Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
USERS' SCORE
Good
Based on 10 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Selenium (elemental) (from 20 mg L-Selenomethionine)
100 mcg
182%
Top Medical Research Studies
9
We examined the impact of selenium supplements on thyroid autoantibody levels in patients with Hashimoto's thyroiditis.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
Read More
9
We examined how selenium supplementation affects patients with autoimmune thyroid disease (AITD) by reviewing 17 randomized controlled trials involving nearly 2,000 participants.
The results revealed promising benefits; selenium significantly reduced levels of free triiodothyronine (FT3), free thyroxine (FT4), and anti-thyroid peroxidase antibodies (TPOAb).
However, thyroid-stimulating hormone (TSH) and anti-thyroglobulin antibody (TGAb) levels showed no significant changes. Overall, these findings indicate that selenium plays a crucial role in managing AITD.
The results revealed promising benefits; selenium significantly reduced levels of free triiodothyronine (FT3), free thyroxine (FT4), and anti-thyroid peroxidase antibodies (TPOAb).
However, thyroid-stimulating hormone (TSH) and anti-thyroglobulin antibody (TGAb) levels showed no significant changes. Overall, these findings indicate that selenium plays a crucial role in managing AITD.
Read More
8
We searched extensive studies to evaluate selenium supplementation's impact on Hashimoto thyroiditis (HT). Our analysis of 35 trials revealed that selenium can significantly lower TSH and thyroid antibodies in those not undergoing thyroid hormone replacement therapy. Despite these positive effects, there were no noticeable changes in thyroid hormone levels or other immune markers. Importantly, selenium was deemed safe, with no increased side effects compared to control groups. Overall, while selenium shows promise in managing certain aspects of HT, its effects on hormone production remain limited.
Read More
Most Useful Reviews
9
Normalised thyroid function
2 people found this helpful
After my hypothyroidism diagnosis, the doctor advised me to take selenium alongside vitamins. Fortunately, after a month, analysis showed my thyroid levels had returned to normal, even with the presence of antibodies related to Hashimoto's.
Read More
9
Essential supplement
1 people found this helpful
This is an essential supplement for me as I have Hashimoto's, and it significantly reduces the anti-TPO antibodies.
Read More
7.5
Control achieved
1 people found this helpful
My antibodies associated with Hashimoto's are now under control with this specific selenium.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
- All Researches
9
We examined the impact of selenium supplements on thyroid autoantibody levels in patients with Hashimoto's thyroiditis.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
Read More
9
We examined how selenium supplementation affects patients with autoimmune thyroid disease (AITD) by reviewing 17 randomized controlled trials involving nearly 2,000 participants.
The results revealed promising benefits; selenium significantly reduced levels of free triiodothyronine (FT3), free thyroxine (FT4), and anti-thyroid peroxidase antibodies (TPOAb).
However, thyroid-stimulating hormone (TSH) and anti-thyroglobulin antibody (TGAb) levels showed no significant changes. Overall, these findings indicate that selenium plays a crucial role in managing AITD.
The results revealed promising benefits; selenium significantly reduced levels of free triiodothyronine (FT3), free thyroxine (FT4), and anti-thyroid peroxidase antibodies (TPOAb).
However, thyroid-stimulating hormone (TSH) and anti-thyroglobulin antibody (TGAb) levels showed no significant changes. Overall, these findings indicate that selenium plays a crucial role in managing AITD.
Read More
8
We searched extensive studies to evaluate selenium supplementation's impact on Hashimoto thyroiditis (HT). Our analysis of 35 trials revealed that selenium can significantly lower TSH and thyroid antibodies in those not undergoing thyroid hormone replacement therapy. Despite these positive effects, there were no noticeable changes in thyroid hormone levels or other immune markers. Importantly, selenium was deemed safe, with no increased side effects compared to control groups. Overall, while selenium shows promise in managing certain aspects of HT, its effects on hormone production remain limited.
