We examined a case of a 4-year-old boy who experienced severe bone pain and related symptoms after taking high doses of vitamin A for three months. Despite typical liver-related complications usually associated with vitamin A toxicity, he presented with significant musculoskeletal issues and skin changes. Following the discontinuation of vitamin A, the boy showed a remarkable recovery within two months. This case highlights that excessive vitamin A intake can lead to serious bone pain and other health problems, though he did not develop liver disease as expected.
Read More
7
ATRA shows mixed effects on pain
All-trans retinoic acid in combination with alpha-interferon and dexamethasone for advanced multiple myeloma.
We explored the effects of all-trans retinoic acid (ATRA) when combined with dexamethasone and alpha-interferon in treating advanced multiple myeloma. Out of 10 treated patients, eight completed the regimen.
Notably, three experienced a stable plateau phase with improvement in their overall performance and relief from bone pain. However, only two showed a lasting partial response, while three patients did not improve.
Thus, while there was some positive impact on bone pain, further research is needed to confirm these findings and assess ATRA's full potential.
Read More
Most Useful Reviews
9
Effective for bone pain
7 people found this helpful
I purchased this hoping to enhance my vision and improve my mucous membranes. Surprisingly, it was remarkably effective against my bone pain associated with hernias. After starting it, my back pain resolved in just four days. When I resumed taking it after a minor back injury, it worked instantly. I feel the combination with B vitamins has a positive effect, and while I'm unsure about my eyesight, my skin appears clearer.
Read More
9
Prevents bone pain
2 people found this helpful
I’ve managed my gout with medications for lowering uric acid, but I've read that vitamin A can help prevent bone pain. Initially, I took multiple liver oil tablets daily, but this product's high IU value allows me to take just one or two. It seems more effective when combined with 2g of vitamin C.
Read More
9
Eased bone pain
1 people found this helpful
Excellent! My bone pain has eased significantly. There's no need for compresses anymore.
We examined a case of a 4-year-old boy who experienced severe bone pain and related symptoms after taking high doses of vitamin A for three months. Despite typical liver-related complications usually associated with vitamin A toxicity, he presented with significant musculoskeletal issues and skin changes. Following the discontinuation of vitamin A, the boy showed a remarkable recovery within two months. This case highlights that excessive vitamin A intake can lead to serious bone pain and other health problems, though he did not develop liver disease as expected.
Read More
7
ATRA shows mixed effects on pain
All-trans retinoic acid in combination with alpha-interferon and dexamethasone for advanced multiple myeloma.
We explored the effects of all-trans retinoic acid (ATRA) when combined with dexamethasone and alpha-interferon in treating advanced multiple myeloma. Out of 10 treated patients, eight completed the regimen.
Notably, three experienced a stable plateau phase with improvement in their overall performance and relief from bone pain. However, only two showed a lasting partial response, while three patients did not improve.
Thus, while there was some positive impact on bone pain, further research is needed to confirm these findings and assess ATRA's full potential.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
All Reviews
Positive Reviews
Negative Reviews
9
Effective for bone pain
7 people found this helpful
I purchased this hoping to enhance my vision and improve my mucous membranes. Surprisingly, it was remarkably effective against my bone pain associated with hernias. After starting it, my back pain resolved in just four days. When I resumed taking it after a minor back injury, it worked instantly. I feel the combination with B vitamins has a positive effect, and while I'm unsure about my eyesight, my skin appears clearer.
Read More
9
Prevents bone pain
2 people found this helpful
I’ve managed my gout with medications for lowering uric acid, but I've read that vitamin A can help prevent bone pain. Initially, I took multiple liver oil tablets daily, but this product's high IU value allows me to take just one or two. It seems more effective when combined with 2g of vitamin C.
Read More
9
Eased bone pain
1 people found this helpful
Excellent! My bone pain has eased significantly. There's no need for compresses anymore.
Read More
9
Reduced bone pain
1 people found this helpful
Since my cancer diagnosis and reconstruction, I’ve suffered from joint pain and inflammation. Since starting NAC over two years ago, I’ve noticed a huge difference; my bone pain has greatly diminished. I store them in the fridge due to a sulphur smell, but they haven’t caused any upset.
Read More
0
Stopped due to pain
4 people found this helpful
When I took this daily, I experienced joint pain and brittle bones, so I've stopped. I hadn’t realised that excessive vitamin A could be harmful. I wonder if my body will recover to its original state.
Bone pain is a discomfort or ache that originates within the bones themselves and can range from mild to severe. It is different from muscle or joint pain, as it directly affects the skeletal structure. Bone pain can be caused by a variety of factors, including injuries, medical conditions such as osteoarthritis or osteoporosis, infections, or tumors. Symptoms may vary depending on the underlying cause but often include a dull, penetrating ache that may worsen with movement or pressure.
