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Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Our analysis included ten studies, with eight of them providing sufficient data for a quantitative comparison. In comparing the vitamin D3 group to control groups, we observed a significant reduction in eczema severity, evidenced by lower scores on the SCORAD and EASI scales. Specifically, participants taking vitamin D3 had a mean difference of -5.96, indicating a meaningful improvement in their symptoms.
This evidence suggests that incorporating vitamin D3 into eczema management could be beneficial. We believe this finding is important as it highlights a potential therapeutic avenue for eczema sufferers looking for effective solutions.
We found that children who received vitamin D3 experienced a significant improvement in their eczema symptoms. Specifically, those taking vitamin D3 saw a notable reduction in their Eczema Area and Severity Index (EASI) score compared to those on placebo, with a difference that was both clinically and statistically significant.
Importantly, kids in the vitamin D3 group also received education on skincare and emollients, ensuring a comprehensive approach to managing their condition. No adverse effects were reported in either the vitamin D3 or placebo groups, highlighting its safety.
Overall, our findings suggest that vitamin D3 is a promising treatment for alleviating winter-related eczema in children, particularly in regions where vitamin D deficiency is prevalent during the colder months.
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Our findings revealed that as the severity of eczema increased, the levels of vitamin A and 25-(OH)D3 decreased. Meanwhile, we noticed a rise in inflammatory markers such as TG2, IL-4, and IL-13. Interestingly, we found a strong negative correlation between the levels of vitamin A and 25-(OH)D3 and the eczema severity scores, indicating that lower vitamin D levels were associated with more severe eczema symptoms.
After three months of treatment, children across all severity groups showed significant improvement in their vitamin A and D3 levels, along with changes in the inflammatory markers. Notably, 25-(OH)D3 demonstrated the best accuracy in diagnosing the severity of eczema compared to the other markers examined. This suggests that monitoring vitamin D3 could be quite valuable for assessing and managing eczema in children.
Overall, our study indicates that vitamin D3 plays a significant role in the severity of eczema symptoms, reinforcing the importance of maintaining healthy vitamin D levels for children suffering from this condition.
The results were quite promising. After the treatment, not only did the children's vitamin D levels increase, but there was also a noticeable decrease in eczema severity as measured by the SCORAD index. Our findings revealed that both the vitamin D receptor and a skin defense protein called Cathelicidin saw significant increases—especially in areas affected by eczema. However, we found that levels of Thymic Stromal Lymphopoietin (another important skin factor) did not change after the treatment.
Overall, this study suggests that oral vitamin D3 can play a beneficial role in managing eczema in children, helping improve their skin health alongside enhancing important skin functions. This gives us new insights into how vitamin D3 might serve as a supportive treatment option.
We tracked the prevalence of atopic eczema in their children at ages 12, 24, and 48 months, using recognized criteria for diagnosis. Our findings suggest that maternal cholecalciferol supplementation plays a beneficial role, as we noted a potential protective effect against the development of infantile atopic eczema. This effect might be due to increased levels of vitamin D3 in breast milk, which may help bolster the child’s immune system.
These results add valuable information to the conversation about how prenatal interventions can influence childhood health, particularly in relation to skin conditions like eczema.
Following the nbUVB therapy, we noted a remarkable increase in the median serum vitamin D levels—from 45 nmol/l before treatment to 169 nmol/l after treatment. Alongside this boost in vitamin D levels, we also observed a noteworthy reduction in eczema severity, with the average score dropping significantly.
However, our findings did not show a clear connection between the increase in vitamin D levels and the improvement in eczema severity. This suggests that while patients with eczema may benefit from increased vitamin D due to treatments like nbUVB, the direct relationship between vitamin D levels and eczema severity isn't confirmed by our study.
Overall, while patients with atopic dermatitis may be at risk of vitamin D deficiency, our results imply that simply increasing vitamin D levels might not guarantee improvements in eczema severity.
Over the course of the study, we observed that as eczema severity increased, serum levels of vitamin A and 25-(OH)D3 (a form of vitamin D) tended to decrease. Conversely, levels of tissue transglutaminase (TG2), interleukin-4 (IL-4), and interleukin-13 (IL-13), which are markers of inflammation, increased. Significant correlations emerged showing that lower levels of vitamin A and 25-(OH)D3 were linked to higher SCORAD scores (a measure of eczema severity), while increases in TG2, IL-4, and IL-13 levels paralleled worsening symptoms.
