NOW Supplements Selenium

The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.

Most Relevant Research

We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.

The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.

We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.

Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.

9.5

Significant hair recovery

Most Useful Review

After suffering from covid, my wife was told by a doctor that her hair was beyond saving. After researching and trying various treatments, I decided to give her selenium in a 100mcg capsule, three times a day. Within a month, she noticed significant improvements - her dry, itchy scalp cleared up, and new hair began growing, bringing back her confidence and lifting her mood. I strongly recommend selenium to anyone facing similar issues; it genuinely worked wonders for us.

Bruise details

Good vitamins at a reasonable price. Once advised at work, they are now essential for me in winter and spring. I feel better; the bruises under my eyes have vanished, and I no longer suffer from insomnia. Highly recommend.

Cancer details

SCIENTIFIC SCORE

Moderately Effective

Based on 14 Researches

Selenium drug shows selective toxicity

Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy.

Most Relevant Research

We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.

The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.

Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.

9.5

Anti-cancer properties

Most Useful Review

Selenium is recognised for its potent anti-cancer properties and is effective in preventing various diseases. Its roles in DNA repair and enhancing immune functions, along with antioxidant benefits, imply selenium's significant role in cancer prevention. Studies indicate that a daily intake of 200 mcg can notably lower the risk of colorectal, prostate, and lung cancers while reducing overall cancer-related mortality.

Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Most Relevant Research

We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.

Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.

Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.

However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.

8.8

Reduced hair loss

Most Useful Review

I have been taking selenium for two years as prescribed by my endocrinologist for hypothyroidism, with 1 tablet at breakfast. I chose this brand for being yeast-free, affordable, and containing selenomethionine, which is better absorbed. I’ve noticed less hair loss and more energy; even with hormones, I previously faced chronic fatigue. It's especially effective in tandem with Vitamin D. Selenium is a powerful antioxidant critical for glutathione’s functioning and assists in removing heavy metals and chemicals from the body.

Leg Cramps details

I have been purchasing this for my mother for many years, as she suffers greatly from knee pain. Once she starts taking it, the pain just flies away. Hence, she completes at least three months of courses followed by a break of one to two months. The capsules are not large, making them easy to swallow, and there have been no side effects—only positive progress with no pain in her legs. I highly recommend it.

Migraine details

Migraine relief achieved

Most Useful Review

Fine! I appreciated Selenium from this company immensely; my family and I enjoy it together. Alongside, we take Omega and D3 with K2, as well as Yodomarin and Aevit from Russian manufacturers. Regarding efficacy, I was utterly exhausted for a long period, lying in bed without the strength or motivation for daily chores. Now, I wake up refreshed and am active throughout the day! After suffering from migraines for the past four years, particularly with weather changes, I found relief once I introduced Selenium and D3K2. I'm also pleased to say hangovers are a thing of the past; I wake up fresher and more cheerful than ever. I highly recommend staying active and healthy!

Whooping Cough details

Effective aftereffects relief

Most Useful Review

Oh my, after I contracted Corona, I was left with a cough, fatigue, and struggled with the aftereffects. I purchased this supplement due to its selenium content, known for its excellent anti-inflammatory and antioxidant properties. After taking one for breakfast and lunch, I found the aftereffects of Corona had disappeared. I also noticed a reduction in unpleasant secretions during menstruation, so I can confidently say that the effect was very positive.

Arteriosclerosis details

Cardiovascular protection

Most Useful Review

Selenium is an essential trace element beneficial to metabolic health. Once converted into selenoproteins, it fights free radicals and enhances metabolic circulation, thus supporting overall health. Selenium prevents arteriosclerosis, reduces inflammation, and mitigates cardiovascular disease risks. It also maintains thyroid function, as the thyroid contains the most selenium, and correct supplementation can avert thyroiditis. Additionally, its remarkable antioxidant properties can diminish acne incidents, promote bone health, and bolster the immune system through antioxidant support.

Chronic Fatigue Syndrome details

After two months of selenium, I feel fantastic. My skin glows, my mood has improved, and my fatigue has dissipated. I believe this is one of the best products for overall health maintenance, and the tablets are easy to swallow.

