Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.2
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
10 mcg (400 IU)
50%
Top Medical Research Studies
8
We're delving into the potential effects of vitamin D on asthma management. The focus of this study is whether vitamin D supplementation can help asthmatic patients reduce their flare-ups and enhance their lung function.
To answer this question, we analyzed several randomized controlled trials that scrutinized the impact of vitamin D on patients with asthma. The findings were promising, as we observed that vitamin D supplementation not only improved lung function, measured through the predicted FEV1 value, but also successfully elevated the levels of serum 25-hydroxyvitamin D in participants.
Overall, this study supports the idea that vitamin D may play a beneficial role in asthma care by potentially reducing the frequency of asthma attacks and improving lung health. It's an exciting area for further research, especially considering the varying results from asthma studies worldwide.
To answer this question, we analyzed several randomized controlled trials that scrutinized the impact of vitamin D on patients with asthma. The findings were promising, as we observed that vitamin D supplementation not only improved lung function, measured through the predicted FEV1 value, but also successfully elevated the levels of serum 25-hydroxyvitamin D in participants.
Overall, this study supports the idea that vitamin D may play a beneficial role in asthma care by potentially reducing the frequency of asthma attacks and improving lung health. It's an exciting area for further research, especially considering the varying results from asthma studies worldwide.
Read More
5
We conducted a robust study to understand how vitamin D3 supplementation affects adults with asthma. Over 12 weeks, we closely monitored 32 participants with mild to moderate asthma. They were randomly assigned to receive either a daily supplement of 125 µg of vitamin D or a placebo, which allowed us to measure the real impact of vitamin D on lung function and asthma symptoms.
Our findings showed a slight improvement in lung function among those who received vitamin D compared to those on the placebo. Specifically, there was a modest increase in the ratio of forced expiratory volume (FEV) to forced vital capacity (FVC), indicating better lung mechanics. However, we didn’t observe any significant changes in asthma control scores or the inflammatory markers we measured.
It's worth noting that we found a meaningful association between initial vitamin D levels and markers of inflammation, suggesting that those with lower vitamin D might benefit more from supplementation. Overall, while vitamin D3 might not be a miracle solution, our results indicate it could be a helpful addition to current asthma management strategies, especially for those with low vitamin D levels.
Our findings showed a slight improvement in lung function among those who received vitamin D compared to those on the placebo. Specifically, there was a modest increase in the ratio of forced expiratory volume (FEV) to forced vital capacity (FVC), indicating better lung mechanics. However, we didn’t observe any significant changes in asthma control scores or the inflammatory markers we measured.
It's worth noting that we found a meaningful association between initial vitamin D levels and markers of inflammation, suggesting that those with lower vitamin D might benefit more from supplementation. Overall, while vitamin D3 might not be a miracle solution, our results indicate it could be a helpful addition to current asthma management strategies, especially for those with low vitamin D levels.
Read More
9
Vitamin D3 improves asthma symptoms
We aimed to understand how vitamin D3 supplementation might affect asthma, particularly focusing on children and adults who struggle with this condition. By analyzing various groups and a controlled murine model, we investigated the immunomodulatory effects of vitamin D3 and discovered encouraging results.
Our findings indicated that individuals receiving vitamin D3 showed milder asthma symptoms and a decreased reliance on steroid medications. Notably, children and adults alike experienced better control over their asthma. Furthermore, we observed that vitamin D3 levels correlated with an increased expression of a protein called Blimp-1, which plays a vital role in immune response regulation.
In our animal studies, mice supplemented with vitamin D3 exhibited relief from asthma traits, including lower serum IgE levels and reduced airway mucus. Additionally, these mice showed enhanced production of the anti-inflammatory protein IL-10. The results suggest that vitamin D3 promotes a shift from pro-inflammatory states to anti-inflammatory responses, particularly through mechanisms involving Blimp-1 in lung cells.
Overall, we found that vitamin D3 not only eases asthma symptoms for humans but also improves immunity in experimental models. This positions vitamin D3 as a potential adjunctive treatment for managing asthma more effectively.
Our findings indicated that individuals receiving vitamin D3 showed milder asthma symptoms and a decreased reliance on steroid medications. Notably, children and adults alike experienced better control over their asthma. Furthermore, we observed that vitamin D3 levels correlated with an increased expression of a protein called Blimp-1, which plays a vital role in immune response regulation.
