' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.3
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%
Top Medical Research Studies
9.5
Vitamin D3 aids sinusitis relief
The role of oral vitamin D3 supplementation in the treatment of Chronic Rhinosinusitis in adults with Vitamin D deficiency.
High relevance to sinusitis treatment
We focused on understanding the role of vitamin D3 in treating chronic rhinosinusitis (CRS), a condition affecting the nasal passages and sinuses. Our study analyzed 200 patients with vitamin D deficiency, dividing them into two groups: one group was given oral vitamin D supplements, while the other received a placebo.
Over a span of three months, we monitored changes in vitamin D levels and symptoms using the Total Nasal Symptom Score (TNSS). Initially, the average vitamin D level was quite low at 12.31 ng/ml. Remarkably, after treatment, this level surged to 29.71 ng/ml, indicating a significant improvement.
Additionally, we observed a reduction in TNSS scores, showing that while the average score started at 11.92, it decreased by about 10.65 points after three months of vitamin D treatment. This significant drop highlights the positive impact vitamin D supplementation can have on alleviating symptoms of CRS.
Overall, our exploration revealed a previously high prevalence of vitamin D deficiency among CRS patients, suggesting that addressing this deficiency through supplementation can be beneficial in managing their symptoms effectively.
Over a span of three months, we monitored changes in vitamin D levels and symptoms using the Total Nasal Symptom Score (TNSS). Initially, the average vitamin D level was quite low at 12.31 ng/ml. Remarkably, after treatment, this level surged to 29.71 ng/ml, indicating a significant improvement.
Additionally, we observed a reduction in TNSS scores, showing that while the average score started at 11.92, it decreased by about 10.65 points after three months of vitamin D treatment. This significant drop highlights the positive impact vitamin D supplementation can have on alleviating symptoms of CRS.
Overall, our exploration revealed a previously high prevalence of vitamin D deficiency among CRS patients, suggesting that addressing this deficiency through supplementation can be beneficial in managing their symptoms effectively.
Read More
9
Vitamin D3 enhances sinus health
Intranasal Calcitriol Accelerates Improvement of Sinonasal Inflammation and Olfactory Impairment in Mice After Cessation of Chronic Cigarette-Smoke Exposure.
Direct application to sinusitis.
We aimed to understand whether intranasal delivery of calcitriol, a form of vitamin D, can reduce inflammation in the nose and improve olfactory function after exposure to cigarette smoke. Our study used a mouse model, where the animals were subjected to cigarette smoke for nine months, simulating a chronic exposure similar to that seen in smokers.
Afterward, we treated these mice with calcitriol three times a week for four weeks. We observed that calcitriol significantly reduced inflammation and improved the overall condition of the sinonasal tissue. Specifically, our results showed an 18% reduction in inflammation severity compared to just a 5% reduction with smoke cessation alone.
In addition, we noted that calcitriol treatment reduced the influx of neutrophils—white blood cells that contribute to inflammation—and improved the mice's sense of smell, which had been impaired due to smoke exposure. These exciting findings suggest that local delivery of calcitriol could be a promising new approach for treating sinonasal inflammation and may offer benefits for individuals suffering from sinusitis.
Afterward, we treated these mice with calcitriol three times a week for four weeks. We observed that calcitriol significantly reduced inflammation and improved the overall condition of the sinonasal tissue. Specifically, our results showed an 18% reduction in inflammation severity compared to just a 5% reduction with smoke cessation alone.
In addition, we noted that calcitriol treatment reduced the influx of neutrophils—white blood cells that contribute to inflammation—and improved the mice's sense of smell, which had been impaired due to smoke exposure. These exciting findings suggest that local delivery of calcitriol could be a promising new approach for treating sinonasal inflammation and may offer benefits for individuals suffering from sinusitis.
Read More
8
Vitamin D3's effect on inflammation
Impaired local Vitamin D3 metabolism contributes to IL-36g overproduction in epithelial cells in chronic rhinosinusitis with nasal polyps.