If you're experiencing persistent bone pain, it’s essential to consult with a healthcare professional for a proper diagnosis and treatment plan. Imaging tests like X-rays, MRI, or CT scans may be utilized to determine the root cause of the pain. Treatment can vary widely, ranging from medications to alleviate pain and inflammation to physical therapy or, in some cases, surgical interventions. Understanding the underlying cause is crucial to effectively managing bone pain and ensuring the best path to recovery.
Vitamin A is a fat-soluble vitamin that's essential for several critical bodily functions, including vision, immune response, and cell differentiation. It comes in two primary forms: preformed vitamin A (retinol) found in animal products like liver, fish, and dairy, and provitamin A carotenoids, primarily found in colorful fruits and vegetables such as carrots, sweet potatoes, and spinach. The body can convert carotenoids into retinol, making these plant sources a valuable dietary option, especially for those following a vegetarian or vegan lifestyle.
Aside from its role in maintaining healthy vision—particularly in low-light conditions—vitamin A plays a significant role in skin health and the functioning of the heart, lungs, and kidneys. It also supports the immune system by promoting the development and function of white blood cells. While it's uncommon to experience a deficiency in countries where a balanced diet is accessible, a lack of vitamin A can lead to serious health problems, including night blindness and increased susceptibility to infections. In contrast, excessive intake of vitamin A, particularly through supplements, can be toxic and lead to several health issues, making it crucial to maintain a balanced intake.
Based on user reviews, the time it takes to see results from this supplement for bone pain varies, with many users reporting improvements within a short period. For instance, one individual noted a significant easing of their bone pain after just four days of use Read Review. Another user mentioned that after five days, not only did their severe dry eye syndrome improve, but their bone pain was alleviated as well Read Review. This suggests that some users can experience noticeable relief in under a week.
However, other users indicate the need for longer usage to fully gauge effectiveness. One individual emphasized that for optimal benefits, they needed to take the supplement for an extended duration following an injury Read Review. Additionally, a user who has been on the supplement for nearly three years reported ongoing improvements in their health related to bone pain Read Review. Overall, while some may see quick results, consistent long-term use appears necessary for others to achieve full benefits.
While there is some indication that specific forms of vitamin A, particularly all-trans retinoic acid (ATRA), may have beneficial effects on bone pain, the evidence remains preliminary. A study examining ATRA in combination with other treatments for advanced multiple myeloma reported that three out of ten patients experienced relief from bone pain during the therapy, although results varied significantly among patients [2]. This suggests a possible, albeit limited, role of ATRA in managing bone pain associated with certain medical conditions.
Additionally, another study drew attention to bone pain linked to excessive vitamin A intake, noting a case where a child experienced severe discomfort after taking high doses. After discontinuing vitamin A, the child showed significant improvement [1]. While these research findings highlight the complex relationship between vitamin A and bone health, the overall support for vitamin A or its derivatives as a reliable supplement for managing bone pain is still lacking. Further research is essential to fully understand their efficacy and safety.
Users have reported a variety of improvements in their symptoms after using this supplement, particularly in relation to bone pain. For example, one reviewer experienced significant relief from back pain within just four days of starting the supplement, particularly noting its effectiveness when combined with B vitamins Read Review. Similarly, another user noted a considerable easing of bone pain, stating that they no longer required compresses for relief Read Review. Enhanced management of chronic conditions such as gout was also reported, with some users finding that fewer tablets were necessary while still achieving satisfactory results Read Review.
However, it's important to note that individual experiences can vary significantly. While some users have found rapid relief, others have indicated that consistent long-term use is essential for optimal results, as highlighted by a user with joint pain due to a cancer diagnosis who noted a considerable reduction in bone pain after over two years of use Read Review. Overall, while many aspects of symptom improvement, particularly concerning bone pain, have been positively noted, results can differ based on personal health circumstances and duration of usage.
Users have reported varied experiences when combining this supplement with others for managing bone pain. One reviewer highlighted that pairing the supplement with B vitamins significantly improved their back pain, noting relief within just four days of use Read Review. Another user found that combining the supplement with vitamin C allowed them to manage their gout more effectively while reducing the number of supplements they needed to take Read Review. These combinations seem to amplify the benefits of the supplement in alleviating bone pain, suggesting that users may achieve better results when integrating it with other supportive nutrients.
