' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 13 Researches
7.9
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%
Top Medical Research Studies
9
Vitamin D3 shows promise for Alzheimer's
Chronic vitamin D supplementation alleviates cognition impairment via inhibition of oxidative stress regulated by PI3K/AKT/Nrf2 in APP/PS1 transgenic mice.
Direct assessment of vitamin D3
We explored the impact of vitamin D3 supplementation on cognitive decline in transgenic mice that model Alzheimer's disease. Over a 20-week treatment period, we conducted a series of tests, including a Morris Water Maze test to assess cognitive function and various analyses to gauge oxidative stress and Alzheimer-related pathology.
Our observations indicated that vitamin D3 treatment not only improved the memory performance of the mice but also positively influenced brain health. Specifically, we found that vitamin D3 led to a reduction in amyloid beta (Aβ) buildup, a hallmark of Alzheimer's, and decreased levels of proteins associated with the disease, such as APP, tau, and phosphorylated tau (p-tau).
Moreover, vitamin D3 appeared to bolster the brain's defenses against oxidative stress, enhancing key antioxidant levels while lowering harmful substances related to oxidative damage. The treatment activated important pathways involved in cellular protection, further supporting the notion that vitamin D3 may offer neuroprotective effects.
In conclusion, our study suggests that vitamin D3 could play a beneficial role in improving cognition and reducing Alzheimer-like changes in the brain. These findings invite further exploration into the potential of vitamin D3 as a supportive treatment in Alzheimer’s disease management.
Our observations indicated that vitamin D3 treatment not only improved the memory performance of the mice but also positively influenced brain health. Specifically, we found that vitamin D3 led to a reduction in amyloid beta (Aβ) buildup, a hallmark of Alzheimer's, and decreased levels of proteins associated with the disease, such as APP, tau, and phosphorylated tau (p-tau).
Moreover, vitamin D3 appeared to bolster the brain's defenses against oxidative stress, enhancing key antioxidant levels while lowering harmful substances related to oxidative damage. The treatment activated important pathways involved in cellular protection, further supporting the notion that vitamin D3 may offer neuroprotective effects.
In conclusion, our study suggests that vitamin D3 could play a beneficial role in improving cognition and reducing Alzheimer-like changes in the brain. These findings invite further exploration into the potential of vitamin D3 as a supportive treatment in Alzheimer’s disease management.
Read More
7
Vitamin D3 mitigates brain abnormalities
Vitamin D3 supplementation may attenuate morphological and molecular abnormalities of the olfactory bulb in a mouse model of Down syndrome.
Highly relevant to Alzheimer's research
We investigated the impact of vitamin D3 on neurological abnormalities, especially in the context of Alzheimer’s disease (AD) among individuals with Down syndrome (DS). Our focus was on how vitamin D3 might alleviate issues within the olfactory bulb, a brain region linked to both smell perception and cognitive functions.
We examined adult female mice with Down syndrome and looked at their nerve cell structure and functioning. Our findings showed that these trisomic mice had several morphological changes, including a reduced volume in the outer layer of the olfactory bulb and fewer mitral and granule cells. Additionally, there was an uptick in certain harmful markers like amyloid-β 42 and caspase-3, which are associated with neurodegeneration and cell death.
After administering vitamin D3, we observed some impressive outcomes. Treatment with this vitamin appeared to reverse some structural issues in the olfactory bulb and reduced the levels of certain harmful markers. This suggests that vitamin D3 has potential as a therapeutic agent, helping to mitigate some of the adverse effects associated with the genetic factors of Down syndrome that could also contribute to Alzheimer’s disease.
Overall, our findings strengthen the notion that vitamin D3 could serve as a meaningful intervention in addressing both morphological and molecular changes in the brain related to these conditions.
We examined adult female mice with Down syndrome and looked at their nerve cell structure and functioning. Our findings showed that these trisomic mice had several morphological changes, including a reduced volume in the outer layer of the olfactory bulb and fewer mitral and granule cells. Additionally, there was an uptick in certain harmful markers like amyloid-β 42 and caspase-3, which are associated with neurodegeneration and cell death.
