Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8
USERS' SCORE
Good
Based on 26 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Selenium (elemental) (from 20 mg L-Selenomethionine)
100 mcg
182%
Top Medical Research Studies
8
This study focused on how selenium-loaded porous silica nanospheres (Se@PSN) could help repair the heart following a myocardial infarction (MI). These tiny particles are designed to neutralize harmful molecules called reactive oxygen species, which play a significant role in heart damage during MI.
We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.
We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.
9
Selenium nanoparticles aid heart recovery
Our exploration focused on the potential of selenium nanoparticles (SeNPs) to reduce damage from ischemia/reperfusion injury, a common aftermath of heart attacks. We found that these SeNPs, introduced through intravenous injection, demonstrated powerful antioxidant and anti-inflammatory effects.
By disrupting a harmful cellular cycle, they protected heart cells and minimized inflammation. In tests, SeNPs not only improved heart function but also decreased cell death and tissue scarring. These findings suggest that selenium nanoparticles could be a valuable addition to heart attack treatments.
By disrupting a harmful cellular cycle, they protected heart cells and minimized inflammation. In tests, SeNPs not only improved heart function but also decreased cell death and tissue scarring. These findings suggest that selenium nanoparticles could be a valuable addition to heart attack treatments.
9
We explored the potential of selenium-doped copper formate (Cuf-Se) nanozymes in treating atherosclerosis, a key contributor to cardiovascular diseases. By targeting inflammation and oxidative stress, Cuf-Se shows promise by reducing reactive oxygen species and preventing the formation of foam cells.
Although this study primarily tests the effectiveness in mice, findings indicate a notable reduction in plaque formation and inflammation. Cuf-Se led to a five-fold decrease in plaque area, highlighting its potential as a novel treatment strategy for atherosclerosis.
Although this study primarily tests the effectiveness in mice, findings indicate a notable reduction in plaque formation and inflammation. Cuf-Se led to a five-fold decrease in plaque area, highlighting its potential as a novel treatment strategy for atherosclerosis.
Most Useful Reviews
9.5
Reduces cardiovascular risk
Selenium is essential for the heart, immunity, and thyroid gland. It has an antioxidant effect, decreasing free radicals and minimising their harmful impact. This is particularly beneficial for individuals with poor habits, as it reduces the risk of cardiovascular disease. Selenium detoxifies heavy metals, lowers bad cholesterol, and combats oxidative stress and inflammation, providing protection against atherosclerosis and heart-related issues. A top-quality supplement that I highly recommend for overall health!
7.5
Boosts overall health
I have incorporated NOW Foods Selenium into my diet for extra health support, following my doctor’s advice, and the results have been gratifying. Selenium is crucial for a robust immune system, combating oxidative stress. After a few weeks, I felt more energetic and alert, without any stomach discomfort from the capsules. I appreciate the high quality and natural ingredients. I will continue using this product, as it significantly benefits my overall health.
9.5
Effective for recovery
My husband bought me selenium while I was unwell, and I found it significantly aids in fighting off viral diseases, allowing for quicker recovery. It has proved very effective for me, especially given its long-term cumulative benefits. I truly view selenium as a blessing for my health.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8
- All Researches
9
Selenium nanoparticles aid heart recovery
Our exploration focused on the potential of selenium nanoparticles (SeNPs) to reduce damage from ischemia/reperfusion injury, a common aftermath of heart attacks. We found that these SeNPs, introduced through intravenous injection, demonstrated powerful antioxidant and anti-inflammatory effects.
By disrupting a harmful cellular cycle, they protected heart cells and minimized inflammation. In tests, SeNPs not only improved heart function but also decreased cell death and tissue scarring. These findings suggest that selenium nanoparticles could be a valuable addition to heart attack treatments.
By disrupting a harmful cellular cycle, they protected heart cells and minimized inflammation. In tests, SeNPs not only improved heart function but also decreased cell death and tissue scarring. These findings suggest that selenium nanoparticles could be a valuable addition to heart attack treatments.
9
We explored the potential of selenium-doped copper formate (Cuf-Se) nanozymes in treating atherosclerosis, a key contributor to cardiovascular diseases. By targeting inflammation and oxidative stress, Cuf-Se shows promise by reducing reactive oxygen species and preventing the formation of foam cells.
Although this study primarily tests the effectiveness in mice, findings indicate a notable reduction in plaque formation and inflammation. Cuf-Se led to a five-fold decrease in plaque area, highlighting its potential as a novel treatment strategy for atherosclerosis.