Eczema details

SCIENTIFIC SCORE

Questionable

Based on 4 Researches

Selenium's combined benefits for sheep

Evaluation of intraruminal devices for combined facial eczema control and trace element supplementation in sheep.

Most Relevant Research

We explored the use of intraruminal devices containing zinc oxide, designed to prevent facial eczema in sheep while also addressing trace element deficiencies. Specifically, we looked at how adding selenium and cobalt to these devices might improve the health of pregnant ewes by monitoring changes in blood selenium and serum Vitamin B12 levels.

The devices we tested included 16.4 mg of selenium, in the form of sodium selenate, and 20.4 mg of cobalt, provided as cobalt sulfate. Our findings revealed that these devices were effective in raising and sustaining higher blood selenium levels for at least 84 days, with notable increases in serum Vitamin B12 for up to 42 days.

This dual action means that the devices not only offer protection against facial eczema but also help prevent trace element deficiencies in sheep, demonstrating a valuable approach for improving overall animal health.

9.5

Rapid improvement

Most Useful Review

I get eczema on my hands from heavy metals like nuts and cocoa. I had trouble with my hand eczema for more than a month, but after starting selenium, my fingers returned to their original clean state within a few days, much to my family’s surprise! Selenium aids detoxification and the excretion of heavy metals such as mercury, cadmium, lead, and arsenic. It has a strong antioxidant effect that protects blood vessels and skin from oxidative damage. I take 1-2 pills a day and plan to continue.

Frozen Shoulder details

Neck tightness alleviated

Most Useful Review

I bought selenium casually, and it works wonders—it’s now my favourite supplement. For years, I struggled with stiff shoulders and neck that nothing could resolve. When I stop taking it, my neck tightens again, so I believe it is the effect of selenium. I will continue using it.

Hypertension details

Supports cardiovascular health

Most Useful Review

Selenium is a microelement that carries out crucial functions in the body. It is essential for hormones and enzymes, protects cells from damage, and helps prevent ageing processes. It's vital for maintaining the beauty and health of skin, hair, and nails, as well as being necessary for arrhythmia, coronary heart disease, hypertension, and atherosclerosis. Selenium aids in fat metabolism and cholesterol regulation, protecting blood vessels and heart muscle from harm, while also reducing the risk of developing hypertension. We are pleased with the quality; I recommend it!

Liver Disease details

Liver health improved

Most Useful Review

Selenium, along with N-acetylcysteine, aids glutathione production. Although children can produce it, those over 60 struggle. I originally bought N-Acetylcysteine, which is pricey, but selenium is affordable and ideal for daily use. Since adding it with zinc, I've notably improved my liver function, and I rarely catch colds.

SCIENTIFIC SCORE

Possibly Effective

Based on 11 Researches

Antidiabetic effects of selenium

Physicochemical properties, structural characterization, and antidiabetic activity of selenylated low molecular weight apple pectin in HFD/STZ-induced type 2 diabetic mice.

Most Relevant Research

We investigated the impact of a novel selenylated low molecular weight apple pectin on diabetes management. The study focused on mice induced with type 2 diabetes through a high-fat diet and streptozotocin treatment.

Our findings revealed that this modified pectin significantly improved several diabetic symptoms. It reduced weight loss, lower blood sugar levels, and oxidative stress, while also protecting organs like the liver and kidneys.

Additionally, we observed enhanced glucose tolerance and improvements in lipid metabolism and insulin sensitivity among the mice receiving the treatment. The selenylated apple pectin not only had a notable effect on glucose metabolism but also appeared to offer protective benefits against inflammation and tissue damage.

9.5

Reduces oxidative stress

Most Useful Review

Selenium aids in glutathione production and immune function, vital for combating infections and cancer prevention. It improves insulin sensitivity, which is essential for diabetes management. A selenium deficiency can elevate diabetes risk and other health concerns, thus maintaining adequate levels is important.

Heart Attack details

SCIENTIFIC SCORE

Possibly Effective

Based on 14 Researches

Selenium nanoparticles for heart health

A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction.

