Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.6
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%
Top Medical Research Studies
9
We conducted a rigorous study to explore how vitamin D3 supplementation might influence headaches in people suffering from migraines. By utilizing a well-structured, placebo-controlled, double-blind design, we included 80 participants with episodic migraines, assigning them either a daily dose of vitamin D3 or a placebo for 12 weeks.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
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8
We conducted a rigorous study to determine whether vitamin D3 supplementation could help improve the lives of adults suffering from migraines. Our approach involved a well-structured, randomized, double-blinded, placebo-controlled trial, which included 36 women and 12 men, aged between 18 to 65 years.
Participants underwent a 4-week baseline period before being randomly assigned to receive either 100 μg/day of D3 vitamin or a placebo for 24 weeks. Throughout the study, we kept track of migraine attacks and various symptoms through self-reported diaries, logging important details like the frequency and severity of their migraines.
Our findings were quite promising. Those taking D3 vitamin experienced fewer migraine days compared to those on the placebo, suggesting that vitamin D3 could serve as an effective preventative treatment for migraine management. However, we noted that further studies with larger sample sizes would be beneficial to solidify these claims and fully understand the potential role of vitamin D3 in migraine prevention.
Participants underwent a 4-week baseline period before being randomly assigned to receive either 100 μg/day of D3 vitamin or a placebo for 24 weeks. Throughout the study, we kept track of migraine attacks and various symptoms through self-reported diaries, logging important details like the frequency and severity of their migraines.
Our findings were quite promising. Those taking D3 vitamin experienced fewer migraine days compared to those on the placebo, suggesting that vitamin D3 could serve as an effective preventative treatment for migraine management. However, we noted that further studies with larger sample sizes would be beneficial to solidify these claims and fully understand the potential role of vitamin D3 in migraine prevention.
Read More
8
We explored the potential connection between vitamin D levels and headaches through a thorough investigation using two-sample Mendelian randomization analysis. Our goal was to determine if there’s a causal relationship between high vitamin D levels and the risk of experiencing headaches.
Our findings revealed that higher levels of vitamin D are linked to a lower risk of headaches. Specifically, we found that vitamin D may have a preventive effect, reducing the likelihood of headaches occurring. However, we also observed that there is no evidence to suggest that headaches cause changes in vitamin D levels.
This means while supplementing vitamin D may help keep headaches at bay, headaches themselves do not appear to affect vitamin D levels. This information contributes valuable insights into how maintaining sufficient vitamin D could play a role in headache management.
Our findings revealed that higher levels of vitamin D are linked to a lower risk of headaches. Specifically, we found that vitamin D may have a preventive effect, reducing the likelihood of headaches occurring. However, we also observed that there is no evidence to suggest that headaches cause changes in vitamin D levels.
This means while supplementing vitamin D may help keep headaches at bay, headaches themselves do not appear to affect vitamin D levels. This information contributes valuable insights into how maintaining sufficient vitamin D could play a role in headache management.
Read More
Most Useful Reviews
9
Immediate relief
The quality is excellent with natural ingredients. It helped straight away; my headache ceased almost instantly.
Read More
9
Headache eliminated
One pill per week alleviates my bone and joint pain, as well as my headaches and fatigue.
Read More
9
Headache gone
ยอดเยี่ยม! My nanny said her headache vanished after taking 2 pills post-meal!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.6
- All Researches
9.5
We conducted a study to explore the effectiveness of simvastatin combined with vitamin D3 in preventing headaches for adults suffering from episodic migraines. The study involved 57 participants who were randomly assigned either the active treatment or a placebo for 24 weeks, following a 12-week baseline period.
Our findings revealed that those taking simvastatin and vitamin D3 experienced a meaningful reduction in the number of migraine days compared to those on the placebo. In fact, participants on the active treatment saw their migraine days decrease by an average of 8 days during the first 12 weeks, and 9 days during the subsequent weeks, with a statistically significant difference that supports the treatment's effectiveness.
It's also worth mentioning that 25% of the participants on simvastatin and vitamin D3 achieved at least a 50% reduction in migraine days at 12 weeks, which increased to 29% by 24 weeks. This is in stark contrast to just 3% of participants in the placebo group. Importantly, the occurrence of side effects was similar between the groups, suggesting that the treatment was well-tolerated.
Overall, we observed a promising potential for simvastatin and vitamin D3 as a preventative option for those grappling with chronic migraines, while also considering the broader health implications regarding vascular health.
