' 
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.2
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%
Top Medical Research Studies
8
Vitamin D reduces eczema severity
Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis.
Directly addresses eczema treatment
We focused on understanding the impact of vitamin D supplementation on atopic dermatitis, commonly known as eczema, in both children and adults. This systematic review analyzed data from eleven randomized controlled trials (RCTs), involving a total of 686 participants.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
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8
Vitamin D3 improves eczema symptoms
Assessment of the Effectiveness of Vitamin Supplement in Treating Eczema: A Systematic Review and Meta-Analysis.
High relevance to the research
We explored the potential benefits of vitamin D3 as a treatment for eczema, a condition that has been increasingly prevalent in recent years. By examining several randomized controlled trials, we were able to focus on how effective vitamin D3 might be in alleviating the symptoms of eczema, as measured by established severity indexes.
Our analysis included ten studies, with eight of them providing sufficient data for a quantitative comparison. In comparing the vitamin D3 group to control groups, we observed a significant reduction in eczema severity, evidenced by lower scores on the SCORAD and EASI scales. Specifically, participants taking vitamin D3 had a mean difference of -5.96, indicating a meaningful improvement in their symptoms.
This evidence suggests that incorporating vitamin D3 into eczema management could be beneficial. We believe this finding is important as it highlights a potential therapeutic avenue for eczema sufferers looking for effective solutions.
Our analysis included ten studies, with eight of them providing sufficient data for a quantitative comparison. In comparing the vitamin D3 group to control groups, we observed a significant reduction in eczema severity, evidenced by lower scores on the SCORAD and EASI scales. Specifically, participants taking vitamin D3 had a mean difference of -5.96, indicating a meaningful improvement in their symptoms.
This evidence suggests that incorporating vitamin D3 into eczema management could be beneficial. We believe this finding is important as it highlights a potential therapeutic avenue for eczema sufferers looking for effective solutions.
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8
Vitamin D3 improves winter eczema
Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children.
Direct evaluation of vitamin D3 effect
We explored the impact of vitamin D3 supplementation on winter-related atopic dermatitis (eczema) in children. Our study involved a randomized, double-blind, placebo-controlled trial conducted in Ulaanbaatar, Mongolia, where kids aged 2 to 17 years were given either vitamin D3 or a placebo for one month.
We found that children who received vitamin D3 experienced a significant improvement in their eczema symptoms. Specifically, those taking vitamin D3 saw a notable reduction in their Eczema Area and Severity Index (EASI) score compared to those on placebo, with a difference that was both clinically and statistically significant.
Importantly, kids in the vitamin D3 group also received education on skincare and emollients, ensuring a comprehensive approach to managing their condition. No adverse effects were reported in either the vitamin D3 or placebo groups, highlighting its safety.
Overall, our findings suggest that vitamin D3 is a promising treatment for alleviating winter-related eczema in children, particularly in regions where vitamin D deficiency is prevalent during the colder months.
We found that children who received vitamin D3 experienced a significant improvement in their eczema symptoms. Specifically, those taking vitamin D3 saw a notable reduction in their Eczema Area and Severity Index (EASI) score compared to those on placebo, with a difference that was both clinically and statistically significant.
Importantly, kids in the vitamin D3 group also received education on skincare and emollients, ensuring a comprehensive approach to managing their condition. No adverse effects were reported in either the vitamin D3 or placebo groups, highlighting its safety.
Overall, our findings suggest that vitamin D3 is a promising treatment for alleviating winter-related eczema in children, particularly in regions where vitamin D deficiency is prevalent during the colder months.
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Most Useful Reviews
9.5
Eczema improvement
This is the best D3 supplement I've found! It’s the only one on iHerb with such a high dose, and it has significantly improved my eczema, which is nearly gone!
Read More
8.8
Improved eczema condition
I began taking the 50,000 IU Vitamin D3 after my doctor diagnosed me with a deficiency. Since taking it once a week, I've felt more energetic and noticed my immunity improved, leading to fewer colds. Most importantly, my skin, prone to dryness and eczema, feels more hydrated and less irritated. I have experienced no negative side effects.
Read More
7.8
Very effective
These are the third bottles I’ve purchased, and they help immensely with my eczema.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.2
- All Researches
9
Vitamin D3 relates to eczema severity
Changes and clinical significance of serum vitamin A, 25-(OH)D3, TG2, IL-4 and IL-13 levels in children with eczema.
Important but limited findings
We explored the effects of vitamin D3 levels on children suffering from eczema in a study involving 159 pediatric patients. The children were grouped based on the severity of their eczema, allowing us to see how varying levels of vitamin A, vitamin D3, and certain inflammatory markers changed with the severity of the condition.
Our findings revealed that as the severity of eczema increased, the levels of vitamin A and 25-(OH)D3 decreased. Meanwhile, we noticed a rise in inflammatory markers such as TG2, IL-4, and IL-13. Interestingly, we found a strong negative correlation between the levels of vitamin A and 25-(OH)D3 and the eczema severity scores, indicating that lower vitamin D levels were associated with more severe eczema symptoms.