Importantly, vitamin D levels had the highest accuracy for assessing eczema severity compared to the other markers studied. After treatment over three months, we noted improvements in the levels of all measured indicators, suggesting that addressing these serum factors could have a positive impact on managing eczema symptoms.
Our findings indicate that monitoring vitamin D levels, along with other serum indicators, might offer valuable insights for clinicians in evaluating and treating eczema in children.
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Frequently Asked Questions
Eczema, also known as atopic dermatitis, is a chronic skin condition characterized by inflamed, itchy, and red patches on the skin. It is most commonly seen in children but can occur at any age. The condition can range from mild to severe and often leads to dry, scaly skin that can become cracked or even bleed. Eczema is believed to be related to a combination of genetic predisposition, skin barrier dysfunction, and environmental factors, including allergens, irritants, and stress.
Treatment for eczema often involves a multi-faceted approach, including the use of moisturizers to keep the skin hydrated, topical corticosteroids to reduce inflammation, and, in some cases, antihistamines to alleviate itching. Identifying and avoiding triggers such as certain soaps, fabrics, or foods can also play a crucial role in managing the condition. While there is currently no cure for eczema, ongoing advancements in research have led to the development of new therapies, including biologic medications that target specific components of the immune response, offering hope for those with moderate to severe cases.
Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.
In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.
While more research is needed, some studies suggest that Vitamin D may play a role in managing eczema symptoms. Vitamin D is known for its immune-modulating properties, which can be beneficial for skin health. Eczema, or atopic dermatitis, is often associated with an overactive immune response, leading to inflammation and irritation. Supplementing with Vitamin D might help in regulating this immune reaction and improving overall skin barrier function.
However, it's essential to approach Vitamin D supplementation carefully, as the right dosage can vary greatly among individuals. If you're considering taking Vitamin D for eczema, consult with a healthcare professional who can provide personalized recommendations based on your specific condition and nutritional needs. Keep in mind that while Vitamin D might help some individuals, it is not a universal solution, and various treatments may be necessary to effectively manage eczema symptoms.
Based on user reviews, individuals taking this vitamin D3 supplement for eczema report varying timelines for seeing results. Some users have indicated that significant improvements can occur quite quickly. For instance, one reviewer noted that their eczema was "nearly gone" after starting the supplement, suggesting a rapid response to the treatment (Read Review). Another user reported feeling improvements in skin hydration and irritation reduction shortly after beginning their regimen (Read Review).
However, results may not be uniform for everyone. While some swear by its effectiveness with long-term use, such as purchasing multiple bottles for ongoing management of their symptoms (Read Review), it is advisable to be patient, as individual responses can vary significantly. Moreover, the suggestion to buy the supplement to assess its effectiveness emphasizes that while some may see improvements quickly, for others, it may take more time (Read Review). As always, consulting a healthcare provider for personalized advice is recommended.
Scientific research increasingly supports the use of vitamin D supplementation as a potential strategy for managing eczema, particularly in children. Several studies have demonstrated that lower levels of vitamin D correlate with more severe eczema symptoms. For instance, a comprehensive systematic review analyzed data from multiple randomized controlled trials (RCTs) and found that vitamin D supplementation led to significant reductions in eczema severity scores compared to control groups, indicating a promising role for vitamin D in treatment [2]. Additionally, specific studies have shown that children diagnosed with eczema exhibited lower serum vitamin D levels, suggesting that maintaining adequate vitamin D levels might help mitigate symptoms [14].
Moreover, evidence suggests that maternal vitamin D levels during pregnancy also play a crucial role in the likelihood of infants developing eczema. Mothers with low vitamin D levels were found to have a higher chance of having infants with atopic dermatitis, highlighting the importance of adequate vitamin D intake during pregnancy for potential long-term benefits in children's skin health [3]. While the findings present a compelling case for vitamin D’s beneficial impact on eczema, further large-scale studies are necessary to fully understand its efficacy and establish detailed treatment guidelines. Thus, incorporating vitamin D supplementation seems to be a valuable consideration for individuals grappling with eczema, specifically when combined with conventional treatments.