After administering vitamin D3, we observed some impressive outcomes. Treatment with this vitamin appeared to reverse some structural issues in the olfactory bulb and reduced the levels of certain harmful markers. This suggests that vitamin D3 has potential as a therapeutic agent, helping to mitigate some of the adverse effects associated with the genetic factors of Down syndrome that could also contribute to Alzheimer’s disease.
Overall, our findings strengthen the notion that vitamin D3 could serve as a meaningful intervention in addressing both morphological and molecular changes in the brain related to these conditions.
Read More
9
Vitamin D3 improves Alzheimer's symptoms
Neuroprotective effects of vitamin D in an Alzheimer's disease rat model: Improvement of mitochondrial dysfunction via calcium/calmodulin-dependent protein kinase kinase 2 activation of Sirtuin1 phosphorylation.
Relevant effects of vitamin D3
We investigated whether vitamin D3 (Vit.D) could help mitigate cognitive decline and restore mitochondrial function in an Alzheimer's disease (AD) rat model. The study involved groups of rats exposed to Alzheimer's-inducing substances, as well as groups receiving vitamin D3 treatment. By employing various cognitive tests and analyzing brain tissue, we aimed to understand how vitamin D3 affects memory and brain health.
Our findings revealed that vitamin D3 did have a positive effect. It was shown to reduce brain injury, cognitive decline, and levels of amyloid beta, a protein involved in Alzheimer's. Furthermore, vitamin D3 also influenced key proteins in the brain that support mitochondrial health, which plays a critical role in cell energy and function. We observed that vitamin D3 helped restore normal levels of calcium in the brain and elevated the function of proteins responsible for energy metabolism.
Overall, it appears that vitamin D3 can alleviate some of the cognitive challenges associated with AD by improving mitochondrial function and reducing oxidative stress. This suggests potential pathways through which vitamin D3 might exert protective effects against Alzheimer's disease.
Our findings revealed that vitamin D3 did have a positive effect. It was shown to reduce brain injury, cognitive decline, and levels of amyloid beta, a protein involved in Alzheimer's. Furthermore, vitamin D3 also influenced key proteins in the brain that support mitochondrial health, which plays a critical role in cell energy and function. We observed that vitamin D3 helped restore normal levels of calcium in the brain and elevated the function of proteins responsible for energy metabolism.
Overall, it appears that vitamin D3 can alleviate some of the cognitive challenges associated with AD by improving mitochondrial function and reducing oxidative stress. This suggests potential pathways through which vitamin D3 might exert protective effects against Alzheimer's disease.
Read More
Most Useful Reviews
8.8
Effective treatment
I have given this to my mother for over two years, at 50,000 IU a day, as she has alzheimer. When her vitamin D levels became excessively high, the doctor advised a temporary stop. After four months, her vitamin D was low again, confirming that this treatment is effective.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 13 Researches
7.9
9
Alzheimer's treatment show promise
Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia.
Vitamin D3's separate effects unclear
We conducted a study to assess the effects of a new combination treatment on memory recovery in rats with scopolamine-induced dementia, a model for Alzheimer's disease. This combination included α-lipoic acid, citicoline, olive tree and green tea extracts, vitamin D3, selenium, and an immune-supporting complex.
During our evaluation, we observed that this combination significantly improved both short- and long-term memory as well as spatial memory. Interestingly, while vitamin D3 was one of the components in the treatment, our study does not allow us to determine its isolated impact.
We monitored several biochemical markers and noted encouraging changes in brain activity, with enhanced SOD, catalase, and GPx activities, and higher levels of BDNF and pCREB. Importantly, we found no significant negative effects, making this combination appear as a safe option in a multitargeted approach to treat Alzheimer's.
During our evaluation, we observed that this combination significantly improved both short- and long-term memory as well as spatial memory. Interestingly, while vitamin D3 was one of the components in the treatment, our study does not allow us to determine its isolated impact.
We monitored several biochemical markers and noted encouraging changes in brain activity, with enhanced SOD, catalase, and GPx activities, and higher levels of BDNF and pCREB. Importantly, we found no significant negative effects, making this combination appear as a safe option in a multitargeted approach to treat Alzheimer's.
