Our research focused on understanding how Vitamin D (VitD) might influence blood clotting, especially in the context of COVID-19. We found that when human endothelial cells were exposed to IL-6—an inflammatory cytokine associated with severe COVID-19—it led to dysfunction in these cells. This dysfunction was marked by increased levels of Tissue Factor (TF) and cell adhesion molecules (CAMs), which promote blood clotting.
Remarkably, when we treated these endothelial cells with VitD, we observed a reversal of these harmful effects. VitD appeared to inhibit the expression of TF and CAMs and even modulated the levels of the ACE2 receptor, which is crucial for the entry of the virus into cells. Our findings suggest that VitD could play a protective role against the blood clotting complications associated with COVID-19 by counteracting IL-6's effects on endothelial cells.
Overall, this study paves the way for further research into VitD as a potential therapeutic option for mitigating thrombotic risks in COVID-19 patients.
Read More
8
Vitamin D's role in blood clots
The Association between Vitamin D Levels and Thrombus Burden in Patients with ST-Elevation Myocardial Infarction.
We sought to understand how vitamin D levels might impact thrombus burden—essentially the amount of blood clotting—specifically in patients suffering from ST-elevation myocardial infarction (STEMI) who are about to undergo primary percutaneous coronary intervention (PCI), a common procedure to restore blood flow to the heart.
Our research involved 257 STEMI patients who were observed in a hospital setting over a year. We divided these patients into two groups: those with high thrombus burden and those with low thrombus burden. After looking at various factors, one clear finding emerged: patients with high thrombus burden had significantly lower vitamin D levels compared to those with low thrombus burden. In fact, the average vitamin D levels in patients with high thrombus burden were only 8.0 ng/mL compared to 17.9 ng/mL in those with low thrombus burden.
We also discovered that patients with high thrombus burden and low vitamin D levels had poorer outcomes post-PCI, including decreased blood flow and lower heart performance. Through further analysis, we found vitamin D levels were an independent predictor of thrombus burden. Those with levels above 17.6 ng/mL showed an impressive 81.8% sensitivity for predicting low thrombus burden.
Overall, our study indicates that maintaining adequate vitamin D levels could play a significant role in reducing the risks associated with blood clotting in heart attack patients undergoing critical interventions.
Read More
8
Vitamin D improves blood clot profiles
Ex vivo Vitamin D supplementation improves viscoelastic profiles in prostate cancer patients.
We set out to examine how vitamin D influences blood clot formation in prostate cancer patients. Participants in our study were divided into three groups: metastatic, non-metastatic, and a reference group. We treated their whole blood samples with a specific dose of Calcitriol, a form of vitamin D, to see how it affected clotting dynamics and the structure of blood components.
Our findings from tests like Thromboelastography revealed that while the non-metastatic group showed no major differences before and after treatment, the metastatic group exhibited a concerning hypercoagulable state. Interestingly, after vitamin D supplementation, the viscoelastic properties of the non-metastatic group improved significantly, aligning more closely with those of the healthier reference group.
Overall, our study suggests that vitamin D may create a more favorable environment for blood clotting, potentially leading to less dangerous clots in certain prostate cancer patients. This could be an important consideration for individuals at risk of thromboembolic events associated with their condition.
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Most Useful Reviews
2
No improvement noted
28 people found this helpful
I had a vitamin D deficiency and tried these vitamins for three months, taking 800 units daily. Initially, my vitamin D level increased slightly from 22.7 ng/ml to 24.7 ng/ml. After finishing the jar, my level remained the same. Ultimately, these vitamins didn't help. The solarium, however, effectively raised my vitamin D level to 34.2 ng/ml after 6-7 sessions, demonstrating better results than this supplement.
Read More
1
Negative experience noted
1 people found this helpful
I had a negative experience taking this supplement. I have a history of heart palpitations, and it seemed to exacerbate them, causing a spike in my blood pressure. I was only taking two capsules a day, which is slightly above the recommended daily allowance.
Read More
2
No effect observed
This vitamin D supplement did not work for my teenage son or me after several months. Despite beginning with a very low level of 20, our levels did not improve at all. I later switched to a different manufacturer, which resulted in improved vitamin D indicators.
Our research focused on understanding how Vitamin D (VitD) might influence blood clotting, especially in the context of COVID-19. We found that when human endothelial cells were exposed to IL-6—an inflammatory cytokine associated with severe COVID-19—it led to dysfunction in these cells. This dysfunction was marked by increased levels of Tissue Factor (TF) and cell adhesion molecules (CAMs), which promote blood clotting.
Remarkably, when we treated these endothelial cells with VitD, we observed a reversal of these harmful effects. VitD appeared to inhibit the expression of TF and CAMs and even modulated the levels of the ACE2 receptor, which is crucial for the entry of the virus into cells. Our findings suggest that VitD could play a protective role against the blood clotting complications associated with COVID-19 by counteracting IL-6's effects on endothelial cells.
Overall, this study paves the way for further research into VitD as a potential therapeutic option for mitigating thrombotic risks in COVID-19 patients.
Read More
9
Vitamin D3 impacts blood clotting
1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.
We explored the effects of vitamin D3 on blood clot formation in mice lacking the klotho protein, which plays a role in regulating vitamin D3 levels. In our analysis, we focused on how klotho deficiency impacts platelet function and calcium signaling, pivotal mechanisms involved in clotting.
Our findings revealed that klotho-deficient platelets exhibited significantly reduced responses to activation, indicating that they might not form clots effectively. Specifically, we observed that calcium signaling pathways, essential for platelet activation and aggregation, were notably inhibited in these mice. The investigation utilized multiple methods, including measuring calcium levels and evaluating platelet function through various biochemical and cellular techniques.
Interestingly, when klotho-deficient mice were given a low-vitamin D diet, we discovered that their platelet function improved, suggesting a direct link between vitamin D3 levels and platelet activity. The reduced activity was associated with decreased expression of critical signaling proteins involved in calcium entry, which vitamin D3 helps regulate. Overall, our study presents evidence that vitamin D3 deficiency due to klotho absence may hinder proper blood clotting mechanisms.
Read More
9
Vitamin D3 reduces blood clot risk
Renin angiotensin system blockade and activated vitamin D as a means of preventing deep vein thrombosis in renal transplant recipients.
We evaluated the potential of vitamin D3, specifically calcitriol, in combination with other medications to prevent deep vein thrombosis (VTE) in renal transplant recipients (RTR). Focusing on how these treatments might influence the occurrence of blood clots, we followed a group of 769 RTRs over several months post-transplant.
Our findings revealed that 96 of these recipients experienced a first episode of VTE. We noticed a significant difference in rates of blood clots among those who received calcitriol alongside angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs). In fact, recipients on the combination therapy had a markedly lower rate of VTE, showing a promising 60% reduction in risk.
However, it is important to note that the isolated effect of vitamin D3 without other treatments wasn't fully determined in this study. While calcitriol showed favorable outcomes when used with blood pressure medications, further research could help clarify its individual impact on clot prevention. Overall, this research highlights the importance of collaborative strategies in managing thrombotic complications for transplant patients.
Read More
8
Vitamin D linked to clot risk
Relationship of Serum 25-Hydroxyvitamin D Concentrations, Diabetes, Vitamin D Receptor Gene Polymorphisms and Incident Venous Thromboembolism.
We set out to understand how levels of vitamin D, specifically serum 25-hydroxyvitamin D (25OHD), influence the risk of developing venous thromboembolism (VTE), which includes serious conditions like deep vein thrombosis and pulmonary embolism. To do this, we examined a large cohort of nearly 378,000 participants, all free from VTE at the start of the study.
