Last update
3/17/2026
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Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 56 Reviews
7.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Thiamin (Vitamin B-1) (from Thiamin HCl)
50 mg
4167%
Riboflavin (Vitamin B-2)
50 mg
3846%
Niacin (Vitamin B-3) (as Niacinamide)
50 mg
313%
Vitamin B-6 (from Pyridoxine HCl)
50 mg
2941%
Folate
680 mcg DFE (400 mcg folic acid)
170%
Vitamin B-12 (as Cyanocobalamin)
50 mcg
2083%
Biotin
50 mcg
167%
Pantothenic Acid (from Calcium Pantothenate)
50 mg
1000%
Choline (from Choline Bitartrate)
25 mg
5%
PABA (Para-Aminobenzoic Acid)
25 mg
†
Inositol
25 mg
†
Top Medical Research Studies
7
We examined the effects of vitamin B12 injections, combined with folic acid, on 38 patients with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome.
Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.
However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.
Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.
However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.
Read More
Most Useful Reviews
9
Significant improvement
1 people found this helpful
As a nurse, I've experienced a remarkable improvement in energy levels with this supplement. It has made a substantial difference, even during my long 12-hour shifts, helping to manage my chronic fatigue syndrome.
Read More
9
Mood enhancement
1 people found this helpful
These vitamins are a true godsend for combating fatigue, blues, and chronic fatigue syndrome! I encourage everyone to try them.
Read More
9
Less fatigue
1 people found this helpful
I really like these vitamins as they are well-tolerated and absorbed. Taking them in the morning is best as they help reduce fatigue and improve my day.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
- All Researches
7
We examined the effects of vitamin B12 injections, combined with folic acid, on 38 patients with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome.
Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.
However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.
Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.
However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 56 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant improvement
1 people found this helpful
As a nurse, I've experienced a remarkable improvement in energy levels with this supplement. It has made a substantial difference, even during my long 12-hour shifts, helping to manage my chronic fatigue syndrome.
Read More
9
Mood enhancement
1 people found this helpful
These vitamins are a true godsend for combating fatigue, blues, and chronic fatigue syndrome! I encourage everyone to try them.
Read More
9
Less fatigue
1 people found this helpful
I really like these vitamins as they are well-tolerated and absorbed. Taking them in the morning is best as they help reduce fatigue and improve my day.
Read More
9
Increased energy
1 people found this helpful
After reading Dr. Tokumi Fujikawa’s book, I bought this supplement, and now, after a year, I feel fantastic physically and mentally without concern for the size or smell.
Read More
9
Increased energy
1 people found this helpful
The benefits of B vitamins are remarkable. This formula is a true gift! By the second day, I felt revitalised rather than sluggish. While others were falling ill from fatigue, I felt energetic and motivated. I highly recommend it.
Read More
Frequently Asked Questions
7
We examined the effects of vitamin B12 injections, combined with folic acid, on 38 patients with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome.
Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.
However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.
Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.
However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.
References
- Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. 10.1371/journal.pone.0124648
Data last updated:
