Overview
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We found that supplementing with selenium, either alone or alongside multivitamins, significantly reduced the risk of developing TB compared to those taking a placebo. However, multivitamins on their own did not have the same protective effect.
These findings suggest that selenium supplementation could be an important strategy in tackling TB in HIV-infected individuals, particularly where malnutrition is an issue.
Using methylseleninic acid (MSeA), a selenium donor, we observed its ability to block the growth of MTB in macrophages. This works through important pathways involving autophagy, led by a protein called c-Jun.
Overall, our findings suggest that selenium may be a valuable avenue for improving treatment strategies in PTB.
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SeNPs helped to reduce infection loads and inflammatory lesions while boosting mucosal immunity, indicating their potential for developing effective tuberculosis vaccines. This study highlights the need for further exploration of SeNPs in vaccine formulations for both animals and potentially humans.
We found that supplementing with selenium, either alone or alongside multivitamins, significantly reduced the risk of developing TB compared to those taking a placebo. However, multivitamins on their own did not have the same protective effect.
These findings suggest that selenium supplementation could be an important strategy in tackling TB in HIV-infected individuals, particularly where malnutrition is an issue.
Our findings revealed that the additional therapy made a significant difference. Men who received the spermatoprotective treatment saw marked improvements in sperm count and mobility compared to those who did not.
Therefore, incorporating selenium and other supplements could play an important role in preserving fertility for these patients.
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Frequently Asked Questions
Tuberculosis (TB) is a bacterial infection caused by Mycobacterium tuberculosis, primarily affecting the lungs but can also impact other parts of the body. It spreads through the air when an infected person coughs, sneezes, or talks, making it highly contagious in crowded or poorly ventilated spaces. TB is characterized by symptoms such as a persistent cough, chest pain, fever, night sweats, and weight loss. While some people can carry the bacteria without becoming ill—a condition known as latent TB—others may develop an active infection that requires prompt medical intervention.
Diagnosis typically involves a combination of skin tests, blood tests, and chest X-rays, with treatment usually involving a lengthy course of antibiotics—often lasting six months or longer—to prevent the development of drug-resistant strains. Preventative measures, like vaccination and timely treatment of active cases, play a crucial role in controlling the spread of tuberculosis. Overall, while TB remains a significant global health issue, it is manageable with appropriate medical care.
Selenium is a powerful and widely used open-source tool designed for automating web applications for testing purposes. It enables developers and testers to write code in various programming languages such as Java, Python, C#, and Ruby to simulate user interactions with a web browser. Selenium's flexibility allows users to create complex test scenarios that mimic real-world user behaviors, making it an essential tool for ensuring web application functionality and performance.
In addition to its core functionalities, Selenium consists of several components, including Selenium WebDriver for automating browsers, Selenium Grid for running tests across multiple machines and environments in parallel, and Selenium IDE for record-and-playback test creation. Its compatibility with multiple browser types—such as Chrome, Firefox, Safari, and Edge—makes it a versatile choice for automated testing, catering to a wide range of projects and team needs. For anyone involved in web development or quality assurance, understanding and utilizing Selenium can significantly improve testing efficiency and reliability.
The duration to see results from Selenium supplementation for tuberculosis can vary based on individual health factors and the specific treatment regimen being followed. Generally, supplementation with Selenium may support immune function but is typically not a primary treatment for tuberculosis itself. If Selenium is being supplemented as part of a broader treatment plan, it may take several weeks to a few months to observe any beneficial effects. It's essential to monitor your overall health and consult with a healthcare provider for a tailored timeline based on your specific situation and treatment protocol. Always remember to follow your doctor’s recommendations regarding dosages and expectations from any supplementation, especially in the context of a serious condition like tuberculosis.
Based on user reviews, selenium supplements have garnered positive feedback for their potential health benefits, notably in disease prevention and immune support. Users report that selenium can help prevent various health issues, including heart disease, stroke, and even conditions like Alzheimer’s. For example, one reviewer noted that selenium might significantly lower the risk of strokes and help prevent cardiovascular diseases (Read Review). Additionally, selenium appears to support bodily functions essential for regulating metabolism and hormone levels, which has resonated with users looking to improve their overall health.
Moreover, the antioxidant properties of selenium have been highlighted, with many users discussing its role in enhancing immune responses to threats such as flu and tuberculosis. Those with HIV specifically noted improvements in mortality rates and enhanced immune function while taking selenium supplements (Read Review). Users also raved about its benefits for hair and nail health, as well as its importance in regulating metabolic processes (Read Review). It is essential to keep in mind that individual results can vary widely depending on factors such as diet, health status, and specific conditions.