In our animal studies, mice supplemented with vitamin D3 exhibited relief from asthma traits, including lower serum IgE levels and reduced airway mucus. Additionally, these mice showed enhanced production of the anti-inflammatory protein IL-10. The results suggest that vitamin D3 promotes a shift from pro-inflammatory states to anti-inflammatory responses, particularly through mechanisms involving Blimp-1 in lung cells.
Overall, we found that vitamin D3 not only eases asthma symptoms for humans but also improves immunity in experimental models. This positions vitamin D3 as a potential adjunctive treatment for managing asthma more effectively.
Read More
Most Useful Reviews
10
Resolved asthma flares
2 people found this helpful
This supplement was a game changer for my daughter, who suffered from asthma flares. Her rheumatologist suggested "high dosing" as a possible solution for her fevers. I've purchased 13 bottles in two years, as my entire family uses it. I always keep two backups in case they stop making it or it goes out of stock.
Read More
7.5
Decreased wheezing episodes
1 people found this helpful
We used this for our children in winter, particularly one who has asthma. Along with Juice Plus, we noticed that with age, our child has decreased viral-induced wheezing. We will continue this next winter with once-a-day dosing.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.2
- All Researches
9
In this study, we explored how the combination of fluticasone propionate—a popular asthma medication—and vitamin D affects children with bronchial asthma. We involved 110 patients, dividing them into two groups: one received just the asthma medication, while the other was treated with both the medication and vitamin D. We aimed to see how these treatments influenced various aspects of asthma, including immune function and the metabolism of calcium and phosphorus.
The results were quite interesting. We observed that the group receiving both treatments experienced a quicker relief from symptoms like wheezing and shortness of breath. They showed significant improvements in lung function, including better peak flow and reduced carbon dioxide levels in their blood—an important sign of effective asthma management. Additionally, this dual treatment led to enhancements in overall quality of life.
Importantly, those on combination therapy also had notable increases in vitamin D levels, which were associated with higher levels of immunoglobulins and T lymphocyte subsets—both critical components of the immune system. Furthermore, we found that vitamin D might play a significant role in regulating immune responses and calcium-phosphate metabolism.
Overall, the study suggests that adding vitamin D to standard asthma therapies may enhance their effectiveness and benefit immune function, although how much of this effect is directly attributed to vitamin D alone remains to be seen.
The results were quite interesting. We observed that the group receiving both treatments experienced a quicker relief from symptoms like wheezing and shortness of breath. They showed significant improvements in lung function, including better peak flow and reduced carbon dioxide levels in their blood—an important sign of effective asthma management. Additionally, this dual treatment led to enhancements in overall quality of life.
Importantly, those on combination therapy also had notable increases in vitamin D levels, which were associated with higher levels of immunoglobulins and T lymphocyte subsets—both critical components of the immune system. Furthermore, we found that vitamin D might play a significant role in regulating immune responses and calcium-phosphate metabolism.
Overall, the study suggests that adding vitamin D to standard asthma therapies may enhance their effectiveness and benefit immune function, although how much of this effect is directly attributed to vitamin D alone remains to be seen.
Read More
9
We aimed to explore how Vitamin D levels influence the effectiveness of mepolizumab, an innovative treatment for severe eosinophilic asthma. In our study, we observed 32 patients over the course of a year, tracking their asthma control through various measures such as the Asthma Control Questionnaire (ACQ) scores and the frequency of exacerbations.
After analyzing the results, we found that 12 of these patients achieved clinical remission with mepolizumab treatment. Crucially, a notable finding was that those with higher levels of Vitamin D seemed to respond better to the treatment. This suggests that maintaining adequate Vitamin D levels might enhance the overall effectiveness of mepolizumab for asthma sufferers.
Overall, our study indicates that mepolizumab is significantly beneficial for people with severe asthma, helping them achieve better control and reduce their reliance on corticosteroids. The strong relationship between Vitamin D levels and treatment success highlights an exciting area for further research, emphasizing the role this vitamin may play in asthma management.
After analyzing the results, we found that 12 of these patients achieved clinical remission with mepolizumab treatment. Crucially, a notable finding was that those with higher levels of Vitamin D seemed to respond better to the treatment. This suggests that maintaining adequate Vitamin D levels might enhance the overall effectiveness of mepolizumab for asthma sufferers.
Overall, our study indicates that mepolizumab is significantly beneficial for people with severe asthma, helping them achieve better control and reduce their reliance on corticosteroids. The strong relationship between Vitamin D levels and treatment success highlights an exciting area for further research, emphasizing the role this vitamin may play in asthma management.