Our analysis focused on the relationship between vitamin D levels and VTE risk, particularly in individuals with diabetes compared to those without. Over a median follow-up period of 12.5 years, we recorded just over 10,600 new cases of VTE.
The findings were quite revealing: higher serum 25OHD concentrations were associated with a lower risk of VTE. This inverse relationship was especially pronounced in participants with diabetes. Interestingly, while we assessed various genetic factors that could influence VTE risk, they did not significantly change how vitamin D affected the likelihood of developing a blood clot.
However, we did find that specific genetic variations in the vitamin D receptor appeared to enhance the protective effects of vitamin D against VTE. Overall, we are encouraged by our findings, which suggest that maintaining sufficient levels of vitamin D may help reduce the risk of blood clots, particularly in those already managing diabetes.
Read More
8
Vitamin D mitigates platelet aggregation
1,25-Dihydroxyvitamin D3 attenuates platelet aggregation potentiated by SARS-CoV-2 spike protein via inhibiting integrin αIIbβ3 outside-in signaling.
We explored how 1,25-Dihydroxyvitamin D3, a form of vitamin D, can influence platelet aggregation, particularly in the context of COVID-19. Platelet hyperreactivity is a condition where platelets are overly reactive, contributing to blood clotting issues often seen in COVID-19 patients. Our investigation focused on how vitamin D might help mitigate these issues by examining its direct effects in the laboratory.
We found that vitamin D significantly reduced platelet aggregation, especially when this aggregation was heightened by the SARS-CoV-2 spike protein. This effect appears to be linked to vitamin D's ability to inhibit certain signaling pathways involved in platelet activation. Notably, the treatment reduced the activation of integrin αIIbβ3, which plays a key role in platelet spreading and clumping.
By utilizing a particular Src family kinase inhibitor, we confirmed that there are overlapping pathways being influenced, as both vitamin D and the inhibitor showed similar effects in lowering platelet responses. Our findings suggest that vitamin D could serve as a beneficial treatment to help manage clotting in COVID-19, though further exploration is necessary.
I had a vitamin D deficiency and tried these vitamins for three months, taking 800 units daily. Initially, my vitamin D level increased slightly from 22.7 ng/ml to 24.7 ng/ml. After finishing the jar, my level remained the same. Ultimately, these vitamins didn't help. The solarium, however, effectively raised my vitamin D level to 34.2 ng/ml after 6-7 sessions, demonstrating better results than this supplement.
Read More
1
Negative experience noted
1 people found this helpful
I had a negative experience taking this supplement. I have a history of heart palpitations, and it seemed to exacerbate them, causing a spike in my blood pressure. I was only taking two capsules a day, which is slightly above the recommended daily allowance.
Read More
2
No effect observed
This vitamin D supplement did not work for my teenage son or me after several months. Despite beginning with a very low level of 20, our levels did not improve at all. I later switched to a different manufacturer, which resulted in improved vitamin D indicators.
Read More
Frequently Asked Questions
A blood clot is a mass of blood that changes from a liquid to a gel, effectively forming a plug that can stop bleeding. This natural process, known as coagulation, is critical for preventing excessive blood loss when you sustain an injury. Blood clots can occur in various areas of the body, typically at the site of a wound, but they can also form within blood vessels without an obvious injury, which may lead to serious health complications.
While blood clots are essential for healing, they can pose significant health risks if they form inappropriately. For example, a deep vein thrombosis (DVT) occurs when a clot forms in a deep vein, usually in the legs, and can travel to the lungs, causing a life-threatening condition called a pulmonary embolism. Risk factors for blood clots include prolonged immobility, certain medical conditions, and the use of specific medications, among others. It’s important to recognize the symptoms of abnormal clotting, such as swelling, pain, and redness in the affected area, and seek medical attention if they occur.
Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.
In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.
