' 
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Excellent
Based on 95 Reviews
9
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 180 mg Ferrous Bisglycinate)(Ferrochel™)
36 mg
200%
Top Medical Research Studies
8
CUR-PDT triggers ferroptosis in RA
CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis.
High relevance for RA treatment
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
7
Iron links to MS lesion recovery
Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI.
High relevance for MS therapy
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
Read More
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Study highlights iron's RA role
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
Most Useful Reviews
9.5
Raised hemoglobin levels
This is the best iron for treating my autoimmune disorder during pregnancy. Despite various prescriptions failing to help, I turned to this product. Within three weeks, my haemoglobin rose from 96 to 123, and ferritin increased from 40 to nearly 90. I also experienced no gastrointestinal issues, unlike previous products. I'm glad to share my experience; it really works!
Read More
9.5
Improved energy levels
This supplement worked wonders for my friend with an autoimmune disorder causing severe anaemia. After struggling with other iron supplements, she started this one. Her haemoglobin rose from 117 to 143 without any side effects, helping her feel much better and return to work. Seeing her results inspired me to order for myself to prevent low iron levels.
Read More
9.5
Effective anaemia treatment
This supplement has become my go-to remedy for anaemia related to my autoimmune disorder. I take it in cycles and have almost forgotten my previous struggles with low iron levels. It effectively addresses my deficiencies and I plan to continue ordering this wonderful product.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Study highlights iron's RA role
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
8
CUR-PDT triggers ferroptosis in RA
CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis.
High relevance for RA treatment
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
7
Iron links to MS lesion recovery
Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI.
High relevance for MS therapy
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 95 Reviews
9
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Raised hemoglobin levels
This is the best iron for treating my autoimmune disorder during pregnancy. Despite various prescriptions failing to help, I turned to this product. Within three weeks, my haemoglobin rose from 96 to 123, and ferritin increased from 40 to nearly 90. I also experienced no gastrointestinal issues, unlike previous products. I'm glad to share my experience; it really works!
Read More
9.5
Improved energy levels
This supplement worked wonders for my friend with an autoimmune disorder causing severe anaemia. After struggling with other iron supplements, she started this one. Her haemoglobin rose from 117 to 143 without any side effects, helping her feel much better and return to work. Seeing her results inspired me to order for myself to prevent low iron levels.
Read More
9.5
Effective anaemia treatment
This supplement has become my go-to remedy for anaemia related to my autoimmune disorder. I take it in cycles and have almost forgotten my previous struggles with low iron levels. It effectively addresses my deficiencies and I plan to continue ordering this wonderful product.
8.8
Increased ferritin levels
Effective iron! After my ferritin level dropped to 18.3, I experienced extreme fatigue. I opted for this easily digestible iron bisglycinate after considering many options. I took 1 tablet twice daily, increasing to 2 during menstruation, alongside buffered vitamin C. Within a month, my ferritin significantly improved. The price and quality were excellent, and I advise anyone struggling with low ferritin to try it.
Read More
8.3
Normalised iron levels
I suffer from iron deficiency anaemia. I tried many treatments with limited success until finding this medication, which has a therapeutic dosage of 36 mg. After adjusting my intake, my analysis revealed a significant improvement in my serum iron and haemoglobin levels.