Although this study primarily tests the effectiveness in mice, findings indicate a notable reduction in plaque formation and inflammation. Cuf-Se led to a five-fold decrease in plaque area, highlighting its potential as a novel treatment strategy for atherosclerosis.
8
Dietary antioxidants reduce mortality risk
We evaluated how dietary antioxidants, including vitamins like C and E, affect mortality risks in individuals with cardiovascular disease (CVD). Our analysis incorporated data from nearly 1,400 participants, using advanced statistical models to determine the connections between antioxidant intake and death rates.
The findings showed that higher levels of dietary antioxidants correlate with a lower risk of dying from CVD. Specifically, those in the highest antioxidant consumption group had significantly reduced mortality risks compared to those with lower intake. This points to the potential benefits of increasing antioxidants in the diet for better health outcomes in those managing CVD.
The findings showed that higher levels of dietary antioxidants correlate with a lower risk of dying from CVD. Specifically, those in the highest antioxidant consumption group had significantly reduced mortality risks compared to those with lower intake. This points to the potential benefits of increasing antioxidants in the diet for better health outcomes in those managing CVD.
8
This study focused on how selenium-loaded porous silica nanospheres (Se@PSN) could help repair the heart following a myocardial infarction (MI). These tiny particles are designed to neutralize harmful molecules called reactive oxygen species, which play a significant role in heart damage during MI.
We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.
We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.
8
Selenium nanoparticles show heart benefits
We evaluated the use of selenium-quantum-dot-loaded silica nanoparticles as a new treatment for myocardial ischemia-reperfusion injury, a serious cardiovascular issue. These nanoparticles showed impressive abilities to scavenge harmful reactive oxygen species and improve heart cell function.
While traditional therapies struggle to target key problems like ferroptosis, the selenium nanoparticles effectively reduced this damage and preserved mitochondrial integrity. Our findings suggest that these nanoparticles could significantly lower heart damage and inflammation, bringing us closer to better treatment options for heart conditions.
While traditional therapies struggle to target key problems like ferroptosis, the selenium nanoparticles effectively reduced this damage and preserved mitochondrial integrity. Our findings suggest that these nanoparticles could significantly lower heart damage and inflammation, bringing us closer to better treatment options for heart conditions.
User Reviews
USERS' SCORE
Good
Based on 26 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Reduces cardiovascular risk
Selenium is essential for the heart, immunity, and thyroid gland. It has an antioxidant effect, decreasing free radicals and minimising their harmful impact. This is particularly beneficial for individuals with poor habits, as it reduces the risk of cardiovascular disease. Selenium detoxifies heavy metals, lowers bad cholesterol, and combats oxidative stress and inflammation, providing protection against atherosclerosis and heart-related issues. A top-quality supplement that I highly recommend for overall health!
7.5
Boosts overall health
I have incorporated NOW Foods Selenium into my diet for extra health support, following my doctor’s advice, and the results have been gratifying. Selenium is crucial for a robust immune system, combating oxidative stress. After a few weeks, I felt more energetic and alert, without any stomach discomfort from the capsules. I appreciate the high quality and natural ingredients. I will continue using this product, as it significantly benefits my overall health.
9.5
Effective for recovery
My husband bought me selenium while I was unwell, and I found it significantly aids in fighting off viral diseases, allowing for quicker recovery. It has proved very effective for me, especially given its long-term cumulative benefits. I truly view selenium as a blessing for my health.
8.8
Prevents aging
Selenium serves as a potent antioxidant, preventing premature ageing and significantly enhancing reproductive health in both genders, while also reducing the risk of cardiovascular disease.
8
Reduces neck swelling
I have a thyroid disease and take selenium, which I find essential. It alleviates the swelling in my neck efficiently. Although too much can cause side effects, I find that a dosage of 100 mcg works well for me and it has less odour than other brands, making it easy to consume.
Frequently Asked Questions
7.5
Boosts overall health
I have incorporated NOW Foods Selenium into my diet for extra health support, following my doctor’s advice, and the results have been gratifying. Selenium is crucial for a robust immune system, combating oxidative stress. After a few weeks, I felt more energetic and alert, without any stomach discomfort from the capsules. I appreciate the high quality and natural ingredients. I will continue using this product, as it significantly benefits my overall health.
9.5
Effective for recovery
My husband bought me selenium while I was unwell, and I found it significantly aids in fighting off viral diseases, allowing for quicker recovery. It has proved very effective for me, especially given its long-term cumulative benefits. I truly view selenium as a blessing for my health.
