We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.
Read More
8
Pernicious anemia misdiagnosed as fibromyalgia
A long-standing undiagnosed case of vitamin B12 deficiency: a case report.
We explored a notable case of a woman suffering from pernicious anemia, an autoimmune condition that can be misdiagnosed due to its vague symptoms like fatigue and cognitive issues.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
Read More
8
Nicotinamide suppresses autoimmune activation
Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling.
We explored the influence of Nicotinamide (NAM), a form of vitamin B3, on dendritic cells (DCs) in autoimmune diseases. Our research indicates that NAM can effectively reduce the overactivation of DCs, helping to ease symptoms in conditions like psoriasis.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
Read More
Most Useful Reviews
9
Stable remission achieved
20 people found this helpful
Excellent! I constantly order this drug. After my diagnosis of autoimmune disorder in 2011, I struggled with my quality of life. I realised that normalising my metabolic processes and reducing infections were key. I take B-50 in short courses and at the first sign of respiratory illnesses, which has proven effective. Unlike other brands, B-50 from Now Foods has become my main choice due to its significant benefits.
Read More
9
Significant hair regrowth
7 people found this helpful
After giving birth, my hair was falling out excessively. I read online about B Group vitamins and ordered these. I took one capsule daily and noticed a remarkable reduction in hair loss after three weeks. My hair is now growing beautifully; I’m thrilled with the results!
Read More
9
Increased productivity observed
4 people found this helpful
I'm purchasing these vitamins again from Ukraine due to low energy and stress. My doctor recommended replenishing B vitamins, as a deficiency increases cortisol, leading to anxiety. After taking them for a month, I felt re-energised and significantly calmer. I ordered again for my mother because they must be consistently renewed in the body.
We explored three cases of biotinidase deficiency (BTD) that were misdiagnosed as neuromyelitis optica spectrum disorder (NMOSD) due to similar symptoms and neuroimaging results. Initially, two patients responded to immune therapy but later relapsed, while one showed no improvement. Interestingly, after timely diagnosis and biotin supplementation, two patients exhibited remarkable recoveries in both motor function and vision. This highlights the critical need for accurate diagnosis, as early treatment of BTD can lead to significant improvements.
Read More
8
Pernicious anemia misdiagnosed as fibromyalgia
A long-standing undiagnosed case of vitamin B12 deficiency: a case report.
We explored a notable case of a woman suffering from pernicious anemia, an autoimmune condition that can be misdiagnosed due to its vague symptoms like fatigue and cognitive issues.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
Read More
8
Pernicious anemia case in Uganda
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.
Read More
8
Nicotinamide suppresses autoimmune activation
Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling.
We explored the influence of Nicotinamide (NAM), a form of vitamin B3, on dendritic cells (DCs) in autoimmune diseases. Our research indicates that NAM can effectively reduce the overactivation of DCs, helping to ease symptoms in conditions like psoriasis.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
Read More
7
Vitamin B may indicate GBS severity
Correlation of Serum Vitamin B and Muscle Enzyme (CK-NAC) Level with Severity of Guillain-Barre Syndrome and Its Prediction in Respiratory Failure.
We aimed to see if vitamin B levels could signal the severity of Guillain-Barré syndrome (GBS) and its potential for complications like respiratory failure. Our study involved 50 GBS patients, where we examined their vitamin B and creatine kinase levels alongside their motor abilities.
Interestingly, we found that 44% of patients had low vitamin B levels, which linked strongly to GBS severity. However, while vitamin B showed predictive value, the creatine kinase levels did not relate to GBS severity.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 26 Reviews
7.1
All Reviews
Positive Reviews
Negative Reviews
9
Stable remission achieved
20 people found this helpful
Excellent! I constantly order this drug. After my diagnosis of autoimmune disorder in 2011, I struggled with my quality of life. I realised that normalising my metabolic processes and reducing infections were key. I take B-50 in short courses and at the first sign of respiratory illnesses, which has proven effective. Unlike other brands, B-50 from Now Foods has become my main choice due to its significant benefits.
