We examined how selenium, a trace element known for its role in health, can help those suffering from allergic dermatitis. In our exploration, we focused on how selenium nanoparticles, specifically designed for easier manufacturing and use, can activate the body's natural defenses against allergies.
The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.
Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.
Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.
Read More
9
Selenium polysaccharides reduce allergies
Se-rich tea polysaccharide extracted by high hydrostatic pressure attenuated anaphylaxis by improving gut microbiota and metabolic regulation.
We explored the role of selenium-rich tea polysaccharides (Se-TPS) in managing allergies, focusing on how they influence immune responses and gut health. Using a method called high hydrostatic pressure, we extracted Se-TPS at a pressure of 400 MPa for a specific duration. This process allowed us to isolate several polysaccharide components, particularly Se-TPS3-4, which turned out to be the most effective.
Our research involved both laboratory experiments and tests on mice sensitized to a specific allergen. We observed that these polysaccharides reduced the release of various inflammatory substances, including histamine and interleukin-4, both of which are known to play roles in allergic reactions. In the treated mice, levels of undesirable immune markers decreased, while those associated with a balanced immune response increased.
Importantly, we found that Se-TPS also encouraged the growth of beneficial gut bacteria, such as Lactobacillus, while enhancing metabolites that can support overall gut health. These findings indicate the strong potential of selenium-rich tea polysaccharides as a natural way to reduce allergic reactions by improving immune balance and gut microbiota.
Read More
9
Selenium influences milk allergy response
Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow's Milk Allergy.
We investigated the impact of dietary selenium on cow's milk allergy, a common condition affecting infants. In our study, we used a mouse model and sensitized three-week-old female C3H/HeOuJ mice with whey protein and cholera toxin. These mice were then divided into groups and fed diets with varying levels of selenium: control, low, medium, or high.
After subjecting the mice to a whey challenge, we noted some interesting changes. Notably, the body temperature of mice on a medium selenium diet was significantly higher 60 minutes post-challenge, suggesting a less severe allergic reaction. We also observed decreased levels of allergen-specific immunoglobulin E and reduced release of mouse mast cell protease-1, indicating a dampened immune response.
This research points towards selenium supplementation as a potential method to modulate allergic reactions to whey. By lowering specific antibody responses and mast cell activity, selenium might help lessen the severity of allergies associated with cow's milk. Overall, our findings could open up new avenues for managing food allergies effectively.
Read More
Most Useful Reviews
9
Significant improvement
44 people found this helpful
I had eczema on my hands due to my heavy metal allergies, especially from nuts and cocoa. After taking selenium, my fingers returned to their clean condition within days, which surprised my family! Selenium aids in detoxifying heavy metals like mercury and protects against oxidative damage. I take 1-2 pills daily and wish to continue.
Read More
9
Hoping for results
I take this as directed by my doctor, and it has not caused any allergies. I am hopeful for positive test results.
Read More
9
Protects cells
Selenium protects cells against free radicals and contributes to healthy aging. The tablet size is average, and the supplement does not trigger allergies.
We explored the role of selenium-rich tea polysaccharides (Se-TPS) in managing allergies, focusing on how they influence immune responses and gut health. Using a method called high hydrostatic pressure, we extracted Se-TPS at a pressure of 400 MPa for a specific duration. This process allowed us to isolate several polysaccharide components, particularly Se-TPS3-4, which turned out to be the most effective.
Our research involved both laboratory experiments and tests on mice sensitized to a specific allergen. We observed that these polysaccharides reduced the release of various inflammatory substances, including histamine and interleukin-4, both of which are known to play roles in allergic reactions. In the treated mice, levels of undesirable immune markers decreased, while those associated with a balanced immune response increased.
Importantly, we found that Se-TPS also encouraged the growth of beneficial gut bacteria, such as Lactobacillus, while enhancing metabolites that can support overall gut health. These findings indicate the strong potential of selenium-rich tea polysaccharides as a natural way to reduce allergic reactions by improving immune balance and gut microbiota.
Read More
9
Selenium nanoparticles reduce allergies
Translational Selenium Nanoparticles to Attenuate Allergic Dermatitis through Nrf2-Keap1-Driven Activation of Selenoproteins.
