Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
USERS' SCORE
Good
Based on 13 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Selenium (elemental) (from 20 mg L-Selenomethionine)
100 mcg
182%
Top Medical Research Studies
9.5
Selenium nanoparticles reduce liver toxicity
We investigated how selenium nanoparticles (Se-NPs) and chitosan-encapsulated selenium nanoparticles (Se-CS-NPs) can mitigate liver toxicity induced by carbon tetrachloride (CCl) in rats. In our study, eighty rats were divided into eight groups, including placebo and control.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
Read More
8
We examined how selenium nanoparticles might help combat liver damage caused by cadmium, a dangerous environmental toxin. By studying both animal models and liver cells, we found that these nanoparticles could reduce cell injuries linked to a damaging process called ferroptosis.
Our findings indicated that achieving this protective effect involves enhancing certain liver enzyme activities and altering several protein levels associated with oxidative stress. Overall, while selenium shows promise in mitigating liver damage, particularly against cadmium toxicity, further research could better clarify its mechanisms and potential benefits.
Our findings indicated that achieving this protective effect involves enhancing certain liver enzyme activities and altering several protein levels associated with oxidative stress. Overall, while selenium shows promise in mitigating liver damage, particularly against cadmium toxicity, further research could better clarify its mechanisms and potential benefits.
Read More
9
We explored the potential of selenium in addressing liver damage caused by alcohol. The study employed both in vitro and in vivo methods to assess how selenium affects liver cells exposed to ethanol.
Our findings indicated that selenium improved cell viability, reduced oxidative stress markers, and altered certain protein expressions related to cell death. In particular, selenomethionine showed a notable impact in protecting liver cells.
Overall, selenium appears promising for alleviating ethanol-induced liver injury by regulating important cellular processes. However, results suggest that further research is needed to fully understand its effectiveness.
Our findings indicated that selenium improved cell viability, reduced oxidative stress markers, and altered certain protein expressions related to cell death. In particular, selenomethionine showed a notable impact in protecting liver cells.
Overall, selenium appears promising for alleviating ethanol-induced liver injury by regulating important cellular processes. However, results suggest that further research is needed to fully understand its effectiveness.
Read More
Most Useful Reviews
9
Liver health improved
97 people found this helpful
Selenium, along with N-acetylcysteine, aids glutathione production. Although children can produce it, those over 60 struggle. I originally bought N-Acetylcysteine, which is pricey, but selenium is affordable and ideal for daily use. Since adding it with zinc, I've notably improved my liver function, and I rarely catch colds.
Read More
7.5
Improved well-being
6 people found this helpful
I heard this is good for detoxifying the liver, so I bought it for my partner with a weak liver. After starting to drink it, I felt much better. I used to have a high fever occasionally, but that has subsided. I believe it's effective, and I appreciate that it is reasonably priced.
Read More
7.5
Good nutritional supplement
This is an excellent nutritional supplement that benefits the liver, featuring natural ingredients and attractive packaging.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
- All Researches
9.5
Selenium nanoparticles reduce liver toxicity
We investigated how selenium nanoparticles (Se-NPs) and chitosan-encapsulated selenium nanoparticles (Se-CS-NPs) can mitigate liver toxicity induced by carbon tetrachloride (CCl) in rats. In our study, eighty rats were divided into eight groups, including placebo and control.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
Read More
9
We aimed to investigate the role of selenium and coenzyme Q in addressing liver damage caused by a methionine choline-deficient diet in mice. Over four weeks, mice receiving the combination treatment showed significant reductions in liver inflammation, fibrosis, and oxidative stress.
The results suggested that this combined supplementation might hold therapeutic potential against metabolic dysfunction-associated liver injury. While our findings are promising, they are based on an animal model, and further research is necessary to explore their implications for human liver disease.
The results suggested that this combined supplementation might hold therapeutic potential against metabolic dysfunction-associated liver injury. While our findings are promising, they are based on an animal model, and further research is necessary to explore their implications for human liver disease.
Read More
9
Selenium enhances liver health
We set out to investigate if selenium, along with glutathione, can help reduce liver injury caused by a cancer-inducing substance in mice. Over 20 weeks, we divided male mice into different groups, some receiving selenium and others just glutathione, while monitoring their liver function.
Our findings revealed that both supplements significantly improved liver conditions and antioxidant levels. Interestingly, adding selenium to glutathione treatment worked even better, enhancing the liver’s ability to handle oxidative stress. Overall, selenium appears to be a promising ally in supporting liver health and reducing injury.
Our findings revealed that both supplements significantly improved liver conditions and antioxidant levels. Interestingly, adding selenium to glutathione treatment worked even better, enhancing the liver’s ability to handle oxidative stress. Overall, selenium appears to be a promising ally in supporting liver health and reducing injury.
Read More
9
We explored the potential of selenium in addressing liver damage caused by alcohol. The study employed both in vitro and in vivo methods to assess how selenium affects liver cells exposed to ethanol.
