' 
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 18 Reviews
8.9
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 180 mg Ferrous Bisglycinate)(Ferrochel™)
36 mg
200%
Top Medical Research Studies
9
HP alleviates iron-induced back pain
Inhibits Iron Overload-Induced Oxidative Stress through Activation of Signaling in a Rat Model of Lumbar Spinal Stenosis.
Relevant effects of HP treatment
We investigated how a substance called HP influences iron-related oxidative stress and its connection to back pain in a common condition known as lumbar spinal stenosis (LSS). LSS causes significant discomfort and disability, particularly for older adults, primarily due to hypertrophy of the ligamentum flavum, which can be exacerbated by oxidative stress stemming from imbalanced iron levels.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Read More
9
Iron's indirect role in back pain
Melittin regulates iron homeostasis and mediates macrophage polarization in rats with lumbar spinal stenosis.
Focus on melittin, not iron
We set out to explore how iron treatment impacts back pain, particularly in the context of lumbar spinal stenosis (LSS). This condition, marked by the narrowing of the spinal canal, often leads to nerve compression and chronic inflammation—both linked to heightened iron levels in the body.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
Read More
Most Useful Reviews
9.5
Dizziness reduction
I previously took a Japanese heme iron supplement but experienced dizziness, nausea, and migraines. After switching to a high-quality iron supplement, I noticed an improvement in my dizziness by the second day and my migraines vanished within a week. Though the capsules have an iron smell, I highly recommend this for anyone who has not found relief with Japanese heme iron.
Read More
9.5
Reduced PMS symptoms
After seven years of suffering from pre-menstrual depression and low ferritin levels, I began taking one tablet of iron each morning and evening with vitamin C. Within days, my eyelids changed colour, and my depression improved. The duration of my depressive symptoms shortened, and I no longer experience shortness of breath during exercise.
Read More
9
Eased menstrual pain
I discovered this supplement while dealing with severe menstrual pain and PMS. After three years of taking two tablets daily, my menstrual pains and morning fatigue have significantly decreased, along with dizziness when standing. I worry about running out of supply as it has genuinely helped me.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
- All Researches
9
Iron's indirect role in back pain
Melittin regulates iron homeostasis and mediates macrophage polarization in rats with lumbar spinal stenosis.
Focus on melittin, not iron
We set out to explore how iron treatment impacts back pain, particularly in the context of lumbar spinal stenosis (LSS). This condition, marked by the narrowing of the spinal canal, often leads to nerve compression and chronic inflammation—both linked to heightened iron levels in the body.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
Read More
9
HP alleviates iron-induced back pain
Inhibits Iron Overload-Induced Oxidative Stress through Activation of Signaling in a Rat Model of Lumbar Spinal Stenosis.
Relevant effects of HP treatment
We investigated how a substance called HP influences iron-related oxidative stress and its connection to back pain in a common condition known as lumbar spinal stenosis (LSS). LSS causes significant discomfort and disability, particularly for older adults, primarily due to hypertrophy of the ligamentum flavum, which can be exacerbated by oxidative stress stemming from imbalanced iron levels.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.9
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Dizziness reduction
I previously took a Japanese heme iron supplement but experienced dizziness, nausea, and migraines. After switching to a high-quality iron supplement, I noticed an improvement in my dizziness by the second day and my migraines vanished within a week. Though the capsules have an iron smell, I highly recommend this for anyone who has not found relief with Japanese heme iron.
Read More
9.5
Reduced PMS symptoms
After seven years of suffering from pre-menstrual depression and low ferritin levels, I began taking one tablet of iron each morning and evening with vitamin C. Within days, my eyelids changed colour, and my depression improved. The duration of my depressive symptoms shortened, and I no longer experience shortness of breath during exercise.
Read More
9
Eased menstrual pain
I discovered this supplement while dealing with severe menstrual pain and PMS. After three years of taking two tablets daily, my menstrual pains and morning fatigue have significantly decreased, along with dizziness when standing. I worry about running out of supply as it has genuinely helped me.
Read More
9.5
Improved blood levels
Brings me back to life! After feeling tired and breathless, tests showed low ferritin. I switched to iron bisglycinate, which is better absorbed, and after one can, I felt stronger and in a better mood. My blood levels improved significantly, and there were no side effects.
9.5
Pain-free menstruation
My spouse noticed improvements after taking it for pain relief before and during menstruation. By the third month, the back pain disappeared, and she felt great.
