Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
USERS' SCORE
Good
Based on 11 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
7,500 mcg
833%
Top Medical Research Studies
9
Our exploration into the effects of vitamin A, particularly its active form known as retinoic acid, revealed some interesting insights regarding allergies. Vitamin A plays a key role in our immune system by helping to regulate immune responses, which is crucial for managing allergic reactions.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
Read More
9
We investigated the effects of retinoic acid (RA), a form of vitamin A, on allergies, particularly focusing on the mould allergen Alt a 1. By examining how RA interacts with this allergen, we aimed to understand if it could help alleviate allergic reactions.
Our study involved assessing the RA and Alt a 1 complex in various settings, including lab tests with immune cells from individuals allergic to Alternaria, and experiments using sensitized mice. We found that when Alt a 1 was bound to RA, it significantly decreased certain immune responses associated with allergies, particularly the release of a key marker called IL-13 from immune cells.
Interestingly, this RA complex reduced the allergen's ability to bind to IgE, the antibody responsible for allergic reactions, suggesting that RA may mask allergic triggers. In our mouse experiments, those treated with the RA-bound allergen had fewer severe allergic reactions compared to those treated with the regular allergen.
Overall, our findings point towards the potential of using RA in therapies aimed at managing Alternaria allergies, suggesting a new, promising strategy for enhancing allergic immunotherapy.
Our study involved assessing the RA and Alt a 1 complex in various settings, including lab tests with immune cells from individuals allergic to Alternaria, and experiments using sensitized mice. We found that when Alt a 1 was bound to RA, it significantly decreased certain immune responses associated with allergies, particularly the release of a key marker called IL-13 from immune cells.
Interestingly, this RA complex reduced the allergen's ability to bind to IgE, the antibody responsible for allergic reactions, suggesting that RA may mask allergic triggers. In our mouse experiments, those treated with the RA-bound allergen had fewer severe allergic reactions compared to those treated with the regular allergen.
Overall, our findings point towards the potential of using RA in therapies aimed at managing Alternaria allergies, suggesting a new, promising strategy for enhancing allergic immunotherapy.
Read More
9
We explored the impact of 9-cis-retinoic acid (9cisRA) on dendritic cells and their role in handling delayed-type allergies, particularly in hand eczema. Through our investigation, we found that 9cisRA creates a unique type of dendritic cell that plays a crucial part in reducing allergic responses.
These modified cells were shown to promote the formation of regulatory T cells, which help calm inflammation. However, while 9cisRA aids in adjusting immune responses, the study reveals these effects may not be strong enough to significantly improve allergic conditions on their own.
These modified cells were shown to promote the formation of regulatory T cells, which help calm inflammation. However, while 9cisRA aids in adjusting immune responses, the study reveals these effects may not be strong enough to significantly improve allergic conditions on their own.
Read More
Most Useful Reviews
9
Skin improvement
59 people found this helpful
25,000 IU is a high dose but suitable for my allergies and atrophoderma. Initially, I had skin breakouts, but after a day, my skin improved. Within two weeks, facial inflammation cleared up. The overall condition of my skin has significantly improved, a result I previously only achieved with injections.
Read More
9
Cold allergy cured
3 people found this helpful
After taking two doses of vitamin A, my years-long cold allergy vanished within a week. It seems to effectively target mucous membranes, providing me with significant relief.
Read More
0
Caution advised
3 people found this helpful
Experiencing severe urticaria and asthma after starting vitamin A was alarming. It worsened my eczema and asthma, leading me to stop usage out of concern. I urge allergy sufferers to be cautious with doses.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
- All Researches
9.5
Effective immunotherapy for food allergies
We assessed whether dendritic cell immunotherapy could potentially reverse food allergy sensitivities in mouse models. By using mature retinoic acid-stimulated dendritic cells, we aimed to see if they could induce regulatory T cells that help manage allergic responses.
The results were promising, showing an impressive reduction in anaphylactic reactions to allergens by up to 90%, alongside other beneficial effects. This suggests that such treatments could be valuable in clinical settings for promoting tolerance in food allergies, particularly through the creation of Foxp3 regulatory T cells.