Our findings revealed that those taking simvastatin and vitamin D3 experienced a meaningful reduction in the number of migraine days compared to those on the placebo. In fact, participants on the active treatment saw their migraine days decrease by an average of 8 days during the first 12 weeks, and 9 days during the subsequent weeks, with a statistically significant difference that supports the treatment's effectiveness.
It's also worth mentioning that 25% of the participants on simvastatin and vitamin D3 achieved at least a 50% reduction in migraine days at 12 weeks, which increased to 29% by 24 weeks. This is in stark contrast to just 3% of participants in the placebo group. Importantly, the occurrence of side effects was similar between the groups, suggesting that the treatment was well-tolerated.
Overall, we observed a promising potential for simvastatin and vitamin D3 as a preventative option for those grappling with chronic migraines, while also considering the broader health implications regarding vascular health.
Read More
9
We conducted a clinical trial to investigate the effects of vitamin D supplementation alongside topiramate, a medication commonly used for migraine prevention in children aged 5 to 14. In this double-blind study, participants were divided into two groups: one received vitamin D with their topiramate treatment, while the other received a placebo.
After four months, we observed that those who took vitamin D experienced a significant reduction in the monthly frequency of headache attacks compared to the placebo group. We noted that children taking vitamin D also reported less disability from their migraines and a higher percentage showed a good response to the treatment.
Furthermore, the side effects were relatively similar between both groups, suggesting that combining vitamin D with topiramate is a safe and well-tolerated option. Overall, our findings indicate that vitamin D supplementation could enhance migraine management in pediatric patients.
After four months, we observed that those who took vitamin D experienced a significant reduction in the monthly frequency of headache attacks compared to the placebo group. We noted that children taking vitamin D also reported less disability from their migraines and a higher percentage showed a good response to the treatment.
Furthermore, the side effects were relatively similar between both groups, suggesting that combining vitamin D with topiramate is a safe and well-tolerated option. Overall, our findings indicate that vitamin D supplementation could enhance migraine management in pediatric patients.
Read More
9
In exploring the treatment for headaches associated with post-COVID-19 giant cell arteritis and polymyalgia rheumatica, we observed that vitamin D3 was included alongside more traditional therapies. This was part of a comprehensive treatment approach that also involved pulse methylprednisolone and perineural injection therapy.
While the main focus of treatment appeared to be on corticosteroids and pain management strategies, the exact effect of vitamin D3 on headache relief remains unclear. Since the headaches notably persisted through early treatment stages and improved significantly after additional intervention, we can't conclusively state the efficacy of vitamin D3 in alleviating headache symptoms from this case alone.
It's worth noting that individual responses to treatments can vary widely, and further dedicated studies would be necessary to understand vitamin D3's specific role in headache management. For now, combining it with other treatments was part of a broader strategy to achieve recovery.
While the main focus of treatment appeared to be on corticosteroids and pain management strategies, the exact effect of vitamin D3 on headache relief remains unclear. Since the headaches notably persisted through early treatment stages and improved significantly after additional intervention, we can't conclusively state the efficacy of vitamin D3 in alleviating headache symptoms from this case alone.
It's worth noting that individual responses to treatments can vary widely, and further dedicated studies would be necessary to understand vitamin D3's specific role in headache management. For now, combining it with other treatments was part of a broader strategy to achieve recovery.
Read More
9
Atorvastatin aids migraine control
We explored the relationship between vitamin D3 levels and migraine management in a study involving 68 patients suffering from migraine with aura. Before treatment, participants underwent vitamin D3 level evaluations, and those found to be deficient received vitamin D supplementation. However, while we investigated the effectiveness of adding atorvastatin to sodium valproate for better control of migraine symptoms, the specific effects of vitamin D3 alone on headache were not isolated in this study.
The results indicated that incorporating atorvastatin significantly reduced the severity of pain and the number of attacks. Participants in the atorvastatin group also reported higher satisfaction with their treatment compared to those receiving a placebo. Nonetheless, since the detailed effects of vitamin D3 on headaches were not independently assessed, we can’t conclude anything definitive about its role in headache management from this study alone.
Overall, while statins like atorvastatin show promise in treating migraine, our study did not directly evaluate the benefits of vitamin D3 on headache relief. Further research is needed to clarify vitamin D3's impact in this area.
