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SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 20 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 180 mg Ferrous Bisglycinate)(Ferrochel™)
36 mg
200%
Top Medical Research Studies
9
Rubiadin reduces liver iron overload
Rubiadin Mediates the Upregulation of Hepatic Hepcidin and Alleviates Iron Overload via BMP6/SMAD1/5/9-Signaling Pathway.
Study highly relevant to liver disease
We explored the effects of rubiadin, a beneficial compound derived from a Chinese herb, on iron metabolism and its implications for liver disease. Recognizing the challenges posed by iron overload diseases, we aimed to discover a safe approach to manage excessive iron accumulation in the body. Through experiments involving various analyses, we observed that rubiadin significantly downregulated proteins that are typically elevated in conditions of high iron, such as transferrin receptor 1 and ferroportin 1.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Read More
7
Iron's impact on liver disease
Long-term iron supplementation in four patients with X-linked erythropoietic protoporphyria: associations with serum proteins and erythrocyte protoporphyrin levels-a single-centre retrospective study.
Focus on liver treatment effects
We explored the long-term effects of iron supplementation in four patients suffering from X-linked erythropoietic protoporphyria (XLEPP), a rare genetic disorder that can lead to serious liver problems due to the buildup of a substance called protoporphyrin IX (PPIX) in the blood. This condition often causes severe photosensitivity and can result in liver damage, which, in some cases, may necessitate a liver transplant.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
Read More
Most Useful Reviews
9.5
Significant improvement
Awesome working additive! This iron supplement has notably improved my friend’s condition with liver disease. She struggled with low haemoglobin due to her medications. After taking this iron for three months, her haemoglobin rose significantly! Unlike other treatments, this one didn't cause nausea. She feels great now, and I’ve started it for prevention myself. Many thanks to the manufacturers!
Read More
1.3
Digestive issues
I won't buy this again! It caused stomach pain and discomfort around my liver, unlike the softer Solgar Iron Chelation I had been using.
Read More
9.5
Resolved hidden anemia
The capsules are small and easy to swallow. Since I started taking this iron supplement for my hidden liver disease, my symptoms, such as dizziness, have disappeared. I believe iron wasn't properly supplied to my body before. My craving for liver has also improved, which shows this supplement is effective.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
9
Rubiadin reduces liver iron overload
Rubiadin Mediates the Upregulation of Hepatic Hepcidin and Alleviates Iron Overload via BMP6/SMAD1/5/9-Signaling Pathway.
Study highly relevant to liver disease
We explored the effects of rubiadin, a beneficial compound derived from a Chinese herb, on iron metabolism and its implications for liver disease. Recognizing the challenges posed by iron overload diseases, we aimed to discover a safe approach to manage excessive iron accumulation in the body. Through experiments involving various analyses, we observed that rubiadin significantly downregulated proteins that are typically elevated in conditions of high iron, such as transferrin receptor 1 and ferroportin 1.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Read More
7
Iron's impact on liver disease
Long-term iron supplementation in four patients with X-linked erythropoietic protoporphyria: associations with serum proteins and erythrocyte protoporphyrin levels-a single-centre retrospective study.
Focus on liver treatment effects
We explored the long-term effects of iron supplementation in four patients suffering from X-linked erythropoietic protoporphyria (XLEPP), a rare genetic disorder that can lead to serious liver problems due to the buildup of a substance called protoporphyrin IX (PPIX) in the blood. This condition often causes severe photosensitivity and can result in liver damage, which, in some cases, may necessitate a liver transplant.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8.2
9.5
Significant improvement
Awesome working additive! This iron supplement has notably improved my friend’s condition with liver disease. She struggled with low haemoglobin due to her medications. After taking this iron for three months, her haemoglobin rose significantly! Unlike other treatments, this one didn't cause nausea. She feels great now, and I’ve started it for prevention myself. Many thanks to the manufacturers!
Read More
9.5
Resolved hidden anemia
The capsules are small and easy to swallow. Since I started taking this iron supplement for my hidden liver disease, my symptoms, such as dizziness, have disappeared. I believe iron wasn't properly supplied to my body before. My craving for liver has also improved, which shows this supplement is effective.
Read More
9.5
Anemia improvement
Recommended by my doctor, this iron supplement helped me with my liver disease-related anaemia. After taking two tablets daily for 1.5 months, I've noticed significant improvements in my well-being, including easier mornings and better physical stamina.
9.5
Anemia symptoms reduced
Since I began taking this iron supplement for my pre-menstrual depression linked to hidden liver disease, my symptoms improved remarkably. The redness in my eyelids returned, and my fatigue has decreased. Overall, this product has been truly beneficial!
8.8
Liver damage avoided
I’m taking this iron supplement on Dr. Tokumi Fujikawa’s recommendation. Previously, I experienced liver damage from other iron supplements but have had normal liver values since starting this. I am grateful for this product as I can't get enough iron from my diet alone.