We examined how selenium, a trace element known for its role in health, can help those suffering from allergic dermatitis. In our exploration, we focused on how selenium nanoparticles, specifically designed for easier manufacturing and use, can activate the body's natural defenses against allergies.
The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.
Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.
Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.
Read More
9
Selenium influences milk allergy response
Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow's Milk Allergy.
We investigated the impact of dietary selenium on cow's milk allergy, a common condition affecting infants. In our study, we used a mouse model and sensitized three-week-old female C3H/HeOuJ mice with whey protein and cholera toxin. These mice were then divided into groups and fed diets with varying levels of selenium: control, low, medium, or high.
After subjecting the mice to a whey challenge, we noted some interesting changes. Notably, the body temperature of mice on a medium selenium diet was significantly higher 60 minutes post-challenge, suggesting a less severe allergic reaction. We also observed decreased levels of allergen-specific immunoglobulin E and reduced release of mouse mast cell protease-1, indicating a dampened immune response.
This research points towards selenium supplementation as a potential method to modulate allergic reactions to whey. By lowering specific antibody responses and mast cell activity, selenium might help lessen the severity of allergies associated with cow's milk. Overall, our findings could open up new avenues for managing food allergies effectively.
Read More
9
Selenium compound reduces allergy symptoms
Suppressive effect of 1,4-anhydro-4-seleno-D-talitol (SeTal) on atopic dermatitis-like skin lesions in mice through regulation of inflammatory mediators.
We explored how a novel water-soluble selenium compound, known as SeTal, impacts atopic dermatitis (AD), a common allergic skin condition. In experiments, we applied 2,4-dinitrochlorobenzene (DNCB) to sensitized mice, creating a model for AD symptoms. By treating these mice with either SeTal or hydrocortisone, we aimed to measure the severity of skin lesions and related inflammation.
The results were compelling. SeTal, at concentrations of 1% and 2%, showed significant effectiveness in reducing the symptoms and inflammatory indicators of AD. In fact, the results were comparable to, and in some cases, even better than the results achieved with hydrocortisone, a traditional steroid treatment often used for such conditions.
This study suggests that SeTal could offer a promising alternative for treating atopic dermatitis, providing a new avenue for those seeking relief from this chronic and often bothersome allergy-related skin issue. With common steroid treatments posing potential side effects, our findings around SeTal support exploring safer, more effective options in the future.
Read More
9
Selenium reduces allergy responses
Supplementary seleno-L-methionine suppresses active cutaneous anaphylaxis reaction.
We examined how seleno-L-methionine, a form of selenium, impacts allergic reactions. In our study, female mice were sensitized to a common allergen, ovalbumin, and then given selenium for two weeks before being re-exposed to the allergen to trigger an allergic response.
Our findings showed that selenium significantly reduced allergic reactions in a dose-dependent manner, cutting down specific immune responses associated with allergies. Notably, levels of certain inflammatory markers decreased, suggesting selenium might help regulate allergic responses in the body.
I had eczema on my hands due to my heavy metal allergies, especially from nuts and cocoa. After taking selenium, my fingers returned to their clean condition within days, which surprised my family! Selenium aids in detoxifying heavy metals like mercury and protects against oxidative damage. I take 1-2 pills daily and wish to continue.
Read More
9
Hoping for results
I take this as directed by my doctor, and it has not caused any allergies. I am hopeful for positive test results.
Read More
9
Protects cells
Selenium protects cells against free radicals and contributes to healthy aging. The tablet size is average, and the supplement does not trigger allergies.
Read More
7.5
No adverse effects
Excellent! A good complex, brand, and composition. Easy to swallow and does not cause allergies or discomfort.
Read More
9
Especially beneficial
This is a good supplement, particularly beneficial for those with nut allergies.
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Selenium is a powerful and widely used open-source tool designed for automating web applications for testing purposes. It enables developers and testers to write code in various programming languages such as Java, Python, C#, and Ruby to simulate user interactions with a web browser. Selenium's flexibility allows users to create complex test scenarios that mimic real-world user behaviors, making it an essential tool for ensuring web application functionality and performance.
In addition to its core functionalities, Selenium consists of several components, including Selenium WebDriver for automating browsers, Selenium Grid for running tests across multiple machines and environments in parallel, and Selenium IDE for record-and-playback test creation. Its compatibility with multiple browser types—such as Chrome, Firefox, Safari, and Edge—makes it a versatile choice for automated testing, catering to a wide range of projects and team needs. For anyone involved in web development or quality assurance, understanding and utilizing Selenium can significantly improve testing efficiency and reliability.
