Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
USERS' SCORE
Good
Based on 11 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%
Top Medical Research Studies
8
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
8
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
7
Vitamin D effects on asthma explored
We explored the role of vitamin D, specifically calcitriol, in managing allergic eosinophilic asthma and how it interacts with a key molecule, CD46, in T cells. Our research involved stimulating CD4 T cells from patients and healthy donors with specific antibodies and measuring the production of two important immune signals: IFN-γ and IL-10.
Our findings suggest that lower levels of CD46 on activated CD4 T cells are linked to a more favorable Th1 cell response to calcitriol. This means that individuals with certain profiles might benefit more from vitamin D supplementation, potentially reducing inflammation associated with their asthma.
However, we need further validation of these results in clinical settings. If proven effective, this stratification could pave the way for personalized treatments for people with allergic conditions and possibly other diseases influenced by immune responses.
Our findings suggest that lower levels of CD46 on activated CD4 T cells are linked to a more favorable Th1 cell response to calcitriol. This means that individuals with certain profiles might benefit more from vitamin D supplementation, potentially reducing inflammation associated with their asthma.
However, we need further validation of these results in clinical settings. If proven effective, this stratification could pave the way for personalized treatments for people with allergic conditions and possibly other diseases influenced by immune responses.
Most Useful Reviews
9
Allergy relief
Although the rating is under trial, it suits me well. With all beef ingredients and no fish, it meets my allergy needs. The detailed ingredients, quality, and quantity are excellent, and I feel my immunity has improved.
9
Stronger immunity
This company provides quality ingredients that have helped with my spring allergies. I take this strong dose daily, and my allergies have completely disappeared. I highly recommend it for anyone with similar issues.
9
Skin benefits
This product has wonderfully improved my skin. It caused no allergies and is beneficial for everyone in my family. We take it regularly, and it has increased our immunity, especially for those who lack sun exposure.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
- All Researches
9
We explored the effects of vitamin D in combination with fluticasone propionate on allergy-related symptoms in children with bronchial asthma. In this study, we grouped participants into two treatment plans: one group received only fluticasone, while the other group received both fluticasone and vitamin D. By comparing their progress, we noted various health improvements related to asthma control.
The findings highlighted that the children who received the combination therapy experienced quicker relief from asthma symptoms, such as wheezing and shortness of breath. Their overall lung function also improved, as seen in measures like forced vital capacity and peak expiratory flow. Moreover, the kids taking vitamin D showed better immune responses, indicated by increased levels of specific immunoglobulins and lymphocytes important for fighting off infections.
We also observed significant improvements in well-being and quality of life for those in the combination group. However, it's essential to note that while vitamin D appears to offer additional benefits when taken alongside traditional asthma treatments, the study did not focus solely on vitamin D's effects. Overall, the data suggest that vitamin D could play a positive role in managing allergies associated with asthma, but further research is needed to isolate its effects conclusively.
The findings highlighted that the children who received the combination therapy experienced quicker relief from asthma symptoms, such as wheezing and shortness of breath. Their overall lung function also improved, as seen in measures like forced vital capacity and peak expiratory flow. Moreover, the kids taking vitamin D showed better immune responses, indicated by increased levels of specific immunoglobulins and lymphocytes important for fighting off infections.
We also observed significant improvements in well-being and quality of life for those in the combination group. However, it's essential to note that while vitamin D appears to offer additional benefits when taken alongside traditional asthma treatments, the study did not focus solely on vitamin D's effects. Overall, the data suggest that vitamin D could play a positive role in managing allergies associated with asthma, but further research is needed to isolate its effects conclusively.
9
Vitamin D metabolites aid pulmonary health
We explored the impact of vitamin D metabolites on respiratory health, particularly in the context of hypersensitivity pneumonitis (HP). Our study focused on C57BL/6J mice that were placed on a diet severely lacking in vitamin D to induce deficiency. These mice were then exposed to an antigen linked to HP while inhaling either 25(OH)-vitamin D3 or 1,25(OH)2-vitamin D3.
Over the course of the experiment, we observed significant changes in the respiratory function of vitamin D-deficient mice. The metabolites of vitamin D we tested seemed to counteract many adverse effects associated with vitamin D deficiency. Inhalations of these compounds not only improved respiratory functions but also reduced inflammation and fibrosis that was exacerbated by the HP-causing antigen.
This research suggests that inhaling vitamin D metabolites may restore normal levels of active vitamin D in the lungs of deficient mice, providing a promising avenue for further exploration into how vitamin D may help manage respiratory conditions related to allergies and hypersensitivity.
Over the course of the experiment, we observed significant changes in the respiratory function of vitamin D-deficient mice. The metabolites of vitamin D we tested seemed to counteract many adverse effects associated with vitamin D deficiency. Inhalations of these compounds not only improved respiratory functions but also reduced inflammation and fibrosis that was exacerbated by the HP-causing antigen.