Read More
9
Vitamin D3 mitigates Alzheimer's damage
Hippocampal mitochondrial Ca in experimentally induced Alzheimer's disease, link to calpains and impact of vitamin D3 supplementation.
Relevant to Alzheimer's treatment exploration
We explored the impact of vitamin D3 on the brain’s health in a model of Alzheimer’s disease (AD) induced by aluminum chloride. In our study, we used forty male Wistar rats and divided them into four groups: a control group, an AD group, an AD group treated with vitamin D3 alongside the AD model, and an AD group that received vitamin D3 after the onset of AD symptoms.
Through our experiments, we found that the AD rats exhibited significant changes in their hippocampal region, including increased mitochondrial calcium, decreased levels of ATP and ADP, elevated calpain-1 and calpain-2 levels, and disruptions in the cytochrome C pathway—factors that are linked to mitochondrial dysfunction and neuronal degeneration. Interestingly, when we supplemented the AD rats with vitamin D3, we noted improvements in mitochondrial function, reduced neuronal degeneration, and even improvements in histological changes in the brain.
This improvement suggests that vitamin D3 may play a vital role in breaking the harmful cycle associated with AD, which involves high calcium levels and calpain activation leading to further neurodegeneration. The findings emphasize the potential of vitamin D3 as a supplemental treatment in early intervention and management strategies against Alzheimer’s disease.
Through our experiments, we found that the AD rats exhibited significant changes in their hippocampal region, including increased mitochondrial calcium, decreased levels of ATP and ADP, elevated calpain-1 and calpain-2 levels, and disruptions in the cytochrome C pathway—factors that are linked to mitochondrial dysfunction and neuronal degeneration. Interestingly, when we supplemented the AD rats with vitamin D3, we noted improvements in mitochondrial function, reduced neuronal degeneration, and even improvements in histological changes in the brain.
This improvement suggests that vitamin D3 may play a vital role in breaking the harmful cycle associated with AD, which involves high calcium levels and calpain activation leading to further neurodegeneration. The findings emphasize the potential of vitamin D3 as a supplemental treatment in early intervention and management strategies against Alzheimer’s disease.
Read More
9
Vitamin D3 improves Alzheimer's symptoms
Neuroprotective effects of vitamin D in an Alzheimer's disease rat model: Improvement of mitochondrial dysfunction via calcium/calmodulin-dependent protein kinase kinase 2 activation of Sirtuin1 phosphorylation.
Relevant effects of vitamin D3
We investigated whether vitamin D3 (Vit.D) could help mitigate cognitive decline and restore mitochondrial function in an Alzheimer's disease (AD) rat model. The study involved groups of rats exposed to Alzheimer's-inducing substances, as well as groups receiving vitamin D3 treatment. By employing various cognitive tests and analyzing brain tissue, we aimed to understand how vitamin D3 affects memory and brain health.
Our findings revealed that vitamin D3 did have a positive effect. It was shown to reduce brain injury, cognitive decline, and levels of amyloid beta, a protein involved in Alzheimer's. Furthermore, vitamin D3 also influenced key proteins in the brain that support mitochondrial health, which plays a critical role in cell energy and function. We observed that vitamin D3 helped restore normal levels of calcium in the brain and elevated the function of proteins responsible for energy metabolism.
Overall, it appears that vitamin D3 can alleviate some of the cognitive challenges associated with AD by improving mitochondrial function and reducing oxidative stress. This suggests potential pathways through which vitamin D3 might exert protective effects against Alzheimer's disease.
Our findings revealed that vitamin D3 did have a positive effect. It was shown to reduce brain injury, cognitive decline, and levels of amyloid beta, a protein involved in Alzheimer's. Furthermore, vitamin D3 also influenced key proteins in the brain that support mitochondrial health, which plays a critical role in cell energy and function. We observed that vitamin D3 helped restore normal levels of calcium in the brain and elevated the function of proteins responsible for energy metabolism.
Overall, it appears that vitamin D3 can alleviate some of the cognitive challenges associated with AD by improving mitochondrial function and reducing oxidative stress. This suggests potential pathways through which vitamin D3 might exert protective effects against Alzheimer's disease.