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9
We aimed to uncover the right dosage of vitamin D that helps children with obesity-related asthma achieve healthy vitamin D levels. This was addressed through a two-part clinical trial involving children and adolescents with asthma and obesity.
In the first part of the study, we evaluated four different oral vitamin D regimens over 16 weeks. This helped us determine a safe dose that would elevate serum vitamin D levels to at least 40 ng/mL. Remarkably, while no participants receiving standard care reached the target level, a significant 50-72.7% of those taking our tested vitamin D doses did meet the goal.
The second part compared our chosen vitamin D replacement dose—which consisted of a 50,000 IU loading dose followed by 8,000 IU daily—to standard care over another 16-week period. This time, an impressive 78.6% of the children on the replacement dose achieved the desired vitamin D levels, while none of the standard care group did.
Throughout the study, we noted that the vitamin D treatment was safe, with no serious adverse events reported. This research opens up new insights into effectively treating vitamin D deficiencies in children struggling with both asthma and obesity, emphasizing the substantial role vitamin D may play in their overall health.
In the first part of the study, we evaluated four different oral vitamin D regimens over 16 weeks. This helped us determine a safe dose that would elevate serum vitamin D levels to at least 40 ng/mL. Remarkably, while no participants receiving standard care reached the target level, a significant 50-72.7% of those taking our tested vitamin D doses did meet the goal.
The second part compared our chosen vitamin D replacement dose—which consisted of a 50,000 IU loading dose followed by 8,000 IU daily—to standard care over another 16-week period. This time, an impressive 78.6% of the children on the replacement dose achieved the desired vitamin D levels, while none of the standard care group did.
Throughout the study, we noted that the vitamin D treatment was safe, with no serious adverse events reported. This research opens up new insights into effectively treating vitamin D deficiencies in children struggling with both asthma and obesity, emphasizing the substantial role vitamin D may play in their overall health.
Read More
9
Vitamin D3 improves asthma symptoms
We aimed to understand how vitamin D3 supplementation might affect asthma, particularly focusing on children and adults who struggle with this condition. By analyzing various groups and a controlled murine model, we investigated the immunomodulatory effects of vitamin D3 and discovered encouraging results.
Our findings indicated that individuals receiving vitamin D3 showed milder asthma symptoms and a decreased reliance on steroid medications. Notably, children and adults alike experienced better control over their asthma. Furthermore, we observed that vitamin D3 levels correlated with an increased expression of a protein called Blimp-1, which plays a vital role in immune response regulation.
In our animal studies, mice supplemented with vitamin D3 exhibited relief from asthma traits, including lower serum IgE levels and reduced airway mucus. Additionally, these mice showed enhanced production of the anti-inflammatory protein IL-10. The results suggest that vitamin D3 promotes a shift from pro-inflammatory states to anti-inflammatory responses, particularly through mechanisms involving Blimp-1 in lung cells.
Overall, we found that vitamin D3 not only eases asthma symptoms for humans but also improves immunity in experimental models. This positions vitamin D3 as a potential adjunctive treatment for managing asthma more effectively.
Our findings indicated that individuals receiving vitamin D3 showed milder asthma symptoms and a decreased reliance on steroid medications. Notably, children and adults alike experienced better control over their asthma. Furthermore, we observed that vitamin D3 levels correlated with an increased expression of a protein called Blimp-1, which plays a vital role in immune response regulation.
In our animal studies, mice supplemented with vitamin D3 exhibited relief from asthma traits, including lower serum IgE levels and reduced airway mucus. Additionally, these mice showed enhanced production of the anti-inflammatory protein IL-10. The results suggest that vitamin D3 promotes a shift from pro-inflammatory states to anti-inflammatory responses, particularly through mechanisms involving Blimp-1 in lung cells.
Overall, we found that vitamin D3 not only eases asthma symptoms for humans but also improves immunity in experimental models. This positions vitamin D3 as a potential adjunctive treatment for managing asthma more effectively.
Read More
8
We investigated how vitamin D3 can impact asthma, particularly when used alongside 7,4'-dihydroxyflavone (74DHF). This study took a thorough approach, combining various methods from target identification to bioinformatics analysis and experimental validation.
Our findings highlighted that the combination of 74DHF and vitamin D3 may work together to reduce inflammation associated with asthma. Specifically, we observed that this combination inhibits certain inflammatory responses and impacts gene expressions linked to asthma pathology.