After three months of treatment, children across all severity groups showed significant improvement in their vitamin A and D3 levels, along with changes in the inflammatory markers. Notably, 25-(OH)D3 demonstrated the best accuracy in diagnosing the severity of eczema compared to the other markers examined. This suggests that monitoring vitamin D3 could be quite valuable for assessing and managing eczema in children.
Overall, our study indicates that vitamin D3 plays a significant role in the severity of eczema symptoms, reinforcing the importance of maintaining healthy vitamin D levels for children suffering from this condition.
Our findings revealed that as the severity of eczema increased, the levels of vitamin A and 25-(OH)D3 decreased. Meanwhile, we noticed a rise in inflammatory markers such as TG2, IL-4, and IL-13. Interestingly, we found a strong negative correlation between the levels of vitamin A and 25-(OH)D3 and the eczema severity scores, indicating that lower vitamin D levels were associated with more severe eczema symptoms.
After three months of treatment, children across all severity groups showed significant improvement in their vitamin A and D3 levels, along with changes in the inflammatory markers. Notably, 25-(OH)D3 demonstrated the best accuracy in diagnosing the severity of eczema compared to the other markers examined. This suggests that monitoring vitamin D3 could be quite valuable for assessing and managing eczema in children.
Overall, our study indicates that vitamin D3 plays a significant role in the severity of eczema symptoms, reinforcing the importance of maintaining healthy vitamin D levels for children suffering from this condition.
Read More
9
Vitamin D3 aids children's eczema treatment
Oral vitamin D modulates the epidermal expression of the vitamin D receptor and cathelicidin in children with atopic dermatitis.
Direct correlation with outcomes
We investigated the impact of vitamin D3 supplementation on eczema severity in children. Over six weeks, a group of 22 children with moderate to severe atopic dermatitis took oral vitamin D3 weekly. We measured changes in their skin's expression of important proteins and how their eczema was doing overall.
The results were quite promising. After the treatment, not only did the children's vitamin D levels increase, but there was also a noticeable decrease in eczema severity as measured by the SCORAD index. Our findings revealed that both the vitamin D receptor and a skin defense protein called Cathelicidin saw significant increases—especially in areas affected by eczema. However, we found that levels of Thymic Stromal Lymphopoietin (another important skin factor) did not change after the treatment.
Overall, this study suggests that oral vitamin D3 can play a beneficial role in managing eczema in children, helping improve their skin health alongside enhancing important skin functions. This gives us new insights into how vitamin D3 might serve as a supportive treatment option.
The results were quite promising. After the treatment, not only did the children's vitamin D levels increase, but there was also a noticeable decrease in eczema severity as measured by the SCORAD index. Our findings revealed that both the vitamin D receptor and a skin defense protein called Cathelicidin saw significant increases—especially in areas affected by eczema. However, we found that levels of Thymic Stromal Lymphopoietin (another important skin factor) did not change after the treatment.
Overall, this study suggests that oral vitamin D3 can play a beneficial role in managing eczema in children, helping improve their skin health alongside enhancing important skin functions. This gives us new insights into how vitamin D3 might serve as a supportive treatment option.
Read More
9
Vitamin D3 reduces eczema risk
Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life: evidence from a randomized controlled trial.
High relevance due to direct investigation
We investigated how maternal supplementation with vitamin D3 during pregnancy influences the risk of developing atopic eczema in children. Our research was part of the UK Maternal Vitamin D Osteoporosis Study (MAVIDOS), a well-designed, double-blind, randomized placebo-controlled trial. Pregnant women in the study were assigned to take either 1000 IU of cholecalciferol (vitamin D3) or a placebo from around 14 weeks of gestation until delivery.
We tracked the prevalence of atopic eczema in their children at ages 12, 24, and 48 months, using recognized criteria for diagnosis. Our findings suggest that maternal cholecalciferol supplementation plays a beneficial role, as we noted a potential protective effect against the development of infantile atopic eczema. This effect might be due to increased levels of vitamin D3 in breast milk, which may help bolster the child’s immune system.
These results add valuable information to the conversation about how prenatal interventions can influence childhood health, particularly in relation to skin conditions like eczema.
We tracked the prevalence of atopic eczema in their children at ages 12, 24, and 48 months, using recognized criteria for diagnosis. Our findings suggest that maternal cholecalciferol supplementation plays a beneficial role, as we noted a potential protective effect against the development of infantile atopic eczema. This effect might be due to increased levels of vitamin D3 in breast milk, which may help bolster the child’s immune system.
These results add valuable information to the conversation about how prenatal interventions can influence childhood health, particularly in relation to skin conditions like eczema.
