Last update
4/8/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Ubiquinol (Kaneka Ubiquinolâ„¢) (Reduced Form CoQ10)
100 mg
**
Top Medical Research Studies
8
CoQ10 shows promise for arthritis
We explored the effects of Coenzyme Q10 (CoQ10) supplementation on individuals suffering from rheumatoid arthritis, a condition characterized by heightened levels of inflammation. Conducted as a double-blind, randomized controlled trial, our study included 44 participants, divided into two groups: one received 100 mg of CoQ10 daily, while the other took a placebo over a two-month period.
By measuring important markers like malondialdehyde (MDA), total antioxidant capacity (TAC), interleukin (IL)-6, and tumor necrosis factor alpha (TNF-α) before and after the intervention, we aimed to assess how CoQ10 might influence oxidative stress and inflammation.
The results indicated a significant decrease in serum MDA levels among those who took CoQ10, suggesting improved oxidative stress levels. Additionally, we noted a suppression of TNF-α, a key inflammatory cytokine. However, we found no significant changes in TAC or IL-6 levels between the two groups, which indicates that while CoQ10 seems to offer some benefits in reducing certain inflammatory markers, its overall effect on oxidative stress and other pro-inflammatory cytokines may be more limited than anticipated.
Thus, this study highlights the potential of CoQ10 as a supplementary treatment for managing inflammation in rheumatoid arthritis, although further research is needed to fully understand its role compared to other forms such as ubiquinol.
By measuring important markers like malondialdehyde (MDA), total antioxidant capacity (TAC), interleukin (IL)-6, and tumor necrosis factor alpha (TNF-α) before and after the intervention, we aimed to assess how CoQ10 might influence oxidative stress and inflammation.
The results indicated a significant decrease in serum MDA levels among those who took CoQ10, suggesting improved oxidative stress levels. Additionally, we noted a suppression of TNF-α, a key inflammatory cytokine. However, we found no significant changes in TAC or IL-6 levels between the two groups, which indicates that while CoQ10 seems to offer some benefits in reducing certain inflammatory markers, its overall effect on oxidative stress and other pro-inflammatory cytokines may be more limited than anticipated.
Thus, this study highlights the potential of CoQ10 as a supplementary treatment for managing inflammation in rheumatoid arthritis, although further research is needed to fully understand its role compared to other forms such as ubiquinol.
Read More
Most Useful Reviews
9
Eased muscle pain
5 people found this helpful
Highly recommended. CO Q10 is excellent for my arthritis, and with the addition of Ubiquinol, it absorbs faster. I recommend this product as it has been effective for everyone I know taking it, and my doctor confirmed it helps relieve muscle pain and arthritis.
Read More
6
Pain reduction noted
5 people found this helpful
It seems to help. I'm taking other vitamins and supplements, so it's challenging to determine which one delivers on its promises, but I've noticed a reduction in my arthritis pain in the wrists since starting Ubiquinol 100 mg once daily. My husband claims that his hand circulation has also improved, as his finger mobility has increased.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
CoQ10 shows promise for arthritis
We explored the effects of Coenzyme Q10 (CoQ10) supplementation on individuals suffering from rheumatoid arthritis, a condition characterized by heightened levels of inflammation. Conducted as a double-blind, randomized controlled trial, our study included 44 participants, divided into two groups: one received 100 mg of CoQ10 daily, while the other took a placebo over a two-month period.
By measuring important markers like malondialdehyde (MDA), total antioxidant capacity (TAC), interleukin (IL)-6, and tumor necrosis factor alpha (TNF-α) before and after the intervention, we aimed to assess how CoQ10 might influence oxidative stress and inflammation.
The results indicated a significant decrease in serum MDA levels among those who took CoQ10, suggesting improved oxidative stress levels. Additionally, we noted a suppression of TNF-α, a key inflammatory cytokine. However, we found no significant changes in TAC or IL-6 levels between the two groups, which indicates that while CoQ10 seems to offer some benefits in reducing certain inflammatory markers, its overall effect on oxidative stress and other pro-inflammatory cytokines may be more limited than anticipated.
Thus, this study highlights the potential of CoQ10 as a supplementary treatment for managing inflammation in rheumatoid arthritis, although further research is needed to fully understand its role compared to other forms such as ubiquinol.
By measuring important markers like malondialdehyde (MDA), total antioxidant capacity (TAC), interleukin (IL)-6, and tumor necrosis factor alpha (TNF-α) before and after the intervention, we aimed to assess how CoQ10 might influence oxidative stress and inflammation.
The results indicated a significant decrease in serum MDA levels among those who took CoQ10, suggesting improved oxidative stress levels. Additionally, we noted a suppression of TNF-α, a key inflammatory cytokine. However, we found no significant changes in TAC or IL-6 levels between the two groups, which indicates that while CoQ10 seems to offer some benefits in reducing certain inflammatory markers, its overall effect on oxidative stress and other pro-inflammatory cytokines may be more limited than anticipated.
Thus, this study highlights the potential of CoQ10 as a supplementary treatment for managing inflammation in rheumatoid arthritis, although further research is needed to fully understand its role compared to other forms such as ubiquinol.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Eased muscle pain
5 people found this helpful
Highly recommended. CO Q10 is excellent for my arthritis, and with the addition of Ubiquinol, it absorbs faster. I recommend this product as it has been effective for everyone I know taking it, and my doctor confirmed it helps relieve muscle pain and arthritis.
Read More
6
Pain reduction noted
5 people found this helpful
It seems to help. I'm taking other vitamins and supplements, so it's challenging to determine which one delivers on its promises, but I've noticed a reduction in my arthritis pain in the wrists since starting Ubiquinol 100 mg once daily. My husband claims that his hand circulation has also improved, as his finger mobility has increased.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Abdollahzad H, Aghdashi MA, Asghari Jafarabadi M, Alipour B. Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial. Arch Med Res. 2015;46:527. 10.1016/j.arcmed.2015.08.006