The results were promising, showing an impressive reduction in anaphylactic reactions to allergens by up to 90%, alongside other beneficial effects. This suggests that such treatments could be valuable in clinical settings for promoting tolerance in food allergies, particularly through the creation of Foxp3 regulatory T cells.
Read More
9
Our exploration into the effects of vitamin A, particularly its active form known as retinoic acid, revealed some interesting insights regarding allergies. Vitamin A plays a key role in our immune system by helping to regulate immune responses, which is crucial for managing allergic reactions.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
Read More
9
We investigated the effects of retinoic acid (RA), a form of vitamin A, on allergies, particularly focusing on the mould allergen Alt a 1. By examining how RA interacts with this allergen, we aimed to understand if it could help alleviate allergic reactions.
Our study involved assessing the RA and Alt a 1 complex in various settings, including lab tests with immune cells from individuals allergic to Alternaria, and experiments using sensitized mice. We found that when Alt a 1 was bound to RA, it significantly decreased certain immune responses associated with allergies, particularly the release of a key marker called IL-13 from immune cells.
Interestingly, this RA complex reduced the allergen's ability to bind to IgE, the antibody responsible for allergic reactions, suggesting that RA may mask allergic triggers. In our mouse experiments, those treated with the RA-bound allergen had fewer severe allergic reactions compared to those treated with the regular allergen.
Overall, our findings point towards the potential of using RA in therapies aimed at managing Alternaria allergies, suggesting a new, promising strategy for enhancing allergic immunotherapy.
Our study involved assessing the RA and Alt a 1 complex in various settings, including lab tests with immune cells from individuals allergic to Alternaria, and experiments using sensitized mice. We found that when Alt a 1 was bound to RA, it significantly decreased certain immune responses associated with allergies, particularly the release of a key marker called IL-13 from immune cells.
Interestingly, this RA complex reduced the allergen's ability to bind to IgE, the antibody responsible for allergic reactions, suggesting that RA may mask allergic triggers. In our mouse experiments, those treated with the RA-bound allergen had fewer severe allergic reactions compared to those treated with the regular allergen.
Overall, our findings point towards the potential of using RA in therapies aimed at managing Alternaria allergies, suggesting a new, promising strategy for enhancing allergic immunotherapy.
Read More
9
We explored the impact of 9-cis-retinoic acid (9cisRA) on dendritic cells and their role in handling delayed-type allergies, particularly in hand eczema. Through our investigation, we found that 9cisRA creates a unique type of dendritic cell that plays a crucial part in reducing allergic responses.
These modified cells were shown to promote the formation of regulatory T cells, which help calm inflammation. However, while 9cisRA aids in adjusting immune responses, the study reveals these effects may not be strong enough to significantly improve allergic conditions on their own.
These modified cells were shown to promote the formation of regulatory T cells, which help calm inflammation. However, while 9cisRA aids in adjusting immune responses, the study reveals these effects may not be strong enough to significantly improve allergic conditions on their own.
Read More
9
We explored the effects of all trans retinoic acid (ATRA), a form of vitamin A, on the immune system and inflammation using a mice model. Encapsulating ATRA in liposomes improved its effectiveness compared to free ATRA.
Our findings revealed that both forms increased immune responses, but the encapsulated version showed stronger immunostimulatory and anti-inflammatory effects. This was demonstrated through various parameters, like antibody levels and responses to inflammation. While both types showed benefits, liposome-encapsulated ATRA emerged as the superior option in managing immune and inflammatory conditions in the studied mice.
Our findings revealed that both forms increased immune responses, but the encapsulated version showed stronger immunostimulatory and anti-inflammatory effects. This was demonstrated through various parameters, like antibody levels and responses to inflammation. While both types showed benefits, liposome-encapsulated ATRA emerged as the superior option in managing immune and inflammatory conditions in the studied mice.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Skin improvement
59 people found this helpful
25,000 IU is a high dose but suitable for my allergies and atrophoderma. Initially, I had skin breakouts, but after a day, my skin improved. Within two weeks, facial inflammation cleared up. The overall condition of my skin has significantly improved, a result I previously only achieved with injections.