Furthermore, we identified 47 overlapping targets and analyzed multiple pathways related to asthma, reinforcing the idea that vitamin D3, along with 74DHF, could play a role in asthma management. By deciphering these interactions, this research opens the way for developing effective combination therapies in asthma treatment.
Our findings highlighted that the combination of 74DHF and vitamin D3 may work together to reduce inflammation associated with asthma. Specifically, we observed that this combination inhibits certain inflammatory responses and impacts gene expressions linked to asthma pathology.
Furthermore, we identified 47 overlapping targets and analyzed multiple pathways related to asthma, reinforcing the idea that vitamin D3, along with 74DHF, could play a role in asthma management. By deciphering these interactions, this research opens the way for developing effective combination therapies in asthma treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Resolved asthma flares
2 people found this helpful
This supplement was a game changer for my daughter, who suffered from asthma flares. Her rheumatologist suggested "high dosing" as a possible solution for her fevers. I've purchased 13 bottles in two years, as my entire family uses it. I always keep two backups in case they stop making it or it goes out of stock.
Read More
7.5
Decreased wheezing episodes
1 people found this helpful
We used this for our children in winter, particularly one who has asthma. Along with Juice Plus, we noticed that with age, our child has decreased viral-induced wheezing. We will continue this next winter with once-a-day dosing.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Chen Z, Liu X, Feng X, Lyu A, Zhou W. A systematic pharmacological strategy-based to decode the synergistic mechanism of 7,4'-dihydroxyflavone in combination with vitamin D3 against asthma. J Ethnopharmacol. 2025;344:119513. 10.1016/j.jep.2025.119513
- Shadid ILC, Brustad N, Chawes BL, Moes DJAR, Weiss ST, et al. Pharmacokinetic modeling of prenatal vitamin D exposure and the impact on offspring asthma and pulmonary function. Biomed Pharmacother. 2025;183:117859. 10.1016/j.biopha.2025.117859
- Doumat G, El Zein J, Mehta GD, Zhu Z, Espinola JA, et al. Association between vitamin D status at 3 years and eosinophilic asthma in 6-year-old children with a history of severe bronchiolitis. Thorax. 2025;80:180. 10.1136/thorax-2024-222099
- Asseri AA. Serum Vitamin D Profiles of Children with Asthma in Southwest Saudi: A Comparative Cross-Sectional Study. Int J Gen Med. 2024;17:6323. 10.2147/IJGM.S503293
- Ahoon M, Farid-Hosseini R, Tehrani H, Rafat-Panah H, Ahanchian H, et al. Evaluation the Effect of Supplements Containing Vitamin D and Trace Elements in Patients with Moderate to Severe Asthma. Rep Biochem Mol Biol. 2024;13:40. 10.61186/rbmb.13.1.40
- Wu D, Wang J, Wei Y, Zhang X, Hou Z. Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy. Physiol Res. 2024;73:841.
- Rosser FJ, Han YY, Forno E, Guilbert TW, Bacharier LB, et al. Vitamin D Supplementation, Long-Term PM Exposure, and Severe Asthma Exacerbations in Children with Low Vitamin D: A Analysis of a Double-Blind, Randomized, Placebo-controlled Trial (VDKA). Am J Respir Crit Care Med. 2025;211:266. 10.1164/rccm.202407-1353RL
- Jha RS. Achieving clinical remission in asthma with mepolizumab: a subanalysis on vitamin D as a predictor of response. J Asthma. 2024. 10.1080/02770903.2024.2419435
- Fedora K, Setyoningrum RA, Aina Q, Rosyidah LN, Ni'mah NL, et al. Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials. Ann Med. 2024;56:2400313. 10.1080/07853890.2024.2400313
- Stichova J, Slanina P, Chovancova Z, Baros J, Litzman M, et al. Low CD46 expression on activated CD4 T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donors. Front Allergy. 2024;5:1462579. 10.3389/falgy.2024.1462579
