' 
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
10 mcg (400 IU)
50%
Top Medical Research Studies
8
Vitamin D improves asthma outcomes
Asthmatic patients with vitamin D deficiency: Can vitamin D supplementation make a difference.
Directly explores vitamin D's effects
We're delving into the potential effects of vitamin D on asthma management. The focus of this study is whether vitamin D supplementation can help asthmatic patients reduce their flare-ups and enhance their lung function.
To answer this question, we analyzed several randomized controlled trials that scrutinized the impact of vitamin D on patients with asthma. The findings were promising, as we observed that vitamin D supplementation not only improved lung function, measured through the predicted FEV1 value, but also successfully elevated the levels of serum 25-hydroxyvitamin D in participants.
Overall, this study supports the idea that vitamin D may play a beneficial role in asthma care by potentially reducing the frequency of asthma attacks and improving lung health. It's an exciting area for further research, especially considering the varying results from asthma studies worldwide.
To answer this question, we analyzed several randomized controlled trials that scrutinized the impact of vitamin D on patients with asthma. The findings were promising, as we observed that vitamin D supplementation not only improved lung function, measured through the predicted FEV1 value, but also successfully elevated the levels of serum 25-hydroxyvitamin D in participants.
Overall, this study supports the idea that vitamin D may play a beneficial role in asthma care by potentially reducing the frequency of asthma attacks and improving lung health. It's an exciting area for further research, especially considering the varying results from asthma studies worldwide.
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8
Vitamin D3 improves asthma control
Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials.
High relevance for study topic
We explored the effectiveness of vitamin D3 in reducing asthma exacerbations among children through a systematic review and meta-analysis of randomized controlled trials. In our investigation, we analyzed data from ten studies, which included a total of 1,243 children with asthma. Among these, 631 received vitamin D3 supplementation while 612 were given a placebo.
Our pooled analysis revealed promising results: vitamin D3 supplementation significantly reduced the overall number of asthma exacerbations. Specifically, we found a risk ratio of 0.62, indicating a notable decrease in attacks. Notably, a subgroup analysis showed that children receiving the standard daily dose of vitamin D experienced an even more significant improvement, with a risk ratio of 0.41.
Overall, we concluded that vitamin D3 supplementation holds the potential to lower asthma exacerbations in children. This is particularly encouraging as it also correlates with improved lung function, measured through FEV1. Hence, vitamin D3 could be a valuable addition to asthma management for young patients.
Our pooled analysis revealed promising results: vitamin D3 supplementation significantly reduced the overall number of asthma exacerbations. Specifically, we found a risk ratio of 0.62, indicating a notable decrease in attacks. Notably, a subgroup analysis showed that children receiving the standard daily dose of vitamin D experienced an even more significant improvement, with a risk ratio of 0.41.
Overall, we concluded that vitamin D3 supplementation holds the potential to lower asthma exacerbations in children. This is particularly encouraging as it also correlates with improved lung function, measured through FEV1. Hence, vitamin D3 could be a valuable addition to asthma management for young patients.
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5
Vitamin D3 may aid asthma
A 12-week double-blind randomised controlled trial investigating the effect of dietary supplementation with 125 g/d vitamin D in adults with asthma.
Direct investigation of asthma treatment
We conducted a robust study to understand how vitamin D3 supplementation affects adults with asthma. Over 12 weeks, we closely monitored 32 participants with mild to moderate asthma. They were randomly assigned to receive either a daily supplement of 125 µg of vitamin D or a placebo, which allowed us to measure the real impact of vitamin D on lung function and asthma symptoms.
Our findings showed a slight improvement in lung function among those who received vitamin D compared to those on the placebo. Specifically, there was a modest increase in the ratio of forced expiratory volume (FEV) to forced vital capacity (FVC), indicating better lung mechanics. However, we didn’t observe any significant changes in asthma control scores or the inflammatory markers we measured.
It's worth noting that we found a meaningful association between initial vitamin D levels and markers of inflammation, suggesting that those with lower vitamin D might benefit more from supplementation. Overall, while vitamin D3 might not be a miracle solution, our results indicate it could be a helpful addition to current asthma management strategies, especially for those with low vitamin D levels.
Our findings showed a slight improvement in lung function among those who received vitamin D compared to those on the placebo. Specifically, there was a modest increase in the ratio of forced expiratory volume (FEV) to forced vital capacity (FVC), indicating better lung mechanics. However, we didn’t observe any significant changes in asthma control scores or the inflammatory markers we measured.
It's worth noting that we found a meaningful association between initial vitamin D levels and markers of inflammation, suggesting that those with lower vitamin D might benefit more from supplementation. Overall, while vitamin D3 might not be a miracle solution, our results indicate it could be a helpful addition to current asthma management strategies, especially for those with low vitamin D levels.
Read More
Most Useful Reviews
10
Resolved asthma flares
This supplement was a game changer for my daughter, who suffered from asthma flares. Her rheumatologist suggested "high dosing" as a possible solution for her fevers. I've purchased 13 bottles in two years, as my entire family uses it. I always keep two backups in case they stop making it or it goes out of stock.
