Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
USERS' SCORE
Good
Based on 10 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Thiamin (Vitamin B-1) (from Thiamin HCl)
50 mg
4167%
Riboflavin (Vitamin B-2)
50 mg
3846%
Niacin (Vitamin B-3) (as Niacinamide)
50 mg
313%
Vitamin B-6 (from Pyridoxine HCl)
50 mg
2941%
Folate
680 mcg DFE (400 mcg folic acid)
170%
Vitamin B-12 (as Cyanocobalamin)
50 mcg
2083%
Biotin
50 mcg
167%
Pantothenic Acid (from Calcium Pantothenate)
50 mg
1000%
Choline (from Choline Bitartrate)
25 mg
5%
PABA (Para-Aminobenzoic Acid)
25 mg
†
Inositol
25 mg
†
Top Medical Research Studies
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
Read More
7
We investigated the connection between vitamin B6 and alcohol-associated liver disease (ALD) using a mouse model. Through a detailed analysis of the gut microbiota, we observed that disruptions significantly lowered vitamin B6 production. This reduction heightened oxidative stress and worsened liver damage. Our results indicate that maintaining vitamin B6 levels could be vital in protecting against ALD progression by influencing important metabolic processes. Despite some promising findings, the protective effects of vitamin B6 against ALD warrant further exploration before drawing definitive conclusions.
Read More
7
Vitamin B and Folate Related to Mortality
We explored how serum folate and vitamin B levels relate to all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Utilizing data from the Third National Health and Nutrition Examination Survey, we followed nearly 3,636 MASLD subjects for over 20 years.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Read More
Most Useful Reviews
9
Normal liver function
7 people found this helpful
Since my liver function exceeded the limit, I’ve taken this supplement with Milk Thistle for half a year. My liver values have normalised despite daily alcohol consumption, which was alarming but I aim to persist in taking it.
Read More
7.5
Improved liver condition
108 people found this helpful
Good day. I'm from Ukraine and bought this supplement to improve my liver condition. It helped alleviate bloating and improved my sleep. One jar was too small for my family, so I will order more. The pills taste a bit like seaweed. If my review is helpful, please give it a like. It also accelerates metabolism and stabilises the nervous system.
Read More
7.5
Alleviated bloating
33 people found this helpful
One of the first supplements I purchased for liver disease. It reduced bloating after meals and helped me sleep better. I tried one jar, but it was too small for my family, so I will order more. The pills have a seaweed-like taste, which my husband didn’t notice. If this review is helpful, please like it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
- All Researches
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
Read More
8
Antioxidants may protect liver health
We explored the impact of four potential protective agents—ATP, thiamine pyrophosphate, melatonin, and Liv-52—against liver damage caused by the antibiotic pyrazinamide in a rat model.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
Read More
7
Vitamin B and Folate Related to Mortality
We explored how serum folate and vitamin B levels relate to all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Utilizing data from the Third National Health and Nutrition Examination Survey, we followed nearly 3,636 MASLD subjects for over 20 years.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Read More
7
We investigated the connection between vitamin B6 and alcohol-associated liver disease (ALD) using a mouse model. Through a detailed analysis of the gut microbiota, we observed that disruptions significantly lowered vitamin B6 production. This reduction heightened oxidative stress and worsened liver damage. Our results indicate that maintaining vitamin B6 levels could be vital in protecting against ALD progression by influencing important metabolic processes. Despite some promising findings, the protective effects of vitamin B6 against ALD warrant further exploration before drawing definitive conclusions.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Normal liver function
7 people found this helpful
Since my liver function exceeded the limit, I’ve taken this supplement with Milk Thistle for half a year. My liver values have normalised despite daily alcohol consumption, which was alarming but I aim to persist in taking it.
Read More
7.5
Improved liver condition
108 people found this helpful
Good day. I'm from Ukraine and bought this supplement to improve my liver condition. It helped alleviate bloating and improved my sleep. One jar was too small for my family, so I will order more. The pills taste a bit like seaweed. If my review is helpful, please give it a like. It also accelerates metabolism and stabilises the nervous system.
Read More
7.5
Alleviated bloating
33 people found this helpful
One of the first supplements I purchased for liver disease. It reduced bloating after meals and helped me sleep better. I tried one jar, but it was too small for my family, so I will order more. The pills have a seaweed-like taste, which my husband didn’t notice. If this review is helpful, please like it.