Most Relevant Research

We examined the role of selenium in treating myocardial infarction (MI), a major cause of death worldwide that can lead to serious heart problems. The study focused on how this antioxidant works across different phases of a heart attack, where harmful reactive oxygen species (ROS) play a significant role in worsening the condition.

Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.

Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.

9.5

Keeps heart healthy

Most Useful Review

Keeps my HEART healthy!!! Works wonderfully!

Kidney Stones details

For me, selenium has proven to be exceptional. I struggled with soreness in the small joints of my arms and legs, muscle pain, and kidney issues (urolithiasis), as well as thyroid problems (hypothyroidism). Since taking selenium, I can now walk for hours without the heaviness in my legs that I used to feel. Previously, I would desperately search for a chair after an hour’s walk, but now I can even work on my PC for long periods without experiencing tunnel syndrome.

Osteoporosis details

This wonderful product provides essential elements for the body, improving fertility and aiding in weight loss. It also promotes hair growth and is beneficial for osteoporosis. Overall, it is a fantastic product and represents great value for the price.

Pneumonia details

Visible health benefits

Most Useful Review

I have been purchasing this product for my father for some time, and I have seen very effective results. His skin condition and overall health stabilised significantly after his battle with pneumonia.

Sleep Apnea details

Sleep improved significantly

Most Useful Review

I have a thyroid problem and take selenium as prescribed by my doctor. This drug has been effective; my nodes have decreased, chronic fatigue is gone, my sleep has improved, and the uncomfortable lump in my throat has subsided. The price is very reasonable compared to other medications, and I definitely recommend this product.

Ulcer details

Selenium enhances the production of thyroid hormones and iodine absorption, exhibiting antiviral and antioxidant effects. It plays a vital role in the immune system and positively impacts the treatment of chronic conditions such as pyelonephritis, chronic obstructive bronchitis, gastritis, duodenal ulcer, and chronic gastroduodenitis.

Angina details

Best! It's easy to consume, and I have ordered it multiple times. Its effectiveness is proven; I have almost forgotten what a sore throat feels like! This is especially significant considering my chronic angina. The quality for the price is excellent!

Brain Tumor details

Selenium improves immunity and brain function. Initially purchased for immunity, I've learned it works best with Iodine. It’s crucial for preventing free radicals and maintaining cell health, which plays a vital role in brain function.

Cardiovascular Disease details

Reduces cardiovascular risk

Most Useful Review

Selenium is essential for the heart, immunity, and thyroid gland. It has an antioxidant effect, decreasing free radicals and minimising their harmful impact. This is particularly beneficial for individuals with poor habits, as it reduces the risk of cardiovascular disease. Selenium detoxifies heavy metals, lowers bad cholesterol, and combats oxidative stress and inflammation, providing protection against atherosclerosis and heart-related issues. A top-quality supplement that I highly recommend for overall health!

Multiple Sclerosis details

Selenium is crucial and can effectively alleviate acute pancreatitis. The recommended dosage is 200 mcg, which relieves pancreatic attacks, leading to recovery in three days if combined with fasting. However, taking over 400 mcg daily can be toxic. Selenium also reduces cancer incidence by 40% and acts as an immunomodulator and antioxidant. A deficiency may compromise the body's defence against various diseases, including asthma, oncology, rheumatism, and cardiovascular issues. Furthermore, it helps eliminate toxic metals such as lead and mercury. Low glutathione levels may indicate selenium deficiency, which could also link to sclerosis.

Pancreatitis details

Selenium has been shown to enhance the antioxidant defence, improving skin and hair conditions. It positively impacts various conditions, including hepatitis and pancreatitis, and supports overall health. An adult's daily intake should be 70-100 mcg, with adjustments during pregnancy.

Allergies details

SCIENTIFIC SCORE

Moderately Effective

Based on 6 Researches

Selenium nanoparticles reduce allergies

Translational Selenium Nanoparticles to Attenuate Allergic Dermatitis through Nrf2-Keap1-Driven Activation of Selenoproteins.