This research suggests that inhaling vitamin D metabolites may restore normal levels of active vitamin D in the lungs of deficient mice, providing a promising avenue for further exploration into how vitamin D may help manage respiratory conditions related to allergies and hypersensitivity.
8
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
8
We conducted an extensive review of multiple studies to understand how vitamin D might influence atopic dermatitis (AD), a skin condition that impacts many people, particularly children. Our focus was on randomized controlled trials that compared vitamin D supplementation with a placebo group.
After analyzing data from eleven studies involving a total of 686 participants, we found compelling evidence that vitamin D supplementation can significantly reduce the severity of AD. Participants who received vitamin D showed a marked improvement compared to those who did not, with a notable decrease in their disease severity scores.
It's important to highlight that while our findings are promising, we also recognize the need for larger and longer-term studies to confirm these results. By understanding the role of vitamin D, we can better explore potential treatments for managing allergy-related conditions like atopic dermatitis.
After analyzing data from eleven studies involving a total of 686 participants, we found compelling evidence that vitamin D supplementation can significantly reduce the severity of AD. Participants who received vitamin D showed a marked improvement compared to those who did not, with a notable decrease in their disease severity scores.
It's important to highlight that while our findings are promising, we also recognize the need for larger and longer-term studies to confirm these results. By understanding the role of vitamin D, we can better explore potential treatments for managing allergy-related conditions like atopic dermatitis.
8
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Allergy relief
Although the rating is under trial, it suits me well. With all beef ingredients and no fish, it meets my allergy needs. The detailed ingredients, quality, and quantity are excellent, and I feel my immunity has improved.
9
Stronger immunity
This company provides quality ingredients that have helped with my spring allergies. I take this strong dose daily, and my allergies have completely disappeared. I highly recommend it for anyone with similar issues.
9
Skin benefits
This product has wonderfully improved my skin. It caused no allergies and is beneficial for everyone in my family. We take it regularly, and it has increased our immunity, especially for those who lack sun exposure.
7.5
Improved health
1 people found this helpful
I drink it every day, and my health and allergies have improved significantly. I highly recommend it to everyone.
9
Effective and safe
This excellent quality product posed no negative reactions for me. The large package lasted long, and I noticed improvements in my metabolism and the nervous system after just a week. It’s effective for both immunity and allergies.
Frequently Asked Questions
9
Effective and safe
This excellent quality product posed no negative reactions for me. The large package lasted long, and I noticed improvements in my metabolism and the nervous system after just a week. It’s effective for both immunity and allergies.
9
Stronger immunity
This company provides quality ingredients that have helped with my spring allergies. I take this strong dose daily, and my allergies have completely disappeared. I highly recommend it for anyone with similar issues.
7.5
Improved health
1 people found this helpful
I drink it every day, and my health and allergies have improved significantly. I highly recommend it to everyone.
9
Skin benefits
This product has wonderfully improved my skin. It caused no allergies and is beneficial for everyone in my family. We take it regularly, and it has increased our immunity, especially for those who lack sun exposure.
9
Quick absorption
The pleasant smell and easy-to-use package make this product great. Its quality is excellent, size is large, and it does not cause allergies. It absorbs quickly and has helped me, particularly with my allergies.
8
Healthy winter
The product has no smell and is very effective for adults. It greatly moisturises during winter without causing allergies. This nutritional supplement has improved my health significantly, especially for my bones. I use it daily.
5
We examined the role of vitamin D supplementation in managing allergic rhinitis through a systematic review and meta-analysis. By reviewing randomized controlled trials focused on patients with allergic rhinitis, we aimed to determine the effectiveness of vitamin D in alleviating symptoms.
Our findings indicate that vitamin D may help reduce allergic rhinitis symptoms compared to placebos; however, the improvement was not statistically significant. We also discovered considerable variation among the studies we analyzed, pointing toward the complexities of measuring vitamin D's effects.
Interestingly, factors like the proportion of female participants and the use of corticosteroids impacted how patients responded to vitamin D. Specifically, vitamin D supplementation that was not paired with corticosteroids showed a more substantial impact on relieving symptoms.
While vitamin D appears to offer some benefits for allergic rhinitis, the overall effect may depend on individual circumstances, including gender and medication use. Thus, it's essential to consider these aspects when evaluating treatment options for allergies.
Our findings indicate that vitamin D may help reduce allergic rhinitis symptoms compared to placebos; however, the improvement was not statistically significant. We also discovered considerable variation among the studies we analyzed, pointing toward the complexities of measuring vitamin D's effects.
Interestingly, factors like the proportion of female participants and the use of corticosteroids impacted how patients responded to vitamin D. Specifically, vitamin D supplementation that was not paired with corticosteroids showed a more substantial impact on relieving symptoms.
While vitamin D appears to offer some benefits for allergic rhinitis, the overall effect may depend on individual circumstances, including gender and medication use. Thus, it's essential to consider these aspects when evaluating treatment options for allergies.