Read More
9
Significant hair regrowth
7 people found this helpful
After giving birth, my hair was falling out excessively. I read online about B Group vitamins and ordered these. I took one capsule daily and noticed a remarkable reduction in hair loss after three weeks. My hair is now growing beautifully; I’m thrilled with the results!
Read More
9
Increased productivity observed
4 people found this helpful
I'm purchasing these vitamins again from Ukraine due to low energy and stress. My doctor recommended replenishing B vitamins, as a deficiency increases cortisol, leading to anxiety. After taking them for a month, I felt re-energised and significantly calmer. I ordered again for my mother because they must be consistently renewed in the body.
Read More
10
Boosted energy levels
3 people found this helpful
Whenever seizures occur, B-50 resolves the issue in just two days. These supplements are far superior to others I've used, providing me with three times the energy. They effectively improve my complexion, erasing dryness and dark circles. On a nostalgic note, they reminded me of the vitamins my aunt gave me as a child. Perfectly effective!
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7.5
Calmness and pain relief
3 people found this helpful
I have been taking these vitamins for over two months, and I truly feel calmer. Remarkably, my back pain has disappeared. Previously, my doctor prescribed B vitamin injections, but I find these capsules much more convenient and effective.
An autoimmune disorder occurs when the body's immune system mistakenly attacks its own healthy cells and tissues, believing them to be foreign invaders, such as bacteria or viruses. This reaction can lead to inflammation, tissue damage, and impaired function of the affected organs. There are over 80 known autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes, each with its own specific symptoms and treatment options. The exact cause of these disorders is still unclear, but a combination of genetic, environmental, and hormonal factors is believed to play a role in their development.
Diagnosis of autoimmune disorders often involves a combination of physical examinations, assessment of symptoms, blood tests, and imaging studies to evaluate organ involvement. Treatment typically focuses on managing symptoms and controlling the immune response using medications such as corticosteroids, immunosuppressants, and biologics. In addition to medication, lifestyle modifications, such as stress management and a balanced diet, can be beneficial in managing symptoms. If you suspect you have an autoimmune condition, it's important to consult a healthcare professional for proper evaluation and tailored treatment options.
Vitamin B Complex refers to a group of water-soluble vitamins that play important roles in cell metabolism and overall health. This group typically includes eight essential vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). Each of these vitamins contributes uniquely to various bodily functions, such as energy production, red blood cell formation, and nervous system function. For instance, B12 and folate are crucial in preventing anemia, while B6 is vital for brain development and function.
Many people can obtain their daily requirements of B vitamins through a balanced diet that includes whole grains, meats, eggs, nuts, leafy greens, and dairy products. However, certain groups—like vegetarians, pregnant women, and older adults—may benefit from supplementation to meet their nutritional needs. It's important to consult with a healthcare professional before starting any supplement regimen, as excessive intake of certain B vitamins can lead to adverse effects. Overall, ensuring adequate intake of Vitamin B Complex is vital for maintaining energy levels and supporting overall health.
Based on user reviews, the timeline for noticing results from taking B-50 vitamins can vary significantly. Many users report feeling improvements within a couple of weeks; for instance, one reviewer mentioned feeling significantly calmer and more balanced just two weeks into taking the vitamins Read Review. Another user observed a remarkable reduction in hair loss after three weeks of daily consumption Read Review. Additionally, one individual noted feeling re-energized and significantly calmer after a month of consistent use Read Review.
However, not all experiences align with rapid results; one reviewer indicated that after trying B vitamins for back pain related to an autoimmune disorder, there were no positive changes, leading to the decision to stop taking the vitamins Read Review. Overall, while many users notice benefits in a few weeks, the time frame may vary depending on individual health conditions and responses to the supplement.
The relationship between certain B vitamins and autoimmune disorders is supported by several scientific studies. For instance, research has shown that vitamin B12 deficiency can be a significant factor in autoimmune conditions such as pernicious anemia. In one study, a woman experienced severe cognitive and fatigue-related symptoms due to low vitamin B12 levels. Upon treatment, she demonstrated marked neurological improvements, underscoring the necessity of recognizing deficiencies in autoimmune contexts [2]. Another case from Uganda confirmed that timely intervention with vitamin B12 could significantly improve neurological symptoms related to this autoimmune condition [3].