Read More
9
Cold allergy cured
3 people found this helpful
After taking two doses of vitamin A, my years-long cold allergy vanished within a week. It seems to effectively target mucous membranes, providing me with significant relief.
Read More
0
Caution advised
3 people found this helpful
Experiencing severe urticaria and asthma after starting vitamin A was alarming. It worsened my eczema and asthma, leading me to stop usage out of concern. I urge allergy sufferers to be cautious with doses.
Read More
9
Winter nose issues
1 people found this helpful
I loved this vitamin A, as it alleviated my winter nose problems and allergies. I recommend it to anyone experiencing similar issues.
Read More
9
Skin conditions improved
This drug is excellent for skin problems. I noticed my allergies weren't triggered anymore, making it a great treatment option for me.
Read More
Frequently Asked Questions
9
Cold allergy cured
3 people found this helpful
After taking two doses of vitamin A, my years-long cold allergy vanished within a week. It seems to effectively target mucous membranes, providing me with significant relief.
9
Skin improvement
59 people found this helpful
25,000 IU is a high dose but suitable for my allergies and atrophoderma. Initially, I had skin breakouts, but after a day, my skin improved. Within two weeks, facial inflammation cleared up. The overall condition of my skin has significantly improved, a result I previously only achieved with injections.
0
Caution advised
3 people found this helpful
Experiencing severe urticaria and asthma after starting vitamin A was alarming. It worsened my eczema and asthma, leading me to stop usage out of concern. I urge allergy sufferers to be cautious with doses.
7.5
Allergy relief
47 people found this helpful
I suffered from various symptoms due to allergies, including dry skin and nasal discomfort. Taking vitamin A improved my skin condition, reduced dryness, and even helped with menstrual issues. I feel vitamin A is crucial for my well-being and may prevent deficiencies that lead to various complications.
9
Eczema gone
20 people found this helpful
Be cautious with the 25,000 IU dose; it's high but not toxic. It greatly helped my allergies and skin condition. After starting vitamin A, my eczema disappeared, and my skin improved dramatically. I recommend pairing it with vitamin E for better results.
9
Winter nose issues
1 people found this helpful
I loved this vitamin A, as it alleviated my winter nose problems and allergies. I recommend it to anyone experiencing similar issues.
9
Our exploration into the effects of vitamin A, particularly its active form known as retinoic acid, revealed some interesting insights regarding allergies. Vitamin A plays a key role in our immune system by helping to regulate immune responses, which is crucial for managing allergic reactions.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
9
We investigated the effects of retinoic acid (RA), a form of vitamin A, on allergies, particularly focusing on the mould allergen Alt a 1. By examining how RA interacts with this allergen, we aimed to understand if it could help alleviate allergic reactions.
Our study involved assessing the RA and Alt a 1 complex in various settings, including lab tests with immune cells from individuals allergic to Alternaria, and experiments using sensitized mice. We found that when Alt a 1 was bound to RA, it significantly decreased certain immune responses associated with allergies, particularly the release of a key marker called IL-13 from immune cells.
Interestingly, this RA complex reduced the allergen's ability to bind to IgE, the antibody responsible for allergic reactions, suggesting that RA may mask allergic triggers. In our mouse experiments, those treated with the RA-bound allergen had fewer severe allergic reactions compared to those treated with the regular allergen.
Overall, our findings point towards the potential of using RA in therapies aimed at managing Alternaria allergies, suggesting a new, promising strategy for enhancing allergic immunotherapy.
Our study involved assessing the RA and Alt a 1 complex in various settings, including lab tests with immune cells from individuals allergic to Alternaria, and experiments using sensitized mice. We found that when Alt a 1 was bound to RA, it significantly decreased certain immune responses associated with allergies, particularly the release of a key marker called IL-13 from immune cells.
Interestingly, this RA complex reduced the allergen's ability to bind to IgE, the antibody responsible for allergic reactions, suggesting that RA may mask allergic triggers. In our mouse experiments, those treated with the RA-bound allergen had fewer severe allergic reactions compared to those treated with the regular allergen.
Overall, our findings point towards the potential of using RA in therapies aimed at managing Alternaria allergies, suggesting a new, promising strategy for enhancing allergic immunotherapy.