Read More
8
We explored the potential benefits of selenium supplementation for patients with Hashimoto thyroiditis (HT). In our systematic review of seven controlled trials with 342 participants, we found that while there was no notable change in thyroid peroxidase antibodies (TPOAb) levels after three months, there was a significant reduction in TPOAb and thyroglobulin antibodies (TgAb) levels after six months of treatment.
Although these findings indicate positive effects of selenium, further research is necessary to assess overall health quality and disease progression in HT patients.
Although these findings indicate positive effects of selenium, further research is necessary to assess overall health quality and disease progression in HT patients.
Read More
8
Selenium intake may reduce HT risk
We examined how dietary selenium influences Hashimoto's thyroiditis (HT) using data from the National Health and Nutrition Examination Survey, involving over 8,700 participants. The findings suggest that higher selenium intake is linked to a lower risk of developing HT.
We also noted a negative correlation between selenium and thyroid peroxidase antibodies, indicating that selenium might help manage this autoimmune condition effectively. This suggests that incorporating selenium into our diet could serve as a beneficial, affordable strategy for preventing and treating HT.
We also noted a negative correlation between selenium and thyroid peroxidase antibodies, indicating that selenium might help manage this autoimmune condition effectively. This suggests that incorporating selenium into our diet could serve as a beneficial, affordable strategy for preventing and treating HT.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Normalised thyroid function
2 people found this helpful
After my hypothyroidism diagnosis, the doctor advised me to take selenium alongside vitamins. Fortunately, after a month, analysis showed my thyroid levels had returned to normal, even with the presence of antibodies related to Hashimoto's.
Read More
9
Essential supplement
1 people found this helpful
This is an essential supplement for me as I have Hashimoto's, and it significantly reduces the anti-TPO antibodies.
Read More
7.5
Control achieved
1 people found this helpful
My antibodies associated with Hashimoto's are now under control with this specific selenium.
Read More
9
Effective treatment
I take selenium for Hashimoto’s, having been diagnosed with autoimmune Hashimoto's thyroiditis. My doctor prescribed 200 mcg to be taken periodically throughout the year. It has been incredibly helpful, possibly my only salvation. The selenium from NOW is very effective, and I appreciate the assurance of authenticity when purchasing from iHerb, which is vital for treatment.
Read More
7.5
Condition stable
1 people found this helpful
Diagnosed with Hashimoto's a year ago, I started this supplement straight away. My condition hasn’t worsened over the year, which is a relief. The best!
Read More
Frequently Asked Questions
9
Normalised thyroid function
2 people found this helpful
After my hypothyroidism diagnosis, the doctor advised me to take selenium alongside vitamins. Fortunately, after a month, analysis showed my thyroid levels had returned to normal, even with the presence of antibodies related to Hashimoto's.
7.5
Condition stable
1 people found this helpful
Diagnosed with Hashimoto's a year ago, I started this supplement straight away. My condition hasn’t worsened over the year, which is a relief. The best!
6
Lowered symptoms
Recommended supplementation for Hashimoto's thyroid sufferers as it lowers some symptoms and antibodies. The quality is good, though I feel overly sleepy during the day, regardless of taking it before bed. While there are observable benefits in blood work, its overall usability for me is limited.
9
Essential supplement
1 people found this helpful
This is an essential supplement for me as I have Hashimoto's, and it significantly reduces the anti-TPO antibodies.
9
We examined the impact of selenium supplements on thyroid autoantibody levels in patients with Hashimoto's thyroiditis.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
8
We searched extensive studies to evaluate selenium supplementation's impact on Hashimoto thyroiditis (HT). Our analysis of 35 trials revealed that selenium can significantly lower TSH and thyroid antibodies in those not undergoing thyroid hormone replacement therapy. Despite these positive effects, there were no noticeable changes in thyroid hormone levels or other immune markers. Importantly, selenium was deemed safe, with no increased side effects compared to control groups. Overall, while selenium shows promise in managing certain aspects of HT, its effects on hormone production remain limited.
