5/23/2025
Last update
5/23/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.6
USERS' SCORE
Moderately Good
Based on 30 Reviews
7.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Thiamin (Vitamin B-1) (from Thiamin HCl)
50 mg
4167%
Riboflavin (Vitamin B-2)
50 mg
3846%
Niacin (Vitamin B-3) (as Niacinamide)
50 mg
313%
Vitamin B-6 (from Pyridoxine HCl)
50 mg
2941%
Folate
680 mcg DFE (400 mcg folic acid)
170%
Vitamin B-12 (as Cyanocobalamin)
50 mcg
2083%
Biotin
50 mcg
167%
Pantothenic Acid (from Calcium Pantothenate)
50 mg
1000%
Choline (from Choline Bitartrate)
25 mg
5%
PABA (Para-Aminobenzoic Acid)
25 mg
†
Inositol
25 mg
†
Top Medical Research Studies
9
We investigated how benfotiamine might impact stomach ulcers in male rats. The study involved dividing 30 rats into groups receiving different treatments, including benfotiamine at varying doses, following the induction of ulcers using indomethacin.
Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.
However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.
Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.
However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.
Read More
8
We aimed to determine if ImproWin®, a feed additive, could help improve gastric ulcers in Standardbred and Coldblooded trotting racehorses. By conducting a randomized, double-blinded study, we assessed horses' ulcers before and after three weeks of treatment.
Our results showed a significant reduction in ulcer scores for horses treated with ImproWin®, with 78% classified as responders compared to only 54.8% in the placebo group. This indicates that ImproWin® may be beneficial for aiding the healing of gastric ulcers in affected racehorses.
Our results showed a significant reduction in ulcer scores for horses treated with ImproWin®, with 78% classified as responders compared to only 54.8% in the placebo group. This indicates that ImproWin® may be beneficial for aiding the healing of gastric ulcers in affected racehorses.
Read More
8
We examined how different doses of folic acid supplementation affect ulcer formation in rats. Male Wistar rats were treated with varying doses for 21 days while gastric ulcers were induced with indomethacin.
We found that a dose of 2 mg/kg significantly reduced gastric lesions, while a higher dose of 3 mg/kg unexpectedly worsened damage. Our results suggest that low doses of folic acid can be protective for the stomach, but high doses could pose risks.
Thus, it appears that moderation is key when considering folic acid for ulcer treatment.
We found that a dose of 2 mg/kg significantly reduced gastric lesions, while a higher dose of 3 mg/kg unexpectedly worsened damage. Our results suggest that low doses of folic acid can be protective for the stomach, but high doses could pose risks.
Thus, it appears that moderation is key when considering folic acid for ulcer treatment.
Read More
Most Useful Reviews
9
Eliminated mouth ulcers
7 people found this helpful
I can effectively absorb B vitamins now. I used to take several B vitamins daily, which was inconvenient, but switching to Vitamin B-50 has been a game-changer. I take one tablet in the morning and evening, and since then, I've stopped getting mouth ulcers. I love taking it in the morning for an energy boost, and despite its size, it’s not an issue. The excellent cost performance means I will continue buying it.
Read More
9
Cured mouth ulcers
5 people found this helpful
I suffer from mouth ulcers and previously struggled to find relief until I tried this vitamin B. Within a few days of usage, my large ulcer healed quickly. While I'm not depressed, I do feel more mentally stable since taking it.
Read More
9
Fast healing
3 people found this helpful
I've followed Dr. Fujikawa's guidance for two years. This supplement is effective, as it helps heal my mouth ulcers quickly.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.6
- All Researches
9.5
We analyzed the potential connection between folic acid supplementation and gastric ulcers using data from the UK Biobank and advanced statistical methods.
Our findings suggest that folic acid may significantly lower the risk of developing gastric ulcers.
Various robust models reinforced this result, showing consistent outcomes across different analyses.
Ultimately, this research provides genetic evidence supporting the idea that receiving folic acid therapy can be beneficial in reducing gastric ulcer risk.
Our findings suggest that folic acid may significantly lower the risk of developing gastric ulcers.
Various robust models reinforced this result, showing consistent outcomes across different analyses.
Ultimately, this research provides genetic evidence supporting the idea that receiving folic acid therapy can be beneficial in reducing gastric ulcer risk.
Read More
9
We investigated how benfotiamine might impact stomach ulcers in male rats. The study involved dividing 30 rats into groups receiving different treatments, including benfotiamine at varying doses, following the induction of ulcers using indomethacin.
Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.
However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.
Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.
However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.
Read More
9
We explored the effects of Luffa acutangula extracts on gastric ulcers in diabetic rats. By inducing non-insulin dependent diabetes mellitus (NIDDM) and then creating gastric ulcers, we evaluated the extracts' potential for healing.
