Overview
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
5.9
USERS' SCORE
Good
Based on 2 Reviews
8.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Potassium (elemental) (from 619 mg Potassium Gluconate)
99 mg
2%
Top Medical Research Studies
8
We explored the potential connection between dietary potassium intake and the occurrence of severe headaches or migraines. Utilizing data from over 10,000 US adults gathered through a national health survey from 1999 to 2004, we conducted a thorough analysis.
While we found that higher potassium intake was linked to a lower likelihood of migraines, the relationship appeared to be L-shaped, suggesting that there might be an optimal level of intake rather than a straightforward benefit. There's no strong evidence that potassium dramatically decreases headache frequency, but it does seem to play a role worth noting.
While we found that higher potassium intake was linked to a lower likelihood of migraines, the relationship appeared to be L-shaped, suggesting that there might be an optimal level of intake rather than a straightforward benefit. There's no strong evidence that potassium dramatically decreases headache frequency, but it does seem to play a role worth noting.
9.5
Potassium channel influence on migraines
We assessed whether levcromakalim, a potassium channel opener, influences migraine attacks in individuals already treated with erenumab. Conducted as a double-blind, placebo-controlled trial, our findings show that a significant number of participants reported migraines after receiving levcromakalim compared to placebo.
Specifically, 88% experienced migraine attacks following levcromakalim, vs. just 12% after the placebo. The study suggests that potassium channel activation may trigger migraine attacks independently of certain receptors typically associated with migraines.
Specifically, 88% experienced migraine attacks following levcromakalim, vs. just 12% after the placebo. The study suggests that potassium channel activation may trigger migraine attacks independently of certain receptors typically associated with migraines.
8
We aimed to see if levcromakalim, a potassium channel opener, could trigger migraine-like headaches in individuals suffering from persistent post-traumatic headaches. In a robust, double-blind trial, participants received either levcromakalim or a placebo on different days and reported their headache experiences.
Surprisingly, over half of those receiving levcromakalim noted migraine-like headaches, marking a significant difference compared to those who received the placebo. This suggests that potassium channels are crucial in these headaches and may pave the way for new treatments using potassium channel blockers.
Surprisingly, over half of those receiving levcromakalim noted migraine-like headaches, marking a significant difference compared to those who received the placebo. This suggests that potassium channels are crucial in these headaches and may pave the way for new treatments using potassium channel blockers.
Most Useful Reviews
8.8
Headache relief benefit
NOW Foods Potassium Gluconate, 99 mg, 250 tablets offer an excellent combination of quality and value. They help maintain water balance and have eliminated my spasms and headaches. My skin feels more hydrated, and I’ve noticed fewer fine lines. I will definitely purchase more.
3.5
Headache concern
Good product, but I experience a headache whenever I drink it. I can’t quite understand why this happens.
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
5.9
- All Researches
9.5
Potassium channel influence on migraines
We assessed whether levcromakalim, a potassium channel opener, influences migraine attacks in individuals already treated with erenumab. Conducted as a double-blind, placebo-controlled trial, our findings show that a significant number of participants reported migraines after receiving levcromakalim compared to placebo.
Specifically, 88% experienced migraine attacks following levcromakalim, vs. just 12% after the placebo. The study suggests that potassium channel activation may trigger migraine attacks independently of certain receptors typically associated with migraines.
Specifically, 88% experienced migraine attacks following levcromakalim, vs. just 12% after the placebo. The study suggests that potassium channel activation may trigger migraine attacks independently of certain receptors typically associated with migraines.
8
We aimed to see if levcromakalim, a potassium channel opener, could trigger migraine-like headaches in individuals suffering from persistent post-traumatic headaches. In a robust, double-blind trial, participants received either levcromakalim or a placebo on different days and reported their headache experiences.
Surprisingly, over half of those receiving levcromakalim noted migraine-like headaches, marking a significant difference compared to those who received the placebo. This suggests that potassium channels are crucial in these headaches and may pave the way for new treatments using potassium channel blockers.
Surprisingly, over half of those receiving levcromakalim noted migraine-like headaches, marking a significant difference compared to those who received the placebo. This suggests that potassium channels are crucial in these headaches and may pave the way for new treatments using potassium channel blockers.
8
We explored the potential connection between dietary potassium intake and the occurrence of severe headaches or migraines. Utilizing data from over 10,000 US adults gathered through a national health survey from 1999 to 2004, we conducted a thorough analysis.