- Peng B, Xiong Y, Ouyang T, He Q, Qi S, et al. High ratio of epi-25-(OH)-vitamin D3 to 25-(OH)-vitamin D3 increases the risk of asthma attack in American asthma adults: a population study. BMC Public Health. 2024;24:2670. 10.1186/s12889-024-20185-6
- El Abd A, Dasari H, Dodin P, Trottier H, Ducharme FM. Associations between vitamin D status and biomarkers linked with inflammation in patients with asthma: a systematic review and meta-analysis of interventional and observational studies. Respir Res. 2024;25:344. 10.1186/s12931-024-02967-z
- Peng B, Chen MW, Peng CR, Liu YY, Liu D. Association between serum 25-hydroxyvitamin D and asthma: Evidence from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. J Asthma. 2025;62:303. 10.1080/02770903.2024.2400604
- Chang-Chien J, Huang JL, Tsai HJ, Wang SL, Kuo ML, et al. Vitamin D ameliorates particulate matter induced mitochondrial damages and calcium dyshomeostasis in BEAS-2B human bronchial epithelial cells. Respir Res. 2024;25:321. 10.1186/s12931-024-02951-7
- Niu H, He H, Zhao Z, Lu X, Zhao G. Asthmatic patients with vitamin D deficiency: Can vitamin D supplementation make a difference. Technol Health Care. 2024;32:3985. 10.3233/THC-231462
- Watkins S, Harrison T, Mushtaq S. A 12-week double-blind randomised controlled trial investigating the effect of dietary supplementation with 125 g/d vitamin D in adults with asthma. Br J Nutr. 2024;132:738. 10.1017/S0007114524000953
- Tabassum N, Anwar KS, Sarkar PK, Kabir ARML, Mollah MAH, et al. Vitamin D [] Insufficiency is Associated With Childhood Asthma: Recent Case-Control Findings From Bangladesh. Glob Pediatr Health. 2024;11:2333794X241240574. 10.1177/2333794X241240574
- Hernández-DÃazcouder A, Romero-Nava R, Del-RÃo-Navarro BE, Sánchez-Muñoz F, Guzmán-MartÃn CA, et al. The Roles of MicroRNAs in Asthma and Emerging Insights into the Effects of Vitamin D Supplementation. Nutrients. 2024;16. 10.3390/nu16030341
- Ramirez LG, Lee-Sarwar K, Kelly RS, Weiss ST, Litonjua AA. Association of Prenatal Maternal and Infant Vitamin D Supplementation with Offspring Asthma. Ann Am Thorac Soc. 2024;21:279. 10.1513/AnnalsATS.202306-504OC
- Kaur N, Kumar V, Singh J, Jain H, Paras P, et al. Assessment of the Relation Between Asthma Severity and Serum Vitamin D Levels: A Cross-Sectional Study. Cureus. 2023;15:e46826. 10.7759/cureus.46826
- O'Sullivan B, Ounpraseuth S, James L, Majure M, Lang J, et al. Vitamin D Oral Replacement in Children With Obesity Related Asthma: VDORA1 Randomized Clinical Trial. Clin Pharmacol Ther. 2024;115:231. 10.1002/cpt.3086
- Grund JC, Krammer S, Yang Z, Mitländer H, Rauh M, et al. Vitamin D resolved human and experimental asthma via B lymphocyte-induced maturation protein 1 in T cells and innate lymphoid cells. J Allergy Clin Immunol Glob. 2023;2:100099. 10.1016/j.jacig.2023.100099
- Kim M, Brustad N, Ali M, Gürdeniz G, Arendt M, et al. Maternal vitamin D-related metabolome and offspring risk of asthma outcomes. J Allergy Clin Immunol. 2023;152:1646. 10.1016/j.jaci.2023.06.030
- Fan Y, Chen J, Zhu X. Effect of Vitamin D on the HMGB1/RAGE Pathway and Adipokines Levels in Obese Asthmatic Mice. Iran J Allergy Asthma Immunol. 2023;22:254. 10.18502/ijaai.v22i3.13053
- Srivastava S, Tiwari V, Singh S, Karoli R, Bhattacharya P, et al. Low Serum Levels of Zinc, Selenium, and Vitamin D3 Are Biomarkers of Airway Inflammation and Poor Asthma Control: A Two-Centre Study. Cureus. 2023;15:e41082. 10.7759/cureus.41082
- Shadid IL, Brustad N, Lu M, Chawes BL, Bisgaard H, et al. The Impact of Baseline 25-Hydroxyvitamin D Level and Gestational Age on Prenatal Vitamin D Supplementation to Prevent Offspring Asthma or Recurrent Wheezing. Am J Clin Nutr. 2023;117:1342. 10.1016/j.ajcnut.2023.04.019
- Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev. 2023;2:CD011511. 10.1002/14651858.CD011511.pub3
