Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
10 mcg (400 IU)
50%
The product is found useful for the following medical conditions
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.5
USERS' SCORE
Excellent
Based on 12 Reviews
9
8
Vitamin D deficiency linked to allergies
Does vitamin D deficiency predispose to allergic proctocolitis?
Most Relevant Research
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
9.5
Helpful for children
Most Useful Review
Excellent product; it did not cause allergies. I give my child 2 capsules now, although 400 IU might not suffice based on recommendations. They have started to experience less pain.
Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
USERS' SCORE
Good
Based on 20 Reviews
8.8
8
Vitamin D reduces cold severity
Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.
Most Relevant Research
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
10
No colds since
Most Useful Review
NOW Foods Vitamin D is a must-have for cold sufferers. My item arrived on time, and the seller was professional. Since I started taking these vitamin D tablets, I haven’t had a cold. I love the taste and would recommend them to family and friends suffering from colds.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.7
9
Vitamin D3 modulates autoimmune response
Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis.
Most Relevant Research
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
9.5
Improved immunity
Most Useful Review
Strengthening my immune system has been fantastic! I had a deficiency of vitamin D, but after taking it continuously, I've noticed significant improvements in my immune system, a reduction in hair loss, and my nails are in excellent condition. When I stop taking vitamin D, I feel persistently tired. Now, with levels at 65.86 ng/mol, I'm very pleased with the results and recommend it.
Cold Sores details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 4 Reviews
8.7
8
Genetic factors in cold sores
Associations between host genetic variants and Herpes Simplex Labialis in the TwinsUK cohort.
Most Relevant Research
We explored how a specific genetic variant associated with vitamin D might influence the occurrence of cold sores, also known as Herpes Simplex Labialis (HSL). Our research involved nearly 1,800 participants from the TwinsUK registry, with a focus on a group of 595 that completed both blood tests and questionnaires regarding their cold sore experiences.
From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.
However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.
Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.
From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.
However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.
Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.
9.5
Miracle vitamin
Most Useful Review
If I had known earlier how this miracle vitamin could combat colds and flu, I would have taken it sooner. Vitamin D3 is an incredible prohormone that strengthens bone structure and protects against viruses, bacteria, and fungi. I’ve recommended it to everyone.
Flu details
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.8
USERS' SCORE
Good
Based on 10 Reviews
8.7
8
Vitamin D reduces flu risk
Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
Most Relevant Research
We explored the potential benefits of vitamin D supplementation for reducing the risk of influenza infections. Through a comprehensive analysis of multiple Randomized Controlled Trials (RCTs), we aimed to clarify whether taking vitamin D can help prevent the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
9.5
Vitamin D improvement
Most Useful Review
Love it! I need sublinguals due to severe digestive issues. Most vitamins cause extreme flushing for me, but these are gentler. After three months of use, my Vitamin D level improved from a 7 to 30, crucial for my recovery, alongside a better diet.
Common Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.1
USERS' SCORE
Good
Based on 14 Reviews
8.6
8
Vitamin D3 improves cold symptoms
Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study.
Most Relevant Research
We conducted a thorough investigation into how 25-hydroxyvitamin D3, commonly referred to as vitamin D3, impacts upper respiratory tract infections (URTIs), particularly the common cold. This study was carried out as a randomized, double-blind, placebo-controlled trial, engaging 428 participants, all aged between 45 and 74, across three clinics in Japan.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
9.5
Prevented colds
Most Useful Review
If I’d known this miraculous vitamin could combat the common cold so effectively, I would have started much earlier. It’s a powerful protector against viruses and bacteria. I recommend it to everyone; it should be a staple in every household.
Osteoporosis details
SCIENTIFIC SCORE
Moderately Effective
Based on 24 Researches
8
USERS' SCORE
Good
Based on 10 Reviews
8.6
8
Vitamin D's impact on osteoporosis
The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis.
Most Relevant Research
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
9.5
Improves bone density
Most Useful Review
After being diagnosed with osteoporosis following a lumbar compression fracture, I noticed a 4% improvement in bone density after taking supplements for six months, alongside calcium. Although I initially questioned the supplement's effectiveness, the osteoporosis test results confirmed its benefits. I stopped taking the hospital-prescribed vitamin D3 after two weeks (laughs).
Pneumonia details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
Enhanced immunity support
Most Useful Review
Physicians recommend D3 for its benefits, including increased calcium absorption, immunity enhancement, and lower infection risks associated with pneumonia. This product is high quality, and I recommend it to anyone in need.
Rash details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Symptoms resolved
Most Useful Review
Effective and good low dosage. My husband was having head rashes during winter and spent all his time indoors. Once he began taking this Vitamin D, his symptoms ceased. Since Vitamin D can accumulate in the body, it’s advisable to opt for a lower dosage.
Asthma details
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin D improves asthma outcomes
Asthmatic patients with vitamin D deficiency: Can vitamin D supplementation make a difference.
