Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Moderately Good
Based on 43 Reviews
7.9
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Coenzyme Q10 (CoQ10)
100 mg
*
Hawthorn Berry (Crataegus laevigata and/or monogyna) (Fruit)
400 mg
*

Top Medical Research Studies

We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.

In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
Read More
We explored the protective effects of Coenzyme Q10 (CoQ10) and its liposomal form on heart health, particularly in response to copper toxicity caused by copper sulfate (CuSO4). In this study, rats received daily doses of CuSO4 to induce heart injury, while some were also treated with CoQ10 or L-CoQ10 to see if these supplements could mitigate the damage.

The results showed that CuSO4 led to elevated cardiac injury markers and increased oxidative stress, which is known to contribute to heart issues. However, the inclusion of CoQ10 and L-CoQ10 helped lower the levels of harmful markers, improve antioxidant capacity, and reduce inflammation. These supplements effectively restored balance and reduced signs of heart injury, highlighting their potential cardioprotective roles.

Overall, the findings suggest that CoQ10 could serve as a valuable defense for individuals at risk of copper toxicity, reinforcing its relevance in supporting cardiovascular health.
Read More
9
Coenzyme Q10 enhances heart failure outcomes
We explored the effectiveness of coenzyme Q10 in treating heart failure through a thorough analysis of various randomized controlled trials. Our investigation involved a comprehensive search across numerous databases, looking specifically for studies that focused on the impact of coenzyme Q10 on heart failure patients.

The findings were quite promising. We observed that coenzyme Q10 not only reduced the rate of all-cause mortality but also decreased hospitalizations due to heart failure. Improvements were noted in several key health metrics such as the New York Heart Association classification and brain natriuretic peptide levels. Furthermore, participants benefited from enhanced left ventricular ejection fraction and better performance on the six-minute walk test.

Importantly, these benefits were achieved without major adverse effects, suggesting that coenzyme Q10 could be a safe and effective option for those managing heart failure. Overall, our analysis indicates that coenzyme Q10 offers significant advantages for heart failure patients, enhancing their quality of life and potentially extending longevity.
Read More

Most Useful Reviews

9
Elderly essential
114 people found this helpful
Coenzyme Q10 positively affects the heart and helps reduce the risk of cardiovascular disease. As we age, our body’s natural production decreases, leading to serious health issues. It's a crucial supplement for the elderly.
Read More
9
Cellular energy supplier
7 people found this helpful
After a month of using this coenzyme, I’m thrilled with the results. Coenzyme Q10 supplies energy to cells, vital for cardiovascular health, while also serving as a strong antioxidant, slowing the ageing process.
Read More
9
Cellular energy support
3 people found this helpful
Coenzyme Q10, a vitamin-like compound, plays a vital role in cellular energy production. Its levels drop with age, impacting cardiovascular health. CoQ10 effectively neutralises free radicals, supporting heart, liver, and kidney functions and maintaining cardiovascular health.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
  • All Researches
We explored the protective effects of Coenzyme Q10 (CoQ10) and its liposomal form on heart health, particularly in response to copper toxicity caused by copper sulfate (CuSO4). In this study, rats received daily doses of CuSO4 to induce heart injury, while some were also treated with CoQ10 or L-CoQ10 to see if these supplements could mitigate the damage.

The results showed that CuSO4 led to elevated cardiac injury markers and increased oxidative stress, which is known to contribute to heart issues. However, the inclusion of CoQ10 and L-CoQ10 helped lower the levels of harmful markers, improve antioxidant capacity, and reduce inflammation. These supplements effectively restored balance and reduced signs of heart injury, highlighting their potential cardioprotective roles.

Overall, the findings suggest that CoQ10 could serve as a valuable defense for individuals at risk of copper toxicity, reinforcing its relevance in supporting cardiovascular health.
Read More
9
Coenzyme Q10 enhances heart failure outcomes
We explored the effectiveness of coenzyme Q10 in treating heart failure through a thorough analysis of various randomized controlled trials. Our investigation involved a comprehensive search across numerous databases, looking specifically for studies that focused on the impact of coenzyme Q10 on heart failure patients.