The results indicated that incorporating atorvastatin significantly reduced the severity of pain and the number of attacks. Participants in the atorvastatin group also reported higher satisfaction with their treatment compared to those receiving a placebo. Nonetheless, since the detailed effects of vitamin D3 on headaches were not independently assessed, we can’t conclude anything definitive about its role in headache management from this study alone.
Overall, while statins like atorvastatin show promise in treating migraine, our study did not directly evaluate the benefits of vitamin D3 on headache relief. Further research is needed to clarify vitamin D3's impact in this area.
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9
We conducted a study to compare the effectiveness of topiramate, a medication traditionally used for migraine prevention, along with vitamin D3 in children. In a controlled, randomized clinical trial, we looked at children aged 5 to 15 who were experiencing migraines. Half of the participants received topiramate alone, while the other half received topiramate combined with vitamin D3 over two months.
Our findings revealed that both treatments significantly reduced the frequency and severity of migraines. However, the children who took topiramate along with vitamin D3 enjoyed even greater benefits. Specifically, those receiving the combination treatment reported fewer headache days and a lower level of disability due to migraines compared to those on topiramate alone. This combination treatment also led to a higher percentage of participants feeling a good response to their migraine management.
While some mild side effects were noted, they were temporary and similar across both treatment groups, suggesting that this combination is generally safe. Overall, we see that supplementing topiramate with vitamin D3 appears to be a promising strategy for protecting children against migraines.
Our findings revealed that both treatments significantly reduced the frequency and severity of migraines. However, the children who took topiramate along with vitamin D3 enjoyed even greater benefits. Specifically, those receiving the combination treatment reported fewer headache days and a lower level of disability due to migraines compared to those on topiramate alone. This combination treatment also led to a higher percentage of participants feeling a good response to their migraine management.
While some mild side effects were noted, they were temporary and similar across both treatment groups, suggesting that this combination is generally safe. Overall, we see that supplementing topiramate with vitamin D3 appears to be a promising strategy for protecting children against migraines.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Immediate relief
The quality is excellent with natural ingredients. It helped straight away; my headache ceased almost instantly.
Read More
9
Headache eliminated
One pill per week alleviates my bone and joint pain, as well as my headaches and fatigue.
Read More
9
Headache gone
ยอดเยี่ยม! My nanny said her headache vanished after taking 2 pills post-meal!
Read More
9
Effective headache relief
Excellent. I use this medication before my period as it acts as an analgesic, relieving both period pain and headaches. I only took a 5000-dose Dal pill, which is much stronger than my usual dosage.
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7.5
Effective for headaches
The quality and ingredients are top-notch. With a dosage of one pill per week, it boosts immunity against bone pain and headaches, proving effective and rapidly absorbable.
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Frequently Asked Questions
9
Headache gone
ยอดเยี่ยม! My nanny said her headache vanished after taking 2 pills post-meal!
7.5
Energy boost
The composition is excellent, with prompt delivery and quality packaging. Although the capsules are slightly large, they swallow easily, tasting of citrus. After 10 days, I've noticed more energy; my headaches have stopped, and I've got a great mood throughout the day.
7.5
Recommended regularly
It considerably boosts D3 levels, which is beneficial. I recommend taking it regularly but stopping if you feel uncomfortable or develop a headache.
9
Immediate relief
The quality is excellent with natural ingredients. It helped straight away; my headache ceased almost instantly.
9
Headache eliminated
One pill per week alleviates my bone and joint pain, as well as my headaches and fatigue.
1
High dose issues
4 people found this helpful
The dosage may be too high. Though the supplement isn't definitively the cause, it could lead to headaches; I usually tolerate 10,000 IU without issues, but 50,000 IU might be excessive for me.
9
Effective headache relief
Excellent. I use this medication before my period as it acts as an analgesic, relieving both period pain and headaches. I only took a 5000-dose Dal pill, which is much stronger than my usual dosage.
7.5
Effective for headaches
The quality and ingredients are top-notch. With a dosage of one pill per week, it boosts immunity against bone pain and headaches, proving effective and rapidly absorbable.
1
Negative side effects
The product appears very strong. Initially, I experienced nausea, headache, itching, and mild diarrhoea, leading me to stop its use immediately.
7
We aimed to explore the relationship between vitamin D levels and migraine prevalence, using data from over 9,100 participants in the National Health and Nutrition Examination Survey conducted between 2001 and 2004. Our focus was on how serum vitamin D, specifically 25OHD2 and 25OHD3, might impact headache occurrences.