Read More
7.5
Decreased wheezing episodes
We used this for our children in winter, particularly one who has asthma. Along with Juice Plus, we noticed that with age, our child has decreased viral-induced wheezing. We will continue this next winter with once-a-day dosing.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.3
- All Researches
9
Vitamin D may enhance asthma treatment
Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy.
Leverages multiple treatments' effects
In this study, we explored how the combination of fluticasone propionate—a popular asthma medication—and vitamin D affects children with bronchial asthma. We involved 110 patients, dividing them into two groups: one received just the asthma medication, while the other was treated with both the medication and vitamin D. We aimed to see how these treatments influenced various aspects of asthma, including immune function and the metabolism of calcium and phosphorus.
The results were quite interesting. We observed that the group receiving both treatments experienced a quicker relief from symptoms like wheezing and shortness of breath. They showed significant improvements in lung function, including better peak flow and reduced carbon dioxide levels in their blood—an important sign of effective asthma management. Additionally, this dual treatment led to enhancements in overall quality of life.
Importantly, those on combination therapy also had notable increases in vitamin D levels, which were associated with higher levels of immunoglobulins and T lymphocyte subsets—both critical components of the immune system. Furthermore, we found that vitamin D might play a significant role in regulating immune responses and calcium-phosphate metabolism.
Overall, the study suggests that adding vitamin D to standard asthma therapies may enhance their effectiveness and benefit immune function, although how much of this effect is directly attributed to vitamin D alone remains to be seen.
The results were quite interesting. We observed that the group receiving both treatments experienced a quicker relief from symptoms like wheezing and shortness of breath. They showed significant improvements in lung function, including better peak flow and reduced carbon dioxide levels in their blood—an important sign of effective asthma management. Additionally, this dual treatment led to enhancements in overall quality of life.
Importantly, those on combination therapy also had notable increases in vitamin D levels, which were associated with higher levels of immunoglobulins and T lymphocyte subsets—both critical components of the immune system. Furthermore, we found that vitamin D might play a significant role in regulating immune responses and calcium-phosphate metabolism.
Overall, the study suggests that adding vitamin D to standard asthma therapies may enhance their effectiveness and benefit immune function, although how much of this effect is directly attributed to vitamin D alone remains to be seen.
Read More
9
Vitamin D enhances asthma treatment
Achieving clinical remission in asthma with mepolizumab: a subanalysis on vitamin D as a predictor of response.
Importance of Vitamin D in treatment
We aimed to explore how Vitamin D levels influence the effectiveness of mepolizumab, an innovative treatment for severe eosinophilic asthma. In our study, we observed 32 patients over the course of a year, tracking their asthma control through various measures such as the Asthma Control Questionnaire (ACQ) scores and the frequency of exacerbations.
After analyzing the results, we found that 12 of these patients achieved clinical remission with mepolizumab treatment. Crucially, a notable finding was that those with higher levels of Vitamin D seemed to respond better to the treatment. This suggests that maintaining adequate Vitamin D levels might enhance the overall effectiveness of mepolizumab for asthma sufferers.
Overall, our study indicates that mepolizumab is significantly beneficial for people with severe asthma, helping them achieve better control and reduce their reliance on corticosteroids. The strong relationship between Vitamin D levels and treatment success highlights an exciting area for further research, emphasizing the role this vitamin may play in asthma management.
After analyzing the results, we found that 12 of these patients achieved clinical remission with mepolizumab treatment. Crucially, a notable finding was that those with higher levels of Vitamin D seemed to respond better to the treatment. This suggests that maintaining adequate Vitamin D levels might enhance the overall effectiveness of mepolizumab for asthma sufferers.
Overall, our study indicates that mepolizumab is significantly beneficial for people with severe asthma, helping them achieve better control and reduce their reliance on corticosteroids. The strong relationship between Vitamin D levels and treatment success highlights an exciting area for further research, emphasizing the role this vitamin may play in asthma management.
Read More
9
Combined effects on asthma treatment
A systematic pharmacological strategy-based to decode the synergistic mechanism of 7,4'-dihydroxyflavone in combination with vitamin D3 against asthma.
Moderate relevance due to limitations
We explored how vitamin D3 can play a role in asthma treatment, particularly when combined with 7,4'-dihydroxyflavone (74DHF). Our study took a systems pharmacology approach, which means we looked at how these two compounds might work together at a molecular level to combat asthma.
Through our analysis, we identified 47 overlapping targets, 20 core targets, and key pathways associated with asthma relief. We observed that this combination could help reduce inflammatory responses in immune cells and counteract changes in bronchial epithelial cells that contribute to asthma severity.
Although the potential benefits of vitamin D3 combined with 74DHF are promising, we must emphasize that the specific isolated effects of vitamin D3 alone were not assessed, making it challenging to determine its individual contribution. Nonetheless, this study highlights an innovative strategy for developing combination therapies in asthma management.
Through our analysis, we identified 47 overlapping targets, 20 core targets, and key pathways associated with asthma relief. We observed that this combination could help reduce inflammatory responses in immune cells and counteract changes in bronchial epithelial cells that contribute to asthma severity.
