Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
USERS' SCORE
Moderately Good
Based on 20 Reviews
7.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 180 mg Ferrous Bisglycinate)(Ferrochel™)
36 mg
200%
Top Medical Research Studies
9
We explored the effects of rubiadin, a beneficial compound derived from a Chinese herb, on iron metabolism and its implications for liver disease. Recognizing the challenges posed by iron overload diseases, we aimed to discover a safe approach to manage excessive iron accumulation in the body. Through experiments involving various analyses, we observed that rubiadin significantly downregulated proteins that are typically elevated in conditions of high iron, such as transferrin receptor 1 and ferroportin 1.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Read More
9
We explored how parasitic infection from protoscolex (PSC) impacts liver health, particularly through a process known as ferroptosis, which leads to cell death. In our study, both live rat models and cultured liver cells were used to investigate how PSC infection disrupts iron metabolism, contributing to liver damage.
While we found that ferroptosis resulted from PSC infection, using a ferroptosis inhibitor called Ferrostatin-1 showed promising results in reducing liver cell damage and preventing the formation of fibrotic cysts. This suggests that targeting ferroptosis could be a new avenue for addressing liver issues caused by PSC infection.
While we found that ferroptosis resulted from PSC infection, using a ferroptosis inhibitor called Ferrostatin-1 showed promising results in reducing liver cell damage and preventing the formation of fibrotic cysts. This suggests that targeting ferroptosis could be a new avenue for addressing liver issues caused by PSC infection.
Read More
8
We explored the effects of Shugan Xiaozhi (SGXZ) decoction on metabolic dysfunction-associated steatohepatitis (MASH), a challenging liver disease. By using various advanced methods, we identified how SGXZ works on a mouse model of MASH.
The results showed that SGXZ decoction can significantly improve liver health by regulating specific pathways involved in cell death. Its therapeutic mechanisms appear to involve the p53/SLC7A11/GPX4 pathway, which plays a role in reducing a specific type of cell death linked to iron metabolism, known as ferroptosis.
Overall, SGXZ decoction shows promise as a treatment option for MASH.
The results showed that SGXZ decoction can significantly improve liver health by regulating specific pathways involved in cell death. Its therapeutic mechanisms appear to involve the p53/SLC7A11/GPX4 pathway, which plays a role in reducing a specific type of cell death linked to iron metabolism, known as ferroptosis.
Overall, SGXZ decoction shows promise as a treatment option for MASH.
Read More
Most Useful Reviews
9
Significant improvement
391 people found this helpful
Awesome working additive! This iron supplement has notably improved my friend’s condition with liver disease. She struggled with low haemoglobin due to her medications. After taking this iron for three months, her haemoglobin rose significantly! Unlike other treatments, this one didn't cause nausea. She feels great now, and I’ve started it for prevention myself. Many thanks to the manufacturers!
Read More
0
Digestive issues
9 people found this helpful
I won't buy this again! It caused stomach pain and discomfort around my liver, unlike the softer Solgar Iron Chelation I had been using.
Read More
9
Resolved hidden anemia
5 people found this helpful
The capsules are small and easy to swallow. Since I started taking this iron supplement for my hidden liver disease, my symptoms, such as dizziness, have disappeared. I believe iron wasn't properly supplied to my body before. My craving for liver has also improved, which shows this supplement is effective.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
- All Researches
9
We explored the effects of rubiadin, a beneficial compound derived from a Chinese herb, on iron metabolism and its implications for liver disease. Recognizing the challenges posed by iron overload diseases, we aimed to discover a safe approach to manage excessive iron accumulation in the body. Through experiments involving various analyses, we observed that rubiadin significantly downregulated proteins that are typically elevated in conditions of high iron, such as transferrin receptor 1 and ferroportin 1.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Read More
9
We explored how parasitic infection from protoscolex (PSC) impacts liver health, particularly through a process known as ferroptosis, which leads to cell death. In our study, both live rat models and cultured liver cells were used to investigate how PSC infection disrupts iron metabolism, contributing to liver damage.
While we found that ferroptosis resulted from PSC infection, using a ferroptosis inhibitor called Ferrostatin-1 showed promising results in reducing liver cell damage and preventing the formation of fibrotic cysts. This suggests that targeting ferroptosis could be a new avenue for addressing liver issues caused by PSC infection.
While we found that ferroptosis resulted from PSC infection, using a ferroptosis inhibitor called Ferrostatin-1 showed promising results in reducing liver cell damage and preventing the formation of fibrotic cysts. This suggests that targeting ferroptosis could be a new avenue for addressing liver issues caused by PSC infection.
Read More
8
We explored the effects of Shugan Xiaozhi (SGXZ) decoction on metabolic dysfunction-associated steatohepatitis (MASH), a challenging liver disease. By using various advanced methods, we identified how SGXZ works on a mouse model of MASH.
The results showed that SGXZ decoction can significantly improve liver health by regulating specific pathways involved in cell death. Its therapeutic mechanisms appear to involve the p53/SLC7A11/GPX4 pathway, which plays a role in reducing a specific type of cell death linked to iron metabolism, known as ferroptosis.
