Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
USERS' SCORE
Good
Based on 18 Reviews
8.1
Supplement Facts
Serving Size: 1 Fish Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Cholesterol
<5 mg
1%
Vitamin D3 (as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
Fish Oil Concentrate
1.2 g (1,200 mg)
†
Omega-3 Fatty Acids:
Eicosapentaenoic Acid (EPA)
600 mg
†
Docosahexaenoic Acid (DHA)
300 mg
†
Top Medical Research Studies
8
We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
Read More
9
We investigated how docosahexaenoic acid (DHA) impacts osteoarthritis (OA), which is a common joint disease in older adults. Using both human and rat models, we found that DHA can enhance chondrocyte (cartilage cells) growth while reducing cell death.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Read More
8
We conducted a study to understand how various dietary factors, including oily fish, affect rheumatoid arthritis (RA). Through advanced genetic analysis, we found that higher consumption of certain foods, particularly oily fish, appears to lower the risk of developing RA. This suggests that incorporating more oily fish and cereal into our diets could be beneficial for those at risk or living with RA. However, other dietary factors did not show significant links to RA risk.
Read More
Most Useful Reviews
9
Reduced inflammation
This is a fantastic Omega 3 supplement that benefits my rheumatoid arthritis significantly when taken consistently. It is good value for money, with a large package for less than other brands, and helps decrease inflammation.
Read More
9
Arthritis relief
The excellent ratio of EPA to DHA in Omega 3 has been beneficial for me in relieving arthritis and supporting heart health.
Read More
8
Effective and high quality
Great high-quality Omega with excellent quantity! I took it for my elderly mother and found it beneficial for improving arthritis and reducing cholesterol levels.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
- All Researches
9
We investigated how docosahexaenoic acid (DHA) impacts osteoarthritis (OA), which is a common joint disease in older adults. Using both human and rat models, we found that DHA can enhance chondrocyte (cartilage cells) growth while reducing cell death.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Read More
8
We explored whether omega-3 fatty acids could help slow down osteoarthritis (OA) by changing how chondrocytes, the cells in our cartilage, respond to mechanical forces.
Our findings indicated that omega-3s significantly reduced chondrocyte sensitivity to compression and certain chemical signals linked to OA progression.
Interestingly, we also discovered that another type of fatty acid, omega-6, may actually make chondrocyte membranes more prone to damage.
This research showcases the importance of specific fatty acids in managing joint health and offers new ideas for nutritional strategies to combat OA.
Our findings indicated that omega-3s significantly reduced chondrocyte sensitivity to compression and certain chemical signals linked to OA progression.
Interestingly, we also discovered that another type of fatty acid, omega-6, may actually make chondrocyte membranes more prone to damage.
This research showcases the importance of specific fatty acids in managing joint health and offers new ideas for nutritional strategies to combat OA.
Read More
8
We conducted a study to understand how various dietary factors, including oily fish, affect rheumatoid arthritis (RA). Through advanced genetic analysis, we found that higher consumption of certain foods, particularly oily fish, appears to lower the risk of developing RA. This suggests that incorporating more oily fish and cereal into our diets could be beneficial for those at risk or living with RA. However, other dietary factors did not show significant links to RA risk.
Read More
8
We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
Read More
8
We investigated the effectiveness of a smart cage system for measuring locomotor activity in mice with inflammatory arthritis. The study induced arthritis and tracked changes over time, focusing on mice fed diets with or without fish oil.
Our findings revealed that despite traditional measurements like clinical index and ankle thickness not showing significant differences based on diet, mice given fish oil demonstrated notably increased locomotor activity. This suggests that omega-3 fish oil may enhance mobility during arthritis, highlighting the potential of smart cages for assessing disease impacts more comprehensively.
Our findings revealed that despite traditional measurements like clinical index and ankle thickness not showing significant differences based on diet, mice given fish oil demonstrated notably increased locomotor activity. This suggests that omega-3 fish oil may enhance mobility during arthritis, highlighting the potential of smart cages for assessing disease impacts more comprehensively.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced inflammation
This is a fantastic Omega 3 supplement that benefits my rheumatoid arthritis significantly when taken consistently. It is good value for money, with a large package for less than other brands, and helps decrease inflammation.
Read More
9
Arthritis relief
The excellent ratio of EPA to DHA in Omega 3 has been beneficial for me in relieving arthritis and supporting heart health.
