritis. Interestingly, the effects were comparable to colchicine, a medication frequently used to treat gout.
Moreover, we observed that resveratrol works by inhibiting the activation of the NLRP3 inflammasome and reducing the secretion of IL-1β—key players in the inflammatory process. Resveratrol also seemed to influence HIF-1α, an important factor in managing inflammation. This combination of actions highlights resveratrol's potential as a promising treatment option for gouty arthritis.
Read More
Most Useful Reviews
8.8
Gout treatment benefits
Resveratrol is a potent natural antioxidant that not only provides cardioprotection and acts as an antiviral and chemopreventive agent against cancer but also effectively improves gout and arthritis. Now Foods' Resveratrol Natural offers easily digestible 200 mg capsules, perfect for those requiring higher doses. I highly endorse this product for its positive impacts on gout management.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.4
9
Resveratrol shows potential for gout
Investigating the mechanisms of resveratrol in the treatment of gouty arthritis through the integration of network pharmacology and metabolics.
Highly relevant to gout treatment.
We set out to understand how resveratrol, a compound often linked to various health benefits, could potentially help people suffering from gouty arthritis (GA). To explore this, we combined network pharmacology with advanced metabolomics techniques. This approach allowed us to predict how resveratrol interacts with biological processes related to gout and verify its effects in an experimental setting.
Using a rat model of gout induced by monosodium urate (MSU), we observed significant changes in the rats when subjected to resveratrol treatment. The results revealed that resveratrol might exert its effects by regulating important inflammatory pathways such as NF-κB, MAPK, and JAK/STAT. With these pathways activated, we saw that resveratrol helped reduce inflammation and pathological damage in the rats, indicating its potential role in managing GA symptoms.
Further analysis through metabolomics showed that resveratrol positively influenced the metabolic pathways associated with gout. These included pathways related to the metabolism of arachidonic acid and amino acids, among others. By restoring key metabolic processes disrupted in gout, resveratrol demonstrated a multi-faceted approach to mitigating inflammation during gout attacks.
This study highlights resveratrol's promise as a natural treatment for gout, showcasing its ability to address inflammation and metabolic disturbances. The findings encourage further exploration of resveratrol while emphasizing its complexity in treating this painful condition.
Using a rat model of gout induced by monosodium urate (MSU), we observed significant changes in the rats when subjected to resveratrol treatment. The results revealed that resveratrol might exert its effects by regulating important inflammatory pathways such as NF-κB, MAPK, and JAK/STAT. With these pathways activated, we saw that resveratrol helped reduce inflammation and pathological damage in the rats, indicating its potential role in managing GA symptoms.
Further analysis through metabolomics showed that resveratrol positively influenced the metabolic pathways associated with gout. These included pathways related to the metabolism of arachidonic acid and amino acids, among others. By restoring key metabolic processes disrupted in gout, resveratrol demonstrated a multi-faceted approach to mitigating inflammation during gout attacks.
This study highlights resveratrol's promise as a natural treatment for gout, showcasing its ability to address inflammation and metabolic disturbances. The findings encourage further exploration of resveratrol while emphasizing its complexity in treating this painful condition.
Read More
9
Resveratrol shows promise for GN
Integrating network pharmacology and renal metabonomics to reveal the protective mechanism of resveratrol on gouty nephropathy.
High relevance for gout treatment
We explored the effects of resveratrol, a natural compound found in grapes and berries, specifically on gouty nephropathy (GN). Utilizing a combination of network pharmacology and renal metabonomics, we aimed to uncover the mechanisms behind resveratrol's benefits for this condition.
In our analysis, we identified 24 important metabolites that changed in kidney tissues of rats with GN after they were treated with resveratrol. Remarkably, these metabolite levels returned to normal after treatment. This suggests a significant restorative effect of resveratrol on the kidney.
We also pinpointed 24 key targets linked to resveratrol's action against GN. Among these, two genes, PTGS1 and PTGS2, were crucial as they play roles in the arachidonic acid metabolism pathway. Molecular docking experiments confirmed that resveratrol effectively binds to these targets, supporting its therapeutic potential.
Overall, the data points to resveratrol possibly mitigating the impact of GN by regulating arachidonic acid metabolism, indicating a promising avenue for future treatments.
In our analysis, we identified 24 important metabolites that changed in kidney tissues of rats with GN after they were treated with resveratrol. Remarkably, these metabolite levels returned to normal after treatment. This suggests a significant restorative effect of resveratrol on the kidney.
We also pinpointed 24 key targets linked to resveratrol's action against GN. Among these, two genes, PTGS1 and PTGS2, were crucial as they play roles in the arachidonic acid metabolism pathway. Molecular docking experiments confirmed that resveratrol effectively binds to these targets, supporting its therapeutic potential.
Overall, the data points to resveratrol possibly mitigating the impact of GN by regulating arachidonic acid metabolism, indicating a promising avenue for future treatments.
Read More
9
Resveratrol shows promise for gout
Resveratrol alleviates MSU-induced gouty arthritis in rats through inhibition of HIF-1α- and NLRP3-derived IL-1β secretion in macrophages.