4
We explored how vitamin A supplementation influences allergic diseases, including conditions like allergic rhinitis and asthma. By analyzing various randomized controlled trials, we found that while vitamin A may increase the risk of atopy—an allergic reaction—there was no clear connection to wheezing.
These findings suggest that vitamin A is not the reliable treatment for allergies some may hope for. More research is needed to clarify these effects and their implications for allergy management.
These findings suggest that vitamin A is not the reliable treatment for allergies some may hope for. More research is needed to clarify these effects and their implications for allergy management.
9
We explored the impact of 9-cis-retinoic acid (9cisRA) on dendritic cells and their role in handling delayed-type allergies, particularly in hand eczema. Through our investigation, we found that 9cisRA creates a unique type of dendritic cell that plays a crucial part in reducing allergic responses.
These modified cells were shown to promote the formation of regulatory T cells, which help calm inflammation. However, while 9cisRA aids in adjusting immune responses, the study reveals these effects may not be strong enough to significantly improve allergic conditions on their own.
These modified cells were shown to promote the formation of regulatory T cells, which help calm inflammation. However, while 9cisRA aids in adjusting immune responses, the study reveals these effects may not be strong enough to significantly improve allergic conditions on their own.
References
- Lotfi R. Retinoic Acid (RA): A Critical Immunoregulatory Molecule in Asthma and Allergies. Immun Inflamm Dis. 2024;12:e70051. doi:10.1002/iid3.70051
- Fakhimahmadi A, Roth-Walter F, Hofstetter G, Wiederstein M, Jensen SA, et al. Mould allergen Alt a 1 spiked with the micronutrient retinoic acid reduces Th2 response and ameliorates Alternaria allergy in BALB/c mice. Allergy. 2024;79:2144. doi:10.1111/all.16181
- Su J, Li T, Pan H. Association of vitamin A supplementation with immune-related allergic diseases: A meta-analysis. Front Nutr. 2022;9:984161. doi:10.3389/fnut.2022.984161
- Kraus LF, Scheurmann N, Frenzel DF, Tasdogan A, Weiss JM. 9-cis-Retinoic acid induces a distinct regulatory dendritic cell phenotype that modulates murine delayed-type allergy. Contact Dermatitis. 2018;78:41. doi:10.1111/cod.12868
- Dawicki W, Li C, Town J, Zhang X, Gordon JR. Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3CD49bFoxp3 regulatory T cells. J Allergy Clin Immunol. 2017;139:1608. doi:10.1016/j.jaci.2016.07.042
- Tan J, McKenzie C, Vuillermin PJ, Goverse G, Vinuesa CG, et al. Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways. Cell Rep. 2016;15:2809. doi:10.1016/j.celrep.2016.05.047
- Lee SY, Kim BS, Kwon SO, Oh SY, Shin HL, et al. Modification of additive effect between vitamins and ETS on childhood asthma risk according to GSTP1 polymorphism: a cross -sectional study. BMC Pulm Med. 2015;15:125. doi:10.1186/s12890-015-0093-0
- Grace VM, Rimashree B. Liposome encapsulated all trans retinoic acid (ATRA) has enhanced immunomodulatory and inflammation reducing activities in mice model. Anticancer Agents Med Chem. 2015;15:196.
- Maslova E, Hansen S, Strøm M, Halldorsson TI, Olsen SF. Maternal intake of vitamins A, E and K in pregnancy and child allergic disease: a longitudinal study from the Danish National Birth Cohort. Br J Nutr. 2014;111:1096. doi:10.1017/S0007114513003395
- Kim HH, Kim DS, Kim SW, Lim SH, Kim DK, et al. Inhibitory effects of Diospyros kaki in a model of allergic inflammation: role of cAMP, calcium and nuclear factor-κB. Int J Mol Med. 2013;32:945. doi:10.3892/ijmm.2013.1465
- Berlin GV. Evaluation of immunomodulatory and antitumor activity of all trans retinoic acid (ATRA) in solid tumor bearing mice. Immunopharmacol Immunotoxicol. 2013;35:110. doi:10.3109/08923973.2012.712137