High relevance to sinusitis treatment
We explored the role of vitamin D3 in chronic rhinosinusitis, especially in patients with nasal polyps. By analyzing 25-hydroxyvitamin D3 levels in serum and tissue samples, we found that these levels were notably lower in individuals suffering from this condition compared to healthy individuals. Additionally, key enzymes and receptors that help convert vitamin D3 into its active form were also found to be reduced in the nasal epithelial cells of these patients.
Our investigation revealed that both vitamin D3 and its active form, 1,25-hydroxyvitamin D3, play crucial roles in regulating inflammation. Specifically, we observed that these compounds suppressed the production of IL-36γ, a substance linked with inflammation in sinus tissues. These findings suggest that impaired vitamin D3 metabolism may lead to an increase in inflammatory responses among chronic rhinosinusitis patients.
Ultimately, the study indicates that lower levels of systemic vitamin D3, along with diminished local conversion to its active form, disrupt normal signaling in nasal cells. This imbalance appears to exacerbate inflammation associated with chronic rhinosinusitis and nasal polyps, particularly through the overproduction of IL-36γ.
Our investigation revealed that both vitamin D3 and its active form, 1,25-hydroxyvitamin D3, play crucial roles in regulating inflammation. Specifically, we observed that these compounds suppressed the production of IL-36γ, a substance linked with inflammation in sinus tissues. These findings suggest that impaired vitamin D3 metabolism may lead to an increase in inflammatory responses among chronic rhinosinusitis patients.
Ultimately, the study indicates that lower levels of systemic vitamin D3, along with diminished local conversion to its active form, disrupt normal signaling in nasal cells. This imbalance appears to exacerbate inflammation associated with chronic rhinosinusitis and nasal polyps, particularly through the overproduction of IL-36γ.
Read More
Most Useful Reviews
8.8
Supports immune function
Vitamin D3 is vital for preventing and treating sinusitis due to its role in strengthening the immune system and reducing inflammation. I recommend taking it regularly, particularly in autumn and winter when natural sunlight levels are low.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.3
9.5
Vitamin D3 aids sinusitis relief
The role of oral vitamin D3 supplementation in the treatment of Chronic Rhinosinusitis in adults with Vitamin D deficiency.
High relevance to sinusitis treatment
We focused on understanding the role of vitamin D3 in treating chronic rhinosinusitis (CRS), a condition affecting the nasal passages and sinuses. Our study analyzed 200 patients with vitamin D deficiency, dividing them into two groups: one group was given oral vitamin D supplements, while the other received a placebo.
Over a span of three months, we monitored changes in vitamin D levels and symptoms using the Total Nasal Symptom Score (TNSS). Initially, the average vitamin D level was quite low at 12.31 ng/ml. Remarkably, after treatment, this level surged to 29.71 ng/ml, indicating a significant improvement.
Additionally, we observed a reduction in TNSS scores, showing that while the average score started at 11.92, it decreased by about 10.65 points after three months of vitamin D treatment. This significant drop highlights the positive impact vitamin D supplementation can have on alleviating symptoms of CRS.
Overall, our exploration revealed a previously high prevalence of vitamin D deficiency among CRS patients, suggesting that addressing this deficiency through supplementation can be beneficial in managing their symptoms effectively.
Over a span of three months, we monitored changes in vitamin D levels and symptoms using the Total Nasal Symptom Score (TNSS). Initially, the average vitamin D level was quite low at 12.31 ng/ml. Remarkably, after treatment, this level surged to 29.71 ng/ml, indicating a significant improvement.
Additionally, we observed a reduction in TNSS scores, showing that while the average score started at 11.92, it decreased by about 10.65 points after three months of vitamin D treatment. This significant drop highlights the positive impact vitamin D supplementation can have on alleviating symptoms of CRS.
Overall, our exploration revealed a previously high prevalence of vitamin D deficiency among CRS patients, suggesting that addressing this deficiency through supplementation can be beneficial in managing their symptoms effectively.