While research is ongoing, there is some evidence to suggest that Vitamin D may play a role in cardiovascular health, potentially influencing factors related to blood clotting. Vitamin D is known to have anti-inflammatory properties and can contribute to overall vascular health, but the relationship between Vitamin D levels and the prevention or treatment of blood clots is not yet fully understood. Some studies have indicated that sufficient levels of Vitamin D may help maintain a healthy endothelial function, which is critical for preventing clot formation; however, these findings are not definitive.
It's important to note that relying solely on Vitamin D for managing blood clot risk is not advisable. If you're concerned about blood clotting issues, it's crucial to consult with a healthcare professional for a comprehensive evaluation and personalized recommendations. They can help you understand the best approaches for managing cardiovascular health, which may include lifestyle changes, medications, or other interventions alongside any supplementation.
Vitamin D supplementation can be beneficial for a variety of health issues, including blood clot prevention and management. However, the timeframe for seeing results may vary significantly among individuals. Generally, you might begin to notice improvements within a few weeks to several months, depending on your specific health condition, the dosage of Vitamin D you are taking, and your body's response to the supplementation. For optimal results, it's essential to monitor your vitamin D levels through regular blood tests, as this will help healthcare providers assess whether your supplementation is effective or needs adjustment.
It's also crucial to emphasize that while Vitamin D can play a supportive role in overall health, it shouldn't replace prescribed blood clot treatment or therapies. Always consult your healthcare provider regarding the use of vitamin D and how it fits into your individual health plan, especially if you're dealing with clotting issues. They can provide guidance on expected timelines for improvements based on your unique circumstances, which often includes monitoring your vitamin D levels and adjusting your dosage accordingly.
Recent research has shown that vitamin D may have a protective role against blood clots, particularly in vulnerable populations. A study involving nearly 378,000 participants indicated that higher serum levels of vitamin D were consistently associated with a lower risk of developing venous thromboembolism (VTE), especially in individuals with diabetes [1]. Another study involving heart attack patients revealed that those with high thrombus burden had significantly lower vitamin D levels compared to those with low thrombus burden, establishing a clear link between low vitamin D levels and increased blood clot formation [5].
Additionally, research has highlighted vitamin D’s potential impact in various contexts, including COVID-19 patients, where maintaining adequate vitamin D levels may mitigate clotting risks associated with the virus [2]. However, findings are not uniformly conclusive across all studies. In one clinical trial focused on individuals with VTE, vitamin D supplementation did not significantly affect key blood clotting markers or lower thrombotic events, suggesting that while vitamin D may influence clotting factors, its role isn't fully understood [10]. Thus, while vitamin D appears to be associated with reduced thrombotic risks in certain populations, further research is needed to clarify its effectiveness as a treatment option for blood clot prevention.
Based on user reviews, experiences with this vitamin D supplement appear to vary significantly. Some users, like the reviewer with ID '846fcee5-9a7d-408d-87d9-23158bb56fa8', reported a slight increase in their vitamin D levels over a few months, moving from 22.7 ng/ml to 24.7 ng/ml. However, this marginal improvement did not persist after finishing the jar, prompting the user to seek alternative solutions that proved more effective. Similarly, another user expressed disappointment, noting that both they and their teenage son saw no improvement in their vitamin D levels despite months of supplementation with starting levels as low as 20 ng/ml Read Review.
On the other hand, the reviews also highlight potential negative effects. One user mentioned experiencing heightened heart palpitations and increased blood pressure after taking the supplement, which suggests that while some might consider the benefits minimal, others could face undesirable symptoms that overshadow any purported positive outcomes Read Review. This variability in results underlines the importance of individual responses to dietary supplements, and underscores that what works for one person may not hold true for another.