Read More
9
Vitamin D3 helps cognitive function
Vitamin D supplementation ameliorates cognitive impairment and alters neurodegenerative and inflammatory markers in scopolamine induced rat model.
Research directly evaluates vitamin D3 effects
We investigated the effects of vitamin D3 supplementation on cognitive impairment linked to Alzheimer's disease. Using a rat model, we induced cognitive deficits through scopolamine injections and then provided vitamin D for 21 days. Our findings highlighted significant improvements in cognitive abilities, including learning and memory functions, thanks to the vitamin D treatment.
We observed that rats receiving vitamin D showed lower levels of toxic Aβ plaques and hyperphosphorylated tau proteins—both key players in Alzheimer's pathology. This suggests that vitamin D may help enhance the brain's ability to clear away harmful proteins while simultaneously reducing inflammation and oxidative stress.
The results were reinforced by detailed analyses of brain tissue and behavior, indicating a promising role for vitamin D3 in delaying Alzheimer's progression. These outcomes support the notion that vitamin D supplementation could be beneficial for cognitive health and management of Alzheimer's disease.
We observed that rats receiving vitamin D showed lower levels of toxic Aβ plaques and hyperphosphorylated tau proteins—both key players in Alzheimer's pathology. This suggests that vitamin D may help enhance the brain's ability to clear away harmful proteins while simultaneously reducing inflammation and oxidative stress.
The results were reinforced by detailed analyses of brain tissue and behavior, indicating a promising role for vitamin D3 in delaying Alzheimer's progression. These outcomes support the notion that vitamin D supplementation could be beneficial for cognitive health and management of Alzheimer's disease.
Read More
9
Vitamin D3 shows promise for Alzheimer's
Chronic vitamin D supplementation alleviates cognition impairment via inhibition of oxidative stress regulated by PI3K/AKT/Nrf2 in APP/PS1 transgenic mice.
Direct assessment of vitamin D3
We explored the impact of vitamin D3 supplementation on cognitive decline in transgenic mice that model Alzheimer's disease. Over a 20-week treatment period, we conducted a series of tests, including a Morris Water Maze test to assess cognitive function and various analyses to gauge oxidative stress and Alzheimer-related pathology.
Our observations indicated that vitamin D3 treatment not only improved the memory performance of the mice but also positively influenced brain health. Specifically, we found that vitamin D3 led to a reduction in amyloid beta (Aβ) buildup, a hallmark of Alzheimer's, and decreased levels of proteins associated with the disease, such as APP, tau, and phosphorylated tau (p-tau).
Moreover, vitamin D3 appeared to bolster the brain's defenses against oxidative stress, enhancing key antioxidant levels while lowering harmful substances related to oxidative damage. The treatment activated important pathways involved in cellular protection, further supporting the notion that vitamin D3 may offer neuroprotective effects.
In conclusion, our study suggests that vitamin D3 could play a beneficial role in improving cognition and reducing Alzheimer-like changes in the brain. These findings invite further exploration into the potential of vitamin D3 as a supportive treatment in Alzheimer’s disease management.
Our observations indicated that vitamin D3 treatment not only improved the memory performance of the mice but also positively influenced brain health. Specifically, we found that vitamin D3 led to a reduction in amyloid beta (Aβ) buildup, a hallmark of Alzheimer's, and decreased levels of proteins associated with the disease, such as APP, tau, and phosphorylated tau (p-tau).
Moreover, vitamin D3 appeared to bolster the brain's defenses against oxidative stress, enhancing key antioxidant levels while lowering harmful substances related to oxidative damage. The treatment activated important pathways involved in cellular protection, further supporting the notion that vitamin D3 may offer neuroprotective effects.
In conclusion, our study suggests that vitamin D3 could play a beneficial role in improving cognition and reducing Alzheimer-like changes in the brain. These findings invite further exploration into the potential of vitamin D3 as a supportive treatment in Alzheimer’s disease management.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
8.8
Effective treatment
I have given this to my mother for over two years, at 50,000 IU a day, as she has alzheimer. When her vitamin D levels became excessively high, the doctor advised a temporary stop. After four months, her vitamin D was low again, confirming that this treatment is effective.