Our findings indicated that about 20.5% of the adults we studied reported experiencing migraines. Notably, those with lower levels of vitamin D were more likely to suffer from migraines. In fact, participants in the highest quartile of vitamin D levels had a 16% lower likelihood of experiencing migraines compared to those in the lowest quartile. This was confirmed through various analytical methods, including logistic regression and stratified analysis.
While the results suggest a significant negative correlation between vitamin D levels and migraine prevalence, it’s important to remember that this study does not directly address whether vitamin D treatment could alleviate headaches. Rather, it highlights the need for further research to understand the role of vitamin D in migraine development.
Our findings indicated that about 20.5% of the adults we studied reported experiencing migraines. Notably, those with lower levels of vitamin D were more likely to suffer from migraines. In fact, participants in the highest quartile of vitamin D levels had a 16% lower likelihood of experiencing migraines compared to those in the lowest quartile. This was confirmed through various analytical methods, including logistic regression and stratified analysis.
While the results suggest a significant negative correlation between vitamin D levels and migraine prevalence, it’s important to remember that this study does not directly address whether vitamin D treatment could alleviate headaches. Rather, it highlights the need for further research to understand the role of vitamin D in migraine development.
8
Combined treatment benefits migraines
We conducted a randomized, triple-blinded, placebo-controlled trial focusing on the effects of vitamin D and probiotic co-supplementation on migraine headaches. This study included adult patients aged 18 to 55 diagnosed with migraines, specifically using the International Classification of Headache Disorders-3 criteria.
Over a 12-week period, participants received either 50,000 IU of vitamin D plus a daily probiotic or a placebo. We assessed their migraine symptoms through reliable questionnaires and self-reported diaries, tracking headache frequency, duration, and intensity. We also measured their mental health, daily functioning, and inflammation markers during the trial.
Our findings indicated that the combination of vitamin D and probiotics provided beneficial effects on migraine characteristics, including improved mental health outcomes. Although we did not isolate the impact of vitamin D alone, the results suggest that it may play a role in migraine management when paired with probiotics. Further studies are needed to firmly establish these effects and better understand the potential of vitamin D as a treatment option for headaches.
Over a 12-week period, participants received either 50,000 IU of vitamin D plus a daily probiotic or a placebo. We assessed their migraine symptoms through reliable questionnaires and self-reported diaries, tracking headache frequency, duration, and intensity. We also measured their mental health, daily functioning, and inflammation markers during the trial.
Our findings indicated that the combination of vitamin D and probiotics provided beneficial effects on migraine characteristics, including improved mental health outcomes. Although we did not isolate the impact of vitamin D alone, the results suggest that it may play a role in migraine management when paired with probiotics. Further studies are needed to firmly establish these effects and better understand the potential of vitamin D as a treatment option for headaches.
9
We conducted a clinical trial to investigate the effects of vitamin D supplementation alongside topiramate, a medication commonly used for migraine prevention in children aged 5 to 14. In this double-blind study, participants were divided into two groups: one received vitamin D with their topiramate treatment, while the other received a placebo.
After four months, we observed that those who took vitamin D experienced a significant reduction in the monthly frequency of headache attacks compared to the placebo group. We noted that children taking vitamin D also reported less disability from their migraines and a higher percentage showed a good response to the treatment.
Furthermore, the side effects were relatively similar between both groups, suggesting that combining vitamin D with topiramate is a safe and well-tolerated option. Overall, our findings indicate that vitamin D supplementation could enhance migraine management in pediatric patients.
After four months, we observed that those who took vitamin D experienced a significant reduction in the monthly frequency of headache attacks compared to the placebo group. We noted that children taking vitamin D also reported less disability from their migraines and a higher percentage showed a good response to the treatment.
Furthermore, the side effects were relatively similar between both groups, suggesting that combining vitamin D with topiramate is a safe and well-tolerated option. Overall, our findings indicate that vitamin D supplementation could enhance migraine management in pediatric patients.
8
We explored the potential connection between vitamin D levels and headaches through a thorough investigation using two-sample Mendelian randomization analysis. Our goal was to determine if there’s a causal relationship between high vitamin D levels and the risk of experiencing headaches.
Our findings revealed that higher levels of vitamin D are linked to a lower risk of headaches. Specifically, we found that vitamin D may have a preventive effect, reducing the likelihood of headaches occurring. However, we also observed that there is no evidence to suggest that headaches cause changes in vitamin D levels.