Users report varying timelines for seeing results when taking selenium as a supplement for allergies. One user noted significant improvement regarding their heavy metal allergies within just a few days, mentioning their eczema on hands cleared up surprisingly fast after starting the supplement Read Review. While this anecdote suggests that some individuals may experience rapid effects, other users are more cautious, mentioning the need for patience and continued monitoring for efficacy, especially if one is hoping for long-term allergy relief or improved immune function Read Review.
On the whole, experiences with selenium supplementation can differ greatly based on individual body responses and specific allergy triggers. Some users have reported favorable outcomes without immediate side effects Read Review, while others express uncertainty or caution, suggesting trial and careful observation are essential Read Review. Therefore, if you're considering using selenium for allergy relief, it may take anywhere from a few days to weeks to notice changes, depending on your unique circumstances.
Current scientific research suggests that selenium may play a beneficial role in managing certain allergic conditions. For instance, a comprehensive study demonstrated that higher serum selenium concentrations are associated with a reduced risk of allergic rhinitis, indicating its potential usefulness in this specific allergy [1]. Additional evidence supports selenium's impact on food allergies, with studies showing it helps modulate allergic responses to whey proteins in mice [5]. Furthermore, prenatal selenium exposure was linked with a decreased risk of allergic diseases like atopic dermatitis and allergic rhinitis in children [3].
Moreover, selenium-rich tea polysaccharides have shown promise in reducing histamine release and promoting a balanced immune response, suggesting that this form of selenium may also aid in allergy management [2]. Other studies explored novel selenium compounds, finding significant reductions in allergic reactions, indicating a pathway toward developing effective treatments for allergic conditions, including allergic dermatitis [4]. While the results are promising, they emphasize the need for continued research to unravel the complexities of mercury's interactions and the broader implications of selenium supplementation in allergy prevention and management.
Based on user reviews, many individuals have shared positive improvements in their symptoms after taking selenium supplements. One user noted that their eczema due to heavy metal allergies cleared up surprisingly quickly, within just a few days, after starting their selenium regimen Read Review. Another user with a nickel allergy reported significant benefits from the supplement, allowing them to better tolerate other necessary nutrients like iodine Read Review.
While some users had very positive experiences, others emphasized the need for caution due to allergic reactions, with one individual expressing that they experienced itching after taking the product Read Review. Overall, while many report relief and health benefits, results can vary widely depending on the individual's sensitivities and specific health conditions. Therefore, it's essential to approach selenium supplementation thoughtfully, considering personal health backgrounds and monitoring for any adverse effects.
Based on user reviews, individuals have reported mixed experiences when combining selenium with other supplements to manage allergies. Some users found that selenium helped them tolerate additional nutrients better, especially in the case of those with specific allergies. For instance, one user mentioned that selenium greatly assists with their nickel allergy, allowing for better tolerance of iodine, a necessary nutrient for them Read Review. Another review highlighted the use of selenium to alleviate allergy symptoms in a family member during spring, showcasing its potential as a complementary supplement in allergy management Read Review.
However, caution is advised, as some users experienced allergic reactions themselves while using this supplement. One review described experiencing itching and discomfort, indicating that not all users may react positively to selenium Read Review. Additionally, another user expressed that they faced similar reactions and suggested starting with smaller doses to assess suitability Read Review. Thus, while there are positive reports of combining selenium with other supplements to manage allergy symptoms, individual reactions can vary significantly, warranting a careful approach when introducing new supplements.
Based on user reviews, there appears to be a varied approach to determining the right dose of selenium for treating allergies. Some users reported positive experiences taking 1-2 pills daily, highlighting its effectiveness in alleviating symptoms related to allergies, such as eczema from heavy metal sensitivities. One user noted a significant improvement in their skin condition within days of starting a selenium regimen, stating, "I take 1-2 pills daily and wish to continue" Read Review. Another user recommended that their mother take one pill each evening to help alleviate her spring allergies after following similar advice from health experts Read Review.