Read More
9
Vitamin D3 enhances sinus health
Intranasal Calcitriol Accelerates Improvement of Sinonasal Inflammation and Olfactory Impairment in Mice After Cessation of Chronic Cigarette-Smoke Exposure.
Direct application to sinusitis.
We aimed to understand whether intranasal delivery of calcitriol, a form of vitamin D, can reduce inflammation in the nose and improve olfactory function after exposure to cigarette smoke. Our study used a mouse model, where the animals were subjected to cigarette smoke for nine months, simulating a chronic exposure similar to that seen in smokers.
Afterward, we treated these mice with calcitriol three times a week for four weeks. We observed that calcitriol significantly reduced inflammation and improved the overall condition of the sinonasal tissue. Specifically, our results showed an 18% reduction in inflammation severity compared to just a 5% reduction with smoke cessation alone.
In addition, we noted that calcitriol treatment reduced the influx of neutrophils—white blood cells that contribute to inflammation—and improved the mice's sense of smell, which had been impaired due to smoke exposure. These exciting findings suggest that local delivery of calcitriol could be a promising new approach for treating sinonasal inflammation and may offer benefits for individuals suffering from sinusitis.
Afterward, we treated these mice with calcitriol three times a week for four weeks. We observed that calcitriol significantly reduced inflammation and improved the overall condition of the sinonasal tissue. Specifically, our results showed an 18% reduction in inflammation severity compared to just a 5% reduction with smoke cessation alone.
In addition, we noted that calcitriol treatment reduced the influx of neutrophils—white blood cells that contribute to inflammation—and improved the mice's sense of smell, which had been impaired due to smoke exposure. These exciting findings suggest that local delivery of calcitriol could be a promising new approach for treating sinonasal inflammation and may offer benefits for individuals suffering from sinusitis.
Read More
9
Vitamin D reduces inflammation in sinusitis
Vitamin D decreases the secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis.
Direct link but lacks isolation
Our research aimed to understand how vitamin D, particularly its derivatives, affects the health of nasal tissue in patients suffering from chronic rhinosinusitis with nasal polyps (CRSwNP). We conducted experiments using fibroblast cells taken from nasal polyp tissues during surgery. Specifically, we looked at how these fibroblasts responded when stimulated with tumor necrosis factor-α (TNF-α), a protein that promotes inflammation.
After exposing the fibroblasts to TNF-α, we treated them with vitamin D derivatives, including calcitriol and tacalcitol. The results were promising! We found that TNF-α significantly increased the secretion of matrix metalloproteinases (MMP-2 and MMP-9), proteins linked to inflammation and tissue remodeling. Importantly, introducing vitamin D derivatives effectively suppressed this excess secretion, indicating a potential therapeutic role for vitamin D in managing inflammation related to sinusitis.
Though the study shines a light on the positive effects of vitamin D derivatives in this context, it also highlights the need for more specific studies on vitamin D3 alone. Nevertheless, our findings support the idea that vitamin D could be a useful addition to treatment strategies for individuals with CRSwNP, especially among Taiwanese patients.
After exposing the fibroblasts to TNF-α, we treated them with vitamin D derivatives, including calcitriol and tacalcitol. The results were promising! We found that TNF-α significantly increased the secretion of matrix metalloproteinases (MMP-2 and MMP-9), proteins linked to inflammation and tissue remodeling. Importantly, introducing vitamin D derivatives effectively suppressed this excess secretion, indicating a potential therapeutic role for vitamin D in managing inflammation related to sinusitis.
Though the study shines a light on the positive effects of vitamin D derivatives in this context, it also highlights the need for more specific studies on vitamin D3 alone. Nevertheless, our findings support the idea that vitamin D could be a useful addition to treatment strategies for individuals with CRSwNP, especially among Taiwanese patients.
Read More
9
Vitamin D reduces inflammatory responses
Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps.