7
We examined the impact of selenium supplementation on autoimmune thyroiditis (AIT) by assessing data from various databases. Although findings indicated a potential reduction in thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (Tg-Ab) at three and six months for those not treated with levothyroxine (LT4), the certainty of this evidence remains low.
In contrast, the effects on those treated with LT4 were mixed, with some antibody levels showing improvement. However, the overall conclusion suggests that while selenium might offer some benefits, the evidence isn’t strong enough to make definitive claims.
In contrast, the effects on those treated with LT4 were mixed, with some antibody levels showing improvement. However, the overall conclusion suggests that while selenium might offer some benefits, the evidence isn’t strong enough to make definitive claims.
8
We explored the potential benefits of selenium supplementation for patients with Hashimoto thyroiditis (HT). In our systematic review of seven controlled trials with 342 participants, we found that while there was no notable change in thyroid peroxidase antibodies (TPOAb) levels after three months, there was a significant reduction in TPOAb and thyroglobulin antibodies (TgAb) levels after six months of treatment.
Although these findings indicate positive effects of selenium, further research is necessary to assess overall health quality and disease progression in HT patients.
Although these findings indicate positive effects of selenium, further research is necessary to assess overall health quality and disease progression in HT patients.
8
We conducted a thorough investigation tracking the long-term effects of selenium deficiency on Hashimoto thyroiditis (HT) over six years in two neighboring counties in China.
Our findings revealed that those with low selenium intake had a significantly higher risk of developing HT, as indicated by the rise in thyroid peroxidase autoantibodies (TPO-Abs).
Specifically, nearly 90% of participants from the low-selenium area showed deficiency, compared to 46% from the adequate selenium area. Overall, this suggests that improving selenium levels might help manage HT risk.
Our findings revealed that those with low selenium intake had a significantly higher risk of developing HT, as indicated by the rise in thyroid peroxidase autoantibodies (TPO-Abs).
Specifically, nearly 90% of participants from the low-selenium area showed deficiency, compared to 46% from the adequate selenium area. Overall, this suggests that improving selenium levels might help manage HT risk.
8
We explored the role of selenium supplementation in patients with autoimmune thyroiditis (AIT). Although selenium is widely prescribed by endocrinologists in Europe, we found the existing evidence suggests mixed benefits.
Selenium may help reduce symptoms, lower thyroid autoantibodies, and improve the quality of life for many, including pregnant women by lowering risks of complications. However, the balance is crucial, as both deficiency and excess can negatively impact health.
More research is necessary to develop thorough guidelines for safe selenium use in different patient populations.
Selenium may help reduce symptoms, lower thyroid autoantibodies, and improve the quality of life for many, including pregnant women by lowering risks of complications. However, the balance is crucial, as both deficiency and excess can negatively impact health.
More research is necessary to develop thorough guidelines for safe selenium use in different patient populations.
8
We explored the impacts of selenium supplementation on patients with Hashimoto's thyroiditis, a common autoimmune condition. After studying 100 participants over six months, we found that those who received 200 micrograms of selenium yeast showed an improvement in their selenium levels.
Most importantly, we observed a significant reduction in thyroid antibodies, TGAb and TPOAb, suggesting that selenium may help manage this condition by lowering these autoantibodies. While selenium deficiency was common initially, supplementation appears beneficial in these patients.
Most importantly, we observed a significant reduction in thyroid antibodies, TGAb and TPOAb, suggesting that selenium may help manage this condition by lowering these autoantibodies. While selenium deficiency was common initially, supplementation appears beneficial in these patients.
7
Selenium shows potential in Hashimoto's
We explored the impact of selenium supplementation on women who had just been diagnosed with Hashimoto's thyroiditis in an area known for low selenium levels. For six months, participants received 100 µg/day of sodium selenite.
After the treatment, we noted increased selenium levels in their serum, indicating successful supplementation. Although this may help protect against overt hypothyroidism, it didn't significantly affect other health parameters, like antioxidant status.
After the treatment, we noted increased selenium levels in their serum, indicating successful supplementation. Although this may help protect against overt hypothyroidism, it didn't significantly affect other health parameters, like antioxidant status.