However, it’s important to note that not all experiences have been positive. Some users have reported allergic reactions after taking selenium, indicating that those with sensitivities may need to start with a lower dose or a smaller package to gauge their tolerance Read Review. Overall, while many found selenium beneficial for managing allergy symptoms, it is advisable for individuals to consult healthcare professionals before starting supplementation, especially if they have a history of allergies.
9
Significant improvement
44 people found this helpful
I had eczema on my hands due to my heavy metal allergies, especially from nuts and cocoa. After taking selenium, my fingers returned to their clean condition within days, which surprised my family! Selenium aids in detoxifying heavy metals like mercury and protects against oxidative damage. I take 1-2 pills daily and wish to continue.
7.5
Raised immunity
1 people found this helpful
A wonderful product that I can take once or twice a year. I bought it for my mother to alleviate her spring allergies and boost her immunity. She takes a pill every evening, and selenium is vital for maintaining thyroid function, as advised by Dr. Berg and Dr. Karim.
7.5
Perfect match
The Now brand is an excellent supplement for me. I usually react to many supplements, but this one does not cause me issues. It greatly helps with my nickel allergy and allows me to tolerate the iodine I need.
2
Causes allergy symptoms
Selenium works well but causes allergic reactions for me. I should try the smallest package to see if it's suitable. The quality is good, ingredients are well composed, and the taste is acceptable.
0
Did not suit me
Unfortunately, the product did not suit me, as I experienced an allergy and itching in certain areas of my body.
7
Selenium's role in allergy management
Micronutrients and Allergic Diseases: A Mendelian Randomization Study.
We explored the connection between selenium, a key dietary micronutrient, and its effects on three common allergic diseases: allergic asthma, atopic dermatitis, and allergic rhinitis. Using a rigorous Mendelian randomization approach, we aimed to better understand if higher levels of selenium in the body could actually help reduce the risk of these allergies.
Our findings revealed that increased serum selenium concentrations are linked to a lower risk of allergic rhinitis. This suggests that selenium might play a beneficial role in managing this particular allergic condition. It's important to note, however, that while selenium shows promise for allergic rhinitis, we didn't find it connected to significant improvements in allergic asthma or atopic dermatitis.
This study encourages further exploration into how different micronutrients, including selenium, might influence allergic responses. The results highlight the need for ongoing research to clarify the role of dietary supplements in allergy prevention and management.
9
Selenium influences milk allergy response
Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow's Milk Allergy.
We investigated the impact of dietary selenium on cow's milk allergy, a common condition affecting infants. In our study, we used a mouse model and sensitized three-week-old female C3H/HeOuJ mice with whey protein and cholera toxin. These mice were then divided into groups and fed diets with varying levels of selenium: control, low, medium, or high.
After subjecting the mice to a whey challenge, we noted some interesting changes. Notably, the body temperature of mice on a medium selenium diet was significantly higher 60 minutes post-challenge, suggesting a less severe allergic reaction. We also observed decreased levels of allergen-specific immunoglobulin E and reduced release of mouse mast cell protease-1, indicating a dampened immune response.
This research points towards selenium supplementation as a potential method to modulate allergic reactions to whey. By lowering specific antibody responses and mast cell activity, selenium might help lessen the severity of allergies associated with cow's milk. Overall, our findings could open up new avenues for managing food allergies effectively.
8
Prenatal selenium reduces allergy risk
Prenatal exposure to selenium, mercury, and manganese during pregnancy and allergic diseases in early childhood: The Japan Environment and Children's study.
We delved into the connections between prenatal exposure to certain metals—specifically, selenium, mercury, and manganese—and the risk of allergic diseases during early childhood. Using data from 94,794 mother-infant pairs from the Japan Environment and Children's study, we analyzed maternal blood samples taken during mid-pregnancy to assess levels of these metallic elements.
Our findings point to a promising role for selenium: it appears to be linked with a reduced risk of atopic dermatitis, food allergies, allergic rhinitis, and overall allergic diseases in children by their third birthday. Notably, this beneficial effect seems even more pronounced when mercury exposure during pregnancy is lower.
While we also explored the interaction between selenium and mercury, the highlights of our results firmly place selenium in a positive light regarding its potential to mitigate allergy risks in early childhood.
9
Selenium polysaccharides reduce allergies
Se-rich tea polysaccharide extracted by high hydrostatic pressure attenuated anaphylaxis by improving gut microbiota and metabolic regulation.