Most Relevant Research
We're delving into the potential effects of vitamin D on asthma management. The focus of this study is whether vitamin D supplementation can help asthmatic patients reduce their flare-ups and enhance their lung function.
To answer this question, we analyzed several randomized controlled trials that scrutinized the impact of vitamin D on patients with asthma. The findings were promising, as we observed that vitamin D supplementation not only improved lung function, measured through the predicted FEV1 value, but also successfully elevated the levels of serum 25-hydroxyvitamin D in participants.
Overall, this study supports the idea that vitamin D may play a beneficial role in asthma care by potentially reducing the frequency of asthma attacks and improving lung health. It's an exciting area for further research, especially considering the varying results from asthma studies worldwide.
To answer this question, we analyzed several randomized controlled trials that scrutinized the impact of vitamin D on patients with asthma. The findings were promising, as we observed that vitamin D supplementation not only improved lung function, measured through the predicted FEV1 value, but also successfully elevated the levels of serum 25-hydroxyvitamin D in participants.
Overall, this study supports the idea that vitamin D may play a beneficial role in asthma care by potentially reducing the frequency of asthma attacks and improving lung health. It's an exciting area for further research, especially considering the varying results from asthma studies worldwide.
10
Resolved asthma flares
Most Useful Review
This supplement was a game changer for my daughter, who suffered from asthma flares. Her rheumatologist suggested "high dosing" as a possible solution for her fevers. I've purchased 13 bottles in two years, as my entire family uses it. I always keep two backups in case they stop making it or it goes out of stock.
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 9 Reviews
8.5
9
Vitamin D3 correction improves pain
Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty.
Most Relevant Research
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
9.5
Essential health boost
Most Useful Review
I am extremely satisfied with the Vitamin D-3 supplement for both bone health and my immune system. It has become vital in my daily routine, notably helping with my bone pain and overall vitality. I highly recommend it for anyone wanting to increase their vitamin D intake.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.1
USERS' SCORE
Good
Based on 5 Reviews
8.5
9
Vitamin D3 improves depressive symptoms
Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial.
Most Relevant Research
We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
9.5
Avoided seasonal depression
Most Useful Review
I find Cospa very effective, especially during times when sun exposure is limited. I take it daily to prevent vitamin D deficiency and have successfully avoided seasonal depression. There are claims that vitamin D may also help combat COVID-19, which motivates me to take it regularly. The small capsule size is a minor drawback, but the ingredient quality is excellent.
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.4
9.5
Eliminated bone pain
Most Useful Review
The quality and packaging are excellent. It’s beneficial for health with safe ingredients and convenient dosage. My vitamin D levels improved significantly after taking it once a day during winter and autumn. My back and leg bone pain disappeared, and my immunity improved.
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.5
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
8
Vitamin D3 offers anti-cancer benefits
Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.
Most Relevant Research
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
9.5
Essential for adults
Most Useful Review
Contrary to popular belief, vitamin D3 is crucial for adults, especially in areas with limited sunlight. It aids in the rapid absorption of magnesium and calcium, fortifies immunity, and is vital for bone health while preventing the growth of cancer cells.
Blood Clot details
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.8
USERS' SCORE
Medium or Average
Based on 3 Reviews
6.9
9
Vitamin D counteracts blood clotting
Vitamin D Inhibits IL-6 Pro-Atherothrombotic Effects in Human Endothelial Cells: A Potential Mechanism for Protection against COVID-19 Infection?
Most Relevant Research
Our research focused on understanding how Vitamin D (VitD) might influence blood clotting, especially in the context of COVID-19. We found that when human endothelial cells were exposed to IL-6—an inflammatory cytokine associated with severe COVID-19—it led to dysfunction in these cells. This dysfunction was marked by increased levels of Tissue Factor (TF) and cell adhesion molecules (CAMs), which promote blood clotting.
Remarkably, when we treated these endothelial cells with VitD, we observed a reversal of these harmful effects. VitD appeared to inhibit the expression of TF and CAMs and even modulated the levels of the ACE2 receptor, which is crucial for the entry of the virus into cells. Our findings suggest that VitD could play a protective role against the blood clotting complications associated with COVID-19 by counteracting IL-6's effects on endothelial cells.
Overall, this study paves the way for further research into VitD as a potential therapeutic option for mitigating thrombotic risks in COVID-19 patients.
Remarkably, when we treated these endothelial cells with VitD, we observed a reversal of these harmful effects. VitD appeared to inhibit the expression of TF and CAMs and even modulated the levels of the ACE2 receptor, which is crucial for the entry of the virus into cells. Our findings suggest that VitD could play a protective role against the blood clotting complications associated with COVID-19 by counteracting IL-6's effects on endothelial cells.
Overall, this study paves the way for further research into VitD as a potential therapeutic option for mitigating thrombotic risks in COVID-19 patients.
2.3
No effect observed
Most Useful Review
This vitamin D supplement did not work for my teenage son or me after several months. Despite beginning with a very low level of 20, our levels did not improve at all. I later switched to a different manufacturer, which resulted in improved vitamin D indicators.