7
Vitamin D's role in allergies explored
We set out to examine the relationship between vitamin D levels and atopic dermatitis (AD), a common chronic inflammatory condition in children that involves skin sensitivity and allergies. In our study, we evaluated blood samples from 51 children with AD and compared their vitamin D levels and other immune markers to those of 20 healthy kids.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
7
We explored how calcitriol, the active form of vitamin D3, influences the immune response related to allergies. Our focus was on two key cytokines—IL-4 and IL-13—which play a significant role in allergic reactions. Through our experiments, we found that calcitriol reduced the production of these cytokines in both murine and human T-helper 2 (Th2) cells.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
7
We conducted a study focusing on the intriguing relationship between vitamin D3 levels and allergies, specifically in patients with chronic and allergic sinusitis. Our research involved 90 subjects divided into three groups: healthy controls, chronic sinusitis patients, and those suffering from allergic sinusitis.
Throughout the study, we measured serum levels of vitamin D3 and immunoglobulin E (IgE) using an ELISA method. The results revealed that a significant portion of our participants—60%—had insufficient vitamin D, with those afflicted by allergic sinusitis showing even higher deficiencies.
Interestingly, we observed that female participants were more likely to experience vitamin D deficiency. Additionally, cravings for higher levels of IgE protein were primarily noted in the allergic sinusitis group, further linking low vitamin D levels with allergy severity.
Our findings suggest that vitamin D deficiency may play a role in increasing susceptibility to allergic sinusitis, presenting a case for considering vitamin D supplementation as a potential adjunctive therapy for these patients.
Throughout the study, we measured serum levels of vitamin D3 and immunoglobulin E (IgE) using an ELISA method. The results revealed that a significant portion of our participants—60%—had insufficient vitamin D, with those afflicted by allergic sinusitis showing even higher deficiencies.
Interestingly, we observed that female participants were more likely to experience vitamin D deficiency. Additionally, cravings for higher levels of IgE protein were primarily noted in the allergic sinusitis group, further linking low vitamin D levels with allergy severity.
Our findings suggest that vitamin D deficiency may play a role in increasing susceptibility to allergic sinusitis, presenting a case for considering vitamin D supplementation as a potential adjunctive therapy for these patients.
References
- Kawada K, Sato C, Ishida T, Nagao Y, Yamamoto T, et al. Vitamin D Supplementation and Allergic Rhinitis: A Systematic Review and Meta-Analysis. Medicina (Kaunas). 2025;61. doi:10.3390/medicina61020355
- Molatefi R, Fouladi N, Asghariazar V, Samemaleki S, Golizadeh M, et al. The evaluation of the serum levels of vitamin D and interleukin-33 in children with atopic dermatitis and its association with diseases severity. Arch Dermatol Res. 2025;317:182. doi:10.1007/s00403-024-03709-3
- Akbulut O, Köksal BT, Aydın B, Oznacar T, Haberal A, et al. Does vitamin D deficiency predispose to allergic proctocolitis?. Nutrition. 2025;131:112659. doi:10.1016/j.nut.2024.112659
- Nielsen AY, Høj S, Thomsen SF, Meteran H. Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis. Nutrients. 2024;16. doi:10.3390/nu16234128
- Wu D, Wang J, Wei Y, Zhang X, Hou Z. Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy. Physiol Res. 2024;73:841.
- Lemieszek MK, Chojnacki M, Paśnik I, Gawryś W, Wilczyńska A, et al. Beneficial Impact of Inhaled 25(OH)-Vitamin D3 and 1,25(OH)2-Vitamin D3 on Pulmonary Response in the Murine Model of Hypersensitivity Pneumonitis. Int J Mol Sci. 2024;25. doi:10.3390/ijms251910289
- Stichova J, Slanina P, Chovancova Z, Baros J, Litzman M, et al. Low CD46 expression on activated CD4 T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donors. Front Allergy. 2024;5:1462579. doi:10.3389/falgy.2024.1462579
- Biswas B, Chattopadhyay S, Hazra S, Goswami R. Calcitriol Impairs the Secretion of IL-4 and IL-13 in Th2 Cells via Modulating the VDR-Gata3-Gfi1 Axis. J Immunol. 2024;213:831. doi:10.4049/jimmunol.2400078
- Zeng R, Lodge CJ, Koplin JJ, Lopez DJ, Erbas B, et al. Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age. Nutrients. 2024;16. doi:10.3390/nu16091303
- Al-Allaff RGM, Bakr Al-Sawaf TM. Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis. Pak J Biol Sci. 2024;27:27. doi:10.3923/pjbs.2024.27.34
- Bagheri P, Nouri M, Eskandarzadeh H, Darvishi M. Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study. Recent Adv Inflamm Allergy Drug Discov. 2024;18:108. doi:10.2174/0127722708281623240116100806
