Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
USERS' SCORE
Good
Based on 18 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 180 mg Ferrous Bisglycinate)(Ferrochel™)
36 mg
200%
Top Medical Research Studies
9
We investigated how a substance called HP influences iron-related oxidative stress and its connection to back pain in a common condition known as lumbar spinal stenosis (LSS). LSS causes significant discomfort and disability, particularly for older adults, primarily due to hypertrophy of the ligamentum flavum, which can be exacerbated by oxidative stress stemming from imbalanced iron levels.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Read More
9
We set out to explore how iron treatment impacts back pain, particularly in the context of lumbar spinal stenosis (LSS). This condition, marked by the narrowing of the spinal canal, often leads to nerve compression and chronic inflammation—both linked to heightened iron levels in the body.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
Read More
8
Chitogel with Deferiprone aids recovery
We explored the potential of a Chitogel and Deferiprone mixture in preventing harmful scarring after spinal surgery. In this study, fifteen sheep underwent laminectomy, a common spinal procedure, and were treated with various gels, including a control group without treatment.
After three months, we evaluated the outcomes using MRI and tissue examination. The results showed that the combination of Chitogel with Deferiprone at 20 mM was not only safe but also effectively reduced inflammation and the formation of adhesions. This suggests a promising approach to improving post-surgery recovery in patients.
After three months, we evaluated the outcomes using MRI and tissue examination. The results showed that the combination of Chitogel with Deferiprone at 20 mM was not only safe but also effectively reduced inflammation and the formation of adhesions. This suggests a promising approach to improving post-surgery recovery in patients.
Read More
Most Useful Reviews
9
Dizziness reduction
11 people found this helpful
I previously took a Japanese heme iron supplement but experienced dizziness, nausea, and migraines. After switching to a high-quality iron supplement, I noticed an improvement in my dizziness by the second day and my migraines vanished within a week. Though the capsules have an iron smell, I highly recommend this for anyone who has not found relief with Japanese heme iron.
Read More
9
Reduced PMS symptoms
2 people found this helpful
After seven years of suffering from pre-menstrual depression and low ferritin levels, I began taking one tablet of iron each morning and evening with vitamin C. Within days, my eyelids changed colour, and my depression improved. The duration of my depressive symptoms shortened, and I no longer experience shortness of breath during exercise.
Read More
8
Eased menstrual pain
2 people found this helpful
I discovered this supplement while dealing with severe menstrual pain and PMS. After three years of taking two tablets daily, my menstrual pains and morning fatigue have significantly decreased, along with dizziness when standing. I worry about running out of supply as it has genuinely helped me.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
- All Researches
9
We set out to explore how iron treatment impacts back pain, particularly in the context of lumbar spinal stenosis (LSS). This condition, marked by the narrowing of the spinal canal, often leads to nerve compression and chronic inflammation—both linked to heightened iron levels in the body.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
Read More
9
We investigated how a substance called HP influences iron-related oxidative stress and its connection to back pain in a common condition known as lumbar spinal stenosis (LSS). LSS causes significant discomfort and disability, particularly for older adults, primarily due to hypertrophy of the ligamentum flavum, which can be exacerbated by oxidative stress stemming from imbalanced iron levels.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Read More
8
Chitogel with Deferiprone aids recovery
We explored the potential of a Chitogel and Deferiprone mixture in preventing harmful scarring after spinal surgery. In this study, fifteen sheep underwent laminectomy, a common spinal procedure, and were treated with various gels, including a control group without treatment.
After three months, we evaluated the outcomes using MRI and tissue examination. The results showed that the combination of Chitogel with Deferiprone at 20 mM was not only safe but also effectively reduced inflammation and the formation of adhesions. This suggests a promising approach to improving post-surgery recovery in patients.
After three months, we evaluated the outcomes using MRI and tissue examination. The results showed that the combination of Chitogel with Deferiprone at 20 mM was not only safe but also effectively reduced inflammation and the formation of adhesions. This suggests a promising approach to improving post-surgery recovery in patients.