We explored the role of selenium-rich tea polysaccharides (Se-TPS) in managing allergies, focusing on how they influence immune responses and gut health. Using a method called high hydrostatic pressure, we extracted Se-TPS at a pressure of 400 MPa for a specific duration. This process allowed us to isolate several polysaccharide components, particularly Se-TPS3-4, which turned out to be the most effective.
Our research involved both laboratory experiments and tests on mice sensitized to a specific allergen. We observed that these polysaccharides reduced the release of various inflammatory substances, including histamine and interleukin-4, both of which are known to play roles in allergic reactions. In the treated mice, levels of undesirable immune markers decreased, while those associated with a balanced immune response increased.
Importantly, we found that Se-TPS also encouraged the growth of beneficial gut bacteria, such as Lactobacillus, while enhancing metabolites that can support overall gut health. These findings indicate the strong potential of selenium-rich tea polysaccharides as a natural way to reduce allergic reactions by improving immune balance and gut microbiota.
9
Selenium nanoparticles reduce allergies
Translational Selenium Nanoparticles to Attenuate Allergic Dermatitis through Nrf2-Keap1-Driven Activation of Selenoproteins.
We examined how selenium, a trace element known for its role in health, can help those suffering from allergic dermatitis. In our exploration, we focused on how selenium nanoparticles, specifically designed for easier manufacturing and use, can activate the body's natural defenses against allergies.
The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.
Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.
Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.
References
Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. 10.1159/000540376
Ma J, Zhao M, Wang Y, Lv L, Qin L, et al. Se-rich tea polysaccharide extracted by high hydrostatic pressure attenuated anaphylaxis by improving gut microbiota and metabolic regulation. Int J Biol Macromol. 2024;269:132128. 10.1016/j.ijbiomac.2024.132128
Miyazaki J, Ikehara S, Tanigawa K, Kimura T, Ueda K, et al. Prenatal exposure to selenium, mercury, and manganese during pregnancy and allergic diseases in early childhood: The Japan Environment and Children's study. Environ Int. 2023;179:108123. 10.1016/j.envint.2023.108123
Xie B, Zeng D, Yang M, Tang Z, He L, et al. Translational Selenium Nanoparticles to Attenuate Allergic Dermatitis through Nrf2-Keap1-Driven Activation of Selenoproteins. ACS Nano. 2023;17:14053. 10.1021/acsnano.3c04344
Zhao X, Thijssen S, Chen H, Garssen J, Knippels LMJ, et al. Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow's Milk Allergy. Nutrients. 2021;13. 10.3390/nu13082479
Voss GT, de Oliveira RL, Davies MJ, Domingues WB, Campos VF, et al. Suppressive effect of 1,4-anhydro-4-seleno-D-talitol (SeTal) on atopic dermatitis-like skin lesions in mice through regulation of inflammatory mediators. J Trace Elem Med Biol. 2021;67:126795. 10.1016/j.jtemb.2021.126795
Dubrovina VI, Starovoitova TP, Yur'eva OV, Pyatidesyatnikova AB, Potapov VA, et al. Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV. Bull Exp Biol Med. 2021;171:651. 10.1007/s10517-021-05287-0
Groth S, Budke C, Weber T, Neugart S, Brockmann S, et al. Relationship between Phenolic Compounds, Antioxidant Properties, and the Allergenic Protein Mal d 1 in Different Selenium-Biofortified Apple Cultivars (). Molecules. 2021;26. 10.3390/molecules26092647
Lodge CJ, Dharmage SC. Breastfeeding and perinatal exposure, and the risk of asthma and allergies. Curr Opin Allergy Clin Immunol. 2016;16:231. 10.1097/ACI.0000000000000266
Qin S, Huang B, Ma J, Wang X, Zhang J, et al. Effects of selenium-chitosan on blood selenium concentration, antioxidation status, and cellular and humoral immunity in mice. Biol Trace Elem Res. 2015;165:145. 10.1007/s12011-015-0243-5
Carneiro MF, Rhoden CR, Amantéa SL, Barbosa F. Low concentrations of selenium and zinc in nails are associated with childhood asthma. Biol Trace Elem Res. 2011;144:244. 10.1007/s12011-011-9080-3