Users have reported notable improvements in their eczema symptoms after taking this vitamin D3 supplement. Many describe a significant reduction in the severity of their eczema, with one user stating that their condition was "nearly gone" after starting the treatment (Read Review). Additionally, others have experienced an increase in skin hydration and a decrease in irritation, reinforcing the supplement's beneficial impact on skin health (Read Review).
While several users have found relief and have repeatedly purchased the product for ongoing management (Read Review), it’s important to note that individual results can vary. Some recommend giving it time to assess effectiveness, as experiences differ widely among users (Read Review). As with any supplement, results may take a while to manifest, and it's essential to consult with a healthcare professional for tailored advice.
Based on user reviews, many individuals have found that higher doses of Vitamin D, particularly Vitamin D3, can significantly improve their eczema symptoms. One user reported that after starting a regimen of 50,000 IU Vitamin D3 once a week, they experienced increased hydration in their skin, which had been prone to dryness and irritation due to eczema, highlighting the connection between adequate Vitamin D levels and skin health (Read Review). Furthermore, another user emphasized that a large dose of D3 is beneficial for sensitive skin and recommended trying it for effective results (Read Review).
Additionally, users have shared their positive experiences with a high-dose Vitamin D3 supplement, with one reporting significant improvements in eczema and nearly complete resolution of symptoms after using a potent formulation (Read Review). Overall, feedback suggests that higher doses of Vitamin D3 may provide relief for those suffering from eczema, making it a potential consideration for treatment in consultation with a healthcare professional.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Our findings revealed that as the severity of eczema increased, the levels of vitamin A and 25-(OH)D3 decreased. Meanwhile, we noticed a rise in inflammatory markers such as TG2, IL-4, and IL-13. Interestingly, we found a strong negative correlation between the levels of vitamin A and 25-(OH)D3 and the eczema severity scores, indicating that lower vitamin D levels were associated with more severe eczema symptoms.
After three months of treatment, children across all severity groups showed significant improvement in their vitamin A and D3 levels, along with changes in the inflammatory markers. Notably, 25-(OH)D3 demonstrated the best accuracy in diagnosing the severity of eczema compared to the other markers examined. This suggests that monitoring vitamin D3 could be quite valuable for assessing and managing eczema in children.
Overall, our study indicates that vitamin D3 plays a significant role in the severity of eczema symptoms, reinforcing the importance of maintaining healthy vitamin D levels for children suffering from this condition.
The results showed that infants born to mothers with low vitamin D levels faced a significantly higher risk of developing eczema. Specifically, mothers with vitamin D deficiency had a 77% increased risk of their infants developing AD. Interestingly, this heightened risk was mostly observed in naturally conceived pregnancies, while those conceived through assisted reproductive techniques didn't show the same association.
Additionally, we found that mothers who took vitamin D or multivitamin supplements during pregnancy had a lower risk of having infants with AD. This suggests that adequate vitamin D intake may play a protective role against eczema in infants. Our findings underscore the importance of monitoring vitamin D levels in expectant mothers, as doing so could help reduce the risk of eczema in their future children.
References
- Li Y, Wang Z, Li X, Ma K, Shi Z. Changes and clinical significance of serum vitamin A, 25-(OH)D3, TG2, IL-4 and IL-13 levels in children with eczema. Arch Dermatol Res. 2025;317:375. doi:10.1007/s00403-025-03887-8
- Nielsen AY, Høj S, Thomsen SF, Meteran H. Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis. Nutrients. 2024;16. doi:10.3390/nu16234128
- Zhang Q, Yang D, Shen Q, Li W, Li R, et al. Correlation of Maternal Vitamin D Status in Early Pregnancy and Vitamin D Supplementation during Pregnancy with Atopic Dermatitis in Infants: A Prospective Birth Cohort Study. Nutrients. 2024;16. doi:10.3390/nu16132168