The findings were quite promising. We observed that coenzyme Q10 not only reduced the rate of all-cause mortality but also decreased hospitalizations due to heart failure. Improvements were noted in several key health metrics such as the New York Heart Association classification and brain natriuretic peptide levels. Furthermore, participants benefited from enhanced left ventricular ejection fraction and better performance on the six-minute walk test.

Importantly, these benefits were achieved without major adverse effects, suggesting that coenzyme Q10 could be a safe and effective option for those managing heart failure. Overall, our analysis indicates that coenzyme Q10 offers significant advantages for heart failure patients, enhancing their quality of life and potentially extending longevity.
Read More
We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.

In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
Read More
9
Coenzyme Q10 improves heart health
We conducted a thorough investigation into the effects of coenzyme Q10 on cardiovascular health in patients suffering from Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD). In this well-structured study, we utilized a randomized double-blind approach, dividing sixty participants to receive either 240 mg of coenzyme Q10 or a placebo daily for six months.

Our findings revealed that those taking coenzyme Q10 experienced significant improvements in several cardiovascular and liver health markers. Specifically, we noted reduced liver fat and enhanced endothelial function, indicating healthier blood vessels. Measurements showed positive changes in their vascular and myocardial functions, which are critical indicators of heart health.

Conversely, patients in the placebo group did not show any improvement throughout the study period. The results were compelling, underscoring not only the potential of coenzyme Q10 in mitigating liver steatosis but also its role in significantly boosting cardiovascular health.

Overall, by the end of our six-month research period, we observed a marked connection between improvements in liver function and cardiovascular markers, suggesting that coenzyme Q10 might be a beneficial treatment for those grappling with MASLD and associated cardiovascular risks.
Read More
9
CoQ10 aids in mitigating tissue damage
We aimed to understand how Coenzyme Q10 (CoQ10) might help counteract the damage caused by doxorubicin, a common chemotherapy drug known for its harmful side effects on the heart and lungs. To investigate this, we conducted a study involving 27 rats divided into three groups: one group received CoQ10, another received doxorubicin, and the last group received both.

At the end of the study, we examined the hearts and lungs of the rats. Our findings revealed that doxorubicin led to significant harm to the cellular structures in both organs, confirming the drug's cardiotoxic and pulmonary damaging effects. However, when CoQ10 was administered, it showed a promising ability to alleviate these adverse effects, almost restoring the normal appearance of the tissues.

In summary, our study suggests that CoQ10 could act as a protective agent, helping to maintain healthy lung and heart tissues in the context of doxorubicin treatment. This could potentially offer a valuable strategy for enhancing the safety and efficacy of chemotherapy regimens.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 43 Reviews
7.9
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Elderly essential
114 people found this helpful
Coenzyme Q10 positively affects the heart and helps reduce the risk of cardiovascular disease. As we age, our body’s natural production decreases, leading to serious health issues. It's a crucial supplement for the elderly.
Read More
9
Cellular energy supplier
7 people found this helpful
After a month of using this coenzyme, I’m thrilled with the results. Coenzyme Q10 supplies energy to cells, vital for cardiovascular health, while also serving as a strong antioxidant, slowing the ageing process.
Read More
9
Cellular energy support
3 people found this helpful
Coenzyme Q10, a vitamin-like compound, plays a vital role in cellular energy production. Its levels drop with age, impacting cardiovascular health. CoQ10 effectively neutralises free radicals, supporting heart, liver, and kidney functions and maintaining cardiovascular health.
Read More
9
Skin and hair improvement
1 people found this helpful
I took one capsule daily for a month, experiencing enhanced complexion, skin elasticity, and shinier hair. My mother also felt less heart discomfort and lower cholesterol after taking this alongside Omega 3-6-9, supporting our cardiovascular health.
Read More
9
Daytime energy boost
1 people found this helpful
A fantastic way to start the day! These capsules are easy to swallow and provide energy by replenishing mitochondria. They also support cardiovascular health. I take two in the morning and feel energised throughout the day.
Read More