Conversely, not all feedback was positive regarding additional supplementation. One user reported joint pain and brittle bones after taking the supplement daily, which led them to stop use, raising concerns about excessive vitamin A Read Review. Additionally, while some individuals experienced significant pain relief after a short period of use, others emphasized the necessity of longer-term usage for full benefits, particularly after serious health diagnoses Read Review. Overall, combining this supplement with other vitamins and focused support can enhance effectiveness, but users should proceed with caution and consider individual health factors.
Based on user reviews, there's a varied consensus regarding the effective dosage of Vitamin A for treating bone pain. Some users reported significant relief from bone pain with doses as low as one or two capsules daily due to the high IU (International Unit) concentration in their supplements. For instance, one reviewer mentioned they transitioned from taking multiple liver oil tablets to just one or two of the Vitamin A product, which seemed effective in alleviating their bone pain associated with gout Read Review.
Conversely, other users highlighted the importance of moderation. One reviewer experienced joint pain and brittle bones after daily intake, pointing out that excessive Vitamin A can be detrimental Read Review. Additionally, another user noted improvements in bone pain after five days of usage but expressed caution about long-term use Read Review. This suggests that while Vitamin A may offer relief for some individuals, dosage adjustments and mindful consumption are crucial to prevent potential side effects.
9
Effective for bone pain
7 people found this helpful
I purchased this hoping to enhance my vision and improve my mucous membranes. Surprisingly, it was remarkably effective against my bone pain associated with hernias. After starting it, my back pain resolved in just four days. When I resumed taking it after a minor back injury, it worked instantly. I feel the combination with B vitamins has a positive effect, and while I'm unsure about my eyesight, my skin appears clearer.
7.5
Improved bone pain
3 people found this helpful
After five days of use, my severe dry eye syndrome significantly improved, and my bone pain was also alleviated. I no longer feel pain in my eyes, and the acne on my skin has improved as well. However, I understand that long-term use of vitamin A isn't advisable, so I may take it again after a break.
7.5
Joint pain relief
1 people found this helpful
Works well! After spraining my elbow joint, the pain subsided. I just need to take it for a longer duration.
7.5
Bone pain management
1 people found this helpful
I’ve been taking it for nearly three years due to collagen disease. My health is gradually improving; even after having my lower wisdom tooth removed, I didn't experience severe bone pain post-extraction. I took an extra pill beforehand, which may have helped in avoiding discomfort.
9
Eased bone pain
1 people found this helpful
Excellent! My bone pain has eased significantly. There's no need for compresses anymore.
9
Prevents bone pain
2 people found this helpful
I’ve managed my gout with medications for lowering uric acid, but I've read that vitamin A can help prevent bone pain. Initially, I took multiple liver oil tablets daily, but this product's high IU value allows me to take just one or two. It seems more effective when combined with 2g of vitamin C.
9
Reduced bone pain
1 people found this helpful
Since my cancer diagnosis and reconstruction, I’ve suffered from joint pain and inflammation. Since starting NAC over two years ago, I’ve noticed a huge difference; my bone pain has greatly diminished. I store them in the fridge due to a sulphur smell, but they haven’t caused any upset.
0
Stopped due to pain
4 people found this helpful
When I took this daily, I experienced joint pain and brittle bones, so I've stopped. I hadn’t realised that excessive vitamin A could be harmful. I wonder if my body will recover to its original state.
7
ATRA shows mixed effects on pain
All-trans retinoic acid in combination with alpha-interferon and dexamethasone for advanced multiple myeloma.
We explored the effects of all-trans retinoic acid (ATRA) when combined with dexamethasone and alpha-interferon in treating advanced multiple myeloma. Out of 10 treated patients, eight completed the regimen.
Notably, three experienced a stable plateau phase with improvement in their overall performance and relief from bone pain. However, only two showed a lasting partial response, while three patients did not improve.
Thus, while there was some positive impact on bone pain, further research is needed to confirm these findings and assess ATRA's full potential.
We examined a case of a 4-year-old boy who experienced severe bone pain and related symptoms after taking high doses of vitamin A for three months. Despite typical liver-related complications usually associated with vitamin A toxicity, he presented with significant musculoskeletal issues and skin changes. Following the discontinuation of vitamin A, the boy showed a remarkable recovery within two months. This case highlights that excessive vitamin A intake can lead to serious bone pain and other health problems, though he did not develop liver disease as expected.
References
Baineni R, Gulati R, Delhi CK. Vitamin A toxicity presenting as bone pain. Arch Dis Child. 2017;102:556. doi:10.1136/archdischild-2016-310631
Musto P, Sajeva MR, Sanpaolo G, D'Arena G, Scalzulli PR, et al. All-trans retinoic acid in combination with alpha-interferon and dexamethasone for advanced multiple myeloma. Haematologica. 1997;82:354.