Last update
4/17/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.7
USERS' SCORE
Good
Based on 11 Reviews
8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1.3 g
2%*
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
<0.5 g
†
Evening Primrose Oil(Oenothera biennis) (Seed) (Cold-Pressed, Hexane-Free)
1.3 g (1,300 mg)
†
Gamma Linolenic Acid (GLA)
120 mg
†
Top Medical Research Studies
8
Evening primrose oil shows promise
We analyzed how different types of dietary fats might influence breast cancer growth. In our study, we used athymic mice with human breast cancer cells and supplemented their diets with evening primrose oil and fish oil, while others received olive oil or a standard diet without essential fatty acids.
We found that the tumors in the mice receiving evening primrose oil were significantly smaller compared to those on a standard diet — suggesting that increasing essential fatty acids could play a beneficial role in managing breast cancer.
We found that the tumors in the mice receiving evening primrose oil were significantly smaller compared to those on a standard diet — suggesting that increasing essential fatty acids could play a beneficial role in managing breast cancer.
Read More
7
Evening primrose oil enhances tamoxifen
We explored the potential of evening primrose oil (EPO) to enhance the effects of tamoxifen—an established breast cancer treatment. In laboratory tests using human breast cancer cell lines, EPO showed promising results, working alongside tamoxifen to encourage cancer cell death and stop cell growth.
While our findings suggest that EPO can improve tamoxifen's anticancer abilities, more research is needed to fully understand its impact on breast cancer treatment in patients.
While our findings suggest that EPO can improve tamoxifen's anticancer abilities, more research is needed to fully understand its impact on breast cancer treatment in patients.
Read More
5
Evening primrose oil shows limited effects
We conducted a randomized, double-blind, controlled trial to explore the effects of fish oil and evening primrose oil (EPO) on breast cancer patients undergoing chemotherapy. Over 12 weeks, participants received either the oil supplements or a placebo.
While we noted improvements in fatty acid profiles in the treatment group, the study showed no significant changes in inflammatory markers between the two groups. Despite a decrease in IL-6 levels in the intervention group, there was no major benefit observed overall.
Ultimately, our findings suggest that while this supplementation can help with lipid metabolism, it does not deliver significant anti-inflammatory effects for breast cancer patients undergoing chemotherapy.
While we noted improvements in fatty acid profiles in the treatment group, the study showed no significant changes in inflammatory markers between the two groups. Despite a decrease in IL-6 levels in the intervention group, there was no major benefit observed overall.
Ultimately, our findings suggest that while this supplementation can help with lipid metabolism, it does not deliver significant anti-inflammatory effects for breast cancer patients undergoing chemotherapy.
Read More
Most Useful Reviews
7.5
Relief from hot flashes
42 people found this helpful
Power surges. As a recent breast cancer survivor, I struggled with hot flashes. A friend recommended evening primrose oil, particularly the NOW brand. After following her dosage advice, I experienced relief from power surges, especially at night. I’m grateful for this effective solution.
Read More
9
Clears lumps
4 people found this helpful
After just two weeks, I noticed significant results with evening primrose oil. My breast lumps began to clear, positively impacting my situation related to breast cancer.
Read More
9
Breast pain alleviation
2 people found this helpful
Evening primrose oil has stopped my breast pain before menstruation.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.7
- All Researches
8
Evening primrose oil shows promise
We analyzed how different types of dietary fats might influence breast cancer growth. In our study, we used athymic mice with human breast cancer cells and supplemented their diets with evening primrose oil and fish oil, while others received olive oil or a standard diet without essential fatty acids.
We found that the tumors in the mice receiving evening primrose oil were significantly smaller compared to those on a standard diet — suggesting that increasing essential fatty acids could play a beneficial role in managing breast cancer.
We found that the tumors in the mice receiving evening primrose oil were significantly smaller compared to those on a standard diet — suggesting that increasing essential fatty acids could play a beneficial role in managing breast cancer.
Read More
7
Evening primrose oil enhances tamoxifen
We explored the potential of evening primrose oil (EPO) to enhance the effects of tamoxifen—an established breast cancer treatment. In laboratory tests using human breast cancer cell lines, EPO showed promising results, working alongside tamoxifen to encourage cancer cell death and stop cell growth.
While our findings suggest that EPO can improve tamoxifen's anticancer abilities, more research is needed to fully understand its impact on breast cancer treatment in patients.
While our findings suggest that EPO can improve tamoxifen's anticancer abilities, more research is needed to fully understand its impact on breast cancer treatment in patients.
Read More
5
Evening primrose oil shows limited effects
We conducted a randomized, double-blind, controlled trial to explore the effects of fish oil and evening primrose oil (EPO) on breast cancer patients undergoing chemotherapy. Over 12 weeks, participants received either the oil supplements or a placebo.