Furthermore, vitamin B3, particularly in its form known as Nicotinamide (NAM), has been proposed as a potential treatment avenue for managing autoimmune diseases. The research indicates that NAM may modulate dendritic cell activation, alleviating symptoms in autoimmune conditions like psoriasis [4]. This suggests that B vitamins not only aid in addressing the underlying deficiencies but may also play a role in the broader management of autoimmune disorders. Overall, these findings advocate for the integration of vitamin B supplementation into treatment strategies for these conditions.
Based on user reviews, B-50 vitamins have been associated with a variety of symptom improvements. Many users express gratitude for the vitamins' role in alleviating specific health issues. For instance, one reviewer highlighted significant benefits in managing autoimmunity and respiratory illnesses, noting that B-50 has become their preferred choice due to its effectiveness Read Review. Another user reported a remarkable reduction in hair loss after three weeks of use, emphasizing the vitamins' positive impact on their hair growth Read Review.
Additionally, several individuals have noted improved energy levels and reduced stress. One reviewer shared that after a month of taking B-50, they felt re-energized and significantly calmer, reinforcing the benefits of replenishing B vitamins to alleviate anxiety Read Review. Other users mentioned improvements in skin conditions, back pain, and even a boost in overall vitality following recovery from COVID Read Review. It’s important to remember, however, that individual results can vary, with some users not experiencing the same benefits or facing issues like discomfort or lack of noticeable effect Read Review. Nonetheless, the overall feedback underscores the potential effectiveness of B-50 vitamins in enhancing physical well-being.
Based on user reviews, many individuals have reported positive experiences when combining B-50 vitamins with other supplements to manage autoimmune disorders. For example, one reviewer noted significant improvements in postpartum depression, linked to their autoimmune condition, when using B-50 alongside other vitamins under their doctor's guidance Read Review. Another user highlighted the effectiveness of taking B-50 with magnesium, which they found enhanced the absorption of the B vitamins and contributed to their overall sense of calm and balance Read Review.
Conversely, not all experiences with combining supplements have been positive. One user reported discomfort and a lack of noticeable benefits when taking B vitamins along with another supplement, expressing frustration that while they noticed a boost in energy, it did not extend to improvements in their hair or skin condition Read Review. This suggests that while many users find B-50 beneficial in combination with other supplements, results can be highly individualized, underscoring the importance of consulting healthcare professionals when managing complex health issues like autoimmune disorders.
Users have reported varied experiences regarding the ideal dosage of Vitamin B Complex, specifically B-50, for managing autoimmune disorders. Many find success with a daily intake, stating that one to two capsules per day can significantly improve energy levels and overall well-being. For instance, one user noted that taking 1-2 tablets daily yielded quick results, particularly for conditions linked to autoimmune issues like arthritis and radiculitis Read Review. Additionally, another reviewer highlighted the importance of taking B vitamins post-meal to aid absorption, suggesting that this timing might enhance their effectiveness, especially for those with sensitive digestive systems Read Review.
However, some users expressed caution regarding the dosage, emphasizing the need for careful management to avoid potential overdoses, as excessive intake can lead to negative side effects Read Review. Despite a general trend towards positive outcomes, not all experiences were beneficial; one user reported no positive changes after a prescribed course for back pain associated with their autoimmune disorder, ultimately deciding to stop the vitamins Read Review. Overall, while daily dosages seem to work for many, it’s advisable for individuals to consult healthcare professionals to tailor their intake appropriately for their specific health needs.
7.5
Enhanced calmness experienced
7 people found this helpful
I ordered these vitamins to support my nervous system, overwhelmed by constant stress and irritability. After two weeks, I've noticed significant improvements; I feel calmer, more balanced, and cheerful. It's wise to combine them with magnesium for better absorption.