Based on user reviews, there seems to be no consensus on the right dose of Vitamin D specifically for treating blood clots. One user reported taking 800 units daily for three months with minimal improvement in their vitamin D levels, indicating that this dosage may not be effective for everyone. They highlighted that alternative methods, like solarium sessions, proved more beneficial in raising their vitamin D levels significantly from 22.7 ng/ml to 34.2 ng/ml (Read Review). Another user experienced negative side effects, including exacerbated heart palpitations and increased blood pressure, while taking slightly above the recommended daily allowance of two capsules a day (Read Review).
Overall, users have reported varying results with Vitamin D supplementation, and many did not see significant improvements, even after extended periods of use. One user mentioned their level remained stagnant despite starting with a low baseline, prompting them to switch products to find better results (Read Review). This highlights a potential need for customized dosages or alternative approaches to effectively manage vitamin D levels and address conditions like blood clots.
2
No effect observed
This vitamin D supplement did not work for my teenage son or me after several months. Despite beginning with a very low level of 20, our levels did not improve at all. I later switched to a different manufacturer, which resulted in improved vitamin D indicators.
1
Negative experience noted
1 people found this helpful
I had a negative experience taking this supplement. I have a history of heart palpitations, and it seemed to exacerbate them, causing a spike in my blood pressure. I was only taking two capsules a day, which is slightly above the recommended daily allowance.
2
No improvement noted
28 people found this helpful
I had a vitamin D deficiency and tried these vitamins for three months, taking 800 units daily. Initially, my vitamin D level increased slightly from 22.7 ng/ml to 24.7 ng/ml. After finishing the jar, my level remained the same. Ultimately, these vitamins didn't help. The solarium, however, effectively raised my vitamin D level to 34.2 ng/ml after 6-7 sessions, demonstrating better results than this supplement.
8
Vitamin D linked to clot risk
Relationship of Serum 25-Hydroxyvitamin D Concentrations, Diabetes, Vitamin D Receptor Gene Polymorphisms and Incident Venous Thromboembolism.
We set out to understand how levels of vitamin D, specifically serum 25-hydroxyvitamin D (25OHD), influence the risk of developing venous thromboembolism (VTE), which includes serious conditions like deep vein thrombosis and pulmonary embolism. To do this, we examined a large cohort of nearly 378,000 participants, all free from VTE at the start of the study.
Our analysis focused on the relationship between vitamin D levels and VTE risk, particularly in individuals with diabetes compared to those without. Over a median follow-up period of 12.5 years, we recorded just over 10,600 new cases of VTE.
The findings were quite revealing: higher serum 25OHD concentrations were associated with a lower risk of VTE. This inverse relationship was especially pronounced in participants with diabetes. Interestingly, while we assessed various genetic factors that could influence VTE risk, they did not significantly change how vitamin D affected the likelihood of developing a blood clot.
However, we did find that specific genetic variations in the vitamin D receptor appeared to enhance the protective effects of vitamin D against VTE. Overall, we are encouraged by our findings, which suggest that maintaining sufficient levels of vitamin D may help reduce the risk of blood clots, particularly in those already managing diabetes.
8
Vitamin D's role in blood clots
The Association between Vitamin D Levels and Thrombus Burden in Patients with ST-Elevation Myocardial Infarction.
We sought to understand how vitamin D levels might impact thrombus burden—essentially the amount of blood clotting—specifically in patients suffering from ST-elevation myocardial infarction (STEMI) who are about to undergo primary percutaneous coronary intervention (PCI), a common procedure to restore blood flow to the heart.
Our research involved 257 STEMI patients who were observed in a hospital setting over a year. We divided these patients into two groups: those with high thrombus burden and those with low thrombus burden. After looking at various factors, one clear finding emerged: patients with high thrombus burden had significantly lower vitamin D levels compared to those with low thrombus burden. In fact, the average vitamin D levels in patients with high thrombus burden were only 8.0 ng/mL compared to 17.9 ng/mL in those with low thrombus burden.