Read More
7.5
Moisturised skin
8 people found this helpful
I had been taking B vitamins for a while but tried this product for liver disease. It initially raised my liver values, so I paused for 10 days, resulting in dry skin. Upon resuming, I noticed moisture and positive effects.
Read More
9
Normalised values
7 people found this helpful
I take several vitamins, including for liver disease. Despite being chronic for 20 years, my blood values returned to normal after extensive supplement use. I arranged my regimen over three years based on experiences and am considering further reviews of my progress.
Read More
Frequently Asked Questions
9
Normal liver function
7 people found this helpful
Since my liver function exceeded the limit, I’ve taken this supplement with Milk Thistle for half a year. My liver values have normalised despite daily alcohol consumption, which was alarming but I aim to persist in taking it.
7.5
Alleviated bloating
33 people found this helpful
One of the first supplements I purchased for liver disease. It reduced bloating after meals and helped me sleep better. I tried one jar, but it was too small for my family, so I will order more. The pills have a seaweed-like taste, which my husband didn’t notice. If this review is helpful, please like it.
9
Normalised values
7 people found this helpful
I take several vitamins, including for liver disease. Despite being chronic for 20 years, my blood values returned to normal after extensive supplement use. I arranged my regimen over three years based on experiences and am considering further reviews of my progress.
6
Strengthened immunity
1 people found this helpful
The B-50 vitamins enhance immune function and normalise liver function, while also improving blood sugar levels. I find they support my overall health effectively.
7.5
Improved liver condition
108 people found this helpful
Good day. I'm from Ukraine and bought this supplement to improve my liver condition. It helped alleviate bloating and improved my sleep. One jar was too small for my family, so I will order more. The pills taste a bit like seaweed. If my review is helpful, please give it a like. It also accelerates metabolism and stabilises the nervous system.
7.5
Moisturised skin
8 people found this helpful
I had been taking B vitamins for a while but tried this product for liver disease. It initially raised my liver values, so I paused for 10 days, resulting in dry skin. Upon resuming, I noticed moisture and positive effects.
7.5
Supports liver function
3 people found this helpful
This B-vitamin complex is excellent, notably for liver disease, as it includes vitamin B4, which supports liver function and recovery from toxins. I take one capsule daily for its benefits, including the reduction of fatty acids in blood.
8
Antioxidants may protect liver health
We explored the impact of four potential protective agents—ATP, thiamine pyrophosphate, melatonin, and Liv-52—against liver damage caused by the antibiotic pyrazinamide in a rat model.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
7
Vitamin B and Folate Related to Mortality
We explored how serum folate and vitamin B levels relate to all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Utilizing data from the Third National Health and Nutrition Examination Survey, we followed nearly 3,636 MASLD subjects for over 20 years.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
7
We investigated the connection between vitamin B6 and alcohol-associated liver disease (ALD) using a mouse model. Through a detailed analysis of the gut microbiota, we observed that disruptions significantly lowered vitamin B6 production. This reduction heightened oxidative stress and worsened liver damage. Our results indicate that maintaining vitamin B6 levels could be vital in protecting against ALD progression by influencing important metabolic processes. Despite some promising findings, the protective effects of vitamin B6 against ALD warrant further exploration before drawing definitive conclusions.
References
- Ciftel S, Ciftel S, Altuner D, Huseynova G, Yucel N, et al. Effects of adenosine triphosphate, thiamine pyrophosphate, melatonin, and liv-52 on subacute pyrazinamide proliferation hepatotoxicity in rats. BMC Pharmacol Toxicol. 2025;26:67. 10.1186/s40360-025-00901-7
- Xu W, Wang Y, Cui S, Zheng Q, Lin Y, et al. Methylcobalamin protects against liver failure via engaging gasdermin E. Nat Commun. 2025;16:1233. 10.1038/s41467-024-54826-6
- Zhu J, Liao X, Du L, Lv P, Deng J. Associations of serum folate and vitamin B levels with all-cause mortality among patients with metabolic dysfunction associated steatotic liver disease: a prospective cohort study. Front Endocrinol (Lausanne). 2024;15:1426103. 10.3389/fendo.2024.1426103
- Shen H, Zhou L, Yang Y, Shu H, Wu D, et al. The gut microbiota-produced vitamin B6 mitigates alcohol-associated liver disease by attenuating hepatic oxidative stress damage. Hepatol Commun. 2025;9. 10.1097/HC9.0000000000000599