This means while supplementing vitamin D may help keep headaches at bay, headaches themselves do not appear to affect vitamin D levels. This information contributes valuable insights into how maintaining sufficient vitamin D could play a role in headache management.
Our findings revealed that higher levels of vitamin D are linked to a lower risk of headaches. Specifically, we found that vitamin D may have a preventive effect, reducing the likelihood of headaches occurring. However, we also observed that there is no evidence to suggest that headaches cause changes in vitamin D levels.
This means while supplementing vitamin D may help keep headaches at bay, headaches themselves do not appear to affect vitamin D levels. This information contributes valuable insights into how maintaining sufficient vitamin D could play a role in headache management.
7
We investigated how vitamin D levels relate to migraines and whether vitamin D supplementation can help people who suffer from these headaches. Our analysis included a range of studies, focusing on differences in vitamin D levels between migraine sufferers and those who do not experience migraines.
We found that migraineurs had significantly lower levels of serum 25-hydroxy vitamin D compared to nonmigraineurs, indicating a noteworthy connection. In fact, vitamin D deficiency was shown to be associated with an increased likelihood of experiencing migraines.
When it comes to treatment, we observed that taking vitamin D supplements seemed to help reduce the frequency of migraines. However, it's important to note that while vitamin D supplementation made a difference in how often migraines occurred, it did not significantly impact how long these headaches lasted or their severity.
Overall, it appears that while vitamin D might help lessen the occurrence of migraines for some, it may not be a solution for everyone, particularly in regards to reducing the intensity or duration of such headaches.
We found that migraineurs had significantly lower levels of serum 25-hydroxy vitamin D compared to nonmigraineurs, indicating a noteworthy connection. In fact, vitamin D deficiency was shown to be associated with an increased likelihood of experiencing migraines.
When it comes to treatment, we observed that taking vitamin D supplements seemed to help reduce the frequency of migraines. However, it's important to note that while vitamin D supplementation made a difference in how often migraines occurred, it did not significantly impact how long these headaches lasted or their severity.
Overall, it appears that while vitamin D might help lessen the occurrence of migraines for some, it may not be a solution for everyone, particularly in regards to reducing the intensity or duration of such headaches.
5
We delved into the intriguing connection between vitamin D and primary headaches, specifically migraines and tension-type headaches. Our review analyzed various studies up until October 2019, drawing on data from reputable clinical databases. We looked at a total of 22 studies focused on serum vitamin D levels related to headaches, with eight also exploring the effects of vitamin D supplementation.
Interestingly, 18 of these studies found a notable relationship between serum vitamin D levels and headache occurrence, highlighting a particularly strong link with migraines. While this suggests that vitamin D levels may influence headache frequency, we also noted that the evidence is not robust enough to universally recommend vitamin D supplementation for all individuals experiencing headaches.
However, for those suffering from migraines and particularly for individuals with vitamin D deficiency, supplementing with vitamin D might help lessen the intensity or frequency of headaches. Overall, it appears that there could be benefits for specific groups, but more research is needed to clarify the overall impact of vitamin D3 treatment on headaches.
Interestingly, 18 of these studies found a notable relationship between serum vitamin D levels and headache occurrence, highlighting a particularly strong link with migraines. While this suggests that vitamin D levels may influence headache frequency, we also noted that the evidence is not robust enough to universally recommend vitamin D supplementation for all individuals experiencing headaches.
However, for those suffering from migraines and particularly for individuals with vitamin D deficiency, supplementing with vitamin D might help lessen the intensity or frequency of headaches. Overall, it appears that there could be benefits for specific groups, but more research is needed to clarify the overall impact of vitamin D3 treatment on headaches.