While we found that higher potassium intake was linked to a lower likelihood of migraines, the relationship appeared to be L-shaped, suggesting that there might be an optimal level of intake rather than a straightforward benefit. There's no strong evidence that potassium dramatically decreases headache frequency, but it does seem to play a role worth noting.
While we found that higher potassium intake was linked to a lower likelihood of migraines, the relationship appeared to be L-shaped, suggesting that there might be an optimal level of intake rather than a straightforward benefit. There's no strong evidence that potassium dramatically decreases headache frequency, but it does seem to play a role worth noting.
7
We explored how BK channels might relate to persistent post-traumatic headaches by examining the effects of MaxiPost, a BK channel opener. In a carefully designed study, participants with PPTH received either MaxiPost or a placebo during two sessions, separated by a week.
We found that MaxiPost could induce migraine-like headaches in individuals with PPTH, highlighting a potential target for new headache treatments through BK channel blockade. Further research is necessary to understand this connection and its therapeutic implications.
We found that MaxiPost could induce migraine-like headaches in individuals with PPTH, highlighting a potential target for new headache treatments through BK channel blockade. Further research is necessary to understand this connection and its therapeutic implications.
7
Potassium channel activation may induce headaches
We explored whether opening potassium channels could trigger cluster headache attacks. In a trial involving 41 participants divided into different headache categories, we administered levcromakalim, a potassium channel opener, or a placebo on separate days.
Our findings were intriguing; 60% of those with episodic cluster headaches experienced attacks after levcromakalim, compared to just 10% with the placebo. For chronic headache patients, 29% reported attacks post-levcromakalim, while those in remission showed no significant effects.
These results suggest that activating potassium channels can induce headaches in certain groups, highlighting a possible new avenue for treatment strategies.
Our findings were intriguing; 60% of those with episodic cluster headaches experienced attacks after levcromakalim, compared to just 10% with the placebo. For chronic headache patients, 29% reported attacks post-levcromakalim, while those in remission showed no significant effects.
These results suggest that activating potassium channels can induce headaches in certain groups, highlighting a possible new avenue for treatment strategies.
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Headache relief benefit
NOW Foods Potassium Gluconate, 99 mg, 250 tablets offer an excellent combination of quality and value. They help maintain water balance and have eliminated my spasms and headaches. My skin feels more hydrated, and I’ve noticed fewer fine lines. I will definitely purchase more.
3.5
Headache concern
Good product, but I experience a headache whenever I drink it. I can’t quite understand why this happens.
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Al-Khazali HM, Christensen RH, Dodick DW, Chaudhry BA, Melchior AG, et al. Hypersensitivity to BK channel opening in persistent post-traumatic headache. J Headache Pain. 2024;25:102. doi:10.1186/s10194-024-01808-0
- Kokoti L, Al-Karagholi MA, Zhuang ZA, Amirguliyev S, Amin FM, et al. Non-vascular ATP-sensitive potassium channel activation does not trigger migraine attacks: A randomized clinical trial. Cephalalgia. 2024;44:3331024241248211. doi:10.1177/03331024241248211
- Haghdoost F, Gnanenthiran SR, Shan S, Kaistha P, Huang L, et al. The effect of salt substitution on frequency and severity of headache: results from the SSaSS cluster-randomised controlled trial of 20,995 participants. Eur J Clin Nutr. 2024;78:401. doi:10.1038/s41430-024-01419-7
- Raffaelli B, Do TP, Chaudhry BA, Amin FM, Ashina H, et al. Activation of ATP-sensitive potassium channels triggers migraine attacks independent of calcitonin gene-related peptide receptors: a randomized placebo-controlled trial. Cephalalgia. 2024;44:3331024231222916. doi:10.1177/03331024231222916
- Al-Khazali HM, Deligianni CI, Pellesi L, Al-Karagholi MA, Ashina H, et al. Induction of cluster headache after opening of adenosine triphosphate-sensitive potassium channels: a randomized clinical trial. Pain. 2024;165:1289. doi:10.1097/j.pain.0000000000003130
- Al-Khazali HM, Christensen RH, Dodick DW, Chaudhry BA, Burstein R, et al. Hypersensitivity to opening of ATP-sensitive potassium channels in post-traumatic headache. Cephalalgia. 2023;43:3331024231210930. doi:10.1177/03331024231210930
- Xu L, Zhang C, Liu Y, Shang X, Huang D. Association between dietary potassium intake and severe headache or migraine in US adults: a population-based analysis. Front Nutr. 2023;10:1255468. doi:10.3389/fnut.2023.1255468