Read More
8
We aimed to understand if alkaline mineral supplementation could alleviate low back pain. In our open study, 82 participants took a lactose-based alkaline multimineral supplement for four weeks alongside their regular medications. Remarkably, pain scores dropped by 49%, and 76 out of 82 patients experienced relief.
We noted significant increases in blood buffering capacity and pH, suggesting that an acid-base imbalance could play a role in back pain. However, minerals like iron did not show significant changes. Ultimately, this simple supplement appears to greatly help those suffering from chronic low back pain.
We noted significant increases in blood buffering capacity and pH, suggesting that an acid-base imbalance could play a role in back pain. However, minerals like iron did not show significant changes. Ultimately, this simple supplement appears to greatly help those suffering from chronic low back pain.
Read More
5
We examined how magnetostimulation impacts upper-back pain in a clinical trial involving 55 participants, including healthy individuals and those with cervico-brachial pain. Using the innovative GMT 2.0 device, the treatment involved 40-minute sessions over 10 days for those in the treatment group.
The results revealed that while there were some positive changes in movement and certain health markers, there was no direct indication that magnetostimulation specifically alleviated back pain. The treatment did, however, normalize certain tissue properties and improve overall well-being.
The results revealed that while there were some positive changes in movement and certain health markers, there was no direct indication that magnetostimulation specifically alleviated back pain. The treatment did, however, normalize certain tissue properties and improve overall well-being.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Dizziness reduction
11 people found this helpful
I previously took a Japanese heme iron supplement but experienced dizziness, nausea, and migraines. After switching to a high-quality iron supplement, I noticed an improvement in my dizziness by the second day and my migraines vanished within a week. Though the capsules have an iron smell, I highly recommend this for anyone who has not found relief with Japanese heme iron.
Read More
9
Reduced PMS symptoms
2 people found this helpful
After seven years of suffering from pre-menstrual depression and low ferritin levels, I began taking one tablet of iron each morning and evening with vitamin C. Within days, my eyelids changed colour, and my depression improved. The duration of my depressive symptoms shortened, and I no longer experience shortness of breath during exercise.
Read More
8
Eased menstrual pain
2 people found this helpful
I discovered this supplement while dealing with severe menstrual pain and PMS. After three years of taking two tablets daily, my menstrual pains and morning fatigue have significantly decreased, along with dizziness when standing. I worry about running out of supply as it has genuinely helped me.
Read More
9
Improved blood levels
1 people found this helpful
Brings me back to life! After feeling tired and breathless, tests showed low ferritin. I switched to iron bisglycinate, which is better absorbed, and after one can, I felt stronger and in a better mood. My blood levels improved significantly, and there were no side effects.
Read More
9
Pain-free menstruation
1 people found this helpful
My spouse noticed improvements after taking it for pain relief before and during menstruation. By the third month, the back pain disappeared, and she felt great.
Read More
Frequently Asked Questions
7.5
Eased back pain
2 people found this helpful
I started taking this supplement to offset iron loss after menstruation. I drink it a week before my period, initially on an empty stomach, but switched to after meals without issues. Since starting this, my pre-menstrual lower back pain has become lighter. I encourage those with PMS-related back pain to give it a try.
9
Pain-free menstruation
1 people found this helpful
My spouse noticed improvements after taking it for pain relief before and during menstruation. By the third month, the back pain disappeared, and she felt great.
8
Joint pain relief
I suffer from chronic joint pain, and these supplements gave me significant relief. My back pain decreased, and I noticed improved joint mobility. They truly work!
9
Dizziness reduction
11 people found this helpful
I previously took a Japanese heme iron supplement but experienced dizziness, nausea, and migraines. After switching to a high-quality iron supplement, I noticed an improvement in my dizziness by the second day and my migraines vanished within a week. Though the capsules have an iron smell, I highly recommend this for anyone who has not found relief with Japanese heme iron.