We also discovered that patients with high thrombus burden and low vitamin D levels had poorer outcomes post-PCI, including decreased blood flow and lower heart performance. Through further analysis, we found vitamin D levels were an independent predictor of thrombus burden. Those with levels above 17.6 ng/mL showed an impressive 81.8% sensitivity for predicting low thrombus burden.
Overall, our study indicates that maintaining adequate vitamin D levels could play a significant role in reducing the risks associated with blood clotting in heart attack patients undergoing critical interventions.
7
Vitamin D's Role in Blood Clots
Adequate serum 25-hydroxy-vitamin D levels are correlated with low anti-PF4 levels in mild COVID-19 Patients: An observational study.
We aimed to explore the relationship between vitamin D levels and anti-PF4 antibodies in individuals with mild COVID-19. Conducting our study at two hospitals in Jakarta with 160 patients, we discovered a significant negative correlation. Essentially, as serum levels of vitamin D—specifically measured as 25-hydroxy-cholecalciferol—decreased, we observed that anti-PF4 antibody levels increased among these patients.
Interestingly, our findings showed that the average vitamin D level was notably low at 15.1 ng/mL. Considering the recommended minimum levels above 30 ng/mL, it seems that maintaining adequate vitamin D levels could be beneficial. This could potentially help in managing inflammatory responses and thrombosis, which are prevalent in COVID-19 cases.
Furthermore, we noted that levels of P-selectin, a marker related to platelet activation, were significantly higher in moderate COVID-19 patients compared to those severely affected. These insights suggest that monitoring and optimizing vitamin D levels may play a crucial role in mitigating clotting risks among COVID-19 patients, particularly those with milder symptoms.
2
Vitamin D treatment shows no benefit
The Effect of Treatment of Vitamin D Deficiency on the Level of P-Selectin and hs-CRP in Patients With Thromboembolism: A Pilot Randomized Clinical Trial.
In our exploration of how vitamin D might affect blood clotting, we conducted a pilot randomized clinical trial involving 40 patients diagnosed with either deep vein thrombosis or pulmonary embolism. These individuals were vitamin D deficient, which is already known to contribute to the development of blood clots.
We divided the patients into two groups: one received a high dose of vitamin D—50,000 IU weekly for eight weeks followed by less frequent doses—while the control group did not receive any vitamin D. After one and three months, we measured levels of two key biomarkers related to blood clotting: P-selectin and hs-CRP.
We discovered that there was no significant decrease in either biomarker in both groups over the study period. This suggests that treating vitamin D deficiency doesn’t meaningfully impact these specific markers of thrombosis in patients with clotting issues.
However, we did find something interesting. Those who received vitamin D treatment appeared to manage their anticoagulant therapy with warfarin more effectively, using lower doses of the medication. While our initial hypothesis about vitamin D’s direct effect on blood clot markers didn’t hold, this potential interaction with warfarin is intriguing and warrants further investigation in larger studies to better understand the relationship between vitamin D and blood clotting.