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- Zeng R, Lodge CJ, Koplin JJ, Lopez DJ, Erbas B, et al. Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age. Nutrients. 2024;16. doi:10.3390/nu16091303
- Ding YJ, Li XN, Xiao Z, Li CY, Jia LH. Low vitamin D during pregnancy is associated with infantile eczema by up-regulation of PI3K/AKT/mTOR signaling pathway and affecting FOXP3 expression: A bidirectional cohort study. J Nutr Biochem. 2024;124:109516. doi:10.1016/j.jnutbio.2023.109516
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- Zeng R, Li Y, Shen S, Qiu X, Chang CL, et al. Is antenatal or early-life vitamin D associated with eczema or food allergy in childhood? A systematic review. Clin Exp Allergy. 2023;53:511. doi:10.1111/cea.14281
- Cabalín C, Pérez-Mateluna G, Iturriaga C, Camargo CA, Borzutzky A. Oral vitamin D modulates the epidermal expression of the vitamin D receptor and cathelicidin in children with atopic dermatitis. Arch Dermatol Res. 2023;315:761. doi:10.1007/s00403-022-02416-1
- Li Q, Zhou Q, Zhang G, Tian X, Li Y, et al. Vitamin D Supplementation and Allergic Diseases during Childhood: A Systematic Review and Meta-Analysis. Nutrients. 2022;14. doi:10.3390/nu14193947
- Sangüesa J, Sunyer J, Garcia-Esteban R, Abellan A, Esplugues A, et al. Prenatal and child vitamin D levels and allergy and asthma in childhood. Pediatr Res. 2023;93:1745. doi:10.1038/s41390-022-02256-9
- El-Heis S, D'Angelo S, Curtis EM, Healy E, Moon RJ, et al. Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life: evidence from a randomized controlled trial. Br J Dermatol. 2022;187:659. doi:10.1111/bjd.21721
- Li Y, Wang Z, Li X, Ma K, Shi Z. Changes and clinical significance of serum vitamin A, 25-(OH)D3, TG2, IL-4 and IL-13 levels in children with eczema. Arch Dermatol Res. 2025;317:375. doi:10.1007/s00403-025-03887-8
- Zeng R, Lodge CJ, Koplin JJ, Lopez DJ, Erbas B, et al. Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age. Nutrients. 2024;16. doi:10.3390/nu16091303
- Cabalín C, Pérez-Mateluna G, Iturriaga C, Camargo CA, Borzutzky A. Oral vitamin D modulates the epidermal expression of the vitamin D receptor and cathelicidin in children with atopic dermatitis. Arch Dermatol Res. 2023;315:761. doi:10.1007/s00403-022-02416-1
- Sangüesa J, Sunyer J, Garcia-Esteban R, Abellan A, Esplugues A, et al. Prenatal and child vitamin D levels and allergy and asthma in childhood. Pediatr Res. 2023;93:1745. doi:10.1038/s41390-022-02256-9
- El-Heis S, D'Angelo S, Curtis EM, Healy E, Moon RJ, et al. Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life: evidence from a randomized controlled trial. Br J Dermatol. 2022;187:659. doi:10.1111/bjd.21721
- Mansour NO, Mohamed AA, Hussein M, Eldemiry E, Daifalla A, et al. The impact of vitamin D supplementation as an adjuvant therapy on clinical outcomes in patients with severe atopic dermatitis: A randomized controlled trial. Pharmacol Res Perspect. 2020;8:e00679. doi:10.1002/prp2.679
- Aldaghi M, Tehrani H, Karrabi M, Abadi FS, Sahebkar M. The effect of multistrain synbiotic and vitamin D3 supplements on the severity of atopic dermatitis among infants under 1 year of age: a double-blind, randomized clinical trial study. J Dermatolog Treat. 2022;33:812. doi:10.1080/09546634.2020.1782319
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- Stanley Xavier A, Selvarajan S, Chandrasekar L, Kamalanathan S. Effect of Cholecalciferol Supplementation on Treatment Response and IL-10 Level in Vitamin D Deficient Dermatitis Patients: A Randomized Double-Blind Placebo-Controlled Trial. J Diet Suppl. 2020;17:415. doi:10.1080/19390211.2019.1619009
- Dani SU. A curious association of chronic homeopathic arsenic ingestion with nonspecific symptoms in a Swiss teenager. Swiss Med Wkly. 2019;149:w20071. doi:10.4414/smw.2019.20071
- Rose RF, Williams C, Oliphant T, Browne F, Turner D, et al. Serum 25-hydroxyvitamin D levels in patients with atopic eczema and the influence of narrowband ultraviolet B phototherapy. Photodermatol Photoimmunol Photomed. 2014;30:287.
- Camargo CA, Ganmaa D, Sidbury R, Erdenedelger Kh, Radnaakhand N, et al. Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children. J Allergy Clin Immunol. 2014;134:831. doi:10.1016/j.jaci.2014.08.002
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