9
Significant hair regrowth
7 people found this helpful
After giving birth, my hair was falling out excessively. I read online about B Group vitamins and ordered these. I took one capsule daily and noticed a remarkable reduction in hair loss after three weeks. My hair is now growing beautifully; I’m thrilled with the results!
9
Increased productivity observed
4 people found this helpful
I'm purchasing these vitamins again from Ukraine due to low energy and stress. My doctor recommended replenishing B vitamins, as a deficiency increases cortisol, leading to anxiety. After taking them for a month, I felt re-energised and significantly calmer. I ordered again for my mother because they must be consistently renewed in the body.
2
No noticeable effect
4 people found this helpful
I did not observe any effect from the B vitamins I ordered for my husband, prescribed for back pain related to his autoimmune disorder. He felt discomfort and no positive changes, stopping the vitamins as a result.
9
Stable remission achieved
20 people found this helpful
Excellent! I constantly order this drug. After my diagnosis of autoimmune disorder in 2011, I struggled with my quality of life. I realised that normalising my metabolic processes and reducing infections were key. I take B-50 in short courses and at the first sign of respiratory illnesses, which has proven effective. Unlike other brands, B-50 from Now Foods has become my main choice due to its significant benefits.
7.5
Improved condition
2 people found this helpful
Compared to other companies' B group supplements, it is cheaper and easy to continue. Using it alongside other supplements, my postpartum depression, linked to my autoimmune disorder, has improved considerably under my doctor's guidance. I feel better and wish to continue.
6
Symptoms persisted
I felt discomfort after taking these vitamins alongside a friend who experienced similar urethral pain. Although I noticed increased energy, there were no benefits for my hair and skin. The pill size is large, but manageable.
7.5
Relieved symptoms
2 people found this helpful
Let's tackle neuralgia! This vitamin contains a complete set of B vitamins in significant dosages. Taking 1-2 tablets daily let me feel results quickly. It's essential for arthritis, arthrosis, radiculitis, spondylosis, and other autoimmune disorders.
7.5
Enhanced energy
1 people found this helpful
After entering menopause, I needed to supplement with B vitamins, which helped my autoimmune disorder. My numb hands and feet after meals are gone. B vitamins are essential for energy conversion, and taking them post-meal aids absorption. Those with sensitive digestive tracts should also take them after eating. B-complex helped my metabolism and I recommend it during the day, although some may find better sleep after evening doses.
6
Regained vitality
228 people found this helpful
This B vitamin complex has been essential in my recovery from a severe neuro-viral infection. Though it helped increase my vitamin B12 levels significantly, caution is necessary due to potential overdoses. I've learned to be careful with vitamin dosages for health reasons.
8
Pernicious anemia misdiagnosed as fibromyalgia
A long-standing undiagnosed case of vitamin B12 deficiency: a case report.
We explored a notable case of a woman suffering from pernicious anemia, an autoimmune condition that can be misdiagnosed due to its vague symptoms like fatigue and cognitive issues.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
8
Pernicious anemia case in Uganda
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.
8
Nicotinamide suppresses autoimmune activation
Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling.
We explored the influence of Nicotinamide (NAM), a form of vitamin B3, on dendritic cells (DCs) in autoimmune diseases. Our research indicates that NAM can effectively reduce the overactivation of DCs, helping to ease symptoms in conditions like psoriasis.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
References
Jatav VS, Sardana V, Bhushan B, Maheshwari D, Garg S, et al. Correlation of Serum Vitamin B and Muscle Enzyme (CK-NAC) Level with Severity of Guillain-Barre Syndrome and Its Prediction in Respiratory Failure. J Assoc Physicians India. 2025;73:48. 10.59556/japi.73.0892
Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. 10.1186/s13256-025-05149-7
Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. 10.1186/s13256-025-05095-4
Cao AP, Wang YY, Shen YY, Liu YH, Liu JY, et al. Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling. Nutrients. 2024;16. 10.3390/nu16162665
Ali F, Mukhtiar K, Raza M, Ibrahim S. Atypical presentation of biotinidase deficiency: masquerading neuromyelitis optica spectrum disorder. BMJ Case Rep. 2024;17. 10.1136/bcr-2023-258703