References
- Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. doi:10.3389/fendo.2024.1445878
- Huwiler VV, Maissen-Abgottspon S, Stanga Z, Mühlebach S, Trepp R, et al. Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Thyroid. 2024;34:295. doi:10.1089/thy.2023.0556
- Wang W, Jiang QL, Xu Q, Zeng Y, Jiang R, et al. Selenium regulates T cell differentiation in experimental autoimmune thyroiditis in mice. Int Immunopharmacol. 2023;124:110993. doi:10.1016/j.intimp.2023.110993
- Wang YS, Liang SS, Ren JJ, Wang ZY, Deng XX, et al. The Effects of Selenium Supplementation in the Treatment of Autoimmune Thyroiditis: An Overview of Systematic Reviews. Nutrients. 2023;15. doi:10.3390/nu15143194
- Kong XQ, Qiu GY, Yang ZB, Tan ZX, Quan XQ. Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis. Medicine (Baltimore). 2023;102:e33791. doi:10.1097/MD.0000000000033791
- Zheng G, Cai Y, Guo Y, Song F, Hu Y, et al. The association between dietary selenium intake and Hashimoto's thyroiditis among US adults: National Health and Nutrition Examination Survey (NHANES), 2007-2012. J Endocrinol Invest. 2023;46:1385. doi:10.1007/s40618-022-01987-0
- Kryczyk-Kozioł J, Prochownik E, Błażewska-Gruszczyk A, Słowiaczek M, Sun Q, et al. Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto's Thyroiditis. Nutrients. 2022;14. doi:10.3390/nu14142869
- Wu Q, Wang Y, Chen P, Wei J, Lv H, et al. Increased Incidence of Hashimoto Thyroiditis in Selenium Deficiency: A Prospective 6-Year Cohort Study. J Clin Endocrinol Metab. 2022;107:e3603. doi:10.1210/clinem/dgac410
- Minnetti M, Sada V, Feola T, Giannetta E, Pozza C, et al. Selenium Supplementation in Pregnant Women with Autoimmune Thyroiditis: A Practical Approach. Nutrients. 2022;14. doi:10.3390/nu14112234
- Wang LF, Sun RX, Li CF, Wang XH. The effects of selenium supplementation on antibody titres in patients with Hashimoto's thyroiditis. Endokrynol Pol. 2021;72:666. doi:10.5603/EP.a2021.0074
- Kryczyk-Kozioł J, Zagrodzki P, Prochownik E, Błażewska-Gruszczyk A, Słowiaczek M, et al. Positive effects of selenium supplementation in women with newly diagnosed Hashimoto's thyroiditis in an area with low selenium status. Int J Clin Pract. 2021;75:e14484. doi:10.1111/ijcp.14484
- Filipowicz D, Majewska K, Kalantarova A, Szczepanek-Parulska E, Ruchała M. The rationale for selenium supplementation in patients with autoimmune thyroiditis, according to the current state of knowledge. Endokrynol Pol. 2021;72:153. doi:10.5603/EP.a2021.0017
- Zuo Y, Li Y, Gu X, Lei Z. The correlation between selenium levels and autoimmune thyroid disease: a systematic review and meta-analysis. Ann Palliat Med. 2021;10:4398. doi:10.21037/apm-21-449
- Qiu Y, Xing Z, Xiang Q, Yang Q, Zhu J, et al. Insufficient evidence to support the clinical efficacy of selenium supplementation for patients with chronic autoimmune thyroiditis. Endocrine. 2021;73:384. doi:10.1007/s12020-021-02642-z
- Hu Y, Feng W, Chen H, Shi H, Jiang L, et al. Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto's thyroiditis: A prospective randomized-controlled trial. Clin Transl Sci. 2021;14:1390. doi:10.1111/cts.12993
- Pace C, Tumino D, Russo M, Le Moli R, Naselli A, et al. Role of selenium and myo-inositol supplementation on autoimmune thyroiditis progression. Endocr J. 2020;67:1093. doi:10.1507/endocrj.EJ20-0062