Read More
8
Effective and high quality
Great high-quality Omega with excellent quantity! I took it for my elderly mother and found it beneficial for improving arthritis and reducing cholesterol levels.
Read More
9
Excellent for arthritis
1 people found this helpful
Very excellent product. I've ordered it twice; it's outstanding for arthritis and presents many benefits. I find this type suitable, and its specifications, according to my research, are among the best.
Read More
9
Supports joint health
1 people found this helpful
Omega 3 fish oil is remarkable in terms of its EPA and DHA quality. Its benefits include promoting joint health, enhancing liver function, and providing essential fats for arthritis, which improves heart vitality.
Read More
Frequently Asked Questions
7.5
Long-term benefits
Excellent product, I’ve bought Omega 3 from this beneficial company twice. It supports heart health, reduces high cholesterol, and aids in arthritis treatment. You must take it consistently for results.
8
Effective and high quality
Great high-quality Omega with excellent quantity! I took it for my elderly mother and found it beneficial for improving arthritis and reducing cholesterol levels.
7.5
Useful for whole family
Omega-3s are beneficial for joint health, prevent osteoporosis, and help mitigate inflammation and bone loss. They aid in reducing joint pain, alleviate symptoms of rheumatoid arthritis, and slow cartilage destruction in arthrosis. My family and I take one capsule daily.
9
Reduced inflammation
This is a fantastic Omega 3 supplement that benefits my rheumatoid arthritis significantly when taken consistently. It is good value for money, with a large package for less than other brands, and helps decrease inflammation.
9
Cholesterol improvement
This product has helped me reduce harmful cholesterol, increase beneficial cholesterol, alleviate arthritis, and improve memory. It is halal and free from alcohol or pig derivatives.
7.5
Stops cartilage destruction
Omega-3 fatty acids prevent osteoporosis, maintain healthy joints, and alleviate pain during flare-ups. They fight bone loss, reduce inflammation, and alleviate symptoms of rheumatoid arthritis, delaying the destruction of joint cartilage in arthrosis.
9
Useful for arthritis
The intake of omega 3 is beneficial for managing rheumatoid arthritis, Alzheimer's, and depression. It's also effective in lowering triglyceride levels and addressing conditions like asthma and ADHD.
7.5
Helps reduce inflammation
NOW Foods is a respected brand, known for quality health products. The Ultra Omega 3 provides 600 mg EPA and 300 mg DHA, which is standard. Omega-3 fatty acids can lower triglyceride levels, increase "good" cholesterol, and reduce inflammation, which can alleviate symptoms of arthritis and promote overall heart and vascular health.
8
We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
4
Omega-3 has limited arthritis impact
We investigated the effects of omega-3 fatty acid supplements on rheumatoid arthritis using data from 23 randomized placebo-controlled trials. Our analysis showed only a small effect in reducing pain, joint tenderness, and swelling.
We observed that while there was a slight reduction in NSAID use, the overall benefit seemed limited. The findings also indicated very low to low quality evidence, suggesting that previous claims of significant benefits could be overstated due to issues with study design.
We observed that while there was a slight reduction in NSAID use, the overall benefit seemed limited. The findings also indicated very low to low quality evidence, suggesting that previous claims of significant benefits could be overstated due to issues with study design.
8
Omega-3s alleviate osteoarthritis progression
We explored how omega-3 polyunsaturated fatty acids (PUFAs) could ease the pain of obesity-related osteoarthritis (OA). In our study, we found that a diet rich in omega-3s helped reduce damage to cartilage in experimental mice.
It appears that these fatty acids decrease inflammation by impacting a specific signaling pathway involving HMGB1. This means that omega-3s might offer a new dietary approach for managing OA by protecting joint health.
It appears that these fatty acids decrease inflammation by impacting a specific signaling pathway involving HMGB1. This means that omega-3s might offer a new dietary approach for managing OA by protecting joint health.
7
We investigated the link between omega-3 fatty acids and osteoarthritis using data from over 22,800 participants in the NHANES study between 2003 and 2016. The findings revealed that omega-3 intake was linked to lower rates of osteoarthritis in adults aged 40 to 59.
However, despite this association, our Mendelian randomization analysis did not establish a causal connection between omega-3 intake and osteoarthritis risk. This suggests that while omega-3s might correlate with better outcomes, they may not directly prevent or treat osteoarthritis.
However, despite this association, our Mendelian randomization analysis did not establish a causal connection between omega-3 intake and osteoarthritis risk. This suggests that while omega-3s might correlate with better outcomes, they may not directly prevent or treat osteoarthritis.