Based on user reviews, many individuals have noted the effectiveness of selenium when combined with other supplements for managing conditions such as tuberculosis. Reviewers highlighted that selenium plays a crucial role in boosting the immune system, particularly for those dealing with severe health challenges like HIV, flu, and tuberculosis. They reported improved overall health and reduced mortality rates among HIV patients using selenium alongside their regular treatment (Read Review).
Furthermore, users emphasized that selenium’s antioxidant properties help strengthen the body's defenses against diseases, potentially working well in tandem with other supplements to support immune function and lung health (Read Review). Many have pointed out that while combining selenium with other supplements can be beneficial, individuals should consult healthcare professionals to tailor their supplement regimen effectively to their needs (Read Review).
Users report that selenium is an essential mineral that plays a crucial role in combating tuberculosis and improving overall health, particularly for individuals with compromised immune systems. While specific dosage recommendations for selenium in treating tuberculosis were not provided in the reviews, it is noted that selenium supplements can significantly reduce mortality rates, especially among HIV patients ((Read Review)). The daily selenium requirement generally ranges from 15 to 70 μg, depending on age and individual health factors ((Read Review)).
Additionally, these users emphasize that selenium supports vital functions such as antioxidant activity, hormone regulation, and immune response, which are essential for fighting infections like tuberculosis ((Read Review)). While there’s a consensus on its benefits, users should consult healthcare providers for personalized advice on dosage tailored to their specific health needs and conditions rather than relying solely on general information.
References
- Ge X, Liang Z, Li K, Dong Y, Wang Y, et al. Selenium nanoparticles enhance mucosal immunity against Mycobacterium bovis infection. Int Immunopharmacol. 2024;137:112384. doi:10.1016/j.intimp.2024.112384
- Parveen S, Sur T, Sarkar S, Roy R. Antagonist Impact of Selenium-Based Nanoparticles Against Mycobacterium tuberculosis. Appl Biochem Biotechnol. 2023;195:3606. doi:10.1007/s12010-023-04315-1
- Zhao R, Miao W, Li B. The Relation Between Trace Elements and Latent Tuberculosis Infection: a Study Based on National Health and Nutritional Examination Survey 2011-2012. Biol Trace Elem Res. 2023;201:1080. doi:10.1007/s12011-022-03240-4
- Chen W, Liu Z, Zheng Y, Wei B, Shi J, et al. Selenium donor restricts the intracellular growth of Mycobacterium tuberculosis through the induction of c-Jun-mediated both canonical autophagy and LC3-associated phagocytosis of alveolar macrophages. Microb Pathog. 2021;161:105269. doi:10.1016/j.micpath.2021.105269
- Ribeiro RCB, de Marins DB, Di Leo I, da Silva Gomes L, de Moraes MG, et al. Anti-tubercular profile of new selenium-menadione conjugates against Mycobacterium tuberculosis H37Rv (ATCC 27294) strain and multidrug-resistant clinical isolates. Eur J Med Chem. 2021;209:112859. doi:10.1016/j.ejmech.2020.112859
- Nizi MG, Desantis J, Nakatani Y, Massari S, Mazzarella MA, et al. Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors. Eur J Med Chem. 2020;201:112420. doi:10.1016/j.ejmech.2020.112420
- Pi J, Shen L, Yang E, Shen H, Huang D, et al. Macrophage-Targeted Isoniazid-Selenium Nanoparticles Promote Antimicrobial Immunity and Synergize Bactericidal Destruction of Tuberculosis Bacilli. Angew Chem Int Ed Engl. 2020;59:3226. doi:10.1002/anie.201912122
- Hussain MI, Ahmed W, Nasir M, Mushtaq MH, Sheikh AA, et al. Immune modulatory and anti-oxidative effect of selenium against pulmonary tuberculosis. Pak J Pharm Sci. 2019;32:779.
- Feleke BE, Feleke TE, Mekonnen D, Beyene MB. Micronutrient levels of tuberculosis patients during the intensive phase, a prospective cohort study. Clin Nutr ESPEN. 2019;31:56. doi:10.1016/j.clnesp.2019.03.001
- Campa A, Baum MK, Bussmann H, Martinez SS, Farahani M, et al. The effect of micronutrient supplementation on active TB incidence early in HIV infection in Botswana. Nutr Diet Suppl. 2017;2017:37. doi:10.2147/NDS.S123545
- Thanna S, Goins CM, Knudson SE, Slayden RA, Ronning DR, et al. Thermal and Photoinduced Copper-Promoted C-Se Bond Formation: Synthesis of 2-Alkyl-1,2-benzisoselenazol-3(2H)-ones and Evaluation against Mycobacterium tuberculosis. J Org Chem. 2017;82:3844. doi:10.1021/acs.joc.7b00440
- Kulchavenya EV, Osadchii AV. [The role of pathogenetic therapy in preserving ejaculate fertility in patients with tuberculosis of prostate]. Urologiia. 2016.