The results showed that the methanolic extract significantly boosted healing, improving protective mucosal glycoproteins and antioxidant levels. This was better than the aqueous extract and standard treatments.
Overall, Luffa acutangula appears to offer promising support for treating gastric ulcers in diabetes, highlighting its dual action in managing both conditions.
The results showed that the methanolic extract significantly boosted healing, improving protective mucosal glycoproteins and antioxidant levels. This was better than the aqueous extract and standard treatments.
Overall, Luffa acutangula appears to offer promising support for treating gastric ulcers in diabetes, highlighting its dual action in managing both conditions.
Read More
9
We explored the effectiveness of mecobalamin and vitamin E in treating recurrent oral ulcers. In a study with 58 patients, those receiving both treatments showed significantly improved healing times and reduced symptoms compared to the control group. They experienced longer periods without ulcer flare-ups and better quality of life scores. Both groups felt pain relief, but the test group had more noticeable benefits. This finding suggests that mecobalamin and vitamin E can be a valuable addition to ulcer treatment, enhancing both comfort and recovery.
Read More
8
We aimed to determine if ImproWin®, a feed additive, could help improve gastric ulcers in Standardbred and Coldblooded trotting racehorses. By conducting a randomized, double-blinded study, we assessed horses' ulcers before and after three weeks of treatment.
Our results showed a significant reduction in ulcer scores for horses treated with ImproWin®, with 78% classified as responders compared to only 54.8% in the placebo group. This indicates that ImproWin® may be beneficial for aiding the healing of gastric ulcers in affected racehorses.
Our results showed a significant reduction in ulcer scores for horses treated with ImproWin®, with 78% classified as responders compared to only 54.8% in the placebo group. This indicates that ImproWin® may be beneficial for aiding the healing of gastric ulcers in affected racehorses.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 30 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Eliminated mouth ulcers
7 people found this helpful
I can effectively absorb B vitamins now. I used to take several B vitamins daily, which was inconvenient, but switching to Vitamin B-50 has been a game-changer. I take one tablet in the morning and evening, and since then, I've stopped getting mouth ulcers. I love taking it in the morning for an energy boost, and despite its size, it’s not an issue. The excellent cost performance means I will continue buying it.
Read More
9
Cured mouth ulcers
5 people found this helpful
I suffer from mouth ulcers and previously struggled to find relief until I tried this vitamin B. Within a few days of usage, my large ulcer healed quickly. While I'm not depressed, I do feel more mentally stable since taking it.
Read More
9
Fast healing
3 people found this helpful
I've followed Dr. Fujikawa's guidance for two years. This supplement is effective, as it helps heal my mouth ulcers quickly.
Read More
9
Healed mouth ulcers
1 people found this helpful
This product worked wonders for my mouth ulcers and colds. After struggling with severe cold symptoms, one tablet in the morning eased my ulcer pain within days. It's more affordable than other vitamins in Japan, and I find it effective.
Read More
9
Ulcers alleviated
1 people found this helpful
My child suffered from orthostatic hypotension and frequent mouth ulcers, but since starting this vitamin B complex, he rarely experiences ulcers. His energy levels have improved as well, and blood tests showed significant improvement after months of taking it.
Read More
Frequently Asked Questions
9
Cured mouth ulcers
5 people found this helpful
I suffer from mouth ulcers and previously struggled to find relief until I tried this vitamin B. Within a few days of usage, my large ulcer healed quickly. While I'm not depressed, I do feel more mentally stable since taking it.
7.5
Satisfied user
I previously took a different vitamin B, but it was costly, so I tried this product. I tend to get ulcers easily, and this one seems satisfactory.
9
Less colds noticed
2 people found this helpful
My children use this product, and I’ve noticed they catch fewer colds now. I've also stopped getting mouth ulcers since I began using it.
9
Eliminated mouth ulcers
7 people found this helpful
I can effectively absorb B vitamins now. I used to take several B vitamins daily, which was inconvenient, but switching to Vitamin B-50 has been a game-changer. I take one tablet in the morning and evening, and since then, I've stopped getting mouth ulcers. I love taking it in the morning for an energy boost, and despite its size, it’s not an issue. The excellent cost performance means I will continue buying it.
9
Family use
The large size is great for family use. I’ve noticed my mouth ulcers heal more quickly now.
9
Ulcers alleviated
1 people found this helpful
My child suffered from orthostatic hypotension and frequent mouth ulcers, but since starting this vitamin B complex, he rarely experiences ulcers. His energy levels have improved as well, and blood tests showed significant improvement after months of taking it.