Overall, SGXZ decoction shows promise as a treatment option for MASH.
The results showed that SGXZ decoction can significantly improve liver health by regulating specific pathways involved in cell death. Its therapeutic mechanisms appear to involve the p53/SLC7A11/GPX4 pathway, which plays a role in reducing a specific type of cell death linked to iron metabolism, known as ferroptosis.
Overall, SGXZ decoction shows promise as a treatment option for MASH.
Read More
8
We investigated how the Biejiajian Pill (BJJP) affects liver cancer cells by regulating a process called ferroptosis. In our experiments, we looked at different groups of hepatocellular carcinoma cells treated with various combinations of BJJP and ferroptosis inducers or inhibitors.
We found that BJJP, particularly at higher doses, significantly increased iron levels and reactive oxygen species, while decreasing important antioxidants in the cells. This indicates that BJJP might play a role in managing liver cancer by influencing cell death pathways, particularly through the p62/Keap1/NRF2 signaling pathway.
We found that BJJP, particularly at higher doses, significantly increased iron levels and reactive oxygen species, while decreasing important antioxidants in the cells. This indicates that BJJP might play a role in managing liver cancer by influencing cell death pathways, particularly through the p62/Keap1/NRF2 signaling pathway.
Read More
8
We explored the rare combination of 46, XY disorders of sex development (DSD) and aceruloplasminaemia (ACP) in a young female patient. Recognizing these two conditions together can be challenging, but it's crucial for proper diagnosis and treatment.
After discovering elevated ferritin levels and further tests, we identified a mutation linked to both disorders. Treatment with deferasirox significantly reduced iron overload, which is vital for preventing organ damage linked to these conditions.
Increasing awareness of these coexisting disorders can lead to better outcomes through timely interventions and genetic testing.
After discovering elevated ferritin levels and further tests, we identified a mutation linked to both disorders. Treatment with deferasirox significantly reduced iron overload, which is vital for preventing organ damage linked to these conditions.
Increasing awareness of these coexisting disorders can lead to better outcomes through timely interventions and genetic testing.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 20 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant improvement
391 people found this helpful
Awesome working additive! This iron supplement has notably improved my friend’s condition with liver disease. She struggled with low haemoglobin due to her medications. After taking this iron for three months, her haemoglobin rose significantly! Unlike other treatments, this one didn't cause nausea. She feels great now, and I’ve started it for prevention myself. Many thanks to the manufacturers!
Read More
0
Digestive issues
9 people found this helpful
I won't buy this again! It caused stomach pain and discomfort around my liver, unlike the softer Solgar Iron Chelation I had been using.
Read More
9
Resolved hidden anemia
5 people found this helpful
The capsules are small and easy to swallow. Since I started taking this iron supplement for my hidden liver disease, my symptoms, such as dizziness, have disappeared. I believe iron wasn't properly supplied to my body before. My craving for liver has also improved, which shows this supplement is effective.
Read More
9
Anemia improvement
3 people found this helpful
Recommended by my doctor, this iron supplement helped me with my liver disease-related anaemia. After taking two tablets daily for 1.5 months, I've noticed significant improvements in my well-being, including easier mornings and better physical stamina.
Read More
9
Anemia symptoms reduced
2 people found this helpful
Since I began taking this iron supplement for my pre-menstrual depression linked to hidden liver disease, my symptoms improved remarkably. The redness in my eyelids returned, and my fatigue has decreased. Overall, this product has been truly beneficial!
Read More
Frequently Asked Questions
9
Anemia improvement
3 people found this helpful
Recommended by my doctor, this iron supplement helped me with my liver disease-related anaemia. After taking two tablets daily for 1.5 months, I've noticed significant improvements in my well-being, including easier mornings and better physical stamina.
9
Resolved hidden anemia
5 people found this helpful
The capsules are small and easy to swallow. Since I started taking this iron supplement for my hidden liver disease, my symptoms, such as dizziness, have disappeared. I believe iron wasn't properly supplied to my body before. My craving for liver has also improved, which shows this supplement is effective.
0
Regular testing needed
I've been taking this for two years without concern until a recent blood test showed elevated ferritin and liver function decline. Regular checks are necessary.
9
Significant improvement
391 people found this helpful
Awesome working additive! This iron supplement has notably improved my friend’s condition with liver disease. She struggled with low haemoglobin due to her medications. After taking this iron for three months, her haemoglobin rose significantly! Unlike other treatments, this one didn't cause nausea. She feels great now, and I’ve started it for prevention myself. Many thanks to the manufacturers!
9
Anemia symptoms reduced
2 people found this helpful
Since I began taking this iron supplement for my pre-menstrual depression linked to hidden liver disease, my symptoms improved remarkably. The redness in my eyelids returned, and my fatigue has decreased. Overall, this product has been truly beneficial!
0
Digestive issues
9 people found this helpful
I won't buy this again! It caused stomach pain and discomfort around my liver, unlike the softer Solgar Iron Chelation I had been using.
0
Energy loss
2 people found this helpful
Since starting this supplement, I’ve lost my energy and suspect it may be affecting my liver. I plan to discontinue it soon.