Read More
9
Vitamin D boosts levels, not symptoms
Serum 25-hydroxyvitamin D levels in patients with atopic eczema and the influence of narrowband ultraviolet B phototherapy.
Investigated vitamin D's effects
We examined how vitamin D3 levels affect atopic dermatitis, commonly known as eczema, particularly in patients undergoing narrowband ultraviolet B (nbUVB) therapy. This study involved 38 patients divided by gender and severity of their dermatitis, and tracked changes in both their vitamin D levels and their eczema severity before and after treatment.
Following the nbUVB therapy, we noted a remarkable increase in the median serum vitamin D levels—from 45 nmol/l before treatment to 169 nmol/l after treatment. Alongside this boost in vitamin D levels, we also observed a noteworthy reduction in eczema severity, with the average score dropping significantly.
However, our findings did not show a clear connection between the increase in vitamin D levels and the improvement in eczema severity. This suggests that while patients with eczema may benefit from increased vitamin D due to treatments like nbUVB, the direct relationship between vitamin D levels and eczema severity isn't confirmed by our study.
Overall, while patients with atopic dermatitis may be at risk of vitamin D deficiency, our results imply that simply increasing vitamin D levels might not guarantee improvements in eczema severity.
Following the nbUVB therapy, we noted a remarkable increase in the median serum vitamin D levels—from 45 nmol/l before treatment to 169 nmol/l after treatment. Alongside this boost in vitamin D levels, we also observed a noteworthy reduction in eczema severity, with the average score dropping significantly.
However, our findings did not show a clear connection between the increase in vitamin D levels and the improvement in eczema severity. This suggests that while patients with eczema may benefit from increased vitamin D due to treatments like nbUVB, the direct relationship between vitamin D levels and eczema severity isn't confirmed by our study.
Overall, while patients with atopic dermatitis may be at risk of vitamin D deficiency, our results imply that simply increasing vitamin D levels might not guarantee improvements in eczema severity.
Read More
8
Vitamin D's role in eczema severity
Changes and clinical significance of serum vitamin A, 25-(OH)D3, TG2, IL-4 and IL-13 levels in children with eczema.
High relevance; partial vitamin D focus
We investigated the levels of vitamin D and other related factors in children suffering from eczema to better understand their relationship with the severity of this condition. Our analysis included 159 children, categorized by the severity of their eczema symptoms into mild, moderate, and severe groups.
Over the course of the study, we observed that as eczema severity increased, serum levels of vitamin A and 25-(OH)D3 (a form of vitamin D) tended to decrease. Conversely, levels of tissue transglutaminase (TG2), interleukin-4 (IL-4), and interleukin-13 (IL-13), which are markers of inflammation, increased. Significant correlations emerged showing that lower levels of vitamin A and 25-(OH)D3 were linked to higher SCORAD scores (a measure of eczema severity), while increases in TG2, IL-4, and IL-13 levels paralleled worsening symptoms.
Importantly, vitamin D levels had the highest accuracy for assessing eczema severity compared to the other markers studied. After treatment over three months, we noted improvements in the levels of all measured indicators, suggesting that addressing these serum factors could have a positive impact on managing eczema symptoms.
Our findings indicate that monitoring vitamin D levels, along with other serum indicators, might offer valuable insights for clinicians in evaluating and treating eczema in children.
Over the course of the study, we observed that as eczema severity increased, serum levels of vitamin A and 25-(OH)D3 (a form of vitamin D) tended to decrease. Conversely, levels of tissue transglutaminase (TG2), interleukin-4 (IL-4), and interleukin-13 (IL-13), which are markers of inflammation, increased. Significant correlations emerged showing that lower levels of vitamin A and 25-(OH)D3 were linked to higher SCORAD scores (a measure of eczema severity), while increases in TG2, IL-4, and IL-13 levels paralleled worsening symptoms.
Importantly, vitamin D levels had the highest accuracy for assessing eczema severity compared to the other markers studied. After treatment over three months, we noted improvements in the levels of all measured indicators, suggesting that addressing these serum factors could have a positive impact on managing eczema symptoms.
Our findings indicate that monitoring vitamin D levels, along with other serum indicators, might offer valuable insights for clinicians in evaluating and treating eczema in children.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Eczema improvement
This is the best D3 supplement I've found! It’s the only one on iHerb with such a high dose, and it has significantly improved my eczema, which is nearly gone!
8.8
Improved eczema condition
I began taking the 50,000 IU Vitamin D3 after my doctor diagnosed me with a deficiency. Since taking it once a week, I've felt more energetic and noticed my immunity improved, leading to fewer colds. Most importantly, my skin, prone to dryness and eczema, feels more hydrated and less irritated. I have experienced no negative side effects.
Read More
7.8
Very effective
These are the third bottles I’ve purchased, and they help immensely with my eczema.
8.8
Helpful for eczema
A large dose of D3 is beneficial for sensitive skin and eczema. I recommend buying it to see the results.