6
Good for children
This is effective for vitamin supplementation. My children often get mouth ulcers, so I give them an extra tablet when that happens. The capsules are small and easy for them to swallow.
9
Prevents ulcers
1 people found this helpful
I take this daily due to my tendency to develop mouth ulcers. I increase the dose when I do get one, as advised by a pharmacist.
8.5
Convenient dosage
I shifted from BB to B-50, taking one capsule twice daily. It works quickly when I have a mouth ulcer, which I'm pleased about.
9.5
We analyzed the potential connection between folic acid supplementation and gastric ulcers using data from the UK Biobank and advanced statistical methods.
Our findings suggest that folic acid may significantly lower the risk of developing gastric ulcers.
Various robust models reinforced this result, showing consistent outcomes across different analyses.
Ultimately, this research provides genetic evidence supporting the idea that receiving folic acid therapy can be beneficial in reducing gastric ulcer risk.
Our findings suggest that folic acid may significantly lower the risk of developing gastric ulcers.
Various robust models reinforced this result, showing consistent outcomes across different analyses.
Ultimately, this research provides genetic evidence supporting the idea that receiving folic acid therapy can be beneficial in reducing gastric ulcer risk.
8
We examined how different doses of folic acid supplementation affect ulcer formation in rats. Male Wistar rats were treated with varying doses for 21 days while gastric ulcers were induced with indomethacin.
We found that a dose of 2 mg/kg significantly reduced gastric lesions, while a higher dose of 3 mg/kg unexpectedly worsened damage. Our results suggest that low doses of folic acid can be protective for the stomach, but high doses could pose risks.
Thus, it appears that moderation is key when considering folic acid for ulcer treatment.
We found that a dose of 2 mg/kg significantly reduced gastric lesions, while a higher dose of 3 mg/kg unexpectedly worsened damage. Our results suggest that low doses of folic acid can be protective for the stomach, but high doses could pose risks.
Thus, it appears that moderation is key when considering folic acid for ulcer treatment.
9
We investigated how benfotiamine might impact stomach ulcers in male rats. The study involved dividing 30 rats into groups receiving different treatments, including benfotiamine at varying doses, following the induction of ulcers using indomethacin.
Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.
However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.
Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.
However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.
8
We explored the effects of nicotinamide on gastric ulcers caused by indomethacin in a laboratory setting. Using a well-established model, we compared the treatment of nicotinamide with sucralfate, a known antiulcer drug.
Our findings revealed that nicotinamide significantly reduced the severity of gastric lesions. It also helped restore vital biochemical parameters affected by the ulcer-inducing drug.
The protective effect of nicotinamide appears to stem from its ability to conserve gastric mucus and nitric oxide, improve gastric microvascular permeability, and exert antioxidant actions.
Our findings revealed that nicotinamide significantly reduced the severity of gastric lesions. It also helped restore vital biochemical parameters affected by the ulcer-inducing drug.
The protective effect of nicotinamide appears to stem from its ability to conserve gastric mucus and nitric oxide, improve gastric microvascular permeability, and exert antioxidant actions.
References
- Li F, Huang F, Tang Y, Zhang F, Jiang H, et al. Causal association of folic acid supplementary therapy and gastric ulcer: a Mendelian randomisation study. Br J Nutr. 2024;132:1348. 10.1017/S0007114524002368
- Shokati Sayyad M, Khanjani MH, Amirbeik M, Seyedabadi M, Talebpour Amiri F, et al. The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study. J Mol Histol. 2024;55:863. 10.1007/s10735-024-10237-x
- Hellings IR, Larsen S. ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses. Acta Vet Scand. 2014;56:13. 10.1186/1751-0147-56-13
- Ajeigbe K, Oladejo E, Emikpe B, Asuk A, Olaleye S. The dual modulatory effect of folic acid supplementation on indomethacin-induced gastropathy in the rat. Turk J Gastroenterol. 2012;23:639.
- Pimple BP, Kadam PV, Patil MJ. Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDM rats: role of gastric mucosal glycoproteins and antioxidants. Asian Pac J Trop Med. 2012;5:610. 10.1016/S1995-7645(12)60126-6
- Abdallah DM. Nicotinamide alleviates indomethacin-induced gastric ulcers: a novel antiulcer agent. Eur J Pharmacol. 2010;627:276. 10.1016/j.ejphar.2009.10.037
- Cui J, Lin W, Ma X, Wang J. Clinical Evaluation and Therapeutic Effects of Combination Treatment with Mecobalamin + Vitamin E in Recurrent Oral Ulcer. Clin Ther. 2022;44:123. 10.1016/j.clinthera.2021.10.015