Although the potential benefits of vitamin D3 combined with 74DHF are promising, we must emphasize that the specific isolated effects of vitamin D3 alone were not assessed, making it challenging to determine its individual contribution. Nonetheless, this study highlights an innovative strategy for developing combination therapies in asthma management.
Read More
9
Vitamin D boosts asthma control
Vitamin D Oral Replacement in Children With Obesity Related Asthma: VDORA1 Randomized Clinical Trial.
Study highlights vitamin D importance
We aimed to uncover the right dosage of vitamin D that helps children with obesity-related asthma achieve healthy vitamin D levels. This was addressed through a two-part clinical trial involving children and adolescents with asthma and obesity.
In the first part of the study, we evaluated four different oral vitamin D regimens over 16 weeks. This helped us determine a safe dose that would elevate serum vitamin D levels to at least 40 ng/mL. Remarkably, while no participants receiving standard care reached the target level, a significant 50-72.7% of those taking our tested vitamin D doses did meet the goal.
The second part compared our chosen vitamin D replacement dose—which consisted of a 50,000 IU loading dose followed by 8,000 IU daily—to standard care over another 16-week period. This time, an impressive 78.6% of the children on the replacement dose achieved the desired vitamin D levels, while none of the standard care group did.
Throughout the study, we noted that the vitamin D treatment was safe, with no serious adverse events reported. This research opens up new insights into effectively treating vitamin D deficiencies in children struggling with both asthma and obesity, emphasizing the substantial role vitamin D may play in their overall health.
In the first part of the study, we evaluated four different oral vitamin D regimens over 16 weeks. This helped us determine a safe dose that would elevate serum vitamin D levels to at least 40 ng/mL. Remarkably, while no participants receiving standard care reached the target level, a significant 50-72.7% of those taking our tested vitamin D doses did meet the goal.
The second part compared our chosen vitamin D replacement dose—which consisted of a 50,000 IU loading dose followed by 8,000 IU daily—to standard care over another 16-week period. This time, an impressive 78.6% of the children on the replacement dose achieved the desired vitamin D levels, while none of the standard care group did.
Throughout the study, we noted that the vitamin D treatment was safe, with no serious adverse events reported. This research opens up new insights into effectively treating vitamin D deficiencies in children struggling with both asthma and obesity, emphasizing the substantial role vitamin D may play in their overall health.
Read More
9
Vitamin D3 improves asthma symptoms
Vitamin D resolved human and experimental asthma via B lymphocyte-induced maturation protein 1 in T cells and innate lymphoid cells.
Direct effects on asthma management
We aimed to understand how vitamin D3 supplementation might affect asthma, particularly focusing on children and adults who struggle with this condition. By analyzing various groups and a controlled murine model, we investigated the immunomodulatory effects of vitamin D3 and discovered encouraging results.
Our findings indicated that individuals receiving vitamin D3 showed milder asthma symptoms and a decreased reliance on steroid medications. Notably, children and adults alike experienced better control over their asthma. Furthermore, we observed that vitamin D3 levels correlated with an increased expression of a protein called Blimp-1, which plays a vital role in immune response regulation.
In our animal studies, mice supplemented with vitamin D3 exhibited relief from asthma traits, including lower serum IgE levels and reduced airway mucus. Additionally, these mice showed enhanced production of the anti-inflammatory protein IL-10. The results suggest that vitamin D3 promotes a shift from pro-inflammatory states to anti-inflammatory responses, particularly through mechanisms involving Blimp-1 in lung cells.
Overall, we found that vitamin D3 not only eases asthma symptoms for humans but also improves immunity in experimental models. This positions vitamin D3 as a potential adjunctive treatment for managing asthma more effectively.
Our findings indicated that individuals receiving vitamin D3 showed milder asthma symptoms and a decreased reliance on steroid medications. Notably, children and adults alike experienced better control over their asthma. Furthermore, we observed that vitamin D3 levels correlated with an increased expression of a protein called Blimp-1, which plays a vital role in immune response regulation.
In our animal studies, mice supplemented with vitamin D3 exhibited relief from asthma traits, including lower serum IgE levels and reduced airway mucus. Additionally, these mice showed enhanced production of the anti-inflammatory protein IL-10. The results suggest that vitamin D3 promotes a shift from pro-inflammatory states to anti-inflammatory responses, particularly through mechanisms involving Blimp-1 in lung cells.
Overall, we found that vitamin D3 not only eases asthma symptoms for humans but also improves immunity in experimental models. This positions vitamin D3 as a potential adjunctive treatment for managing asthma more effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Resolved asthma flares
This supplement was a game changer for my daughter, who suffered from asthma flares. Her rheumatologist suggested "high dosing" as a possible solution for her fevers. I've purchased 13 bottles in two years, as my entire family uses it. I always keep two backups in case they stop making it or it goes out of stock.
Read More
7.5
Decreased wheezing episodes
We used this for our children in winter, particularly one who has asthma. Along with Juice Plus, we noticed that with age, our child has decreased viral-induced wheezing. We will continue this next winter with once-a-day dosing.
