' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.2
USERS' SCORE
Excellent
Based on 3 Reviews
9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%
Top Medical Research Studies
4
Vitamin D3 shows limited effect
Alterations in CD4 T Cell Cytokines Profile in Female Patients with Hashimoto's Thyroiditis Following Vitamin D Supplementation: A Double-blind, Randomized Clinical Trial.
Highly relevant to HT inquiry
We conducted a double-blind, randomized clinical trial to investigate how vitamin D3 supplementation affects Hashimoto's thyroiditis (HT) in female patients. Over three months, participants received either 50,000 IU of vitamin D3 or a placebo. Our focus was on measuring changes in serum cytokine levels and gene expression in CD4+ T cells, which play a critical role in the immune response associated with autoimmune diseases like HT.
Following vitamin D3 supplementation, we observed a significant increase in serum levels of 25-hydroxyvitamin D, while serum calcium levels also rose compared to where they started. However, when checking for changes related to immune response, we noted that supplementation led to a decrease in interleukin-17 (IL-17) levels, but this change didn't differ significantly from those in the placebo group.
On the other hand, the transforming growth factor-beta (TGFβ) gene expression rose significantly with vitamin D3 treatment, yet once again, we didn't see a noticeable difference between the two groups. Importantly, there was no marked effect on other key immune markers, such as interferon-gamma and IL-4 levels. Although we did see some increase in T-bet and GATA3 transcription factors, the overall impact of vitamin D3 on Hashimoto's thyroiditis in our study suggests limited benefits.
This trial sheds light on the complex relationship between vitamin D supplementation and autoimmune conditions like Hashimoto's thyroiditis. While vitamin D3 shows some promise, further long-term studies are essential to truly understand its role and effectiveness in managing HT.
Following vitamin D3 supplementation, we observed a significant increase in serum levels of 25-hydroxyvitamin D, while serum calcium levels also rose compared to where they started. However, when checking for changes related to immune response, we noted that supplementation led to a decrease in interleukin-17 (IL-17) levels, but this change didn't differ significantly from those in the placebo group.
On the other hand, the transforming growth factor-beta (TGFβ) gene expression rose significantly with vitamin D3 treatment, yet once again, we didn't see a noticeable difference between the two groups. Importantly, there was no marked effect on other key immune markers, such as interferon-gamma and IL-4 levels. Although we did see some increase in T-bet and GATA3 transcription factors, the overall impact of vitamin D3 on Hashimoto's thyroiditis in our study suggests limited benefits.
This trial sheds light on the complex relationship between vitamin D supplementation and autoimmune conditions like Hashimoto's thyroiditis. While vitamin D3 shows some promise, further long-term studies are essential to truly understand its role and effectiveness in managing HT.
Read More
9
Vitamin D3 may reduce thyroid damage
Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.
Direct impact on Hashimoto's addressed
We explored the potential benefits of vitamin D3 in treating autoimmune thyroiditis, specifically focusing on Hashimoto's thyroiditis. In a controlled experiment, female NOD/ShiLtJ mice were subjected to a treatment regimen that included a specific dosage of vitamin D3 injected every other day for eight weeks.
Our observations revealed that vitamin D3 significantly reduced thyroid damage caused by the autoimmune response. Mice receiving this treatment showed a decrease in thyroid inflammation, with lower levels of thyroid autoantibodies in their serum. Additionally, vitamin D3 appeared to reverse the changes in immune cell profiles in the thyroid.
Specifically, the treatment helped inhibit the overactive pro-inflammatory T-cell subsets while promoting the function of anti-inflammatory cells. This modulation within the immune system suggests that vitamin D3 supplementation may serve as an effective approach to manage the symptoms and progression of Hashimoto's thyroiditis.
Our observations revealed that vitamin D3 significantly reduced thyroid damage caused by the autoimmune response. Mice receiving this treatment showed a decrease in thyroid inflammation, with lower levels of thyroid autoantibodies in their serum. Additionally, vitamin D3 appeared to reverse the changes in immune cell profiles in the thyroid.
Specifically, the treatment helped inhibit the overactive pro-inflammatory T-cell subsets while promoting the function of anti-inflammatory cells. This modulation within the immune system suggests that vitamin D3 supplementation may serve as an effective approach to manage the symptoms and progression of Hashimoto's thyroiditis.
Read More
9
Vitamin D3 reduces thyroid autoimmunity
A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis.
Directly addresses Hashimoto's treatment
We investigated the potential role of vitamin D3 in managing Hashimoto's thyroiditis, an autoimmune condition that affects the thyroid gland. Over the course of one year, we conducted a study with 100 participants, all diagnosed with Hashimoto's and suffering from vitamin D deficiency.
In our approach, half of the participants received cholecalciferol (vitamin D3) supplements, while the other half were given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase (anti-TPO) antibodies in both groups. Our results revealed a significant decrease in antibody levels among those who received vitamin D3—showing a 30.5% reduction compared to only 16.5% in the placebo group.
This suggests that vitamin D3 supplementation may have a beneficial effect in reducing autoimmune activity in patients with Hashimoto's thyroiditis. However, further studies with larger sample sizes are necessary to fully understand the long-term implications of vitamin D3 on thyroid health.