8.8
Stable condition
After reading Tokumi Fujikawa's blog about its benefits for heart disease, I purchased this supplement immediately. I feel that my physical condition has stabilised, and I take it every day. Thank you.
8.8
Improved Hashimoto symptoms
Excellent quality—this mineral notably alleviated my Hashimoto's disease symptoms.
8.8
Essential for immunity
Selenium plays a critical role in supporting thyroid health, immunity, and metabolism, boasting anti-inflammatory effects. It's an essential trace element, and while monitoring its levels is important, I found that the small daily dosage led to an increase in body selenium. The results confirm its effectiveness, reinforcing my choice of this product, which has helped me feel better overall.
8
Supports reproductive health
Selenium is an essential trace element that serves as an antioxidant, protecting the body from free radicals. It positively impacts reproductive health in both men and women, improving fertility and sperm motility. Moreover, selenium notably reduces the risk of cardiovascular and oncological diseases. I also take it in combination with zinc, vitamin C, and D to support my immune system and address thyroid problems.
9.5
Improves thyroid function
With a thyroid disease diagnosis, I'm committed to ongoing selenium supplementation along with omega, lecithin, vitamin D, and magnesium. The results are a marked improvement in my wellbeing. I happily recommend this selenium product.
7.5
Good antioxidant benefits
My husband and I take selenium together on our doctor's advice primarily to prevent cardiovascular diseases. It acts as a good antioxidant, enhancing our immune systems without causing side effects. Since we supplement with other health products, it's tough to isolate the benefits attributed solely to this supplement. Despite that, I trust this brand for its quality and effectiveness in promoting health.
8
Reduces neck swelling
I have a thyroid disease and take selenium, which I find essential. It alleviates the swelling in my neck efficiently. Although too much can cause side effects, I find that a dosage of 100 mcg works well for me and it has less odour than other brands, making it easy to consume.
7.5
Detoxifies heavy metals
As a mother to a heart disease sufferer, I started taking selenium based on research linking it to heart health. I consume it alongside a protein foundation. Selenium aids in detoxifying heavy metals, and I find no issues with a daily intake of about 200 milligrams. While the taste is somewhat bitter, I manage to take it without complaint, and I sincerely hope for positive results.
8.8
Reduces inflammation
NOW Foods’ selenium supplement may have numerous health benefits due to its antioxidant properties. It assists in cardiovascular health by reducing inflammation and oxidative stress, which can positively impact heart health and lower the risk of cardiovascular disease.
7
Boosts immunity
Selenium is a powerful antioxidant that stimulates the thyroid gland, enhances immunity, and aids reproductive functions. An adult's daily requirement is around 60 mg, while infants require about 20 mg. Overconsumption can be toxic, with a maximum recommended intake of 400 mg daily for adults. Selenium deficiency, particularly in regions like Russia, can lead to increased susceptibility to free radicals, contributing to rheumatoid arthritis and cardiovascular disease. Moreover, a shortage may impair thyroid function, leading to a slowed metabolism and weight gain.
8
Dietary antioxidants reduce mortality risk
We evaluated how dietary antioxidants, including vitamins like C and E, affect mortality risks in individuals with cardiovascular disease (CVD). Our analysis incorporated data from nearly 1,400 participants, using advanced statistical models to determine the connections between antioxidant intake and death rates.
The findings showed that higher levels of dietary antioxidants correlate with a lower risk of dying from CVD. Specifically, those in the highest antioxidant consumption group had significantly reduced mortality risks compared to those with lower intake. This points to the potential benefits of increasing antioxidants in the diet for better health outcomes in those managing CVD.
The findings showed that higher levels of dietary antioxidants correlate with a lower risk of dying from CVD. Specifically, those in the highest antioxidant consumption group had significantly reduced mortality risks compared to those with lower intake. This points to the potential benefits of increasing antioxidants in the diet for better health outcomes in those managing CVD.
8
This study focused on how selenium-loaded porous silica nanospheres (Se@PSN) could help repair the heart following a myocardial infarction (MI). These tiny particles are designed to neutralize harmful molecules called reactive oxygen species, which play a significant role in heart damage during MI.
We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.
We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.
9
Selenium nanoparticles aid heart recovery
Our exploration focused on the potential of selenium nanoparticles (SeNPs) to reduce damage from ischemia/reperfusion injury, a common aftermath of heart attacks. We found that these SeNPs, introduced through intravenous injection, demonstrated powerful antioxidant and anti-inflammatory effects.
By disrupting a harmful cellular cycle, they protected heart cells and minimized inflammation. In tests, SeNPs not only improved heart function but also decreased cell death and tissue scarring. These findings suggest that selenium nanoparticles could be a valuable addition to heart attack treatments.