Most Relevant Research

We examined how selenium, a trace element known for its role in health, can help those suffering from allergic dermatitis. In our exploration, we focused on how selenium nanoparticles, specifically designed for easier manufacturing and use, can activate the body's natural defenses against allergies.

The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.

Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.

Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.

9.5

Significant improvement

Most Useful Review

I had eczema on my hands due to my heavy metal allergies, especially from nuts and cocoa. After taking selenium, my fingers returned to their clean condition within days, which surprised my family! Selenium aids in detoxifying heavy metals like mercury and protects against oxidative damage. I take 1-2 pills daily and wish to continue.

Alzheimer details

Repairs damaged nerves

Most Useful Review

My physician mentioned that selenium can repair damaged nerves and prevent Alzheimer's. This trace element is incredibly beneficial for overall health.

Arthritis details

Relieves arthritis symptoms

Most Useful Review

I am very pleased with this product. The quality is excellent, and it contains natural ingredients suitable for everyone. It compensates for the benefits of fish due to its omega content, regulates cholesterol levels, and notably relieves arthritis symptoms. The packaging is impressive, and the formula enhances skin and heart health, as well as providing essential minerals. It's a wonderful supplement that I would gladly use again.

Bone Pain details

I bought this for the calls! As someone with gastritis and pancreatic issues, I take ranitidine daily. Eating often leads to pain and vomiting, but with selenium, I’ve forgotten about the discomfort and nausea—even during the holidays! It's like a miracle, not just a pill.

Erectile Dysfunction details

Enhanced erectile function

Most Useful Review

I ordered it for my spouse based on a doctor's recommendation. After three days of use, he noticed an improvement in his overall condition. Drowsiness and apathy disappeared, and morning awakenings have become easier. He has more energy now. The facial rash has cleared up. Additionally, when combined with other supplements, the quality of sperm improved, which is crucial for those planning a pregnancy. His erectile function improved, and sensitivity during intercourse was enhanced, as observed by me.

Hyperthyroidism details

Improved thyroid levels

Most Useful Review

Excellent! Ever since I learned that selenium can reduce antibodies and peroxidase related to Hashimoto’s hyperthyroidism, and also protect the thyroid gland, I have been purchasing it for my mother. The peroxidase is now normal, though the antibody level remains slightly high. However, it’s already a significant improvement as medication alone couldn't achieve this. I am very satisfied with the effects of selenium.

Menopause details

Regulates hormones effectively

Most Useful Review

I purchased this product at my doctor's recommendation. After ensuring the ingredient quality and dosage were correct, I've noticed significant improvements, especially in my hormonal regulation. Taken with other supplements, it greatly alleviated my menopause symptoms and their frequency. The taste is quite pleasant, making it easy to consume.

Psoriasis details

This product is fantastic for skin conditions! It helped me with my psoriasis and acne.

Headache details

Headaches completely gone

Most Useful Review

I've had Graves ophthalmopathy for a year, and after taking selenium for six months, my condition has dramatically improved. I had bulging eyes, swelling, and constant headaches, but now my eyes look normal—I can even fully open them without experiencing headaches or pressure anymore. I took 100 mcg in the morning and another 100 mcg in the evening with meals, and it worked wonders for me.

Constipation details

Constipation improvement

Most Useful Review

I really appreciated this product; I've been taking it for over two weeks, and I can feel the results. Having suffered from constipation for ages and tried various remedies, my nutritionist recommended this supplement. Since taking it alongside omega-3 and vitamin D3, I experience almost no constipation now.

Prostate Cancer details

SCIENTIFIC SCORE

Possibly Effective

Based on 15 Researches

Selenium nanoparticles show promise

Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells.

Most Relevant Research

We explored the impact of selenium nanoparticles, known for their potential anti-cancer properties, on aggressive prostate cancer cells, specifically the PC-3 line. The study focused on understanding how sub-toxic levels of selenium functionalized nanoparticles affect cell proliferation and their intracellular behavior.

By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.

This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.

Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.

6.8

Increases semen volume

Most Useful Review

I noticed a significant increase in semen volume when taking it, likely due to enhanced prostate fluid. I recommend it for its antioxidant and detoxifying properties.