References
- Hao S, Qian R, Chen Y, Liu J, Xu X, et al. Association between serum vitamin D and severe headache or migraine: A population-based analysis. PLoS One. 2025;20:e0313082. 10.1371/journal.pone.0313082
- Tirani SA, Khorvash F, Saneei P, Moradmand Z, Askari G. Effects of probiotic and vitamin D co-supplementation on clinical symptoms, mental health, and inflammation in adult patients with migraine headache: a randomized, triple-blinded, placebo-controlled trial. BMC Med. 2024;22:457. 10.1186/s12916-024-03684-6
- Xiong H, Jiang R, Xing L, Zheng J, Tian X, et al. New evidence that vitamin D prevents headache: a bidirectional two-sample Mendelian randomization analysis. Front Neurol. 2024;15:1423569. 10.3389/fneur.2024.1423569
- Ioannidou E, Tsakiris C, Goulis DG, Christoforidis A, Zafeiriou D. The association of serum vitamin D concentrations in paediatric migraine. Eur J Paediatr Neurol. 2023;47:60. 10.1016/j.ejpn.2023.09.007
- Das S, Roy A, Behera SK, Selvarajan S, Kamalanathan S, et al. Effects of Vitamin D on Migraine: A Meta-Analysis. Neurol India. 2023;71:655. 10.4103/0028-3886.383862
- Gaul C, Zaranek L, Goßrau G. [Complementary and supplementary procedures in the treatment of headache]. Schmerz. 2023;37:448. 10.1007/s00482-023-00738-1
- Kotb Elmala M, Suliman HA, Al-Shokary AH, Ibrahim AO, Kamal NM, et al. The Impact of Vitamin D Supplementation to Topiramate Therapy on Pediatric Migraine Prophylaxis. J Child Neurol. 2022;37:833. 10.1177/08830738221092882
- Mursi AM, Mirghani HO, Elbeialy AA. A Case Report of Post COVID19 Giant Cell Arteritis and Polymyalgia Rheumatica With Visual Loss. Clin Med Insights Case Rep. 2022;15:11795476221088472. 10.1177/11795476221088472
- Ganji R, Majdinasab N, Hesam S, Rostami N, Sayyah M, et al. Does atorvastatin have augmentative effects with sodium valproate in prevention of migraine with aura attacks? A triple-blind controlled clinical trial. J Pharm Health Care Sci. 2021;7:12. 10.1186/s40780-021-00198-8
- Ghorbani Z, Rafiee P, Haghighi S, Razeghi Jahromi S, Djalali M, et al. The effects of vitamin D3 supplementation on TGF-β and IL-17 serum levels in migraineurs: post hoc analysis of a randomized clinical trial. J Pharm Health Care Sci. 2021;7:9. 10.1186/s40780-021-00192-0
- Fallah R, Sarraf Yazd S, Sohrevardi SM. Efficacy of Topiramate Alone and Topiramate Plus Vitamin D3 in the Prophylaxis of Pediatric Migraine: A Randomized Clinical Trial. Iran J Child Neurol. 2020;14:77.
- Ghorbani Z, Rafiee P, Fotouhi A, Haghighi S, Rasekh Magham R, et al. The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial. J Headache Pain. 2020;21:22. 10.1186/s10194-020-01090-w
- Nowaczewska M, Wiciński M, Osiński S, Kaźmierczak H. The Role of Vitamin D in Primary Headache-from Potential Mechanism to Treatment. Nutrients. 2020;12. 10.3390/nu12010243
- Ghorbani Z, Togha M, Rafiee P, Ahmadi ZS, Rasekh Magham R, et al. Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial. Neurol Sci. 2020;41:1183. 10.1007/s10072-019-04220-8
- Ghorbani Z, Togha M, Rafiee P, Ahmadi ZS, Rasekh Magham R, et al. Vitamin D in migraine headache: a comprehensive review on literature. Neurol Sci. 2019;40:2459. 10.1007/s10072-019-04021-z
- Gazerani P, Fuglsang R, Pedersen JG, Sørensen J, Kjeldsen JL, et al. A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D supplementation in adult patients with migraine. Curr Med Res Opin. 2019;35:715. 10.1080/03007995.2018.1519503
- Donmez A, Orun E, Sonmez FM. Vitamin D status in children with headache: A case-control study. Clin Nutr ESPEN. 2018;23:222. 10.1016/j.clnesp.2017.09.010
- Prakash S, Rathore C, Makwana P, Dave A, Joshi H, et al. Vitamin D Deficiency in Patients With Chronic Tension-Type Headache: A Case-Control Study. Headache. 2017;57:1096. 10.1111/head.13096
- Buettner C, Nir RR, Bertisch SM, Bernstein C, Schain A, et al. Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial. Ann Neurol. 2015;78:970. 10.1002/ana.24534
- Laursen JC, Cairns BE, Kumar U, Somvanshi RK, Dong XD, et al. Nitric oxide release from trigeminal satellite glial cells is attenuated by glial modulators and glutamate. Int J Physiol Pathophysiol Pharmacol. 2013;5:228.
- Mottaghi T, Khorvash F, Askari G, Maracy MR, Ghiasvand R, et al. The relationship between serum levels of vitamin D and migraine. J Res Med Sci. 2013;18:S66.