Highly relevant gout treatment findings
In our investigation, we explored how resveratrol, a natural compound found in various plants, impacts gouty arthritis in rats. We set up experiments where we induced gouty symptoms by injecting monosodium urate (MSU) crystals into the rats’ ankles. To complement this, we also used THP-1-derived macrophages to study inflammation induced by lipopolysaccharide and MSU in a lab setting.
Our results showed that resveratrol was effective in reducing ankle swelling and inflammation linked to acute gouty arthritis. Interestingly, the effects were comparable to colchicine, a medication frequently used to treat gout.
Moreover, we observed that resveratrol works by inhibiting the activation of the NLRP3 inflammasome and reducing the secretion of IL-1β—key players in the inflammatory process. Resveratrol also seemed to influence HIF-1α, an important factor in managing inflammation. This combination of actions highlights resveratrol's potential as a promising treatment option for gouty arthritis.
Our results showed that resveratrol was effective in reducing ankle swelling and inflammation linked to acute gouty arthritis. Interestingly, the effects were comparable to colchicine, a medication frequently used to treat gout.
Moreover, we observed that resveratrol works by inhibiting the activation of the NLRP3 inflammasome and reducing the secretion of IL-1β—key players in the inflammatory process. Resveratrol also seemed to influence HIF-1α, an important factor in managing inflammation. This combination of actions highlights resveratrol's potential as a promising treatment option for gouty arthritis.
Read More
9
Effectiveness of Resveratrol for Gout
Effect of sodium alginate addition to resveratrol on acute gouty arthritis.
Combination treatment shows promise
We explored the potential benefits of resveratrol, known for its anti-inflammatory and antioxidant properties, in treating acute gouty arthritis. In an insightful study, we utilized 24 SPF Wistar mice, dividing them into four groups to evaluate the effects of resveratrol alone, sodium alginate combined with resveratrol, colchicine, and a placebo.
By inducing acute gouty arthritis with monosodium urate injections directly into the ankle joint, we measured key inflammatory markers in both serum and synovial fluid. The results were promising; the combined treatment of sodium alginate and resveratrol showed a significant reduction in levels of IL-1β, CCR5, and CXCL10, outpacing the commonly used medication colchicine.
This combination not only outperformed colchicine but also provided greater benefits than resveratrol alone. Interestingly, both resveratrol treatments notably decreased NLRP3 expression in synovial tissues, highlighting its role in inflammation. Overall, our findings suggest that adding sodium alginate to resveratrol could offer enhanced therapeutic effects for individuals with acute gouty arthritis.
By inducing acute gouty arthritis with monosodium urate injections directly into the ankle joint, we measured key inflammatory markers in both serum and synovial fluid. The results were promising; the combined treatment of sodium alginate and resveratrol showed a significant reduction in levels of IL-1β, CCR5, and CXCL10, outpacing the commonly used medication colchicine.
This combination not only outperformed colchicine but also provided greater benefits than resveratrol alone. Interestingly, both resveratrol treatments notably decreased NLRP3 expression in synovial tissues, highlighting its role in inflammation. Overall, our findings suggest that adding sodium alginate to resveratrol could offer enhanced therapeutic effects for individuals with acute gouty arthritis.
Read More
9
Resveratrol may reduce gout attacks
The effect of resveratrol on the recurrent attacks of gouty arthritis.
High relevance to gout research
We investigated how resveratrol, a natural compound found in grapes, could help manage gouty arthritis, which is caused by the buildup of urate crystals in the joints. To study this, we induced gouty arthritis in mice using a specific type of urate crystal and also created a condition of high uric acid levels with other substances.
Resveratrol was then administered to see if it could reduce inflammation and lower uric acid levels. We observed that mice treated with resveratrol showed less swelling and inflammation in their affected tissues. Additionally, it helped decrease the overall levels of uric acid in the blood of hyperuricemic mice.
Our findings suggest that resveratrol has the potential to lessen the severity of recurrent gout attacks by addressing both inflammation and uric acid levels. This could offer a promising avenue for prevention and management of gouty arthritis in those prone to flare-ups.
Resveratrol was then administered to see if it could reduce inflammation and lower uric acid levels. We observed that mice treated with resveratrol showed less swelling and inflammation in their affected tissues. Additionally, it helped decrease the overall levels of uric acid in the blood of hyperuricemic mice.
Our findings suggest that resveratrol has the potential to lessen the severity of recurrent gout attacks by addressing both inflammation and uric acid levels. This could offer a promising avenue for prevention and management of gouty arthritis in those prone to flare-ups.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Gout treatment benefits
Resveratrol is a potent natural antioxidant that not only provides cardioprotection and acts as an antiviral and chemopreventive agent against cancer but also effectively improves gout and arthritis. Now Foods' Resveratrol Natural offers easily digestible 200 mg capsules, perfect for those requiring higher doses. I highly endorse this product for its positive impacts on gout management.
Read More