In our approach, half of the participants received cholecalciferol (vitamin D3) supplements, while the other half were given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase (anti-TPO) antibodies in both groups. Our results revealed a significant decrease in antibody levels among those who received vitamin D3—showing a 30.5% reduction compared to only 16.5% in the placebo group.
This suggests that vitamin D3 supplementation may have a beneficial effect in reducing autoimmune activity in patients with Hashimoto's thyroiditis. However, further studies with larger sample sizes are necessary to fully understand the long-term implications of vitamin D3 on thyroid health.
Read More
Most Useful Reviews
9.5
Improves symptoms
This supplement is excellent for addressing my vitamin D deficiency. It supports my Hashimoto's hypothyroidism, and I've noticed numerous benefits. The good size, absorption, and flavourless quality make it a one-ingredient product of high quality that has significantly improved my symptoms.
Read More
8.8
Essential supplement
Vitamin D is a nutritional supplement I frequently purchase from iHerb. As I have Hashimoto's disease, it's essential for me, and taking it once a week is sufficient.
Read More
8.8
Convenient dosage
Hashimoto's requires me to take 20,000 to 30,000 units of vitamin D daily. Previously, the 5,000-unit pills were inconvenient, but this 50,000-unit option is perfect.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.2
9
Vitamin D3 may reduce thyroid damage
Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.
Direct impact on Hashimoto's addressed
We explored the potential benefits of vitamin D3 in treating autoimmune thyroiditis, specifically focusing on Hashimoto's thyroiditis. In a controlled experiment, female NOD/ShiLtJ mice were subjected to a treatment regimen that included a specific dosage of vitamin D3 injected every other day for eight weeks.
Our observations revealed that vitamin D3 significantly reduced thyroid damage caused by the autoimmune response. Mice receiving this treatment showed a decrease in thyroid inflammation, with lower levels of thyroid autoantibodies in their serum. Additionally, vitamin D3 appeared to reverse the changes in immune cell profiles in the thyroid.
Specifically, the treatment helped inhibit the overactive pro-inflammatory T-cell subsets while promoting the function of anti-inflammatory cells. This modulation within the immune system suggests that vitamin D3 supplementation may serve as an effective approach to manage the symptoms and progression of Hashimoto's thyroiditis.
Our observations revealed that vitamin D3 significantly reduced thyroid damage caused by the autoimmune response. Mice receiving this treatment showed a decrease in thyroid inflammation, with lower levels of thyroid autoantibodies in their serum. Additionally, vitamin D3 appeared to reverse the changes in immune cell profiles in the thyroid.
Specifically, the treatment helped inhibit the overactive pro-inflammatory T-cell subsets while promoting the function of anti-inflammatory cells. This modulation within the immune system suggests that vitamin D3 supplementation may serve as an effective approach to manage the symptoms and progression of Hashimoto's thyroiditis.
Read More
9
Vitamin D3 reduces thyroid autoimmunity
A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis.
Directly addresses Hashimoto's treatment
We investigated the potential role of vitamin D3 in managing Hashimoto's thyroiditis, an autoimmune condition that affects the thyroid gland. Over the course of one year, we conducted a study with 100 participants, all diagnosed with Hashimoto's and suffering from vitamin D deficiency.
In our approach, half of the participants received cholecalciferol (vitamin D3) supplements, while the other half were given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase (anti-TPO) antibodies in both groups. Our results revealed a significant decrease in antibody levels among those who received vitamin D3—showing a 30.5% reduction compared to only 16.5% in the placebo group.
This suggests that vitamin D3 supplementation may have a beneficial effect in reducing autoimmune activity in patients with Hashimoto's thyroiditis. However, further studies with larger sample sizes are necessary to fully understand the long-term implications of vitamin D3 on thyroid health.
In our approach, half of the participants received cholecalciferol (vitamin D3) supplements, while the other half were given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase (anti-TPO) antibodies in both groups. Our results revealed a significant decrease in antibody levels among those who received vitamin D3—showing a 30.5% reduction compared to only 16.5% in the placebo group.
This suggests that vitamin D3 supplementation may have a beneficial effect in reducing autoimmune activity in patients with Hashimoto's thyroiditis. However, further studies with larger sample sizes are necessary to fully understand the long-term implications of vitamin D3 on thyroid health.
Read More
8
Vitamin D3's potential in HT
Autoimmune Thyroiditis and Vitamin D.
Significant link but needs clarity
Our exploration into the connection between vitamin D3 and Hashimoto's thyroiditis (HT) revealed exciting insights. We focused on how vitamin D might help modulate the immune system, potentially reducing the risk of this autoimmune disease.
The study reviewed existing literature, which consistently shows that individuals with HT tend to have significantly lower vitamin D levels compared to healthy individuals. This suggests that vitamin D could play a crucial role in immune regulation.
We observed a positive outcome when patients with HT and vitamin D deficiency were supplemented with cholecalciferol, a form of vitamin D. Notably, their thyroid autoantibody levels—markers of the autoimmune response—dropped significantly after treatment. While these results are promising, they also highlight the need for more rigorous research.