While we noted improvements in fatty acid profiles in the treatment group, the study showed no significant changes in inflammatory markers between the two groups. Despite a decrease in IL-6 levels in the intervention group, there was no major benefit observed overall.
Ultimately, our findings suggest that while this supplementation can help with lipid metabolism, it does not deliver significant anti-inflammatory effects for breast cancer patients undergoing chemotherapy.
While we noted improvements in fatty acid profiles in the treatment group, the study showed no significant changes in inflammatory markers between the two groups. Despite a decrease in IL-6 levels in the intervention group, there was no major benefit observed overall.
Ultimately, our findings suggest that while this supplementation can help with lipid metabolism, it does not deliver significant anti-inflammatory effects for breast cancer patients undergoing chemotherapy.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Relief from hot flashes
42 people found this helpful
Power surges. As a recent breast cancer survivor, I struggled with hot flashes. A friend recommended evening primrose oil, particularly the NOW brand. After following her dosage advice, I experienced relief from power surges, especially at night. I’m grateful for this effective solution.
Read More
9
Clears lumps
4 people found this helpful
After just two weeks, I noticed significant results with evening primrose oil. My breast lumps began to clear, positively impacting my situation related to breast cancer.
Read More
9
Breast pain alleviation
2 people found this helpful
Evening primrose oil has stopped my breast pain before menstruation.
Read More
9
Menstrual relief
2 people found this helpful
After my gynecologist recommended it, I started using this. My breast discomfort before menstruation has ceased, my periods are lighter and painless, and my skin has improved significantly.
Read More
7.5
Breast tenderness relief
1 people found this helpful
Works brilliantly for me! I've experienced less breast pain, and my skin has also improved.
Read More
Frequently Asked Questions
9
Clears lumps
4 people found this helpful
After just two weeks, I noticed significant results with evening primrose oil. My breast lumps began to clear, positively impacting my situation related to breast cancer.
7
Evening primrose oil enhances tamoxifen
We explored the potential of evening primrose oil (EPO) to enhance the effects of tamoxifen—an established breast cancer treatment. In laboratory tests using human breast cancer cell lines, EPO showed promising results, working alongside tamoxifen to encourage cancer cell death and stop cell growth.
While our findings suggest that EPO can improve tamoxifen's anticancer abilities, more research is needed to fully understand its impact on breast cancer treatment in patients.
While our findings suggest that EPO can improve tamoxifen's anticancer abilities, more research is needed to fully understand its impact on breast cancer treatment in patients.
5
Evening primrose oil shows limited effects
We conducted a randomized, double-blind, controlled trial to explore the effects of fish oil and evening primrose oil (EPO) on breast cancer patients undergoing chemotherapy. Over 12 weeks, participants received either the oil supplements or a placebo.
While we noted improvements in fatty acid profiles in the treatment group, the study showed no significant changes in inflammatory markers between the two groups. Despite a decrease in IL-6 levels in the intervention group, there was no major benefit observed overall.
Ultimately, our findings suggest that while this supplementation can help with lipid metabolism, it does not deliver significant anti-inflammatory effects for breast cancer patients undergoing chemotherapy.
While we noted improvements in fatty acid profiles in the treatment group, the study showed no significant changes in inflammatory markers between the two groups. Despite a decrease in IL-6 levels in the intervention group, there was no major benefit observed overall.
Ultimately, our findings suggest that while this supplementation can help with lipid metabolism, it does not deliver significant anti-inflammatory effects for breast cancer patients undergoing chemotherapy.
8
Evening primrose oil shows promise
We analyzed how different types of dietary fats might influence breast cancer growth. In our study, we used athymic mice with human breast cancer cells and supplemented their diets with evening primrose oil and fish oil, while others received olive oil or a standard diet without essential fatty acids.
We found that the tumors in the mice receiving evening primrose oil were significantly smaller compared to those on a standard diet — suggesting that increasing essential fatty acids could play a beneficial role in managing breast cancer.
We found that the tumors in the mice receiving evening primrose oil were significantly smaller compared to those on a standard diet — suggesting that increasing essential fatty acids could play a beneficial role in managing breast cancer.
References
- Arsic A, Krstic P, Paunovic M, Nedovic J, Jakovljevic V, et al. Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer patients undergoing chemotherapy: a randomized placebo-controlled trial. Sci Rep. 2023;13:6449. 10.1038/s41598-023-28411-8
- Abd-Alhaseeb MM, Massoud SM, Elsayed F, Omran GA, Salahuddin A. Evening Primrose Oil Enhances Tamoxifen's Anticancer Activity against Breast Cancer Cells by Inducing Apoptosis, Inhibiting Angiogenesis, and Arresting the Cell Cycle. Molecules. 2022;27. 10.3390/molecules27082391
- Pritchard GA, Jones DL, Mansel RE. Lipids in breast carcinogenesis. Br J Surg. 1989;76:1069. PubMed