References
Xiang H, Zhou C, Gan X, Huang Y, He P, et al. Relationship of Serum 25-Hydroxyvitamin D Concentrations, Diabetes, Vitamin D Receptor Gene Polymorphisms and Incident Venous Thromboembolism. Diabetes Metab Res Rev. 2025;41:e70014. doi:10.1002/dmrr.70014
Rachman A, Iriani A, Irawan A, Juanputra S, Betsy R. Adequate serum 25-hydroxy-vitamin D levels are correlated with low anti-PF4 levels in mild COVID-19 Patients: An observational study. Medicine (Baltimore). 2024;103:e39252. doi:10.1097/MD.0000000000039252
Wang R, Tian Z, Wang C, Zhang B, Zhu M, et al. 1,25-Dihydroxyvitamin D3 attenuates platelet aggregation potentiated by SARS-CoV-2 spike protein via inhibiting integrin αIIbβ3 outside-in signaling. Cell Biochem Funct. 2024;42:e4039. doi:10.1002/cbf.4039
Andersen MK, Rüdiger IH, Vestergaard AL, Palarasah Y, Bor P, et al. Vitamin D Deficiency is Associated With Increased Plasminogen Activator Inhibitor 1/Plasminogen Activator Inhibitor 2 Ratio in Pregnancy. Clin Appl Thromb Hemost. 2023;29:10760296231201855. doi:10.1177/10760296231201855
Şaylık F, Selçuk M, Akbulut T, Çınar T. The Association between Vitamin D Levels and Thrombus Burden in Patients with ST-Elevation Myocardial Infarction. J Tehran Heart Cent. 2022;17:48. doi:10.18502/jthc.v17i2.9835
Uguz B, Oztas S, Zengin I, Topal D, Tiryakioglu SK, et al. Relationship between vitamin D deficiency and thrombus load in patients with ST-elevation myocardial infarction. Eur Rev Med Pharmacol Sci. 2022;26:7015. doi:10.26355/eurrev_202210_29885
Hajimoradi B, Hosseini B, Alirezaei T, Pourmotahari F. 25-Hydroxy vitamin D level is associated with mean platelet volume in patients with acute coronary syndrome. Cardiovasc Hematol Disord Drug Targets. 2022. doi:10.2174/1871529X22666220418111905
Hoek M, Schultz M, Alummoottil S, Aneck-Hahn N, Mathabe K, et al. Ex vivo Vitamin D supplementation improves viscoelastic profiles in prostate cancer patients. Clin Hemorheol Microcirc. 2022;81:221. doi:10.3233/CH-211353
Cimmino G, Conte S, Morello M, Pellegrino G, Marra L, et al. Vitamin D Inhibits IL-6 Pro-Atherothrombotic Effects in Human Endothelial Cells: A Potential Mechanism for Protection against COVID-19 Infection?. J Cardiovasc Dev Dis. 2022;9. doi:10.3390/jcdd9010027
Hejazi ME, Modarresi-Ghazani F, Hamishehkar H, Mesgari-Abbasi M, Dousti S, et al. The Effect of Treatment of Vitamin D Deficiency on the Level of P-Selectin and hs-CRP in Patients With Thromboembolism: A Pilot Randomized Clinical Trial. J Clin Pharmacol. 2017;57:40. doi:10.1002/jcph.774
Blondon M, Rodabough RJ, Budrys N, Johnson KC, Berger JS, et al. The effect of calcium plus vitamin D supplementation on the risk of venous thromboembolism. From the Women's Health Initiative Randomized Controlled Trial. Thromb Haemost. 2015;113:999. doi:10.1160/TH14-05-0478
Gholami K, Talasaz AH, Entezari-Maleki T, Salarifar M, Hadjibabaie M, et al. The Effect of High-Dose Vitamin D3 on Soluble P-Selectin and hs-CRP Level in Patients With Venous Thromboembolism: A Randomized Clinical Trial. Clin Appl Thromb Hemost. 2016;22:483. doi:10.1177/1076029614568715
Borst O, Münzer P, Schmid E, Schmidt EM, Russo A, et al. 1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice. FASEB J. 2014;28:2108. doi:10.1096/fj.13-239277
Moscarelli L, Zanazzi M, Bertoni E, Caroti L, Rosso G, et al. Renin angiotensin system blockade and activated vitamin D as a means of preventing deep vein thrombosis in renal transplant recipients. Clin Nephrol. 2011;75:440.
Jorde R, Sneve M, Torjesen P, Figenschau Y, Hansen JB. Parameters of the thrombogram are associated with serum 25-hydroxyvitamin D levels at baseline, but not affected during supplementation with vitamin D. Thromb Res. 2010;125:e210. doi:10.1016/j.thromres.2009.12.011
Wu-Wong JR. Are vitamin D receptor activators useful for the treatment of thrombosis?. Curr Opin Investig Drugs. 2009;10:919.