By disrupting a harmful cellular cycle, they protected heart cells and minimized inflammation. In tests, SeNPs not only improved heart function but also decreased cell death and tissue scarring. These findings suggest that selenium nanoparticles could be a valuable addition to heart attack treatments.
8
Selenium nanoparticles show heart benefits
We evaluated the use of selenium-quantum-dot-loaded silica nanoparticles as a new treatment for myocardial ischemia-reperfusion injury, a serious cardiovascular issue. These nanoparticles showed impressive abilities to scavenge harmful reactive oxygen species and improve heart cell function.
While traditional therapies struggle to target key problems like ferroptosis, the selenium nanoparticles effectively reduced this damage and preserved mitochondrial integrity. Our findings suggest that these nanoparticles could significantly lower heart damage and inflammation, bringing us closer to better treatment options for heart conditions.
While traditional therapies struggle to target key problems like ferroptosis, the selenium nanoparticles effectively reduced this damage and preserved mitochondrial integrity. Our findings suggest that these nanoparticles could significantly lower heart damage and inflammation, bringing us closer to better treatment options for heart conditions.
9
We explored the potential of selenium-doped copper formate (Cuf-Se) nanozymes in treating atherosclerosis, a key contributor to cardiovascular diseases. By targeting inflammation and oxidative stress, Cuf-Se shows promise by reducing reactive oxygen species and preventing the formation of foam cells.
Although this study primarily tests the effectiveness in mice, findings indicate a notable reduction in plaque formation and inflammation. Cuf-Se led to a five-fold decrease in plaque area, highlighting its potential as a novel treatment strategy for atherosclerosis.
Although this study primarily tests the effectiveness in mice, findings indicate a notable reduction in plaque formation and inflammation. Cuf-Se led to a five-fold decrease in plaque area, highlighting its potential as a novel treatment strategy for atherosclerosis.
7
This population-based study involved over 16,000 adults with hypertension to explore how dietary antioxidants like selenium impact mortality rates. By tracking participants for nearly eight years, we discovered that those with the highest intake of antioxidants showed a significantly lower risk of dying from any cause or cardiovascular disease.
Specifically, selenium appeared beneficial, suggesting it might play a role in improving health outcomes for those with hypertension. However, further research, particularly randomized controlled trials, is essential to confirm these valuable insights.
Specifically, selenium appeared beneficial, suggesting it might play a role in improving health outcomes for those with hypertension. However, further research, particularly randomized controlled trials, is essential to confirm these valuable insights.
References
- Hu X, Zhao Z, An Q, Li Y, Wang B. Association of independent dietary antioxidant intake, and CDAI level with risks of all-cause and cardiovascular-cause death among population with cardiovascular disease. BMC Public Health. 2025;25:1327. doi:10.1186/s12889-025-22481-1
- Li T, Liu X, Yang B, Wang Z, Chen Y, et al. Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy. Free Radic Biol Med. 2025;232:292. doi:10.1016/j.freeradbiomed.2025.03.004
- Li T, Yang B, Liu X, Shi D, Wang Z, et al. Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction. Int J Nanomedicine. 2025;20:1843. doi:10.2147/IJN.S500810
- Chen C, Ma J, Duan S, Xue M, Yang Z, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. doi:10.1016/j.biomaterials.2025.123119
- Zhao S, Cao Y, Liu H, Liu A. Joint and independent associations of dietary antioxidant intakes with all-cause and cardiovascular mortality among patients with hypertension: a population-based cohort study. Nutr J. 2025;24:14. doi:10.1186/s12937-024-01062-9
- Huang X, Zhou Y, Guo Y, Yan D, Sun P, et al. Selenium-Doped Copper Formate Nanozymes with Antisenescence and Oxidative Stress Reduction for Atherosclerosis Treatment. Nano Lett. 2025;25:2662. doi:10.1021/acs.nanolett.4c05348
- Li B, Liu H, Mishra D, Yuan Z, Zhang Y, et al. The association between blood metals and cardiovascular diseases: findings from National Health and Nutrition Examination Survey 2011-2020. Front Cardiovasc Med. 2024;11:1479665. doi:10.3389/fcvm.2024.1479665
- Li X, Liu W, Jin T, Zhang T. Diet-derived circulating antioxidants and functional outcome after ischemic stroke: Evidence from genetic studies. J Stroke Cerebrovasc Dis. 2024;33:108039. doi:10.1016/j.jstrokecerebrovasdis.2024.108039