Frequently Asked Questions

9
Cellular energy supplier
7 people found this helpful
After a month of using this coenzyme, I’m thrilled with the results. Coenzyme Q10 supplies energy to cells, vital for cardiovascular health, while also serving as a strong antioxidant, slowing the ageing process.
9
Skin and hair improvement
1 people found this helpful
I took one capsule daily for a month, experiencing enhanced complexion, skin elasticity, and shinier hair. My mother also felt less heart discomfort and lower cholesterol after taking this alongside Omega 3-6-9, supporting our cardiovascular health.
9
Improves heart function
1 people found this helpful
Long-term intake of Coenzyme Q10 has improved my heart function and energy metabolism while normalising my rhythm. I believe it reduces the risk of cardiovascular disease and lowers side effects from statins.
6
Chronic fatigue aid
33 people found this helpful
Coenzyme Q10 offers natural energy and is particularly beneficial for those with cardiovascular disease, liver or kidney issues, and chronic fatigue syndrome. Long-term usage can rejuvenate the body. It is vital to consume it with fats for maximum absorption, especially for individuals over 35.
8
Energy boost
9 people found this helpful
This product effectively supports heart function and helps manage cardiovascular disease. I bought it for my parents, and they've noticed more energy and stabilisation of blood pressure. It's important to take CoQ10 with fatty foods for proper absorption.
9
Skin improvement
1 people found this helpful
I'm very pleased with Coenzyme Q10; it has significantly improved my skin while also being a great antioxidant. The packaging is convenient for a 90-day course, promoting cardiovascular health, and the taste is neutral.
7.5
Balanced blood pressure
1 people found this helpful
This is a great product! I’ve tried various CoQ10 brands, but this one integrates seamlessly into my routine. The addition of Hawthorn Berry helps regulate my blood pressure during inflammation, supporting my cardiovascular health effectively.
7.5
Antioxidant properties
5 people found this helpful
Coenzyme Q-10 is essential for cellular energy, enhancing physical endurance and combating chronic fatigue. Its antioxidant benefits also protect against cardiovascular disease and premature ageing.
9
Daily heart health
I take this Hawthorn Berry with CoQ10 daily for cardiovascular health. The combination is fantastic, and I trust the quality of NOW Brand products. I would highly recommend this supplement for heart support.
8
Natural cardiovascular support
1 people found this helpful
NOW Foods CoQ10 is a reliable supplement for heart health. It offers great value, blending CoQ10 with hawthorn berry for added cardiovascular benefits. The potency supports heart health, energy levels, and provides antioxidant protection.
7.5
Hawthorn benefits
185 people found this helpful
I won't repeat the benefits of Q10, as most people know about this coenzyme. I buy it regularly. I found my favourite dietary supplement containing both Q10 and hawthorn, which is beneficial for cardiovascular disease. This combination is especially good for elderly individuals suffering from angina pectoris and hypertension.
We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.

In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
We explored the protective effects of Coenzyme Q10 (CoQ10) and its liposomal form on heart health, particularly in response to copper toxicity caused by copper sulfate (CuSO4). In this study, rats received daily doses of CuSO4 to induce heart injury, while some were also treated with CoQ10 or L-CoQ10 to see if these supplements could mitigate the damage.

The results showed that CuSO4 led to elevated cardiac injury markers and increased oxidative stress, which is known to contribute to heart issues. However, the inclusion of CoQ10 and L-CoQ10 helped lower the levels of harmful markers, improve antioxidant capacity, and reduce inflammation. These supplements effectively restored balance and reduced signs of heart injury, highlighting their potential cardioprotective roles.

Overall, the findings suggest that CoQ10 could serve as a valuable defense for individuals at risk of copper toxicity, reinforcing its relevance in supporting cardiovascular health.
8
CoQ10 shows potential benefits
We explored the effects of coenzyme Q10 (CoQ10) on heart health in a study involving male rats with diabetes-induced heart disease, known as diabetic cardiomyopathy. To investigate the potential benefits, researchers used a controlled experiment design, where rats were divided into groups receiving various treatments, including CoQ10 in a solution and a special formulation encapsulated in nanoliposomes, alongside a technique called ultrasound-targeted microbubble destruction (UTMD).

After 12 weeks, we observed that the group treated with CoQ10-PEG-lips combined with UTMD experienced improvements in heart function and reduced signs of heart damage compared to the diabetic group without treatment. The results indicated better myocardial integrity, antioxidant levels, and lower indicators of cell apoptosis—a process where cells self-destruct. However, when comparing the CoQ10-PEG-lips group and the CoQ10 with UTMD treatment group to the normal control group, the differences in heart measurements were not statistically significant.