Our findings indicated that selenium improved cell viability, reduced oxidative stress markers, and altered certain protein expressions related to cell death. In particular, selenomethionine showed a notable impact in protecting liver cells.
Overall, selenium appears promising for alleviating ethanol-induced liver injury by regulating important cellular processes. However, results suggest that further research is needed to fully understand its effectiveness.
Our findings indicated that selenium improved cell viability, reduced oxidative stress markers, and altered certain protein expressions related to cell death. In particular, selenomethionine showed a notable impact in protecting liver cells.
Overall, selenium appears promising for alleviating ethanol-induced liver injury by regulating important cellular processes. However, results suggest that further research is needed to fully understand its effectiveness.
Read More
8
We investigated whether selenium-modified Bletilla striata polysaccharide (Se-BSP) could effectively reduce liver fibrosis. Our findings revealed that Se-BSP not only improved its antioxidant properties but also showed greater efficacy in alleviating liver fibrosis compared to its unmodified version at a specific concentration. This study underscores the potential of Se-BSP as a promising treatment for liver fibrosis, a condition that can lead to more severe liver diseases.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Liver health improved
97 people found this helpful
Selenium, along with N-acetylcysteine, aids glutathione production. Although children can produce it, those over 60 struggle. I originally bought N-Acetylcysteine, which is pricey, but selenium is affordable and ideal for daily use. Since adding it with zinc, I've notably improved my liver function, and I rarely catch colds.
Read More
7.5
Improved well-being
6 people found this helpful
I heard this is good for detoxifying the liver, so I bought it for my partner with a weak liver. After starting to drink it, I felt much better. I used to have a high fever occasionally, but that has subsided. I believe it's effective, and I appreciate that it is reasonably priced.
Read More
7.5
Good nutritional supplement
This is an excellent nutritional supplement that benefits the liver, featuring natural ingredients and attractive packaging.
Read More
7.5
Improved liver function
8 people found this helpful
Excellent! I take one tablet at night to detoxify my body and enhance liver function, and I feel refreshed by morning. I’ve noticed no side effects and will continue taking it. Along with exercise, I believe this has helped me lose body fat.
Read More
7.5
Aids liver detox
6 people found this helpful
Selenium is a promising liver detoxifier, and I've incorporated it into my routine. I take one tablet daily with oily meals, and I feel my skin has improved. While seafood is rich in mercury, selenium may assist in its excretion. I'm curious about the overdose potential with supplements.
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Frequently Asked Questions
7.5
Increased energy
28 people found this helpful
Solgar Selenium is great for strengthening the immune system and has antioxidant properties. After three weeks, I feel more active and have noticed an improvement in sperm production. I’ve also not been ill.
7.5
Improved well-being
6 people found this helpful
I heard this is good for detoxifying the liver, so I bought it for my partner with a weak liver. After starting to drink it, I felt much better. I used to have a high fever occasionally, but that has subsided. I believe it's effective, and I appreciate that it is reasonably priced.
7.5
Improved liver function
8 people found this helpful
Excellent! I take one tablet at night to detoxify my body and enhance liver function, and I feel refreshed by morning. I’ve noticed no side effects and will continue taking it. Along with exercise, I believe this has helped me lose body fat.
9
Liver health improved
97 people found this helpful
Selenium, along with N-acetylcysteine, aids glutathione production. Although children can produce it, those over 60 struggle. I originally bought N-Acetylcysteine, which is pricey, but selenium is affordable and ideal for daily use. Since adding it with zinc, I've notably improved my liver function, and I rarely catch colds.
7.5
Aids liver detox
6 people found this helpful
Selenium is a promising liver detoxifier, and I've incorporated it into my routine. I take one tablet daily with oily meals, and I feel my skin has improved. While seafood is rich in mercury, selenium may assist in its excretion. I'm curious about the overdose potential with supplements.
6
Enhances liver detoxification
1 people found this helpful
I'm using it to boost my liver's detoxification. A weakened liver hampers energy metabolism, which can negatively affect dieting.
8
We investigated whether selenium-modified Bletilla striata polysaccharide (Se-BSP) could effectively reduce liver fibrosis. Our findings revealed that Se-BSP not only improved its antioxidant properties but also showed greater efficacy in alleviating liver fibrosis compared to its unmodified version at a specific concentration. This study underscores the potential of Se-BSP as a promising treatment for liver fibrosis, a condition that can lead to more severe liver diseases.
9
We aimed to investigate the role of selenium and coenzyme Q in addressing liver damage caused by a methionine choline-deficient diet in mice. Over four weeks, mice receiving the combination treatment showed significant reductions in liver inflammation, fibrosis, and oxidative stress.
The results suggested that this combined supplementation might hold therapeutic potential against metabolic dysfunction-associated liver injury. While our findings are promising, they are based on an animal model, and further research is necessary to explore their implications for human liver disease.