We concur that further randomized, double-blind, placebo-controlled trials are necessary to deepen our understanding of vitamin D's benefits for those suffering from autoimmune thyroid diseases.
The study reviewed existing literature, which consistently shows that individuals with HT tend to have significantly lower vitamin D levels compared to healthy individuals. This suggests that vitamin D could play a crucial role in immune regulation.
We observed a positive outcome when patients with HT and vitamin D deficiency were supplemented with cholecalciferol, a form of vitamin D. Notably, their thyroid autoantibody levels—markers of the autoimmune response—dropped significantly after treatment. While these results are promising, they also highlight the need for more rigorous research.
We concur that further randomized, double-blind, placebo-controlled trials are necessary to deepen our understanding of vitamin D's benefits for those suffering from autoimmune thyroid diseases.
Read More
8
Vitamin D enhances thyroid function
Vitamin D, selenium, and antidiabetic drugs in the treatment of type 2 diabetes mellitus with Hashimoto's thyroiditis.
Moderate relevance due to combination treatment.
We explored the impact of vitamin D in combination with selenium and diabetes medications on patients with Hashimoto's thyroiditis and type 2 diabetes mellitus (T2DM). In this study, 150 patients received either standard treatment, which included a low-iodine diet and diabetes medications, or additional vitamin D and selenium.
Our findings revealed that the addition of vitamin D and selenium significantly improved thyroid function and helped regulate blood sugar and lipid levels. Markers like free T3, TSH, and free T4, as well as autoantibodies, showed notable changes after 3 and 6 months of treatment.
This suggests that vitamin D could play an important role for those managing T2DM alongside Hashimoto's thyroiditis. However, while we have observed positive results with combined treatments, it’s important to recognize that the isolated effect of vitamin D alone wasn’t determined in the study.
Our findings revealed that the addition of vitamin D and selenium significantly improved thyroid function and helped regulate blood sugar and lipid levels. Markers like free T3, TSH, and free T4, as well as autoantibodies, showed notable changes after 3 and 6 months of treatment.
This suggests that vitamin D could play an important role for those managing T2DM alongside Hashimoto's thyroiditis. However, while we have observed positive results with combined treatments, it’s important to recognize that the isolated effect of vitamin D alone wasn’t determined in the study.
Read More
8
Vitamin D3 benefits Hashimoto's patients
Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.
Moderately relevant vitamin D3 study
We explored the effects of vitamin D supplementation on patients with Hashimoto's thyroiditis (HT), particularly focusing on the role of vitamin D3. Our analysis included a comprehensive review of randomized controlled trials that aimed to assess how vitamin D impacted thyroid function and autoantibody levels.
Through our meta-analysis of 12 studies involving 862 participants, we observed that vitamin D supplementation significantly reduced the presence of thyroid-related antibodies, known as TPO-Ab and TG-Ab. These findings suggest that vitamin D can positively influence immune responses in those with HT.
Additionally, we saw improvements in thyroid function as indicated by reduced levels of thyroid-stimulating hormone (TSH) and increased levels of free triiodothyronine (FT3) and free thyroxine (FT4). Notably, active forms of vitamin D, like calcitriol, appeared to perform better than other forms such as vitamin D2 or D3 in reducing antibody levels.
Our analysis also indicated that longer treatment durations, specifically over 12 weeks, led to more significant improvements. Overall, the data imply that incorporating vitamin D into the treatment plan for HT patients could be beneficial for both immune modulation and thyroid function enhancement.
Through our meta-analysis of 12 studies involving 862 participants, we observed that vitamin D supplementation significantly reduced the presence of thyroid-related antibodies, known as TPO-Ab and TG-Ab. These findings suggest that vitamin D can positively influence immune responses in those with HT.
Additionally, we saw improvements in thyroid function as indicated by reduced levels of thyroid-stimulating hormone (TSH) and increased levels of free triiodothyronine (FT3) and free thyroxine (FT4). Notably, active forms of vitamin D, like calcitriol, appeared to perform better than other forms such as vitamin D2 or D3 in reducing antibody levels.
Our analysis also indicated that longer treatment durations, specifically over 12 weeks, led to more significant improvements. Overall, the data imply that incorporating vitamin D into the treatment plan for HT patients could be beneficial for both immune modulation and thyroid function enhancement.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 3 Reviews
9
9.5
Improves symptoms
This supplement is excellent for addressing my vitamin D deficiency. It supports my Hashimoto's hypothyroidism, and I've noticed numerous benefits. The good size, absorption, and flavourless quality make it a one-ingredient product of high quality that has significantly improved my symptoms.
Read More
8.8
Essential supplement
Vitamin D is a nutritional supplement I frequently purchase from iHerb. As I have Hashimoto's disease, it's essential for me, and taking it once a week is sufficient.
8.8
Convenient dosage
Hashimoto's requires me to take 20,000 to 30,000 units of vitamin D daily. Previously, the 5,000-unit pills were inconvenient, but this 50,000-unit option is perfect.