Ultimately, the combination approach appears to effectively reduce heart cell damage in diabetic rats, but the data indicated that CoQ10 alone might not produce significant changes without the support of additional treatment forms. It's important to note the enhanced delivery method using UTMD seemed crucial for achieving these effects, suggesting that simply using CoQ10 in isolation might not yield the same positive outcomes.
9
CoQ10 and trimetazidine effective
We explored the effectiveness of coenzyme Q10 (CoQ10) as a treatment for acute viral myocarditis (AVM) when combined with trimetazidine. This systematic review and meta-analysis looked at various randomized controlled trials to determine how well this combination therapy works compared to CoQ10 alone.

Our analysis included 16 trials with a total of 1,364 patients. Out of these, 687 were treated with both trimetazidine and CoQ10 for about 5 weeks, while another 677 received only CoQ10. We observed that the combination therapy significantly enhanced treatment effectiveness, improving overall outcomes with a risk ratio of 1.19. Importantly, this combined approach also showed better results regarding myocardial enzyme levels and the improvement of cardiac systolic function, without increasing adverse events.

From our findings, it appears that using trimetazidine together with CoQ10 offers a promising and safe option for patients dealing with AVM. Patients can gain more benefits from this duo compared to using CoQ10 alone, marking a significant advancement in treating this condition.

References

  1. Alghibiwi HK, Alhusiani AM, Sarawi WS, Fadda L, Alomar HA, et al. Coenzyme Q10 and its liposomal form prevent copper cardiotoxicity by attenuating oxidative stress, TLR-4/NF-κB signaling and necroptosis in rats. Cell Mol Biol (Noisy-le-grand). 2025;71:118. 10.14715/cmb/2025.70.1.13
  2. Zhang M, Sun MY, He WY, Yu SF, Ma WC. [Experimental study on the treatment of diabetic cardiomyopathy in rats by using ultrasound-targeted microbubble destruction combined with coenzyme Q10 loaded long-circulating nanoliposomes]. Zhonghua Yi Xue Za Zhi. 2024;104:3765. 10.3760/cma.j.cn112137-20240605-01273
  3. Xu J, Xiang L, Yin X, Song H, Chen C, et al. Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 2024;24:592. 10.1186/s12872-024-04232-z
  4. Qazi SU, Bin Naeem MA, Umar M, Zahid MJ, Kan Changez MI, et al. Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis. Future Cardiol. 2024;20:221. 10.1080/14796678.2024.2352308
  5. Intan RE, Balti DR, Nugraha RA, Alkaff FF, Salamah S, et al. Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report. J Pak Med Assoc. 2024;74:S81. 10.47391/JPMA.S6-ACSA-16
  6. Vrentzos E, Ikonomidis I, Pavlidis G, Katogiannis K, Korakas E, et al. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial. Cardiovasc Diabetol. 2024;23:245. 10.1186/s12933-024-02326-8
  7. Ali S, Sulaiman E, Dhiaa S. HISTOLOGICAL EFFECTS OF CO ENZYME Q10 ON DOXORUBICIN-INDUCED DEFICITS OF CARDIOPULMONARY AXIS IN WHITE ALBINO RATS. Georgian Med News. 2024.
  8. Alehagen U, Aaseth J, Schomburg L, Larsson A, Opstad T, et al. Selenoprotein P increases upon selenium and coenzyme Q supplementation and is associated with telomere length, quality of life and reduced inflammation and mortality. Free Radic Biol Med. 2024;222:403. 10.1016/j.freeradbiomed.2024.06.027
  9. Zeng M, Chen Z, Zhang Y, Pang Y. Combination of trimetazidine and coenzyme Q10 for the treatment of acute viral myocarditis: a systematic review and meta-analysis. J Infect Dev Ctries. 2024;18:658. 10.3855/jidc.18776
  10. Du H, Zhao Y, Wen J, Dai B, Hu G, et al. LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1. Circulation. 2024;150:1030. 10.1161/CIRCULATIONAHA.123.067861
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