The results suggested that this combined supplementation might hold therapeutic potential against metabolic dysfunction-associated liver injury. While our findings are promising, they are based on an animal model, and further research is necessary to explore their implications for human liver disease.
7
We investigated the connection between selenium levels in the blood and non-alcoholic fatty liver disease (NAFLD), a common liver issue. Analyzing data from over 7,000 participants in the NHANES survey, we found that higher selenium levels were linked to an increased prevalence of NAFLD in both genders. Interestingly, those with higher selenium levels also showed a decreased prevalence of advanced hepatic fibrosis. This suggests that while selenium might be associated with NAFLD, it may also provide some protective benefits against severe liver damage.
References
- Jiang G, Kong H, Wang Y, Wang Y, Zhou J, et al. Antioxidant and hepatic fibrosis-alleviating effects of selenium-modified Bletilla striata polysaccharide. Int J Biol Macromol. 2025;301:140234. 10.1016/j.ijbiomac.2025.140234
- Choi H, Choi J, Go Y, Chung J. Coenzyme Q and Selenium Co-Supplementation Alleviate Methionine Choline-Deficient Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis in Mice. Nutrients. 2025;17. 10.3390/nu17020229
- Guo W, Weng T, Song Y. Association of serum selenium with MASLD and liver fibrosis: A cross-sectional study. PLoS One. 2024;19:e0314780. 10.1371/journal.pone.0314780
- Yang Z, Lian J, Li J, Guo W, Ni L, et al. Intestinal Microbiomics and Liver Metabolomics Insights into the Ameliorative Effects of Selenium-Enriched FZU3103 on Alcohol-Induced Liver Injury in Mice. J Agric Food Chem. 2025;73:3232. 10.1021/acs.jafc.4c06072
- Shen Q, Liu Y, Li J, Zhou D. Nano-Selenium Modulates NF-κB/NLRP3 Pathway and Mitochondrial Dynamics to Attenuate Microplastic-Induced Liver Injury. Nutrients. 2024;16. 10.3390/nu16223878
- Liu Q, Bi J, Fan G, Wu M, Qin X, et al. Association between multiple metals exposure and metabolic dysfunction-associated fatty liver disease among Chinese adults. J Trace Elem Med Biol. 2024;86:127566. 10.1016/j.jtemb.2024.127566
- Chen X, Lin X. Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway. Poult Sci. 2025;104:104449. 10.1016/j.psj.2024.104449
- Mrwad AA, El-Shafey SE, Said NM. Chitosan-encapsulated selenium nanoparticles alleviate CCl induced hepatotoxicity through synergistically modulating NF-κB and Nrf2 signaling pathways and regulating Bcl-2 and Caspase-3 expression: A comprehensive study with multiple regression analysis. J Trace Elem Med Biol. 2024;86:127563. 10.1016/j.jtemb.2024.127563
- Hsiao YF, Huang SC, Cheng SB, Hsu CC, Huang YC. Glutathione and Selenium Supplementation Attenuates Liver Injury in Diethylnitrosamine-Induced Hepatocarcinogenic Mice by Enhancing Glutathione-Related Antioxidant Capacities. Int J Mol Sci. 2024;25. 10.3390/ijms252111339
- Cengiz M, Gür B, Gür F, Şahintürk V, Bayrakdar A, et al. The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats. Heliyon. 2024;10:e38713. 10.1016/j.heliyon.2024.e38713
- Chen F, Li Q, Xu X, Wang F. Selenium Attenuates Ethanol-induced Hepatocellular Injury by Regulating Ferroptosis and Apoptosis. Turk J Gastroenterol. 2024;35:778. 10.5152/tjg.2024.24159
- Abdel-Wahhab KG, Ashry M, Hassan LK, El-Azma MH, Elqattan GM, et al. Hepatic and immune modulatory effectiveness of lactoferrin loaded Selenium nanoparticles on bleomycin induced hepatic injury. Sci Rep. 2024;14:21066. 10.1038/s41598-024-70894-6
- Shao C, Luo T, Wang S, Li Z, Yu X, et al. Selenium nanoparticles alleviates cadmium induced hepatotoxicity by inhibiting ferroptosis and oxidative stress in vivo and in vitro. Chemosphere. 2024;364:143004. 10.1016/j.chemosphere.2024.143004
- Liu Y, Wang R. Association between serum selenium and non-alcoholic fatty liver disease: Results from NHANES: An observational study. Medicine (Baltimore). 2024;103:e38845. 10.1097/MD.0000000000038845
- Huertas-Abril PV, Prieto-Álamo MJ, Jurado J, Pérez J, Molina-Hernández V, et al. Transcriptional and biochemical changes in mouse liver following exposure to a metal/drug cocktail. Attenuating effect of a selenium-enriched diet. Food Chem Toxicol. 2024;191:114845. 10.1016/j.fct.2024.114845