Direct relevance to sinusitis treatment
We explored how vitamin D derivatives, specifically calcitriol and tacalcitol, influence the secretion of certain inflammatory chemicals in nasal polyp cells from patients suffering from chronic rhinosinusitis with nasal polyps (CRSwNP). In our study, we focused on eotaxin and RANTES, two key substances that attract eosinophils, a type of white blood cell linked to inflammation.
To conduct our research, we collected nasal polyp samples from patients with eosinophilic CRSwNP. The samples were cultured in a laboratory setting, allowing us to examine how these fibroblast cells respond to stimulation. After exposing the cells to interleukin-1 beta, a protein that triggers inflammation, we treated them with vitamin D derivatives to see their effects on eotaxin and RANTES levels.
Our findings showed that treatment with vitamin D compounds effectively reduced the secretion of both eotaxin and RANTES in the stimulated cells. The significant decrease in these inflammatory agents suggests that vitamin D could have beneficial roles beyond its well-known contributions to bone health. This opens potential avenues for using vitamin D in treating CRSwNP, particularly for our Taiwanese patient population.
Overall, this research highlights a potentially new therapeutic angle for vitamin D in managing chronic sinusitis, emphasizing its role in modulating inflammatory responses associated with this challenging condition.
To conduct our research, we collected nasal polyp samples from patients with eosinophilic CRSwNP. The samples were cultured in a laboratory setting, allowing us to examine how these fibroblast cells respond to stimulation. After exposing the cells to interleukin-1 beta, a protein that triggers inflammation, we treated them with vitamin D derivatives to see their effects on eotaxin and RANTES levels.
Our findings showed that treatment with vitamin D compounds effectively reduced the secretion of both eotaxin and RANTES in the stimulated cells. The significant decrease in these inflammatory agents suggests that vitamin D could have beneficial roles beyond its well-known contributions to bone health. This opens potential avenues for using vitamin D in treating CRSwNP, particularly for our Taiwanese patient population.
Overall, this research highlights a potentially new therapeutic angle for vitamin D in managing chronic sinusitis, emphasizing its role in modulating inflammatory responses associated with this challenging condition.
Read More
9
Vitamin D's role in sinusitis
Vitamin D analogs decrease in vitro secretion of RANTES and enhance the effect of budesonide.
Study highlights combination therapy
We explored the impact of vitamin D derivatives on a key player in sinusitis inflammation: RANTES, a known chemoattractant for eosinophils. In a study involving nasal polyp fibroblast cultures from 16 patients, we first stimulated the cells with bacterial components before treating them with increasing concentrations of vitamin D3 compounds, including calcitriol and tacalcitol, alongside the medication budesonide.
We observed that higher doses of calcitriol and tacalcitol significantly reduced RANTES production compared to untreated cells. Notably, when combined with budesonide in specific ratios, these vitamin D compounds managed to suppress RANTES levels even more effectively than when either drug was used alone. This suggests that vitamin D derivatives have a complementary role in treating chronic rhinosinusitis with nasal polyps by helping to regulate inflammatory responses.
Overall, our findings indicate that these vitamin D compounds, particularly when used alongside budesonide, could enhance therapeutic approaches for managing sinus inflammation. This underscores the importance of considering vitamin D not just as a supplement, but as an integrative part of sinusitis treatment strategies.
We observed that higher doses of calcitriol and tacalcitol significantly reduced RANTES production compared to untreated cells. Notably, when combined with budesonide in specific ratios, these vitamin D compounds managed to suppress RANTES levels even more effectively than when either drug was used alone. This suggests that vitamin D derivatives have a complementary role in treating chronic rhinosinusitis with nasal polyps by helping to regulate inflammatory responses.
Overall, our findings indicate that these vitamin D compounds, particularly when used alongside budesonide, could enhance therapeutic approaches for managing sinus inflammation. This underscores the importance of considering vitamin D not just as a supplement, but as an integrative part of sinusitis treatment strategies.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
8.8
Supports immune function
Vitamin D3 is vital for preventing and treating sinusitis due to its role in strengthening the immune system and reducing inflammation. I recommend taking it regularly, particularly in autumn and winter when natural sunlight levels are low.