8
Eased menstrual pain
2 people found this helpful
I discovered this supplement while dealing with severe menstrual pain and PMS. After three years of taking two tablets daily, my menstrual pains and morning fatigue have significantly decreased, along with dizziness when standing. I worry about running out of supply as it has genuinely helped me.
9
Reduced PMS symptoms
2 people found this helpful
After seven years of suffering from pre-menstrual depression and low ferritin levels, I began taking one tablet of iron each morning and evening with vitamin C. Within days, my eyelids changed colour, and my depression improved. The duration of my depressive symptoms shortened, and I no longer experience shortness of breath during exercise.
9
Restored health
1 people found this helpful
This drug is excellent. After childbirth, I had mild anaemia and was prescribed iron. After two weeks of taking this supplement with vitamin C, my ferritin normalised, and my health improved significantly.
7.5
Pain relief
2 people found this helpful
This supplement is easy to take, and I combine three capsules with vitamin C at night, which has reduced my menstrual pain.
9
Consistent hemoglobin
2 people found this helpful
This supplement has been excellent for maintaining my haemoglobin levels during pregnancy, even in later stages. I took two capsules daily, increasing to three in the final months. I feel great and have largely forgotten about menstrual pains and no longer need analgesics.
8
We aimed to understand if alkaline mineral supplementation could alleviate low back pain. In our open study, 82 participants took a lactose-based alkaline multimineral supplement for four weeks alongside their regular medications. Remarkably, pain scores dropped by 49%, and 76 out of 82 patients experienced relief.
We noted significant increases in blood buffering capacity and pH, suggesting that an acid-base imbalance could play a role in back pain. However, minerals like iron did not show significant changes. Ultimately, this simple supplement appears to greatly help those suffering from chronic low back pain.
We noted significant increases in blood buffering capacity and pH, suggesting that an acid-base imbalance could play a role in back pain. However, minerals like iron did not show significant changes. Ultimately, this simple supplement appears to greatly help those suffering from chronic low back pain.
9
We set out to explore how iron treatment impacts back pain, particularly in the context of lumbar spinal stenosis (LSS). This condition, marked by the narrowing of the spinal canal, often leads to nerve compression and chronic inflammation—both linked to heightened iron levels in the body.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
9
We investigated how a substance called HP influences iron-related oxidative stress and its connection to back pain in a common condition known as lumbar spinal stenosis (LSS). LSS causes significant discomfort and disability, particularly for older adults, primarily due to hypertrophy of the ligamentum flavum, which can be exacerbated by oxidative stress stemming from imbalanced iron levels.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
References
- Kim H, Hong JY, Jeon WJ, Lee J, Lee YJ, et al. Melittin regulates iron homeostasis and mediates macrophage polarization in rats with lumbar spinal stenosis. Biomed Pharmacother. 2022;156:113776. 10.1016/j.biopha.2022.113776
- Hong JY, Kim H, Lee J, Jeon WJ, Lee YJ, et al. Inhibits Iron Overload-Induced Oxidative Stress through Activation of Signaling in a Rat Model of Lumbar Spinal Stenosis. Oxid Med Cell Longev. 2022;2022:3472443. 10.1155/2022/3472443
- Vediappan RS, Mascarenhas A, Nguyen-Hoang A, Anne Fong S, Jukes A, et al. Prevention of peridural adhesions in spinal surgery: Assessing safety and efficacy of Chitogel with Deferiprone in a sheep model. J Clin Neurosci. 2020;72:378. 10.1016/j.jocn.2019.12.042
- Dyszkiewicz AJ, Kępiński P, Połeć P, Chachulski D, Nowak-Kostrzewska E. Changeability of tissue's magnetic remanence after galvanic-magnetostimulation in upper-back pain treatment. Comput Biol Med. 2015;66:242. 10.1016/j.compbiomed.2015.08.009
- Vormann J, Worlitschek M, Goedecke T, Silver B. Supplementation with alkaline minerals reduces symptoms in patients with chronic low back pain. J Trace Elem Med Biol. 2001;15:179.