References
- Marushack GK, Savadipour A, Tang R, Garcia-Castorena JM, Rashidi N, et al. Polyunsaturated fatty acids suppress PIEZO ion channel mechanotransduction in articular chondrocytes. FASEB J. 2025;39:e70290. 10.1096/fj.202400544RR
- Wang Y, Hu S, Zhang W, Zhang B, Yang Z. Dietary factors and rheumatoid arthritis: new perspectives from a Mendelian randomisation analysis. Br J Nutr. 2025;133:107. 10.1017/S0007114524002721
- Wang W, Xu Y, Zhou J, Zang Y. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2024;43:2479. 10.1007/s10067-024-07040-0
- Scherer D, Leite BF, Morimoto MA, Oliveira TL, Klemz BNC, et al. Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial. Adv Rheumatol. 2024;64:47. 10.1186/s42358-024-00389-5
- Liu Y, Song F, Liu M, Huang X, Xue S, et al. Association between omega-3 polyunsaturated fatty acids and osteoarthritis: results from the NHANES 2003-2016 and Mendelian randomization study. Lipids Health Dis. 2024;23:147. 10.1186/s12944-024-02139-4
- Kang T, Xi Y, Qian T, Lu S, Du M, et al. Exploring the link between dietary omega-3 and omega-6 fatty acid intake and rheumatoid arthritis risk: NHANES 1999-2020 study. Clin Exp Rheumatol. 2024;42:1720. 10.55563/clinexprheumatol/91tmfb
- Laevski AM, Doucet MR, Doucet MS, LeBlanc AA, Pineau PE, et al. Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model. Eur J Nutr. 2024;63:2221. 10.1007/s00394-024-03397-9
- Doucet MR, Laevski AM, Doiron JA, Boudreau LH, Surette ME. Locomotor activity as an effective measure of the severity of inflammatory arthritis in a mouse model. PLoS One. 2024;19:e0291399. 10.1371/journal.pone.0291399
- Xiong T, Huang S, Wang X, Shi Y, He J, et al. n-3 polyunsaturated fatty acids alleviate the progression of obesity-related osteoarthritis and protect cartilage through inhibiting the HMGB1-RAGE/TLR4 signaling pathway. Int Immunopharmacol. 2024;128:111498. 10.1016/j.intimp.2024.111498
- Yu H, Gong Z, Wang G, Cao R, Yin H, et al. DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis. In Vitro Cell Dev Biol Anim. 2023;59:455. 10.1007/s11626-023-00781-3
- Léger T, Brun A, Lanchais K, Rigaudière JP, Briat A, et al. Docosahexaenoic acid and etanercept could reduce functional and metabolic alterations during collagen-induced arthritis in rats without any synergistic effect. Life Sci. 2023;327:121826. 10.1016/j.lfs.2023.121826
- Marchand NE, Choi MY, Oakes EG, Cook NR, Stevens E, et al. Over-the-counter fish oil supplementation and pro-resolving and pro-inflammatory lipid mediators in rheumatoid arthritis. Prostaglandins Leukot Essent Fatty Acids. 2023;190:102542. 10.1016/j.plefa.2023.102542
- Feng L, Yang Z, Li Y, Hou N, Yang B, et al. Malat1 attenuated the rescuing effects of docosahexaenoic acid on osteoarthritis treatment via repressing its chondroprotective and chondrogenesis activities. Biomed Pharmacother. 2022;154:113608. 10.1016/j.biopha.2022.113608
- Gkiouras K, Grammatikopoulou MG, Myrogiannis I, Papamitsou T, Rigopoulou EI, et al. Efficacy of n-3 fatty acid supplementation on rheumatoid arthritis' disease activity indicators: a systematic review and meta-analysis of randomized placebo-controlled trials. Crit Rev Food Sci Nutr. 2024;64:16. 10.1080/10408398.2022.2104210
- Sigaux J, Bellicha A, Buscail C, Julia C, Flipo RM, et al. Serum Fatty Acid Profiles Are Associated with Disease Activity in Early Rheumatoid Arthritis: Results from the ESPOIR Cohort. Nutrients. 2022;14. 10.3390/nu14142947
- Stonehouse W, Benassi-Evans B, Bednarz J, Vincent AD, Hall S, et al. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2022;116:672. 10.1093/ajcn/nqac125