7.5
Awakening enhanced
Since taking three tablets of this iron supplement, I've seen a substantial improvement in my life affected by liver disease. My anxiety and depression symptoms, related to my condition, have also improved. I recommend this product, especially for those suffering from similar issues!
7.5
Reduced hair loss
4 people found this helpful
I took this iron with vitamin C to combat my hair loss, and it has been fantastic. The falling has eased significantly, and I've learned to take it correctly—once daily on an empty stomach. It’s worked wonders for me.
7.5
Liver damage avoided
5 people found this helpful
I’m taking this iron supplement on Dr. Tokumi Fujikawa’s recommendation. Previously, I experienced liver damage from other iron supplements but have had normal liver values since starting this. I am grateful for this product as I can't get enough iron from my diet alone.
0
Nausea and liver effects
I stopped taking this due to nausea and upset stomach, feeling it aggravated my liver. I cannot tolerate it and have discarded it.
0
Potential overdose risk
9 people found this helpful
Iron is essential for mental health, but this product may cause liver disease due to its high absorption rate. It’s advisable to monitor intake closely and perform regular blood tests.
0
Monitor liver function
I take one tablet cautiously, as excess chelated iron can worsen liver function. I monitor my stool colour and have regular blood tests to ensure safety.
We explored the long-term effects of iron supplementation in four patients suffering from X-linked erythropoietic protoporphyria (XLEPP), a rare genetic disorder that can lead to serious liver problems due to the buildup of a substance called protoporphyrin IX (PPIX) in the blood. This condition often causes severe photosensitivity and can result in liver damage, which, in some cases, may necessitate a liver transplant.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
9
We explored the effects of rubiadin, a beneficial compound derived from a Chinese herb, on iron metabolism and its implications for liver disease. Recognizing the challenges posed by iron overload diseases, we aimed to discover a safe approach to manage excessive iron accumulation in the body. Through experiments involving various analyses, we observed that rubiadin significantly downregulated proteins that are typically elevated in conditions of high iron, such as transferrin receptor 1 and ferroportin 1.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
8
We explored the effects of Shugan Xiaozhi (SGXZ) decoction on metabolic dysfunction-associated steatohepatitis (MASH), a challenging liver disease. By using various advanced methods, we identified how SGXZ works on a mouse model of MASH.
The results showed that SGXZ decoction can significantly improve liver health by regulating specific pathways involved in cell death. Its therapeutic mechanisms appear to involve the p53/SLC7A11/GPX4 pathway, which plays a role in reducing a specific type of cell death linked to iron metabolism, known as ferroptosis.
Overall, SGXZ decoction shows promise as a treatment option for MASH.
The results showed that SGXZ decoction can significantly improve liver health by regulating specific pathways involved in cell death. Its therapeutic mechanisms appear to involve the p53/SLC7A11/GPX4 pathway, which plays a role in reducing a specific type of cell death linked to iron metabolism, known as ferroptosis.
Overall, SGXZ decoction shows promise as a treatment option for MASH.
References
- Minder AE, Granata F, van Breemen F, Schneider-Yin X, Minder EI, et al. Long-term iron supplementation in four patients with X-linked erythropoietic protoporphyria: associations with serum proteins and erythrocyte protoporphyrin levels-a single-centre retrospective study. Front Mol Biosci. 2025;12:1509803. doi:10.3389/fmolb.2025.1509803
- Xie X, Chang L, Zhu X, Gong F, Che L, et al. Rubiadin Mediates the Upregulation of Hepatic Hepcidin and Alleviates Iron Overload via BMP6/SMAD1/5/9-Signaling Pathway. Int J Mol Sci. 2025;26. doi:10.3390/ijms26031385
- Wang S, Du R, Liu J, Zhong W, Zhang C, et al. Multi-approach analysis reveals the mechanism by which Shugan Xiaozhi decoction protects against metabolic dysfunction-associated steatohepatitis. Phytomedicine. 2025;141:156712. doi:10.1016/j.phymed.2025.156712
- Satehi MB, Karimi M, Eskandari A, Mahmoodi H. The effect of aqueous extract of Iranian oak () on lipid profile and liver enzymes in beta-thalassemia patients: a randomized controlled trial, double-blind, placebo-controlled. Front Nutr. 2025;12:1537420. doi:10.3389/fnut.2025.1537420
- Chen W, He C, Wen B, Sun H, Yang X, et al. [Biejiajian Pill Regulates Ferroptosis in Hepatocellular Carcinoma Cells via p62/Keap1/NRF2 Signaling Pathway: A Mechanism Study]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:51. doi:10.12182/20250160502
- Li Y, Zhao M, Liu Y, Wang L, Huang Y, et al. 46, XY disorders of sex development combined with aceruloplasminaemia: a case report and review of the literature. Orphanet J Rare Dis. 2025;20:124. doi:10.1186/s13023-025-03626-2
- Zhai S, Yang Y, Zhou Y, Lai Q, Li K, et al. -Induced Liver Damage Through Ferroptosis in Rat Model. Cells. 2025;14. doi:10.3390/cells14050328
